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Journal of Mathematical Research and Exposition 2010年第1期30卷 186-190页

作者： hua ming su You Du huaNG Jie PAN Department of Mathematics Hefei University of Technology Anhui 230009 P. R. China

This paper presents a generalized form and its application to a problem, which was proposed by F.P. Callham.

关键词： mean value theorem difference quotient difference polynomial.

Stereochemical effects in mass spectra—Studies on mass spectra of epimers of podophyllotoxin and its derivatives

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Chinese Journal of Chemistry 1986年第1期4卷 35-41页

作者： CHEN Yao-Zu hua su-ming CHEN Nen-Yu Department of Chemistry, Lanzhou University, Lanzhou Department of Chemistry Lanzhou University Lanzhou

Mass spectra of thirteen epimers of podophyllotoxin and its derivatives have been exa-mined. By means of high resolution mass spectrometry, metastable ion scanning and isotope-labeling techniques, the effects of configuration of C3-OH and condensed lactone ring on the frag-mentation pattern and the relative abundanees of characteristic ions in the mass spectra of these com-pounds have been studied and rationalized.

关键词： Li Stereochemical effects in mass spectra Studies on mass spectra of epimers of podophyllotoxin and its derivatives

Apoptosis and necrosis of HeLa cells in response to low-energy ion radiation

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Nuclear Science and Techniques 2006年第4期17卷 222-226页

作者： ZHANG Feng-Qiu YA Hui-Yuan LI Jing-Yuan PENG Jian-Jun FANG hua-Sheng su ming-Jie QIN Guang-Yong Henan Key Lab of lonbeam Bioengineering Zhengzhou University Zhengzhou 450052 China

The aim of this study was to investigate the damage of low-energy ions to HeLa cells and to particularly examine the relationship between apoptotic and necrotic effects and the low-energy ion radiation. In this study, HeLa cells were irradiated by low-energy ions (30keV N+) at different doses. The level of apoptosis and necrosis was evalu- ated using flow cytometry. Since vacuum is required for experimental low-energy ion generation and irradiation, the cells must be placed in vacuum. Mineral oil was used to prevent dehydration of cells. The results show that the apoptotic rate reached 7.09% when the ion implantation dose was 1 × 1015 ions/cm2; and when the cells were exposed to and implanted at 2 × 1015 ions/cm2 dose, the apoptotic rate was higher than that at 1 × 1015 ions/cm2, and the necrotic rate was 15.63%. In addition, the survival fraction gradually decreased with the increase in implantation dose. Some rela- tionships have been found between the radiation-induced apoptosis and the incubated time after irradiation.

关键词：人宫颈癌传代细胞细胞凋亡细胞增殖低能离子辐射流式细胞测量术

Design methodology of a mini-missile considering flight performance and guidance precision

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Journal of Systems Engineering and Electronics 2024年第1期35卷 195-210页

作者： ZHANG Licong GONG Chunlin su hua ANDREA Da Ronch Shaanxi Aerospace Flight Vehicle Design Key Laboratory School of AstronauticsNorthwestern Polytechnical UniversityXi’an 710072China Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171BJUnited Kingdom

The design of mini-missiles(MMs)presents several novel *** stringent mission requirement to reach a target with a certain precision imposes a high guidance *** miniaturization of the size of MMs makes the design of the guidance,navigation,and control(GNC)have a larger-thanbefore impact on the main-body design(shape,motor,and layout design)and its design objective,i.e.,flight *** a trade-off between flight performance and guidance precision,all the relevant interactions have to be accounted for in the design of the main body and the GNC ***,a multi-objective and multidisciplinary design optimization(MDO)is *** pertinent to motor,aerodynamics,layout,trajectory,flight dynamics,control,and guidance are included in the proposed MDO *** optimization problem seeks to maximize the range and minimize the guidance *** problem is solved by using the nondominated sorting genetic algorithm *** optimum design that balances a longer range with a smaller guidance error is ***,lessons learned about the design of the MM and insights into the trade-off between flight performance and guidance precision are given by comparing the optimum design to a design provided by the traditional approach.

关键词： mini-missiles(MMs) guidance navigation and control(GNC)system multi-objective optimization multidisciplinary design optimization(MDO) flight performance guidance precision

Hierarchically Macroporous Zeolite ZSM-5 Microspheres for Efficient Catalysis

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Chemical Research in Chinese Universities 2024年第4期40卷 704-711页

作者： ZHENG mingdan CHEN Ya LIU Zhan LYU Jiamin YE Bo suN ming-Hui CHEN Li-hua su Bao-Lian State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070P.R.China Laboratory of Inorganic Materials Chemistry(CMI) University of Namur5000NamurWalloniaBelgium

Hollow zeolite microspheres have recently attracted much attention for their applications in catalysis,microreactors and ***,we present hierarchically structured zeolite ZSM-5 microspheres with unique,abundant macropores that allow more efficient use for *** hierarchically macroporous zeolite ZSM-5 microspheres are synthesized under the assistance of water/oil emulsions and using polystyrene nanospheres as *** zeolite microsphere is assembled by uniform hollow zeolite *** large inner cavities and thin zeolite shells lead to smaller diffusion channel and higher improved accessibility to active sites,contributing to high catalytic performance in the catalytic conversion of benzyl alcohol in *** novel zeolite microspheres with impressive performance will be applied to numerous other industrial catalytic reactions.

关键词： Hierarchically porous structure Hollow structure Microsphere Zeolite ZSM-5 Alkylation

Optical system for extremely large spectroscopic survey telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 158-174页

作者： Ding-qiang su hua Bai Xiangyan Yuan Xiangqun Cui Key Laboratory of the Ministry of Education School of Astronomy and Space ScienceNanjing UniversityNanjing 210023China Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Nanjing 211135China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

This article presents research work on a spectroscopic survey *** idea is as follows:for such a telescope,a pure reflecting optical system is designed,which should have an aperture and a field of view(FOV)both as large as possible and excellent image quality,and then a strip lensm(lens-prism)atmospheric dispersion corrector(S-ADC)is added,only for correcting the atmospheric *** the fund limitation and the simplicity of scaling up,some 12-m telescopes are designed as ***,Korsch,and Meinel put forward the four-mirror Nasmyth systems I and II,which are used in this *** of 1.5°,2°,and 2.5°are *** all systems,the image qualities are *** the S-ADC relaxes the optical glass size restriction,this 12-m telescope with a FOV of 2.5°can be magnified in proportion to a 16-m *** etendue(from Frenchétendue)and focal surface will now be the largest in the *** such a telescope,a pure reflecting optical system can also be obtained.A subsequent coudésystem is designed with excellent image quality.

关键词： telescopes spectroscopic survey

UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua su Lian-lin YAN Shuai Department of General surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(Psuppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

SnO_(2)/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage

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Rare Metals 2024年第7期43卷 3032-3043页

作者： Gui-Long Liu Zi-Han Zhao Jin-Ke Shen Zi-Bo Zhao Nai-Teng Wu Dong-Lei Guo Wei-Wei Yuan Yong Liu Ye-hua su Xian-ming Liu Luoyang Key Laboratory of Green Energy Materials College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Inner Mongolia Shijie Chemical Co. Ltd.Alxa League 737300

Sn-based metal organic complexes with coordination bonds,multi-active sites,and high theoretical capacity have attracted much attention as promising anodes for lithium ion ***,the low electrical conductivity and huge volume changes restricted their electrochemical stability and practical ***,Snbased anode with superior electrochemical performance,including a high reversible capacity of 1050.1 mAh·g^(-1)at 2 A·g^(-1)and a stable capacity of 1105.5 mAh·g^(-1)after 500 cycles at 1 A·g^(-1),was fabricated via a low-temperature calcination strategy from Sn metal organic *** low-temperature calcination process regulates Sn-O bond and prevents the agglomeration of SnO_(2),generating highly dispersed SnO_(2) decorated metal organic complexes and providing sufficient active sites for ion *** situ characterizations expound that the undecomposed Sn-based metal organic complexes could be transformed into SnO_(2) during lithiation and delithiation,which enhances the electrical conductivity and induces a strong pseudo-capacitive behavior,accelerating the electrochemical kinetics;the multiple solid electrolyte interface with inflexible LiF and flexible ROCO_(2)Li buffers the volume variation of the electrode,resulting in its high electrochemical *** work provides a simple strategy for preparing excellent Sn-based anodes from metal organic complexes and reveals the lithium storage mechanism of the prepared Snbased anode.

关键词： Metal organic complex Lithium ion battery Electrochemical activation Low-temperature activation Partial decomposition

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： su-su Feng Si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye ming-Lin Pan Bo Hang Jian-hua Mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-Yi huaNG Lan-Jin WU Zhi-Qing QIN Ying huaNG Wan-Zhong huaNG Ting ZENG Xin HAO hua-Bin su Qiang su Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis