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盈利能力指数排序法的问题及其改进

中国地质大学学报（社会科学版） 2006年第5期6卷 35-37页

作者：胡占祺赵国杰李卓华天津大学管理学院天津300072

求解资金约束条件下相互独立的投资项目优化组合的一种方法是所谓的盈利能力指数法。该方法存在一定的问题,本文严格定义了盈利能力指数,改进了排序解法,给出了获得最优解的条件。

关键词：资金约束独立项目盈利能力指数排序法最优组合条件机会成本

基于多体运动学的超重型数控机床维护周期预测

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燕山大学学报 2012年第3期36卷 201-205,214页

作者：胡占齐刘金超解亚非张雷燕山大学机械工程学院河北秦皇岛066004

以某型号超重型数控落地铣镗床为研究对象,针对重型数控机床样本小、结构复杂等特点,在机床多体运动学模型基础上,建立其空间误差模型,并提出其精度可靠性预测模型,分析运动副的磨损量对机床加工精度的影响程度,找出误差源,确定影响机... 详细信息

以某型号超重型数控落地铣镗床为研究对象,针对重型数控机床样本小、结构复杂等特点,在机床多体运动学模型基础上,建立其空间误差模型,并提出其精度可靠性预测模型,分析运动副的磨损量对机床加工精度的影响程度,找出误差源,确定影响机床加工精度的关键因素,预测机床的维护周期。

关键词：精度可靠性误差模型重型机床维护周期 MRO技术

PRKCQ-AS1通过Akt信号促进气道平滑肌细胞增殖的研究

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中国药理学通报 2025年第1期41卷 88-94页

作者：吴露依胡方启安庆医药高等专科学校临床科研中心安庆市立医院安徽安庆246000

目的探讨PRKCQ-AS1在气道平滑肌细胞(airway smooth muscle cells,ASMCs)的作用。方法首先通过转录组测序技术(RNA-seq)检测哮喘儿童肺泡灌洗液中的差异表达基因(differentially expressed genes,DEGs)。随后,分别构建PRKCQ-AS1慢病毒敲低和过表达载体并转染ASMCs。qRT-PCR方法检测了ASMCs中PRKCQ-AS1的表达;用CCK-8和流式细胞术分别检测ASMCs的增殖和凋亡;酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测ASMCs培养上清液中TNF-α和IL-1β的含量;lncRNA芯片检测PRKCQ-AS1敲低后的DEGs并进行KEGG通路富集;Western blot检测p-Akt和Akt的水平。结果RNA-seq结果显示,PRKCQ-AS1是上调最明显的DEGs之一。PRKCQ-AS1过表达促进了ASMCs的增殖和迁移并抑制了其凋亡,同时,PRKCQ-AS1过表达使上清液中炎性因子TNF-α和IL-1β的水平升高,而PRKCQ-AS1敲低则呈现相反的结果。对PRKCQ-AS1敲低后得到的606个DEGs进行KEGG信号通路富集分析,结果显示PI3K-Akt信号被明显富集。Western blot结果表明,PRKCQ-AS1敲低抑制了Akt的活化;相反,PRKCQ-AS1过表达则促进了Akt的水平。结论PRKCQ-AS1可能通过增强Akt信号促进ASMCs炎症反应,进而加剧了ASMCs的增殖和迁移,最终导致哮喘的发展。

关键词： PRKCQ-AS1 ASMCs 哮喘 Akt信号细胞实验炎性细胞因子

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao zhang Li Jia Xiu-Jun zhan Charity Ngina qing-Rui zhang Xiao-Ge Li qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Remarks on the Three-dimensional Lattice Model

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Chinese Physics Letters 1996年第6期13卷 412-415页

作者： hu zhan-ning Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

We find the connection between the weight functions of the three-dimensional(3D)Bazhanov-Baxter model and the 3D vertex model proposed by Mangazeev et *** the weight function of the 3D integrable model with the modifi... 详细信息

关键词： form. vertex integrable

Thermal Error Compensation of the Wear-Depth Real-Time Detecting of Self-Lubricating Spherical Plain Bearings

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 35-47页

作者： zhan-qi hu Wei Li Yu-Lin Yang Bing-Li Fan Hai-Li Zhou Aviation Key Laboratory of Science and Technology on Generic Technology of Aviation Self-Lubricating Spherical Plain Bearing Yanshan University

The spherical plain bearing test bench is a necessary detecting equipment in the research process of self?lubricating spherical plain bearings. The varying environmental temperatures cause the thermal deformation of the wear?depth detecting system of bearing test benches and then a ect the accuracy of the wear?depth detecting data. However, few researches about the spherical plain bearing test benches can be found with the implementation of the detect?ing error compensation. Based on the self?made modular spherical plain bearing test bench, two main causes of ther?mal errors, the friction heat of bearings and the environmental temperature variation, are analysed. The thermal errors caused by the friction heat of bearings are calculated, and the thermal deformation of the wear?depth detecting sys?tem caused by the varying environmental temperatures is detected. In view of the above results, the environmental temperature variation is the main cause of the two error factors. When the environmental temperatures rise is 10.3 °C, the thermal deformation is approximately 0.01 mm. In addition, the comprehensive compensating model of the thermal error of the wear?depth detecting system is built by multiple linear regression(MLR) and time series analysis. Compared with the detecting data of the thermal errors, the comprehensive compensating model has higher fitting precision, and the maximum residual is only 1 μm. A comprehensive compensating model of the thermal error of the wear?depth detecting system is proposed, which provides a theoretical basis for the improvement of the real?time wear?depth detecting precision of the spherical plain bearing test bench.

关键词： Self?lubricating spherical plain bearing Wear depth Bearing test bench Thermal error Error compensation

Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN Jia-qi zhanG Jia-qi zhan Li hu Li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Multivariate error assessment of response time histories method for dynamic systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第2期13卷 121-131页

作者： Zhen-fei zhan Jie hu Yan FU Ren-Jye YANG Ying-hong PENG Jin qi School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Research and Innovation Center Ford Motor CompanyDearbornM148124USA

In this paper, an integrated validation method and process are developed for multivariate dynamic systems. The principal component analysis approach is used to address multivariate correlation and dimensionality reduction, the dynamic time warping and correlation coefficient are used for error assessment, and the subject matter experts (SMEs)’ opinions and principal component analysis coefficients are incorporated to provide the overall rating of the dynamic system. The proposed method and process are successfully demonstrated through a vehicle dynamic system problem.

关键词： Model validation Multivariate dynamic resnonses. Princioal component analvsis. Dvnamic time warping

Modeling wave attenuation by vegetation with accompanying currents in SWAN

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Acta Oceanologica Sinica 2023年第12期42卷 63-76页

作者： Hong Wang zhan hu School of Marine Sciences Sun Yat-Sen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519000China State Key Laboratory of Internet of Things for Smart City/Department of Ocean Science and Technology University of MacaoMacao 999078China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510000China Pearl River Estuary Marine Ecosystem Research Station Ministry of EducationZhuhai 519000China

Coastal wetlands such as salt marshes and mangroves provide important protection against stormy *** assessments of wetlands’capacity in wave attenuation are required to safely utilize their protection *** studies have shown that tidal currents have a significant impact on wetlands’wave attenuation capacity,but such impact has been rarely considered in numerical models,which may lead to overestimation of wave attenuation in *** study modified the SWAN(Simulating Waves Nearshore)model to account for the effect of accompanying currents on vegetation-induced wave ***,this model was extended to include automatically derived vegetation drag coefficients,spatially varying vegetation height,and Doppler Effect in combined current-wave *** evaluation against an analytical model and flume data shows that the modified model can accurately simulate wave height change in combined current-wave ***,we applied the new model to a mangrove wetland on Hailing Island in China with a special focus on the effect of currents on wave *** is found that the currents can either increase or decrease wave attenuation depending on the ratio of current velocity to the amplitude of the horizontal wave orbital velocity,which is in good agreement with field ***,we used Hailing Island site as an example to simulate wave attenuation by vegetation under hypothetical storm surge *** results indicate that when currents are 0.08–0.15 m/s and the incident wave height is 0.75–0.90 m,wetlands’wave attenuation capacity can be reduced by nearly 10%compared with pure wave conditions,which provides implications for critical design conditions for coastal *** obtained results and the developed model are valuable for the design and implementation of wetland-based coastal *** code of the developed model has been made open source,in the hope to assist further research and coastal managemen

关键词： wave attenuation by vegetation wave-current interaction SWAN model storm waves drag coefficient