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Advanced pancreatic cancer treated with camrelizumab combined with apatinib:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 284-290页

作者： Yun-Hao Luo Ting He Lu Lin Rong-Qiu Wang Hong-Xia Cai wen hu Department of Critical Care Medicine Chengdu First People's HospitalChengdu 610000Sichuan ProvinceChina Department of Radiology Sichuan Second Hospital of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Department of Oncology Chengdu Seventh People's HospitalChengdu 610000Sichuan ProvinceChina Department of Oncology West China Tianfu HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND The 5-year survival rate for patients with pancreatic cancer(PC)is 4%-12%.Surgery is the only treatment that offers curative potential,but only 15%-20%of patients are eligible for *** is prone to recurrence and metastasis,and the antitumor effect of chemotherapy is notably *** SUMMARY Histopathological analysis of a 53-year-old female PC patient who underwent Whipple surgery revealed poorly differentiated tumor cells infiltrating nerves,lymphatics,and blood *** patient received two different first-line chemotherapy regimens consecutively;however,both regimens struggled to control disease *** this period,the patient underwent liver metastasis ablation surgery,Candida albicans liver abscess,and stereotactic body *** the addition of camrelizumab to the modified FOLFIRINOX regimen,tumor control was *** patient subsequently refused to continue chemotherapy,and the antitumor regimen was changed to a combination of camrelizumab and *** patients received a combination of immunotherapy and targeted therapy,the length of hospital stay was significantly ***,all side effects were within acceptable limits,leading to an improved quality of life and prolonged progression-free ***,the pain associated with cancer,coupled with the side effects of opioid analgesics,has led the patient to reject all available anticancer treatment *** one month after camrelizumab and apatinib were discontinued without medical authorization,the PC recurred and rapidly progressed to widespread metastasis,ultimately leading to the patient's death approximately one month *** overall survival was 2 *** Immunotherapy and targeted therapy have the potential to increase both the quality of life and survival time of PC patients,particularly those whose tumor progression is not effectively controlled by chemotherapy ***,further clinical trials a

关键词： Advanced pancreatic cancer Immunotherapy Camrelizumab Targeted therapy Apatinib Case report

山东昌乐刚玉巨晶中的流体和熔融包裹体及其流体组分特征

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地球化学 2006年第4期35卷 377-387页

作者：宋玉财胡文金之钧陈勇南京大学内生金属矿床成矿机制研究国家重点实验室南京大学地球科学系江苏南京210093 中国石化石油勘探开发研究院北京100083 中国石油大学地球化学与岩石圈动力学开放实验室山东东营257061

山东昌乐第三纪玄武岩中产有刚玉巨晶,内含丰富的原生和假次生流体包裹体和熔融包裹体。流体包裹体可分为CO2单相包裹体、H2O-CO2两相和三相包裹体。熔融包裹体类型复杂,其中富流体相包裹体可分为含CO2收缩气泡两相熔融包裹体和气-液-... 详细信息

山东昌乐第三纪玄武岩中产有刚玉巨晶,内含丰富的原生和假次生流体包裹体和熔融包裹体。流体包裹体可分为CO2单相包裹体、H2O-CO2两相和三相包裹体。熔融包裹体类型复杂,其中富流体相包裹体可分为含CO2收缩气泡两相熔融包裹体和气-液-固多相熔融包裹体。诸类包裹体主要赋含在刚玉晶核外的“主体”部分,以CO2单相流体包裹体和两相熔融包裹体最为发育,并且不同类型包裹体常密切伴生,表明它们形成时流体发生了不混溶作用:出现熔浆相(富含挥发分)、气相(CO2为主)和富水相(H2O-CO2为主)等多相体系。激光拉曼分析结果显示,各类包裹体中的气体组分主要是CO2,另有不等量的N2和H2S,据此划分为纯CO2、CO2-N2、CO2-H2S和CO2-N2-H2S等气体组合类型,没有发现O2、CH4和H2等组分。此外,拉曼分析也证实了流体包裹体和熔融包裹体中存在H2O。上述资料表明,昌乐地区深部流体以CO2为主,同时包含H2O、N2和H2S在内的多种组分,这些流体组分也是刚玉母浆系统的重要成分。

关键词：刚玉巨晶流体包裹体熔融包裹体流体组分不混溶作用山东省

Dual roles ofα1,4-galactosyltransferase 1 in spermatogenesis of Drosophila melanogaster

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Insect Science 2025年第1期32卷 127-139页

作者： Yanhong Xiao Bo huang Sibo Chen Zhikai Lin Zhiying Zhu Yuzhen Lu Xiao-Qiang Yu Liang wen Qihao hu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina School of Life Sciences Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCentral China Normal UniversityWuhanChina

Spermatogenesis is critical for insect reproduction and the process is regulated by multiple *** have been shown to participate in the development of Drosophila melanogaster;however,their role in spermatogenesis is still *** this study,we found thatα1,4-galactosyltransferase 1(α4GT1)was expressed at a significantly higher level in the testis than in the ovary of ***,the hatching rate was significantly decreased whenα4GT1 RNA interference(RNAi)males were crossed with w1118 females,with only a few mature sperm being present in the seminal vesicle ofα4GT1 RNAi *** staining further revealed that the individualization complex(IC)in the testes fromα4GT1 RNAi flies was scattered and did not move synchronically,compared with the clustered IC observed in the control *** deoxyribonucleotide transferase(TdT)-mediated dUTP nick end labeling(TUNEL)assay showed that apoptosis signals in the sperm bundles ofα4GT1 RNAi flies were significantly ***,the expression of several individualization-related genes,such as Shrub,Obp44a and Hanabi,was significantly decreased,whereas the expression of several apoptosis-related genes,including Dronc and Drice,was significantly increased in the testes ofα4GT1 RNAi ***,these results suggest thatα4GT1 may play dual roles in Drosophila spermatogenesis by regulating the sperm individualization process and maintaining the survival of sperm bundles.

关键词： apoptosis α4GT1 galactosyltransferase individualization spermatogenesis

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安塞油田延长统煤岩石学特征及其沉积环境

新疆石油地质 2005年第6期26卷 632-636页

作者：薛春燕姚素平胡文瑄南京大学地球科学系南京210093

煤的有机岩石学特征是沉积环境良好的辅助指标之一,鄂尔多斯盆地安塞油田延长统煤和碳质泥岩的有机岩石学研究结果发现,有机岩的宏观岩石学特征、显微组分组成及其组合关系、有机质的赋存状态等能够较好地揭示煤和碳质泥岩形成的沼泽古... 详细信息

煤的有机岩石学特征是沉积环境良好的辅助指标之一,鄂尔多斯盆地安塞油田延长统煤和碳质泥岩的有机岩石学研究结果发现,有机岩的宏观岩石学特征、显微组分组成及其组合关系、有机质的赋存状态等能够较好地揭示煤和碳质泥岩形成的沼泽古地理环境和沉积场所,区分了原地堆积的陆地森林泥炭沼泽、覆水森林沼泽、芦苇沼泽及异地成因的漂浮沼泽等4种沼泽环境,从而为三叠系延长统形成时期古湖岸线的确定、演变以及沉积相带的划分提供了重要的参考。

关键词：鄂尔多斯盆地煤泥炭沼泽沉积环境

山东乳山金矿中金-银碲化物的矿物学特征与沉淀机理

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矿物学报 2005年第2期25卷 177-182页

作者：胡文瑄孙国曦张文兰王昭坤南京大学地球科学系内生金属矿床成矿机制国家重点实验室江苏南京210093 山东黄金集团有限公司山东省黄金工业局山东济南270000

通过显微鉴定和应用电子探针微束分析,查明乳山金矿中碲化物主要为碲银矿和碲金银矿,少量碲铅矿和碲铋矿,它们呈密切共生的集合体或联生体产出在黄铁矿等硫化物及石英等脉石矿物粒间或裂缝中。碲银矿和碲金银矿中Au含量变化较大,w(Au)... 详细信息

通过显微鉴定和应用电子探针微束分析,查明乳山金矿中碲化物主要为碲银矿和碲金银矿,少量碲铅矿和碲铋矿,它们呈密切共生的集合体或联生体产出在黄铁矿等硫化物及石英等脉石矿物粒间或裂缝中。碲银矿和碲金银矿中Au含量变化较大,w(Au)为痕量至26.1%,与银呈负相关,与铋为正相关,可能是以类质同象形式替代Ag进入到碲银矿中;碲铅矿中未检测到金。金在金-银碲化物中的含量随温度降低而升高,相关矿物的形成顺序为碲银矿—碲金银矿—(碲金矿)。将金银碲化物成分投到Au-Ag-Te三元成分-共生图解上发现,它们都不是标准成分的端元矿物,推测这些碲化物(尤其是金银碲化物)是在非平衡状态下快速沉淀形成的,可能与含矿流体的间歇性沸腾作用有关。

关键词：金矿碲化物共生关系沉淀机制

海拉尔盆地乌尔逊凹陷无机CO2充注驱油的流体包裹体证据

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矿物岩石地球化学通报 2009年第1期28卷 80-91页

作者：高玉巧刘立胡文瑄曲希玉南京大学地球科学与工程学院内生金属矿床国家重点实验室南京210093 吉林大学地球科学学院长春130061

CO2充注驱油是一种普遍的地质现象,对揭示油气藏中油气的动态成藏规律具有重要的指示意义。海拉尔盆地乌尔逊凹陷含片钠铝石砂岩既示踪了CO2充注,又记录了油气充注,是进行CO2充注驱油研究的理想岩石类型。通过岩石学和流体包裹体地球化... 详细信息

CO2充注驱油是一种普遍的地质现象,对揭示油气藏中油气的动态成藏规律具有重要的指示意义。海拉尔盆地乌尔逊凹陷含片钠铝石砂岩既示踪了CO2充注,又记录了油气充注,是进行CO2充注驱油研究的理想岩石类型。通过岩石学和流体包裹体地球化学研究,确定了含片钠铝石砂岩的成岩共生序列、油气充注历史和CO2充注驱油的微观证据。研究表明,该区油气充注是一个连续的过程,开始于石英次生加大早期（120 Ma）,在片钠铝石沉淀前（105-95 Ma）达到充注高峰。CO2充注晚于大规模油气充注,充注之后形成的自生矿物组合为片钠铝石与铁白云石。片钠铝石中首次发现一定数量的原生油气包裹体,为CO2充注驱油提供了重要的微观证据。

关键词： CO2充注驱油流体包裹体片钠铝石海拉尔盆地乌尔逊凹陷

Hollow MnO_(2)-based multifunctional nanoplatform for enhanced tumor chemodynamic therapy

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Science China Materials 2025年第1期68卷 292-302页

作者： Dejie Ge Debao Ren Yamin Duan xuan Luo Shuailin He wenjun Qin Fei Wang wen Yin Lixin Ma Yong Yang Cheng Zhang State Key Laboratory of Biocatalysis and Enzyme Engineering College of Life SciencesHubei UniversityWuhan 430062China hubei Key Laboratory of Industrial Biotechnology College of Life SciencesHubei UniversityWuhan 430062China College of Health Science and Engineering Hubei UniversityWuhan 430062China School of Materials Science and Engineering Hubei UniversityWuhan 430062China

The inherent tumor microenvironment(TME)of hypoxia and high glutathione(GSH)hinders the production of reactive oxygen species(ROS),yet which are crucial roles to make the oxygen-independent chemodynamic therapy(CDT)***,we constructed hyaluronic acid(HA)-modified and peroxymonosulfate(PMS)-loaded hollow manganese dioxide(HMn)nanoparticles for not only TME-response drug release but also the distinct ROS donors to strengthen *** enriched in the tumor site,the prepared nanotheranostic agent(HA@HMn/PMS)depleted local GSH to reduce MnO_(2) to Mn^(2+),followed by generating•OH andSO_(4)^(−)through Fenton-like reaction and activation of PMS,*** bring in of•SO_(4)^(−),a rare radical possessing exceptional oxidizing ability and oxygen-independent property,breaks the limitations of traditional ROS and causes serious damage to tumor *** a xenograft mouse tumor model,detailed studies demonstrated that HA@HMn/PMS can significantly inhibit tumor *** work inspires the enormous potential of CDT in investigating the application of multifunctional nanosystems by combining the consumption of GSH and the synergistic effect of multiple radicals in oncotherapy.

关键词： hollow manganese dioxide sulfate radical glutathione chemodynamic therapy tumor therapy

Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong wen-Jian Zhu Yi-Fan hui wen-Li Qiu Yan Wu xuan Li Fei Ke Liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

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流动单元划分新方案及其在临南油田的应用

地球科学（中国地质大学学报） 2006年第2期31卷 191-200页

作者：胡文瑄朱东亚陈庆春王秀鹏曹学伟南京大学地球科学系江苏南京210093 胜利油田临盘采油厂地质研究所山东临邑251500

把沉积学与储层物性相结合,从流动单元体系的角度出发,提出了流动单元划分的新方案.在流动单元体系内部划分出流动单元、亚流动单元和渗流区3个不同层次.在储层精细小层对比的基础上,首先根据区域内连续分布的隔层把储层分成几个独立的... 详细信息

把沉积学与储层物性相结合,从流动单元体系的角度出发,提出了流动单元划分的新方案.在流动单元体系内部划分出流动单元、亚流动单元和渗流区3个不同层次.在储层精细小层对比的基础上,首先根据区域内连续分布的隔层把储层分成几个独立的流体压力系统,即流动单元;然后再根据不连续分布的隔层,把一个流动单元进一步分成若干个亚流动单元;最后根据储层物性的差别把流动单元/亚流动单元划分成不同的渗流区.按照这个思路,选取临南油田的典型高产区块———以三角洲前缘亚相沉积为主的夏52块砂三中段三砂组,进行了流动单元、亚流动单元和渗流区的划分,共划分出7个流动单元、7个亚流动单元和63个渗流区,这样划分出来的流动单元体系同时包括了油藏整体与局部细节的特征,为油藏开发提供了详细的地质依据,也在实际应用中取得了良好的效果.

关键词：流动单元划分方案渗流区储层物性临南油田