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Mechanisms of inhibition of elemene on human lens epithelial cell proliferation in vitro

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 255-258页

作者： Yan-hong hu, Bu-Yuan Hou Department of Ophthalmology Second Affiliated Peoples Hospital of Fujian College of Traditional Chinese Medicine Fuzhou 350003 Fujian Province China Research Center of Pathophysiology Fujian College of Traditional Chinese Medicine Fuzhou 350003 Fujian Province China

AIM: To study the effects of elemene (Ele) on proliferation and cell cycle of human lens epithelial cells 63 (HLE-B3) and the mechanisms of its signal transduction. METHODS: Recombinant human basic fibroblast growth factor (rhbFGF) was used to induce proliferation of HLE-B3 cells, which were incubated with 80mg/L Ele for 24 hours. The inhibitory effects of Ele on the proliferation of HLE-B3 cells were evaluated by MU method. The effect of Ele on HLE-B3 cell cycle was analyzed by flow cytometry (FCM). The expressions of protein kinase A (PKA) and protein kinase G (PKG) of HLE-B3 were also analyzed by FCM. RESULTS: Ele altered the cell cycle of HLE-B3 and effectively inhibited HLE-B3 cell proliferation induced by rhbFGF. Ele up-regulated PKA and down-regulated the expression of PKG in HLE-B3 cell. CONCLUSION: Ele inhibits HLE-B3 proliferation, making it an attractive potential agent in regimens to treat after-cataracts.

关键词： lens epithelial cell cell culture after-cataract elemene

Visible-Light Photoredox-Catalyzed Hydrodecarboxylation and Deuterodecarboxylation of Fatty Acids

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Chinese Journal of Chemistry 2022年第16期40卷 1903-1908页

作者： Yuan-Li Sun Fang-Fang Tan Rong-Gui hu Chun-hong hu Yang Li Center for Organic Chemistry Frontier Institute of Science and TechnologyXi'an Jiaotong UniversityXi'anShaanxi710054 China

We develop an efficient visible-light photoreodox-catalyzed hydrodecarboxylation and deuterodecarboxylation of fatty acids for alkanes and deuterium *** key to the efficient transformation should attribute to the co-catalysis of the suitable methoxy substituted acridine photocatalyst(Mes-1,3,6,8-tetramethoxy-Acr-3″,5″-dimethoxy-Ph)and the hydrogen atom transfer catalyst 4′,4′-dimethyl diphenyldisulfane,possibly via facilitating of quenching the active alkyl radicals to overcome the competitive homocoupling products,olefins via the disproportionation,cracking products via the C—C bondβ-scission.

关键词： Photocatalysis Fatty acids Hydrodecarboxylation Deuterodecarboxylation Alkanes

Andreev Tunneling Through a Ferromagnet/Quantum-Dot/Superconductor System

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Communications in Theoretical Physics 2002年第5期38卷 629-633页

作者： RAO hong-hu Zhu Yu LIN Tsung-Han State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China

We study Andreev tunneling through a ferromagnet/quantum-dot (QD)/superconductor system. By usingnonequilibrum Green function method, the averaged occupation of electrons in QD and the Andreev tunneling currentare studied. Comparing to the norma-metal/quantum-dot/superconductor, the system shows significant changes: (i)The averaged occupations of spin-up and spin-down electrons are not equal. (ii) With the increase of the polarizationof ferromagnetic lead, the Andreev reflection current decreases. (iii) However, even the ferromagnetic lead reaches fullpolarization, the averaged occupation of spin-down electrons is not zero. The physics of these changes is discussed.

关键词： Andreev tunneling, ferromagnet/quantum-dot/superconductor system

Effects of Gully Erosion and Gully Filling on Soil Degradation in the Black Soil Region of Northeast China

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Journal of Mountain Science 2013年第5期10卷 913-922页

作者： TANG Wen-jian LIU hong-hu LIU Bao-yuan College of Hydrology and Water Resources Hohai University Changjiang River Scientific Research Institute Changjiang Water Resources Commission State Key Laboratory of Earth Surface Processes and Resource Ecology School of GeographyBeijing Normal University

Gully erosion has caused soil degradation and even reduced soil productivity. However, only few studies on the effects of gully erosion and artificial controlling measures on soil degradation in the Black Soil Region of Northeast China are available. Thus, this study explores the relationships between gully erosion, gully filling and soil parameters. Two sets of soil samples were collected in the field at：（1） 72 sample points in the gully erosion study area, 60 sample points in the ephemeral and classical gully erosion area （3,518 m2）, 12 sample points in the deposition zone （443 m2）, （2）1o reference points along a slope unaffected by gully erosion representing the original situation before the gully was formed. All soil samples were analyzed for gravel content （GC）, soil organic matter （SOM）, total nitrogen （TN）, available nitrogen （AN）, available phosphorus （AP）, and available potassium （AK）. The soil property values on unaffected slope were fitted by the polynomial curves as the reference values in no gully erosion area. The interpolated soil property values in gully eroded study area were compared with these polynomial curves, respectively, and then, changes of soil property values were analyzed. Gully erosion caused an increase in GC and a decrease in SOM, TN, AN, AP and AK. The change of GC, SOM, TN, AN, AP, AK was 8.8%, -9.04 g kg-1, -0.92 g kg-1, -62.28 mg kg-1, -29.61 mg kg% -79.68 mg kg-1. The soil property values in the study area were below optimal values. Thus, we concluded that gully erosion and gully filling caused both on-site and off-site soil degradation. Soil degradation area was 0.65 % of the cultivated land. In addition, it was proved that gully filling were an improper soil and water conservation measure, which seems to exacerbate the problem. Thus, it is suggested that soil where soil is deep is moved to fill the gully, and then the area around the filled gullies should be covered by grass for preventing the formation and development of the g

关键词： Deposition zone Gully erosion Ephemeral gully Classical gully Soil nutrients Gullyfilling

Variable Separated Solutions and Four-Dromion Excitations for (2+1)-Dimensional Nizhnik-Novikov-Veselov Equation

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Communications in Theoretical Physics 2008年第3期49卷 679-684页

作者： hu Ya-hong MA Zheng-Yi ZHENG Chun-Long College of Science Zhejiang Lishui University Lishui 323000 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

Using the mapping approach via the projective Riccati equations, several types of variable separated solutions of the （2＋1）-dimensional Nizhnik-Novikov-Veselov equation are obtained, including multiple-soliton solutions, periodic-soliton solutions, and Weierstrass function solutions. Based on a periodic-soliton solution, a new type of localized excitation, i.e., the four-dromion soliton, is constructed and some evolutional properties of this localized structure are briefly discussed.

关键词： Imapping approach Nizhnik-Novikov-Veselov equation variable separated solution dromion

Magnetic Properties of Spin-1/2 Ising Superlattice

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Communications in Theoretical Physics 2007年第5期47卷 955-960页

作者： LIU Wei-Jie XIN Zi-hua hu hong-Liang College of Science Shanghai University Shanghai 200444 China

Using the effective-field theory we studied the magnetic properties of a spin-1/2 Ising supedattice, which consist of three different ferromagnet materials. The magnetic behavior of this superlattice is examined. The critical temperature and the compensation temprature of the system are studied as a function of the exchange interactions between the nearest-neiboring spins across the interface and in the intraface. Temperature dependence of magenetizations is also given.

关键词： Ising superlattice effective field theory phase transition compensation point

Microplastics in Surface Waters and Floodplain Sediments of the Dagu River in the Jiaodong Peninsula,China

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Journal of Ocean University of China 2022年第6期21卷 1538-1548页

作者： JIAO Jie CHEN Gang YANG Zechuan LI Zhengyan hu hong College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China College of Marine Life Science Ocean University of ChinaQingdao 266100China

To understand the pollution characteristics and distributions of microplastics in the Dagu River,an important inland river that flows to Jiaozhou Bay,the abundance,particle size,shape,color,and polymer type of microplastics in the surface waters and floodplain sediments were *** results showed that the abundance of microplastics in the surface waters varied between 0.68 and 3.96 items L^(−1).The abundance of microplastics in the floodplain sediments varied between 115.5 and 495 items kg^(−1).The distribution of microplastics in the river has obvious characteristics:1)The abundance of microplastics downstream was significantly higher than that upstream.2)The abundance of microplastics decreased significantly in the estuary.3)The abundance of microplastics was higher in densely populated areas.4)Factors such as effluent discharge from sewage treatment plants and inflow of tributaries affect the abundance of microplastics in *** main polymer types of microplastics were polypropylene(PP),polyethylene(PE),and polyvinyl chloride(PVC).Both the abundance and polymer types of microplastics show a positive correlation between the surface waters and floodplain sediment samples,indicating that the microplastics in surface waters and floodplain sediments come from the same *** present study demonstrates that the abundance,distribution,and sources of microplastics might be affected by geology,hydrogeology,land use types,and anthropogenic *** study provides basic data for the study of microplastics in rivers and provides a reference for the establishment of microplastic control measures.

关键词： microplastics surface water floodplain sediment distribution Dagu River

Dusp 1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity

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Zoological Research 2023年第1期44卷 126-141页

作者： Ying Wang hua-Min Wang Yan Zhou Ling-hong hu Jing-Ming Wan Ji-hui Yang hong-Bo Niu Xiu-Ping hong Peng hu Liang-Biao Chen International Research Center for Marine Biosciences Ministry of Science and TechnologyShanghai Ocean UniversityShanghai 200120China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai 200120China Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding Shanghai Ocean UniversityShanghai 200120China

Temperature tolerance restricts the distribution of a species. However, the molecular and cellular mechanisms that set the thermal tolerance limits of an organism are poorly understood. Here, we report on the function of dual-specificity phosphatase 1(DUSP1) in thermal tolerance regulation. Notably, we found that dusp1-/- zebrafish grew normally but survived within a narrowed temperature range. The higher susceptibility of these mutant fish to both cold and heat challenges was attributed to accelerated cell death caused by aggravated mitochondrial dysfunction and over-production of reactive oxygen species in the gills. The DUSP1-MAPK-DRP1 axis was identified as a key pathway regulating these processes in both fish and human cells. These observations suggest that DUSP1 may play a role in maintaining mitochondrial integrity and redox homeostasis. We therefore propose that maintenance of cellular redox homeostasis may be a key mechanism for coping with cellular thermal stress and that the interplay between signaling pathways regulating redox homeostasis in the most thermosensitive tissue(i.e., gills) may play an important role in setting the thermal tolerance limit of zebrafish.

关键词： Redox homeostasis Zebrafish Ectothermal Mitochondrial fission Thermal stress MAPK

Gamma-aminobutyric acid mediates the nicotine biosynthesis in tobacco under flooding stress

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植物分类与资源学报 2016年第1期38卷 63-69页

作者： Xiaoming Zhang huaming Lin hong hu Xiangyang hu Liwei hu Germplasm Bank of Wild Species in Southwest China Kunming Institute of BotanyChinese Academy of Sciences University of Chinese Academy of Sciences Laboratory of Tobacco Agriculture Zhengzhou Tobacco Research Institute of CNTC

Gamma-aminobutyric acid( GABA) is a four-carbon non-protein amino acid conserved from bacteria to plants and vertebrates. Increasing evidence supports a regulatory role for GABA in plant development and the plant's response to environmental stress. The biosynthesis of nicotine,the main economically important metabolite in tobacco,is tightly regulated. GABA has not hitherto been reported to function in nicotine biosynthesis. Here we found that water flooding treatment( hypoxia) markedly induced the accumulation of GABA and stimulated nicotine biosynthesis. Suppressing GABA accumulation by treatment with glutamate decarboxylase inhibitor impaired flooding-induced nicotine biosynthesis,while exogenous GABA application directly induced nicotine biosynthesis. Based on these results,we propose that GABA triggers nicotine biosynthesis in tobacco seedlings subjected to flooding. Our results provide insight into the molecular mechanism of nicotine biosynthesis in tobacco plants exposed to environmental stress.

关键词：植物学植物分类植物生态学植物演化