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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 1-37页

作者： yu huang Hui Fan Huihui Ti School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Province Precise Medicine Big Date of Traditional Chinese Medicine Engineering Technology Research Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

关键词： Tumor immunotherapy Tumor micr oenvir onment Nanomedicine Tumor repr ogramming

Recent progress of MgO-based materials in CO_(2) adsorption and conversion:Modification methods,reaction condition,and CO_(2) hydrogenation

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Chinese Chemical Letters 2024年第5期35卷 57-65页

作者： Zixuan Zhu Xianjin Shi Yongfang Rao yu huang Key Laboratory of Aerosol Chemistry&Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of Sciences(CAS)Xi’an 710061China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

Integrated CO_(2) capture and conversion of(ICCC)is one of the most effective solutions to reduce anthropogenic CO_(2) emissions,which has attracted extensive public *** functional materials(DFMs),including adsorbent and catalyst,are the key components to achieve *** oxide(MgO)is an ideal adsorbent for ICCC,since it is characterized by high theoretical adsorption capacity,low cost,low energy consumption and extensive *** can also be used as DFMs in combination with the Ni *** not only can act as an adsorbent in DFMs but also enhance the catalytic performance of *** review summarizes the advantages and modification methods of MgO as adsorbent and the influence of its adsorption conditions on the adsorption ***,the important role of MgO in facilitating the catalytic conversion of CO_(2) is *** research focuses are proposed for the development of MgO based DFMs with high adsorption capacity,high stability,conversion,and selectivity as well as low cost and energy consumption.

关键词： CO_(2) ICCC MgO Adsorption Conversion

Promoted surface charge density from interlayer Zn–N_(4) configuration in carbon nitride for enhanced CO_(2) photoreduction

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Nano Research 2024年第4期17卷 2400-2409页

作者： Xianjin Shi yu huang Gangqiang Zhu Wei Peng Meijuan Chen State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China

The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy ***,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCN)photocatalyst with Zn single atoms(Zn1/CN)was designed and synthesized for CO_(2) *** results of the CO_(2) photoreduction studies show that the CO and CH_(4) yields of Zn1/CN increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified ***+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCN in the Zn–N_(4) *** characterizations indicate that the interlayer Zn–N_(4) configuration can amplify light absorption and establish an interlayer charge transfer ***-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–N_(4) configuration,which increases its surface charge ***,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) *** work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts.

关键词： single-atom catalysts photocatalytic CO_(2)reduction interlayer modification charge transfer dynamics surface charge density

Interaction Mechanisms between Natural Debris Flow and Rigid Barrier Deflectors:A New Perspective for Rational Design and Optimal Arrangement

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1679-1699页

作者： yu huang Beilei Liu Dianlei Feng Hao Shi Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai200092China

Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention ***,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further *** date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster *** investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without *** model was validated using laboratory flume test data from the ***,the model was used to investigate the influence of the deflector angle and multi-barrier *** optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow *** investigation considered the energy dissipation process,retention efficiency,and dead-zone *** with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris *** for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.

关键词： Rigid barrier deflectors deflector angle single-barrier dual-barrier arrangements viscous debris flow over-spilling delta-plus-SPH

Sutured scleral fixation of existing subluxated/dislocated acrylic one-piece intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 665-669页

作者： Wei-yu huang yung-Jen Chen Department of Ophthalmology Chi Mei Medical CenterTainan City 710TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalKaohsiung City 833TaiwanChina

AIM:To evaluate the visual and refractive outcomes in cases after sutured scleral fixation of existing subluxated or dislocated acrylic one-piece intraocular lenses(IOLs).METHODS:This study retrospectively enrolled a consecutive series of patients who underwent a surgery of sutured existing subluxated or dislocated IOLs from October 2018 to June *** patients underwent comprehensive preoperative and postoperative ophthalmologic examination,and data were collected including age,sex,surgical indications,best-corrected visual acuity,refractive error,intraocular *** of intraoperative and postoperative surgical complications was ***:A total of 20 consecutive cases were enrolled for analysis with mean final follow-up period 9.8±*** acuity improved from a mean of 0.35(0.46±0.32 logMAR)preoperatively to 0.61(0.21±0.18 logMAR)at the 3-month follow-up(P=0.002).The mean amount of preoperative keratometric astigmatism and total postoperative refractive astigmatism was-1.24±0.80 diopters(D)and-1.42±0.97 D,*** was no statistically significant difference between preoperative and postoperative astigmatism(P=0.156).The mean IOL-induced astigmatism was-0.23±0.53 *** mean spherical equivalent at the 3-month follow-up was-0.1±0.94 *** major complications were noted during the follow-up ***:Surgical techniques using sutured scleral fixation of existing subluxated or dislocated acrylic one-piece IOLs result in favorable visual and refractive outcomes without major complications.

关键词： intraocular lens dislocation intraocular lens subluxation lens dislocation lens subluxation scleral fixation

Wave Attenuation and Turbulence Driven by Submerged Vegetation Under Current-Wave Flow

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China Ocean Engineering 2024年第4期38卷 602-611页

作者： huang yu-ming Ding Lei WANG Yi-fei CHEN Ben YANG Xiao-yu DOU Xi-ping School of Water Resources and Hydropower Engineering Wuhan UniversityWuhan430072China Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China

A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave *** vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged *** show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current ***,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave *** the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and *** time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s *** the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the *** vegetation drag coefficients are obtained by a calibration *** empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.

关键词： wave attenuation rigid vegetation following and opposing currents turbulent kinetic energy

The new challenges for the development of NH_(3)-SCR catalysts under new situation of energy transition in power generation industry

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Chinese Chemical Letters 2024年第6期35卷 95-103页

作者： Feibin Wei Yongfang Rao yu huang Wei Wang Hui Mei Science and Technology on Thermostructural Composite Materials Laboratory School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Aerosol Chemistry and Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

NH_(3)-SCR was one of the most promising de NO_x technologies and it has been widely applied in industrial NO_x ***,with the further development of energy transformation in power generation sector,the development of NH_(3)-SCR catalysts is facing some new *** is becoming an urgent problem to solve low catalytic activity and stability of NH_(3)-SCR catalysts at the working condition of ultra-low temperature(≤200℃)and high concentrations of H_(2)O+SO_(2) due to the gradual deployment of new energy power ***,the traditional coal-fired power plants would need flexible operation with the increasing share of renewable energy *** NH_(3)-SCR catalysts which were applied in coal-fired power industry would be requested to work in a wide temperature window from 200℃ to 500℃ in the near ***,in this review,we summarized the progress of NH_(3)-SCR catalysts in solving these different industrial problems in recent *** the research directions which were deserved to be focused on the development of NH_(3)-SCR catalysts for the energy transition of power generation sector are proposed.

关键词： NH_(3)-SCR NOx reduction Power generation Ultra-low temperature Wide temperature windows

Characterization of the pheromone receptors in Mythimna loreyi reveals the differentiation of sex pheromone recognition in Mythimna species

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Insect Science 2024年第1期31卷 173-185页

作者： Chan Wang Lei Liu Tian-yu huang yu Zhang Yang Liu Gui-Rong Wang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Guangdong Laboratory of Lingnan Modern Agriculture ShenzhenGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina School of Forestry Northeast Forestry UniversityHarbinChina Key Laboratory of Biohazard Monitoring Green Prevention and Control for Artificial GrasslandMinistry of Agriculture and Rural AffairsInstitute of Grassland Research of Chinese Academy of Agricultural SciencesInner Mongolia HohhotChina

Pheromone receptors(PRs)are key proteins in the molecular mechanism of pheromone recognition,and exploring the functional differentiation of PRs between closely related species helps to understand the evolution of moth mating *** components of the agricultural pest Mythimna loreyi have turned into(Z)-9-tetradecen-1-yl acetate(Z9-14:OAc),(Z)-7-dodecen-1-yl acetate(Z7-12:OAc),and(Z)-11-hexadecen-1-yl acetate,while the composition differs from that of *** in the genus *** understand the molecular mechanism of pheromone recognition,we sequenced and analyzed antennal transcriptomes to identify 62 odorant receptor(OR)*** expression levels of all putative ORs were analyzed using differentially expressed gene *** candidate PRs were quantified and functionally characterized in the Xenopus oocytes ***6 and MlorPR3 were determined to be the receptors of major and minor components Z9-14:OAc and Z7-12:***1 and female antennae(FA)-biased MlorPR5 both possessed the ability to detect pheromones of sympatric species,including(Z,E)-9,12-tetradecadien-1-ol,(Z)-9-tetradecen-1-ol,and(Z)-*** on the comparison of PR functions between *** and ***,we analyzed the differentiation of pheromone recognition mechanisms during the evolution of the mating systems of 2 Mythimna species.

关键词： antennal transcriptome Mythimna loreyi pheromone receptor sex pheromone Xenopus oocyte

WeldNet:A voxel-based deep learning network for point cloud annular weld seam detection

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Science China(Technological Sciences) 2024年第4期67卷 1215-1225页

作者： WANG Hui RONG YouMin XU JiaJun XIANG SongMing PENG YiFan huang yu State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Weld seam detection is an important part of automated *** present,few studies have been conducted on annular weld seams,and a lot of defects exist in the point cloud model of the tube sheet obtained by RGB-D cameras and photography *** at the above problems,this paper proposed an annular weld seam detection network named WeldNet where a voxel feature encoding layer was adaptively improved for annular weld seams,the sparse convolutional network and region proposal network(RPN)were used to detect annular weld seam position,and an annular weld seam detection loss function was ***,an annular weld seam dataset was established to train the *** with the random sampling consistency(RANSAC)method,WeldNet has a higher detection accuracy,as well as a higher detection success rate which has increased by 23%.Compared with U-Net,WeldNet has been proven to achieve a better detection result,and the intersection over the union of the weld seam detection is improved by 17.8%.

关键词： deep learning point cloud weld seam detection welding annular weld seam