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山区高速公路隧道式避险车道安全评价研究

国防交通工程与技术 2024年第2期22卷 41-45,70页

作者：王维嘉胡鸿翔杨聪徐海岩四川交投设计咨询研究院有限责任公司四川成都610000 四川农业大学四川成都611830

结合九绵高速K23+870隧道式避险车道项目,深入研究山区高速公路隧道式避险车道设置条件和技术参数;基于层次分析法(analytic hierarchy process,AHP),确定隧道式避险车道评价指标体系,构建了安全评价模型,并成功应用于项目安全评价,给... 详细信息

结合九绵高速K23+870隧道式避险车道项目,深入研究山区高速公路隧道式避险车道设置条件和技术参数;基于层次分析法(analytic hierarchy process,AHP),确定隧道式避险车道评价指标体系,构建了安全评价模型,并成功应用于项目安全评价,给出相应指导意见。相关研究有助于提高隧道式避险车道的整体设计水平,确保其在复杂条件下能够充分发挥安全保障作用。

关键词：山区高速公路隧道式避险车道技术参数评价体系层次分析法

有机肥替代化肥对土壤养分及草莓果实品质的影响

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洛阳理工学院学报（自然科学版） 2024年第2期34卷 10-17页

作者：刘文雯吴智强胡君杰金锐俞金涛胡宏祥安徽农业大学资源与环境学院安徽合肥230036

通过田间小区实验,研究有机肥替代化肥比例对土壤理化性质、草莓产量和品质的影响。供试作物选取“红颜”草莓,设置了空白对照(CK)、常规施肥(CG)、化肥优化施肥(YH)、有机肥替代15%氮肥有机无机配施(TH1)、有机肥替代30%氮肥有机无机配... 详细信息

通过田间小区实验,研究有机肥替代化肥比例对土壤理化性质、草莓产量和品质的影响。供试作物选取“红颜”草莓,设置了空白对照(CK)、常规施肥(CG)、化肥优化施肥(YH)、有机肥替代15%氮肥有机无机配施(TH1)、有机肥替代30%氮肥有机无机配施(TH2)、有机肥替代50%氮肥有机无机配施(TH3)、有机肥替代30%磷肥(TP1)和有机肥替代60%磷肥(TP2)等8组实验条件,于2021年10月—2022年4月进行实验。有机肥替代化肥可以显著改善土壤的pH值、有机质、全氮、全磷和全钾等土壤理化性质。TH3处理可以使土壤pH提升9.63%,有机质提升22.41%,全氮提升26.13%,全磷提高16.36%,全钾提升33.00%。在草莓果实品质方面,TP2处理效果最好,维生素C提高了4.00%,可溶性糖提高了37.56%,可滴定酸降低了34.08%。

关键词：有机肥替代土壤养分草莓果实品质

Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2462-2478页

作者： Wei Gao hongxiang hu Lipeng Dai Miao He Hebao Yuan huixia Zhang Jinhui Liao Bo Wen Yan Li Maria Palmisano Mohamed Dit Mady Traore Simon Zhou Duxin Sun Department of Pharmaceutical Sciences College of PharmacyUniversity of MichiganAnn ArborMI 48109USA Translational Development and Clinical Pharmacology Bristol Myers SquibbSummitNJ 07920USA

Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/*** SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development.

关键词： Structure-activity-relationship(SAR) Structure-tissue exposure/selectivity relationship(STR) Drug optimization Clinical efficacy/toxicity Drug development

Investigation of Fine Velocity Structure of the Basement Layer of the Shallow Crust in Western Yunnan Region

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Earthquake Research in China 1995年第3期9卷 93-101页

作者： hu hongxiang and Gao ShiyuInstitute of Geophysics,SSB,Beijing 100081 China

In this paper the authors have discussed the results of investigation of fine velocity structure in the basement layer of the Simao-Zhongdian DSS profile in western Yunnan *** depth of upper Pz interface of the basement layer is about 0-3.5 km,and the depth of the lower P1 interface is 11.0-17.0 *** velocity of the basement layer on the southern side of the Jinhe-Erhai deep fault is 5.70-6.30 km/s,and has increased to 6.30-6.50 km/s on the northern *** transitional zone is situated near Jianchuan *** the profile some localities,where the faults cut across the lateral variation of Pz interface velocity,are quite obvious in addition to the variation in *** velocity isopleths are relatively sparse in the southern region of JYQ S.P.(shot - point),near the DC S.P.,and in the south ZT *** magma has apparently risen up along the deep faults to the upper crust in these localities,forming a large intrusive rock zone in the basement *** Jinggu region the basaltic magma

关键词： Velocity structure upper crust man-made earthquake western Yunnan.

Lateral Inhomogeneity of Basement Layer in Three Gorges Region of Changjiang River (Yangtze River)

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Earthquake Research in China 1997年第4期11卷 27-34页

作者： Bian Yinju,hu hongxiang,and Gao ShiyuInstitute of Geophysics,SSB,Beijing 100081,China

Seismic tomography from the Pg wave data along the non-longitudinal profile in the Three Gorges Region is presented in this *** seismic tomography method,and the acquisition and analysis of seismic travel time are broadly *** tomography of basement reveals a great amount of significant information and shows that the low-velocity zone is due to the lithologic difference and the fault fracture *** also demonstrates that there exist three high-velocity zones with v>6.4 km/s at the basement; the largest of zones which strikes north-south is located at the southwestern side of huangling Anticlinorium and extends into the anticlinorium *** other two high-velocity zones are,respectively,situated at the eastern side of the anticlinorium and the western side of the *** high-velocity zones are inferred to originate from the upwelling of material with high-velocity from deep crust.

关键词： Three Gorges region seismic tomography basement layer huangling anti-clinorium.

随机激励下非线性能量阱系统减振性能优化研究

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振动与冲击 2022年第24期41卷 27-32,59页

作者：胡宏祥陈林聪华侨大学土木工程学院福建厦门361021 华侨大学福建省智慧基础设施与监测重点实验室福建厦门361021

作为一类具有非线性刚度的典型非线性被动控制装置,非线性能量阱(nonlinear energy sinks,NESs)以其质量轻、频率鲁棒性强等优势引起了工程领域的广泛关注。目前,针对耦合NES的结构系统动力学研究主要是确定性载荷情形,仅少数涉及随机... 详细信息

作为一类具有非线性刚度的典型非线性被动控制装置,非线性能量阱(nonlinear energy sinks,NESs)以其质量轻、频率鲁棒性强等优势引起了工程领域的广泛关注。目前,针对耦合NES的结构系统动力学研究主要是确定性载荷情形,仅少数涉及随机激励情形的研究。该文章研究了随机激励下耦合NES的单自由度(single-degree-of-freedom,SDOF)结构随机振动的参数优化问题。首先应用加权残值法,将原系统等效为具有精确平稳解的随机动力学系统,理论解和蒙特卡洛解模拟(Monte Carlo solution,MCS)在误差允许范围内吻合,显示所提的数值方法有效;然后利用原系统的平稳响应概率密度函数(probability density function,PDF)的近似解析表达式来构造目标函数,提出了一种以主结构位移与速度响应量均方(mean-square,MS)最小为目标的NES参数优化设计策略,讨论了非线性能量阱的阻尼系数、非线性刚度系数、质量比等参数对减振性能的影响。结果表明,增加NES的质量比与阻尼系数,可以实现较强的减振性能,非线性刚度值对NES的减振性能的影响规律与质量比取值相关。相关工作可为NES的设计与应用提供参考。

关键词：随机振动非线性能量阱(NES) 参数优化加权残值法

Kondo effect in quantum dots and molecular devices

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Science Bulletin 2005年第19期 14-21页

作者： JIANG Lang, LI hongxiang, hu Wenping & Zhu Daoben Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China

Kondo effect is a very important many-body phenomenon in condensed matter physics,which explains why the resistance increases as the temperature is lowered (usually <10 K) in dilute magnetic alloy, and why the con-ductance increases as temperature is decreased in quantum dots. This paper simply introduces equilibrium and non- equilibrium Kondo effects in quantum dots together with the Kondo effect in quantum dots with even number of electrons (when the singlet and triplet states are degenerate). Fur-thermore, Kondo effect in single atom/molecular transistors is introduced, which indicates a new way to study Kondo effect.

关键词： Kondo effect Kondo temperature quantum dots mo-lecular devices

基于声发射和人工神经网络的混凝土损伤程度识别

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建筑材料学报 2014年第4期17卷 672-676页

作者：王岩张友桃胡鸿翔刘绍俊袁亮河海大学土木与交通学院江苏南京210098

采用人工神经网络技术对混凝土损伤过程中所伴生的声发射信号进行识别,可实现对混凝土损伤程度的识别.首先建立人工神经网络模型,并在标准工况下采集混凝土损伤声发射信号;然后根据加载曲线将采集到的声发射信号分为3类(分别对应混凝土... 详细信息

采用人工神经网络技术对混凝土损伤过程中所伴生的声发射信号进行识别,可实现对混凝土损伤程度的识别.首先建立人工神经网络模型,并在标准工况下采集混凝土损伤声发射信号;然后根据加载曲线将采集到的声发射信号分为3类(分别对应混凝土的3个损伤阶段:轻度损伤阶段、中度损伤阶段和严重损伤阶段),并将这3类信号作为标准工况数据输入到神经网络学习模块中进行训练,得到混凝土损伤程度识别系统;最后将相同工况下所采集的混凝土声发射信号输入到系统中,即可识别混凝土的损伤程度.实测结果表明,识别准确率可达90%以上.

关键词：混凝土声发射神经网络模式识别损伤程度

页岩气采气管线材料L360N钢的含砂冲蚀行为研究

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石油与天然气化工 2020年第5期49卷 63-69页

作者：吴贵阳谢明胡红祥中国石油西南油气田公司天然气研究院中国科学院金属研究所

页岩气开采初期井口装置存在严重冲刷腐蚀,影响采气安全及经济效益。为了制定有效的防治方案,以L360N管线钢为研究对象,研究了材料在含砂冲蚀条件下的损伤行为规律。利用喷射式冲蚀实验装置,采用失重、形貌观察等方法,研究了模拟液固冲... 详细信息

页岩气开采初期井口装置存在严重冲刷腐蚀,影响采气安全及经济效益。为了制定有效的防治方案,以L360N管线钢为研究对象,研究了材料在含砂冲蚀条件下的损伤行为规律。利用喷射式冲蚀实验装置,采用失重、形貌观察等方法,研究了模拟液固冲蚀条件下,含砂量和攻角对材料冲刷腐蚀损伤的影响规律。结果表明:射流速度为8 m/s、攻角为90°、砂的质量分数为7%时,材料的损伤最大;质量分数为3%时最低,冲蚀240 min后的累积失重约是质量分数为7%时的52%;射流速度为8 m/s、砂的质量分数为5%条件下,30°攻角时损伤最大,60°攻角时损伤最小,约为最大值的48%。

关键词：冲刷腐蚀攻角含砂量 L360N管线钢页岩气