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Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2018-2037页

作者： Li Wang Wei-hua Gong department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy of the digestive *** to global 2018 cancer data,GC has the fifth-highest incidence and the thirdhighest fatality rate among malignant *** than 60%of GC are linked to infection with Helicobacter pylori(***),a gram-negative,active,microaerophilic,and helical *** parasite induces GC by producing toxic factors,such as cytotoxin-related gene A,vacuolar cytotoxin A,and outer membrane ***,or iron-dependent programmed cell death,has been linked to GC,although there has been little research on the link between *** infection-related GC and *** To identify coregulated differentially expressed genes among ferroptosis-related genes(FRGs)in GC patients and develop a ferroptosis-related prognostic model with discrimination *** Gene expression profiles of GC patients and those with ***-associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus(GEO)*** FRGs were acquired from the FerrDb database.A ferroptosis-related gene prognostic index(FRGPI)was created using least absolute shrinkage and selection operator–Cox *** predictive ability of the FRGPI was validated in the GEO ***,we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and *** Four hub genes were identified(NOX4,MTCH1,GABARAPL2,and SLC2A3)and shown to accurately predict GC and ***-associated *** FRGPI based on the hub genes could independently predict GC patient survival;GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk *** FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease ***,the gene expression levels of common immune checkpoint proteins dramatically increased in the highrisk subgroup of the FRGPI *** hub genes were also conf

关键词： Ferroptosis Gastric cancer Helicobacter pylori infection Immune checkpoint protein Prognostic model Ferroptosis-related gene prognostic index

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Transition prediction of a hypersonic boundary layer over a cone at small angle of attack——with the improvement of e^N method

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Science china.Physics,Mechanics & Astronomy) 2009年第1期52卷 115-123页

作者： su CaiHong1 & ZHOU Heng1,2 1 department of Mechanics, Tianjin university, Tianjin 300072, china.2 Liu-Hui Center of Applied mathematics, Nankai university and Tianjin university, Tianjin 300072, china 1. department of Mechanics Tianjin University Tianjin 300072 China 2. Liu-Hui Center of Applied mathematics Nankai University and Tianjin University Tianjin 300072 China

The problem of transition prediction for hypersonic boundary layers over a sharp cone has been studied in this work. The Mach number of the oncoming flow is 6, the cone half-angle is 5°, and the angle of attack is 1°. The conventional e N method is used, but the transition location so obtained is obviously incorrect. The reason is that in the conventional method, only the amplifying waves are taken into account, while in fact, for different meridians the decay processes of the disturbances before they begin to grow are different. Based on our own previous work, new interpretation and essential improvement for the e N method are proposed. Not only the amplification process but also the decay process is considered. The location, where by linear stability theory, the amplitude of disturbance wave is amplified from its initial small value to 1%, is considered to be the transition location. The new result for transition prediction thus obtained is found to be fairly satisfactory. It is also indicated that for the calculation of base flow, boundary layer equations can be used for a small angle of attack. Its computational cost is much smaller than those for DNS.

关键词： angle of attack cone transition eN method

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Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang su Long sun hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina department of Colorectal Tumor surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina department of Cardiothoracic surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore department of Neurosurgery and department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

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Transition prediction for supersonic and hypersonic boundary layers on a cone with angle of attack

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Science china.Physics,Mechanics & Astronomy) 2009年第8期52卷 1223-1232页

作者： su CaiHong1 & ZHOU Heng1,2 1 department of Mechanics,Tianjin university,Tianjin 300072,china.2 Liu-Hui Center of Applied mathematics,Nankai university and Tianjin university,Tianjin 300072,china department of Mechanics Tianjin University Tianjin 300072 China Liu-Hui Center of Applied mathematics Nankai University and Tianjin University Tianjin 300072 China

Transition prediction for boundary layers has always been one of the urgent problems waiting for a solution for the development of aero-space technology,yet there is no reliable and effective method due to the complexity of the *** eN method has been regarded as an effective method for the transition prediction of boundary ***,it heavily relies on experiment or *** in cases with three-dimensional base flow,for instance,the boundary layer on a cone with angle of attack,the result of its application is not *** authors have found its cause and proposed the method for its improvement,which did yield the fairly satisfactory result for a given test case,and also did not rely so much on experiment or ***,before people can really apply this method to practical problems,more test cases have to be *** this paper,more test cases for the application of the improved eN method to problems of transition prediction of supersonic and hypersonic boundary layers on cones with angle of attack will be *** results are compared with those obtained by experiments and/or direct numerical simulations,confirming that the improved eN method is effective and *** also find that there may be more than one ZARF for each meridian plane,and which one should be chosen for the eN method has been clarified.

关键词： angle of attack cone boundary layer transition eN method

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Omnidirectional color wavelength tuning of stretchable chiral liquid crystal elastomers

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Light(Science & Applications) 2024年第6期13卷 1062-1074页

作者： Seungmin Nam Wontae Jung Jun Hyuk Shin su Seok Choi department of Electrical Engineering Pohang University of Science and Technology(POSTECH)PohangKorea

Wavelength-tunable structural colors using stimuli-responsive materials,such as chiral liquid crystals(CLCs),have attracted increasing attention owing to their high functionality in various tunable photonic ***,on-demand omnidirectional wavelength control is highly desirable from the perspective of wavelength-tuning ***,despite numerous previous research efforts on tunable CLC structural colors,only mono-directional wavelength tuning toward shorter wavelengths has been employed in most studies to *** this study,we report the ideally desired omnidirectional wavelength control toward longer and shorter wavelengths with significantly improved tunability over a broadband wavelength *** using areal expanding and contractive strain control of dielectric elastomer actuators(DEAs)with chiral liquid crystal elastomers(CLCEs),simultaneous and omnidirectional structural color-tuning control was *** breakthrough in omnidirectional wavelength control enhances the achievable tuning freedom and versatility,making it applicable to a broad range of high-functional photonic applications.

关键词： tuning tunable directional

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Ambient formaldehyde concentrations in summer in 30 Chinese cities and impacts on air cleaning of built environment

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Energy and Built Environment 2024年第4期5卷 493-499页

作者： Shuolin Qiu Zirui He Guangdong Liu Zhen Ding Zhongming Bu Jianping Cao Wenjing Ji Wei Liu Chunxiao su Xinke Wang Fan Liu Ting Li hua Qian Cong Liu School of Energy and Environment Southeast UniversityNanjingJiangsu210096China china.Green Development Investment Group Co.LTD Beijing100000China department of Environmental Health Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsu210009China department of Energy and Environmental System Engineering Zhejiang University of Science and TechnologyHangzhouZhejiang310023China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong510006China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China Institute for Health and Environment Chongqing University of Science and TechnologyChongqing401331China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an710049ShaanxiChina tsinghua university Beijing100084China

Formaldehyde is an important carcinogen commonly found *** indoor sources have been intensively *** study on outdoor formaldehyde concentration,which is potentially an important source to indoors,remains *** study attempts to characterize temporal and spatial distribution of the atmospheric formalde-hyde concentration in Chinese *** variation of ambient formaldehyde was examined in 6 cities and peak hours were identified between 12:00 pm and 3:00 ***,outdoor formaldehyde concentrations were measured in the peak hours in 30 cities during the summer months of Jul.-Aug.,*** formaldehyde concentrations in the peak hours fell into a range of 0.005-0.087 mg/m^(3)(median value is 0.027 mg/m^(3)),87.7%of which have exceeded the chronic reference exposure criteria of 0.009 mg/m^(3) set by Office of Environmental Health Hazard *** risk analysis suggests that exposure to ambient formaldehyde could cause a median carcinogenic risk of 1.9×10^(−5)(3.17×10^(−6)-6.13×10^(−5)),higher than threshold limit of 10−*** correlation analysis of the 30 cities shows that ambient summertime atmospheric formaldehyde concentrations of the city are positively correlated with its Gross Domestic Product(r=0.48).We also found that the outdoor formaldehyde concentrations in urban areas(median:0.017 mg/m^(3))is slightly higher than those in suburban areas(median:0.013 mg/m^(3)).Results here prove that outdoor formaldehyde is ubiquitous in Chinese cities and reduces effectiveness of ventilation in dilution indoor *** it would underestimate air cleaner capacity needed by a factor of about *** should be accounted for in health analysis and air quality engineering control design of built environment in the future.

关键词： Atmospheric formaldehyde Temporal distribution Health risk Ventilation efficiency

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Small-sized Ni-Co/Mo_(2)C/Co_(6)Mo_(6)C_(2)@C for efficient alkaline and acidic hydrogen evolution reaction by an anchoring calcination strategy

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 95-103页

作者： Jianxia Gu Ying Zhu Haiyan Zheng Chunyi sun Zhongmin su department of Chemistry Xinzhou Normal UniversityXinzhou 034000China School of Chemistry Northeast Normal UniversityChangchun 130024China

A novel,cheap and highly efficient Ni-Co/Mo_(2)C/Co_(6)Mo_(6)C_(2)@C nanocomposite has been successfully constructed through simple one-step carbonization method in a nitrogen *** in the precursor can effectively anchor molybdenum-based Keggin-type polyoxometallate and NiCo-layered double hydroxide through electrostatic and coordination interactions,which avoids the aggregation of catalyst particles during the pyrolysis *** optimization,the obtained Ni-Co/Mo_(2)C/Co_(6)Mo_(6)C_(2)@C possesses small size(3-8 nm),large specific surface area and hierarchical pore *** importantly,Ni-Co/Mo_(2)C/Co_(6)Mo_(6)C_(2)@C presents remarkable hydrogen evolution reaction activity with low overpotentials in 0.5 mol·L^(-1)H_(2)SO_(4)(102.3 mV)and 1 mol·L^(-1)KOH(95 mV)to afford the current density of 10 mA·cm^(-2),as well as small Tafel slopes of 82.49 and 99.92 mV·dec^(-1),***,this catalyst also shows outstanding stability for 12 h without a significant change in current *** excellent catalytic performance of Ni-Co/Mo_(2)C/Co_(6)Mo_(6)C_(2)@C can put down to the synergistic effect between multiple components and the small size of the *** work provides unique insights into the preparation of efficient transition metal-based catalysts for HER.

关键词： polyoxometallates layered double hydroxide transition metal-based electrocatalysts hydrogen evolution reaction

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Redundant Data Detection and Deletion to Meet Privacy Protection Requirements in Blockchain-Based Edge Computing Environment

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china.Communications 2024年第3期21卷 149-159页

作者： Zhang Lejun Peng Minghui su Shen Wang Weizheng Jin Zilong su Yansen Chen Huiling Guo Ran Sergey Gataullin Cyberspace Institute Advanced Technology Guangzhou UniversityGuangzhou 510006China College of Information Engineering Yangzhou UniversityYangzhou 225127China School Math&Computer Science Quanzhou Normal UniversityQuanzhou 362000China Computer Science department City University of Hong KongHong Kong 999077China School of Computer and Software Nanjing University of Information Science and TechnologyNanjing 21004China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and TechnologyAnhui UniversityHefei 230601China department of Computer Science and Artificial Intelligence Wenzhou UniversityWenzhou 325035China Guangzhou university Library Guangzhou UniversityGuangzhou 510006China Central Economic and mathematics Institute Russian Academy of Sciences MIREA-Russian Technological university Moscow RegionRussia

With the rapid development of information technology,IoT devices play a huge role in physiological health data *** exponential growth of medical data requires us to reasonably allocate storage space for cloud servers and edge *** storage capacity of edge nodes close to users is *** should store hotspot data in edge nodes as much as possible,so as to ensure response timeliness and access hit rate;However,the current scheme cannot guarantee that every sub-message in a complete data stored by the edge node meets the requirements of hot data;How to complete the detection and deletion of redundant data in edge nodes under the premise of protecting user privacy and data dynamic integrity has become a challenging *** paper proposes a redundant data detection method that meets the privacy protection *** scanning the cipher text,it is determined whether each sub-message of the data in the edge node meets the requirements of the hot *** has the same effect as zero-knowledge proof,and it will not reveal the privacy of *** addition,for redundant sub-data that does not meet the requirements of hot data,our paper proposes a redundant data deletion scheme that meets the dynamic integrity of the *** use Content Extraction Signature(CES)to generate the remaining hot data signature after the redundant data is *** feasibility of the scheme is proved through safety analysis and efficiency analysis.

关键词： blockchain data integrity edge computing privacy protection redundant data

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An autonomous Unmanned Aerial Vehicle exploration platform with a hierarchical control method for post‐disaster infrastructures

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IET Cyber-Systems and Robotics 2024年第1期6卷 24-37页

作者： Xin Peng Gaofeng su Raja Sengupta department of Civil and Environmental Engineering University of CaliforniaBerkeleyBerkeleyCaliforniaUSA

Catastrophic natural disasters like earthquakes can cause infrastructure ***-gency response agencies need to assess damage precisely while repeating this process for infrastructures with different shapes and *** authors aim for an autonomous Unmanned Aerial Vehicle(UAV)platform equipped with a 3D LiDAR sensor to comprehensively and accurately scan the infrastructure and map it with a predefined resolution *** the inspection,the UAV needs to decide on the Next Best View(NBV)position to maximize the gathered information while avoiding collision at high *** authors propose solving this problem by implementing a hierarchical closed‐loop control system consisting of a global planner and a local *** global NBV planner decides the general UAV direction based on a history of measurements from the LiDAR sensor,and the local planner considers the UAV dynamics and enables the UAV to fly at high speed with the latest LiDAR *** proposed system is vali-dated through the Regional Scale Autonomous Swarm Damage Assessment simulator,which is built by the *** extensive testing in three unique and highly constrained infrastructure environments,the autonomous UAV inspection system suc-cessfully explored and mapped the infrastructures,demonstrating its versatility and applicability across various shapes of infrastructure.

关键词： autonomy hierarchical control structural health inspection Unmanned Aerial Vehicle

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Optimal investment based on relative performance and weighted utility

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Applied mathematics(A Journal of Chinese Universities) 2024年第2期39卷 328-342页

作者： WAng Lei DOng Ying-hui hua Chun-rong department of mathematics Suzhou University of Science and TechnologySuzhou 215009China Changshu Institute of Technology Changshu 215500China

This paper studies the optimal portfolio allocation of a fund manager when he bases decisions on both the absolute level of terminal relative performance and the change value of terminal relative performance comparison to a predefined reference point. We find the optimal investment strategy by maximizing a weighted average utility of a concave utility and an Sshaped utility via a concavification technique and the martingale method. Numerical results are carried out to show the impact of the extent to which the manager pays attention to the change of relative performance related to the reference point on the optimal terminal relative performance.

关键词： relative performance weighted utility S-shaped utility concavification

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