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Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma:A case report

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world Journal of Gastrointestinal Oncology 2025年第3期17卷 410-417页

作者： Ming-Zhi Hao Hai-Lan Lin yu-Bin hu Qi-Zhong Chen Zhang-Xian Chen Lin-Bin Qiu Duan-yu Lin hui Zhang De-Chun Zheng Zhu-Ting Fang Jing-Feng Liu Department of Tumor Interventional Radiology Clinical Ocology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical UniversityFuzhou 350014Fujian ProvinceChina Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFuzhou 350014Fujian ProvinceChina Department of Hepatopancreatobiliary Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Radiology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Hepatobiliary Surgery Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)has become a growing health concern *** invasion and high tumor burden are key factors limiting the curative effect of selective internal radiation therapy(SIRT).CASE SUMMARy This case study reports a 49-year-old woman who was diagnosed with China Liver Cancer Staging(CNLC)IIIa HCC and>15 cm tumor ***,due to insufficient future liver remnant and vascular invasion,the tumor was unresectable;however,radical hepatectomy was performed after successful conversion therapy with SIRT using yttrium-90(90y)resin microspheres followed by hepatic arterial infusion chemotherapy(HAIC)with tyrosine kinase inhibitor(TKI)and anti-programmed death-1(PD-1)*** using 90y resin microspheres was given by the right hepatic artery and chemoembolization was simultaneously performed in the tumor’s feeding vessels from the right diaphragmatic *** was followed every three weeks with lenvatinib and *** 4 months post-SIRT,the tumor was downstaged to CNLC Ib and the patient successfully underwent *** histopathological examination of the resected specimen showed extensive *** This case study provides evidence for an integrated treatment strategy combining SIRT and HAIC with TKI and anti-PD-1 antibodies for patients with large HCC and microvascular *** confirmatory trials are required in the future.

关键词： Selective internal radiation therapy Hepatic arterial infusion chemotherapy yttrium-90 resin microspheres Hepatocellular carcinoma Conversion therapy Case report

Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-yu hu yan-Mei Zeng Qian Ling Jie Zou Cheng Chen Liang-Qi He Xiao-yu wang Hong wei Xu Chen yi-Xin wang yi Shao yao yu Department of Ophthalmology Dahua HospitalShanghai 200237China Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

Natural vibration of cantilever porous twisted plate with variable thickness in different directions

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Defence Technology（防务技术） 2023年第9期27卷 200-216页

作者： y.X.Hao y.y.Liu w.Zhang L.T.Liu K.C.Sun S.w.yang College of Mechanical Engineering Beijing Information Science and Technology UniversityBeijing100192PR China College of Mechanical Engineering Beijing University of TechnologyBeijing100124PR China

In this paper,the blade is assumed to be a rotating variable thickness cantilever twisted plate structure,and the natural vibrations of variable thickness cantilever twisted plate made of metal porous material are *** is assumed that the thickness of the plate changes along spanwise direction and chordwise direction,respectively,and it changes in both *** classical thin shell theory,the first and second fundamental forms of surface and von Karman geometric relationship are employed to derive the total potential energy and kinetic energy of the cantilever twisted plate,in which the centrifugal force potential due to high rotational speed is ***,according to the Rayleigh-Ritz procedure and applying the polynomial functions which satisfy the cantilever boundary conditions,the dynamic system expressed by equations of motion is reduced to an eigenvalue *** numerical simulation,the frequency curves and the mode shapes of the twisted plate can be obtained to reveal the internal connection between natural vibration and the parameters.A series of comparison studies are performed to verify the accuracy of the present formulation and calculations,in which compared data come from experimental,finite element method and theoretical calculation,*** influence of pre-twist angle,three different forms of thickness taper ratio and rotational speed on natural vibration,mode exchange and frequency veering phenomenon of the system is discussed in *** addition,the approach proposed here can efficiently extract analytical expressions of mode functions for rotating variable thickness cantilever twisted plate structures.

关键词： Porous cantilever twisted plate Variable thickness Natural vibration Frequency veering Mode exchange

Nanocrystalline Silicon Thin Films Fabricated at 80℃ by Using Electron Cyclotron Resonance Chemical Vapor Deposition

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Plasma Science and Technology 2010年第5期12卷 608-613页

作者： I.y.y.BU A.J.FLEwITT w.I.MILINE Department of Microelectronics Engineering National Kaohsiung Marine University Electrical Engineering Division Engineering Department Cambridge University

Deposition of nanocrystalline silicon （nc-Si） on glass at very low temperatures by electron cyclotron resonance （ECR） plasma enhanced chemical vapour deposition （PECVD） was investigated. It was shown that nc-Si could be deposited from hydrogen diluted silane gas at a substrate temperature of 80℃ with a crystalline fraction up to 80% and a lateral grain size of around 50 nm. This was achieved by growing the nc-Si in a low pressure regime which ensured that mono-silyl species were the dominant deposition precursor. Furthermore, a high flux of energetic hydrogen ions was required to induce crystallisation of the silicon material through a chemical annealing process.

关键词： low temperature nanocrystalline silicon ECR

Extending the Relational Model to Deal withProbabilistic Data

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Journal of Computer Science & Technology 2000年第3期15卷 230-240页

作者：马宗民 ZHANG w.J MA w.y CityUniversityofHongKong KowloonHongKongP.R.China

According to the soundness and completeness of information in databases, the expressive form and the semantics of incomplete information are discussed in this paper. On the basis of the discussion, the current studies on incomplete data in relational databases are reviewed. In order to represent stochastic uncertainty in most general sense in the real world, probabilistic data are introduced into relational databases. An extended relational data model is presented to express and manipulate probabilistic data and the operations in relational algebra based on the extended model are defined in this paper.

关键词： incomplete information uncertain information extended relational model probabilistic data relational algebra

Microstructure and mechanical optimization of probeless friction stir spot welded joint of an Al-Li alloy

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Journal of Materials Science & Technology 2018年第10期34卷 1739-1746页

作者： Q. Chu w.y. Li X.w. yang J.J. Shen A. Vairis w.y. Feng w.B. wang State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical University Xi'an710072 China Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Geesthacht 21502 Germany Mechanical Engineering Department TEl of Crete Heraklion Crete 71004 Greece China PSw Center Beijing 100024 China

In this work, a third generation AI-Li alloy has been successfully spot welded with probeless friction stir spot welding （P-FSSw）, which is a variant of conventional friction stir welding. The Box-Behnken exper-imental design in response surface methodology （RSM） was applied to optimize the P-FSSw parameters to attain maximum tensile/shear strength of the spot joints. Results show that an optimal failure load of 7.83 kN was obtained under a dwell time of 7.2 s, rotation speed of 950 rpm and plunge rate of 30 mm/rain. Sufficient dwell time is essential for heat conduction, material flow and expansion of the stir zone to form a sound joint. Two fracture modes were observed, which were significantly affected by hook defect. In addition to mechanical testing, electron backscattering diffraction （EBSD） and differential scanning calorimetry （DSC） were used for microstructure evolution and property analysis. The precipitation of GP zone and AI3Li as well as the ultrafine grains were responsible for the high microhardness in the stir zone.

关键词： Probeless friction stir spot welding Precipitation Mechanical property Fracture mechanism

Detection of PRMT1 inhibitors with stopped flow fluorescence

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Signal Transduction and Targeted Therapy 2018年第1期3卷 274-283页

作者： Kun Qian Hao hu hui Xu y George Zheng Department of Pharmaceutical and Biomedical Sciences University of GeorgiaAthensGA 30602USA Present address:The Chemical Proteomics Center and State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Protein arginine methyltransferases(PRMTs)are crucial epigenetic regulators in eukaryotic organisms that serve as histone writers for chromatin *** also methylate a variety of non-histone protein substrates to modulate their function and *** development of potent PRMT inhibitors has become an emerging and imperative research area in the drug discovery field to provide novel therapeutic agents for treating diseases and as tools to investigate the biological functions of ***1 is the major type I enzyme that catalyzes the formation of asymmetric dimethyl arginine,and PRMT1 plays important regulatory roles in signal transduction,transcriptional activation,RNA splicing,and DNA *** expression of PRMT1 is found in many types of cancers,pulmonary diseases,cardiovascular disease,diabetes,and renal ***1 is a highly promising target for therapeutic *** created a stopped flow fluorescence-based assay for PRMT1 inhibitor detection and characterization that has the advantages of being homogeneous,nonradioactive,and mix-and-measure in nature,allowing for continuous measurement of the methylation reaction and its *** our knowledge,this is the first continuous assay for PRMT1 reaction detection and inhibitor *** approach is not only capable of quantitatively determining the potency(IC50)of PRMT1 inhibitors but can also distinguish cofactor-competitive inhibitors,substrate-competitive inhibitors,and mixed-type inhibitors.

关键词： PRMT1 stopped competitive

Study on Amorphous Ni-Mo-Fe-Zn Coating Electrocatalyst forHydrogen Evolution in Alkaline Solution

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Journal of Materials Science & Technology 1996年第3期12卷 190-194页

作者： Luo, DJ hu, wK wang, y Zhang, yS wang, GS NANKAI UNIV INST NEW ENERGY MAT CHEMTIANJIN 300071PEOPLES R CHINA

Amorphous Ni-Mo-Fe-Zn quaternary alloy coatings are developed by means of electrodeposit, and after most of zinc is leached out their electrocatalytic activity toward the hydrogen evolution reaction (HER) in alkaline media is studied using electrochemical polarization and a.c. impedance techniques. The results show these coatings have very high electrocatalytic activity and excellent stability. This might benefit from the increased active surface area, well-pronounced synergism as well as their amorphous structures. The HER proceeds through the Volmer-Heyrovsky mechanism with a rate-determination-step (RDS) of Volmer at high overpotentials and the HER is controlled by Heyrovsky in lower overpotential areas.

关键词： Zn Fe Mo Ni

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1493-1512页

作者： Qian hu Christopher J.Lyon Jesse K.Fletcher wenfu Tang Meihua wan Tony y.hu Department of Integrated Traditional Chinese and western Medicine West China HospitalSichuan UniversityChengdu 610041China Center of Cellular and Molecular Diagnosis Tulane University School of MedicineNew OrleansLA 70112USA Department of Biochemistry&Molecular Biology Tulane University School of MedicineNew OrleansLA 70112USA

Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair *** studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice *** review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases.

关键词： Extracellular vesicles Macrophage Tissue injury Inflammatory disease Interaction loop Stem cell Sepsis Targeted therapy