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Vercytochalasins A and B: Two unprecedented biosynthetically related cytochalasins from the deep-sea-sourced endozoic fungus Curvularia verruculosa

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Chinese Chemical Letters 2023年第2期34卷 407-411页

作者： xueyi hu Xiaoming Li Suiqun Yang Xin Li Bingui Wang Linghong Meng CAS and Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of Sciencesand Laboratory of Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Marine Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Vercytochalasins A(1) and B(2), two biosynthetically related cytochalasins featuring novel structure and substituents, were isolated from the endozoic fungus Curvularia verruculosa which was associated with the deep-sea squat lobster Shinkaia crosnieri collected from the cold seep environment in South China sea. Their structures were elucidated by detailed interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations were confirmed by NOESY experiments as well as by DP4+ and ECD calculations. Differed from common cytochalasins, compound 1 is an uncommon secocytochalasin featuring the ester group cleaved between C-9 and C-23, and incorporating an additional oxygenated C4 unit which coupled with C-20 and C-22 to form a new substituted cyclohexenone moiety, while compound 2 contains an unusual 2–hydroxy-3-oxobutan-2-yl unit at C-22. Both compounds are distinctive from the commonly described cytochalasins. Compound 1 exhibited potent activity against angiotensinI-converting enzyme(ACE) whereas compound 2 showed antibacterial activity. Molecular docking simulations were performed to explore the intermolecular interaction of compounds 1 and 2 with ACE.

关键词： Deep sea Endozoic fungus Curvularia verruculosa Cytochalasins Angiotensin-I-converting enzyme inhibitory activity

Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1287-1302页

作者： Qunjie Bi Xu Song Yangyang Zhao xueyi hu huan Yang Rongrong Jin Yu Nie National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610041China NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial&Institute of Regulatory Science for Medical Devices&NMPA Research Base of Regulatory Science for Medical Devices Sichuan UniversityChengdu 610041China

Establishment of vaginal immune defenses at the mucosal interface layer through gene vaccines promise to prevent infectious diseases among *** barriers composed of a flowing mucus hydrogel and tightly conjugated epithelial cells(ECs),which represent the main technical difficulties for vaccine development,reside in the harsh,acidic human vaginal *** from frequently employed viral vectors,two types of nonviral nanocarriers were designed to concurrently overcome the barriers and induce immune *** design concepts include the charge-reversal property(DRLS)to mimic a virus that uses any cells as factories,as well as the addition of a hyaluronic acid coating(HA/RLS)to directly target dendritic cells(DCs).With a suitable size and electrostatic neutrality,these two nanoparticles penetrate a mucus hydrogel with similar *** DRLS system expressed a higher level of the carried human papillomavirus type 16 L1 gene compared to HA/RLS in *** it induced more robust mucosal,cellular,and humoral immune ***,the DLRS applied to intravaginal immunization induced high IgA levels compared with intramuscularly injected DNA(naked),indicating timely protection against pathogens at the mucus *** findings also offer important approaches for the design and fabrication of nonviral gene vaccines in other mucosal systems.

关键词： Intravaginal gene delivery Nonviral gene vaccination Mucus penetration Epithelial processing Lipopeptide pH-sensitive Virus mimicking

Development and optimization of object detection technology in pavement engineering: A literature review

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Journal of Road Engineering 2024年第2期4卷 163-188页

作者： hui Yao Yaning Fan Yanhao Liu Dandan Cao Ning Chen Tiancheng Luo Jingyu Yang xueyi hu Jie Ji Zhanping You Beijing Key Laboratory of Transportation Engineering Faculty of ArchitectureCivil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China School of Civil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Department of Civil and Environmental Engineering Michigan Technological UniversityHoughtonMI 49931USA

Due to the rapid advancement of the transportation industry and the continual increase in pavement infrastructure,it is difficult to keep up with the huge road maintenance task by relying only on the traditional manual detection *** pavement detection technology with deep learning techniques is available for the research and industry areas by the gradual development of computer vision *** to the different characteristics of pavement distress and the uncertainty of the external environment,this kind of object detection technology for distress classification and location still faces great *** paper discusses the development of object detection technology and analyzes classical convolutional neural network(CNN)*** addition to the one-stage and two-stage object detection frameworks,object detection without anchor frames is introduced,which is divided according to whether the anchor box is used or *** paper also introduces attention mechanisms based on convolutional neural networks and emphasizes the performance of these mechanisms to further enhance the accuracy of object *** network architecture is introduced for mobile and industrial *** stereo cameras and sensors are rapidly developed,a detailed summary of three-dimensional object detection algorithms is also *** reviewing the history of the development of object detection,the scope of this review is not only limited to the area of pavement crack detection but also guidance for researchers in related fields is shared.

关键词： Pavement engineering Object detection Lightweight network Attention mechanism Convolutional neural network

氧化铝-延展型表面活性剂的吸附胶束及其吸附增溶

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高等学校化学学报 2021年第3期42卷 843-849页

作者：胡学一韩璐璐方云夏咏梅江南大学化学与材料工程学院合成与生物胶体教育部重点实验室无锡214122

合成了一系列直链烷基聚氧丙烯醚硫酸钠(C_(c)P_(p)S,c=8或16时,p=9;c=12时,p=3,6或9)并鉴定了其结构.与十二烷基硫酸钠(SDS)类似,C_(12)P_(9)S在氧化铝上的饱和吸附量以及对阳离子染料亚甲基蓝的吸附增溶行为共同证实该延展型表面活性... 详细信息

合成了一系列直链烷基聚氧丙烯醚硫酸钠(C_(c)P_(p)S,c=8或16时,p=9;c=12时,p=3,6或9)并鉴定了其结构.与十二烷基硫酸钠(SDS)类似,C_(12)P_(9)S在氧化铝上的饱和吸附量以及对阳离子染料亚甲基蓝的吸附增溶行为共同证实该延展型表面活性剂在表面上形成了双层吸附胶束,但由聚氧丙烯(PPO)连接基导致的橄榄球状分子及其导致的较大分子吸附面积,使其吸附能力及其对亚甲基蓝的吸附增溶能力均稍弱于SDS.C_(12)P_(9)S@Al_(2)O_(3)对弱极性分子1-苯乙醇和难溶性分子苯乙烯的吸附增溶能力均明显强于SDS,而且对1-苯乙醇的吸附增溶量达到SDS@Al_(2)O_(3)的8.5倍,说明1-苯乙醇主要被增溶在C_(12)P_(9)S双层吸附胶束中PPO连接基所在的膨大部位,这使延展型表面活性剂改性的氧化铝在废水处理和药物传递系统等领域具有潜在的应用前景.

关键词：延展型表面活性剂氧化铝吸附双层吸附胶束吸附增溶

聚氧丙烯链对Extended表面活性剂界面性质的影响

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石油化工 2019年第5期48卷 472-477页

作者：陈骥胡学一方云江南大学化学与材料工程学院合成与生物胶体教育部重点实验室江苏无锡214122

以十二醇、十四醇和十二/十四混合醇为原料,合成了三种直链烷基聚氧丙烯醚硫酸钠-3(C_nP_3S)。利用FTIR,~1H NMR进行了结构表征,分析了表面活性剂的界面和胶束溶液性质,并与十二烷基硫酸钠(SDS)和月桂基聚氧乙烯醚硫酸钠-3(SLE3S)进行... 详细信息

以十二醇、十四醇和十二/十四混合醇为原料,合成了三种直链烷基聚氧丙烯醚硫酸钠-3(C_nP_3S)。利用FTIR,~1H NMR进行了结构表征,分析了表面活性剂的界面和胶束溶液性质,并与十二烷基硫酸钠(SDS)和月桂基聚氧乙烯醚硫酸钠-3(SLE3S)进行了对比。~1H NMR表征结果显示,C_nP_3S的环氧丙烷平均加成数在3.0左右。实验结果表明,聚氧丙烯(PPO)链和烷基链的增长可为C_nP_3S分子提供疏水性,同时PPO链还提供极性作用,因此C_(12)P_3S和C_(14)P_3S降低表面张力的能力及乳化能力优于SDS和SLE_3S,泡沫性质略低于SDS和SLE_3S,润湿力介于SDS和SLE_3S之间,去污力等同或略优于SDS和SLE3S,同时具有优良的低温水溶性及抗钙离子性。由于同系物作用,C_(1214)P_3S混合物在泡沫、去污力和钙离子抗性等性能上表现出一定协同作用。PPO链的双亲性赋予了C_nP_3S优良性质,使其适用于个人护理及家用清洁产品。

关键词： Extended表面活性剂烷基聚氧丙烯醚硫酸钠聚氧丙烯链双亲性界面性能协同作用

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钢铁工业冷却水水源热泵的技术应用分析

暖通空调 2006年第6期36卷 97-99,90页

作者：胡学毅寇彦德北京首钢设计院

钢铁工业的冷却水含有大量的低温热量,可以通过水源热泵利用这部分热量实现区域供热。介绍了一些钢铁工业冷却水水源热泵的应用情况,分析了工业冷却水水源热泵的运行费用和投资费用及提高供水温度和制热效率的方法。

关键词：工业冷却水水源热泵性能系数

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变形监测数据小波去噪分解尺度确定方法

测绘地理信息 2017年第2期42卷 44-48页

作者：胡薛毅黄声享庞辉武汉大学测绘学院湖北武汉430079 精密工程与工业测量国家测绘地理信息局重点实验室湖北武汉430079 河北电力工程监理有限责任公司河北石家庄050021

小波去噪作为一种数据处理方法,分解尺度的选择对去噪效果有影响。在论述基于均方根误差变化率的方法、基于总体评价指标的综合法、多指标融合法和复合评价指标法4种小波去噪分解尺度确定方法的基础上,通过仿真实验和变形监测实测数据... 详细信息

小波去噪作为一种数据处理方法,分解尺度的选择对去噪效果有影响。在论述基于均方根误差变化率的方法、基于总体评价指标的综合法、多指标融合法和复合评价指标法4种小波去噪分解尺度确定方法的基础上,通过仿真实验和变形监测实测数据的去噪处理对比分析,结果表明,基于均方根误差变化率的方法对处理低噪声信号有良好效果,多指标融合法只能确定小波分解尺度的大致范围,基于总体评价指标的综合法和复合评价指标法可以准确判定小波分解尺度,且不受噪声影响。

关键词：小波去噪分解尺度对比分析

维普期刊数据库博看期刊

阳离子纤维素-十二烷基苯磺酸钠的拟聚阴离子研究

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高等学校化学学报 2019年第7期40卷 1464-1471页

作者：胡学一陈苗苗方云冯瑞沁韩慧慧江南大学化学与材料工程学院合成与生物胶体教育部重点实验室

采用浊度法、表面张力法、zeta电位法和毛细管电泳法(CE)研究了典型的阳离子纤维素(JR400)与典型的阴离子表面活性剂十二烷基苯磺酸钠(SDBS)之间的缔合作用.浊度法和zeta电位法实验结果表明,在等电区附近产生的沉淀区随JR400浓度减小而... 详细信息

采用浊度法、表面张力法、zeta电位法和毛细管电泳法(CE)研究了典型的阳离子纤维素(JR400)与典型的阴离子表面活性剂十二烷基苯磺酸钠(SDBS)之间的缔合作用.浊度法和zeta电位法实验结果表明,在等电区附近产生的沉淀区随JR400浓度减小而变窄,加入过量SDBS后沉淀消失,而且发现阳离子纤维素同系物的分子量和取代度对结果的影响较小.表面张力法实验结果显示,该类复合体系的表面张力曲线表观上与典型“中性聚合物-阴离子表面活性剂”体系相似,具有3个拐点(但第二拐点易被沉淀区覆盖)且SDBS与阳离子纤维素间形成缔合物.zeta电位法实验结果表明,沉淀区前少量SDBS存在时该缔合物具有正电位,因而维持聚阳离子特性;沉淀区后过量SDBS存在时该缔合物具有负电位,CE分析进一步证明其为拟聚阴离子.上述实验结果和结论对研究该类复合体系具有较大理论意义和实用价值.

关键词：阳离子纤维素十二烷基苯磺酸钠缔合作用拟聚阴离子毛细管电泳

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大麻二酚类似物的合成及其抗氧化性和抑菌性

精细化工 2022年第3期39卷 584-591页

作者：吴淇邹亮华胡学一夏咏梅江南大学食品科学与技术国家重点实验室江苏无锡214122 江南大学化学与材料工程学院江苏无锡214122 江南大学药学院江苏无锡214122

以α-水芹烯为烷基化试剂,烷基酚为受体,在三氯化铁催化下,通过傅克烷基化反应合成了4种大麻二酚(CBD)的类似物(Ⅰ~Ⅳ);并以8,9-二氢大麻二酚(H2CBD)和2,2,8,9-四氢大麻酚(2,2,8,9-THC)为原料,通过与有机溴化物的O-烷基化反应合成了另外... 详细信息

以α-水芹烯为烷基化试剂,烷基酚为受体,在三氯化铁催化下,通过傅克烷基化反应合成了4种大麻二酚(CBD)的类似物(Ⅰ~Ⅳ);并以8,9-二氢大麻二酚(H2CBD)和2,2,8,9-四氢大麻酚(2,2,8,9-THC)为原料,通过与有机溴化物的O-烷基化反应合成了另外8种CBD类似物(Ⅴ~Ⅻ)。对CBD及其类似物的抗氧化活性及抑菌活性进行了测试。结果表明,所合成化合物中,仅2′-异丙基-5′-甲基-1′,2′-二氢-3′,4′-四氢-[1,1′-联苯]-2,4,6-三醇(类似物Ⅰ)有抑菌性和抗氧化性。类似物Ⅰ具有三羟基结构,表现出比CBD更好的抗氧化能力,其1,1-二苯基-2-三硝基苯肼(DPPH)和2,2′-联氮-双-3-乙基苯并噻唑啉-6-磺酸(ABTS)自由基清除的半最大效应浓度(EC_(50))分别是CBD的23.8%和25.1%,略低于V_(C)。类似物Ⅰ对4种细菌均表现出较好的抑菌活性,最小抑菌浓度均<100μg/m L,表明酚羟基的存在可能是CBD类似物具有抗氧化性和抑菌性的必要条件。

关键词：大麻二酚 α-水芹烯傅克烷基化抑菌性抗氧化性医药原料