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Recent progress in the study of methylated tumor suppressor genes in gastric cancer

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Chinese Journal of Cancer 2013年第1期32卷 31-41页

作者： Xiao-tong hu Chao He Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Department of Colorectal Surgery Sir Run Run Shaw Hospital

Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality *** pathogenesis mechanisms of gastric cancer are still not fully *** of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in *** evidence has shown that epigenetic silencing of the tumor suppressor genes,particularly caused by hypermethylation of CpG islands in promoters,is critical to carcinogenesis and ***,we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric *** also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.

关键词：抑癌基因甲基化胃癌肿瘤抑制基因癌组织发病机制表观遗传恶性肿瘤

Transfer matrix method for free and forced vibrations of multi-level functionally graded material stepped beams with different boundary conditions

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 983-1000页

作者： Xiaoyang SU tong hu Wei ZHANG Houjun KANG Yunyue CONG Quan YUAN School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China Scientific Research Center of Engineering Mechanics Guangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

Functionally graded materials(FGMs)are a novel class of composite materials that have attracted significant attention in the field of engineering due to their unique mechanical *** study aims to explore the dynamic behaviors of an FGM stepped beam with different boundary conditions based on an efficient solving *** the assumptions of the Euler-Bernoulli beam theory,the governing differential equations of an individual FGM beam are derived with Hamilton’s principle and decoupled via the separation-of-variable ***,the free and forced vibrations of the FGM stepped beam are solved with the transfer matrix method(TMM).Two models,i.e.,a three-level FGM stepped beam and a five-level FGM stepped beam,are considered,and their natural frequencies and mode shapes are *** demonstrate the validity of the method in this paper,the simulation results by ABAQUS are also *** this basis,the detailed parametric analyses on the frequencies and dynamic responses of the three-level FGM stepped beam are carried *** results show the accuracy and efficiency of the TMM.

关键词： transfer matrix method(TMM) free vibration forced vibration functionally graded material(FGM) stepped beam

Advances in epigenetic biomarker research in colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4276-4287页

作者： Xi Wang Ye-Ye Kuang Xiao-tong hu Biomedical Research Center Sir Run Run Shaw HospitalZhejiang University and Key Laboratory of Biotherapy of Zhejiang Province

Colorectal cancer(CRC)causes approximately 600000deaths annually and is the third leading cause of cancer mortality *** significant advancements in treatment options,CRC patient survival is still poor owing to a lack of effective tools for early diagnosis and a limited capacity for optimal therapeutic decision *** there exists a need to find new biomarkers to improve diagnosis of CRC,the research on epigenetic biomarkers for molecular diagnostics encourages the translation of this field from the bench to clinical *** alterations are thought to hold great promise as tumor *** this review,we will primarily focus on recent advances in the study of epigenetic biomarkers for colorectal cancer and discuss epigenetic biomarkers,including DNA methylation,microRNA expression and histone modification,in cancer tissue,stool,plasma,serum,cell lines and *** studies have improved the chances that epigenetic biomarkers will find a place in the clinical practices of screening,early diagnosis,prognosis,therapy choice and recurrence surveillance for CRC ***,these studies have typically been small in size,and evaluation at a larger scale of well-controlled randomized clinical trials is the next step that is necessary to increase the quality of epigenetic biomarkers and ensure their widespread clinical use.

关键词： Colorectal cancer Epigenetic biomarker DNA methylation MicroRNA biomarker Histone modification

Sub-pixel high precision dimensional measurement method for aero-engine hollow turbine blade based on industrial computed tomography image

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China Foundry 2022年第4期19卷 307-320页

作者： Ya-nan Wang San-san Shuai Xing-fu Ren tong-tong hu Jiang Wang Zhong-ming Ren State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

Aero-engine hollow turbine blades are work under prolonged high temperature,requiring high dimensional *** profile and wall thickness are important parameters to ensure the comprehensive performance of blades,which need to be measured accurately during manufacturing *** this study,a high accuracy industrial computed tomography(ICT)measuring method was developed based on standard cylindrical pin and ring workpieces of different *** ICT with cubic spline interpolation,a sub-pixel accuracy was achieved in measuring the dimension of *** with the traditional and whole-pixel level image measurement method,the cubic spline interpolation algorithm has the advantages of high accuracy in image edge detection and thus high accuracy of dimensional ***,the technique was employed to measure the profile and wall thickness of a typical aerospace engine turbine blade,and an accuracy higher than 0.015 mm was obtained.

关键词： dimensional accuracy industrial computed tomography cubic spline interpolation sub-pixel accuracy

Facile synthesis of Fe single-atom porous photocatalysts via direct metal atomization achieving efficient photocatalytic nitrogen fixation

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Journal of Materials Science & Technology 2023年第36期167卷 248-257页

作者： tong hu Guanjie Jiang Yupeng Yan Shuai Lan Junjie Xie Qin Zhang Yang Li Key Laboratory of Agricultural Resources and Ecology in Poyang Lake Watershed of Ministry of Agriculture and Rural Affairs in China Jiangxi Agricultural UniversityNanchang 330045China

Photocatalytic nitrogen fixation has been explored as a feasible pathway for ammonia ***-ever,the convenient and efficient preparation of photocatalysts for nitrogen fixation remains a ***,the reaction pathway and mechanism of photocatalytic nitrogen fixation are ***,single-atom Fe-porous g-C_(3)N_(4)(FPx)samples were manufactured using a one-step anneal technique via bubble template and direct metal *** results indicate that FPx has a porous structure and single-atom *** porous structure exposed more active ***,single-atom Fe changes the adsorption mode of N_(2)from physical to chemical and turns the photocatalytic ni-trogen fixation from the associative distal pathway to the associative alternating ***,without any sacrificial agent or cocatalysts,FPx presents a prominent increase in photocatalytic activ-ity,reaching 62.42μmol h^(−1)g^(−1),over fivefold larger than that of bulk g-C_(3)N_(4).This work provides new insights into photocatalytic nitrogen fixation and achieves efficient N_(2)photoreduction by constructing single-atom photocatalysts.

关键词： Single-atom Fe Porous Graphitic carbon nitride Photocatalytic nitrogen fixation

Calibratio performance evaluation of the spaceborne hyperspectral CHRIS imager

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Science China(Technological Sciences) 2006年第Z2期49卷 88-96页

作者： ZHANG Xia ZHANG Bing hu Fangchao tong Qingxi State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing 100101 China

The CHRIS (Compact High Resolution Imaging Spectrometer) is a new imaging spectrometer, carried on board a new space platform called PROBA (Project for On Board Autonomy). The satellite was successfully launched in October 2001 by the European Space Agency (ESA). CHRIS operates over the visible/near infrared band (400-1050 nm). It has five work modes and can reach a maximum of 62 spectral bands. In this research, atmospheric correction based on hyperspectral images was performed on CHRIS images by using the popular radiance transfer code ACORN (Atmospheric Correction Now) and empirical algorithms. ACORN was also used to evaluate the calibration performance of CHRIS by the retrieved spectra of typical vegetation and soil. As a result,the maize reflectance spectrum corrected by ACORN could characterize vegetation reflectance in the range of 498-750 nm, but gave a fairly large deviation beyond 750 nm,showing the deficiency of spectral calibration beyond 750 nm. The ACORN-derived soil reflectance decreased beyond 800 nm, which was quite inconsistent with field-spectrummeasurement and showed that the calibration accuracy couldn't meet the requirements of ACORN for spectral and radiometric calibration within a certain spectral range. In addition,the stripes on the retrieved water-vapor content map indicated that the radiance-calibration performance of CHRIS is not perfect. As the first spaceborne hyperspectral imager of ESA, the calibration performance of CHRIS needs to be improved.

关键词： CHRIS, hyperspectral, calibration performance, image-based atmospheric correction.

Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage

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Neural Regeneration Research 2013年第29期8卷 2693-2702页

作者： Gang Chen tong hu Qi Li Jianke Li Yang Jia Zhong Wang Department of Neurosurgery the First Affiliated Hospital of Soochow University Department of Neurosurgery Yixing People's Hospital

Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid hemorrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage.

关键词： neural regeneration brain injury synaptosomal-associated protein-25 subarachnoid hemorrhage cognition cortex hippocampus cerebellum grants-supported paper neuroregeneration

Visiting the roles of Sr-or Ca-doping on the oxygen reduction reaction activity and stability of a perovskite cathode for proton conducting solid oxide fuel cells

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SusMat 2023年第1期3卷 91-101页

作者： tong hu Yangsen Xu Kang Xu Feng Zhu Yu Chen School of Environment and Energy South China University of TechnologyGuangzhouChina

While double perovskites of PrBaCo_(2)O_(6)(PBC)have been extensively developed as the cathodes for proton-conducting solid oxide fuel cells(H-SOFCs),the effects of Sr-or Ca-doping at the A site on the activity and stability of the oxygen reduction reaction are yet to be fully ***,the effect of A-site doping on the oxygen reduction reaction activity and stability has been studied by evaluating the performance of both symmetrical and single *** is shown that Ca-doped PBC(PrBa_(0.8)Ca_(0.2)Co_(2)O_(6),PBCC)shows a slightly smaller polarization resistance(0.076Ωcm^(2))than that(0.085Ωcm^(2))of Sr-doped PBC(PrBa0.8Sr0.2Co2O6,PBSC)at 700◦C in wet ***,the degradation rate of PBCC is 0.0003Ωcm^(2)h^(−1)(0.3%h−1)in 100 h,about 1/10 of that of PBSC at 700◦C in wet *** addition,it is also confirmed that single cells with PBCC cathode show higher peak power density(1.22Wcm^(−2)vs.1.08Wcm^(−2)at 650◦C)and better durability(degradation rate of 0.1%h^(−1)vs.0.13%h^(−1))than those with PBSC *** distribution of relaxation time analyses suggests that the better stability of the PBCC electrode may come from the fast and stable surface oxygen exchange process in the medium frequency range of the electrochemical impedance spectrum.

关键词： activity and stability cathode oxygen reduction reaction proton-conducting solid oxide fuel cells

Reconstruction Model of Ocean Observing Complex Virtual Instrument

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Journal of Ocean University of China 2018年第5期17卷 1159-1170页

作者： QIU Zhijin GUO Zhongwen WANG Yu hu tong LIU Chao LI Ting Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences) Department of Computer Science and Technology College of Information Science and EngineeringOcean University of China Department of Computer Science College of Computing and InformaticsUniversity of North Carolina at Charlotte

With the newly proposed Global Ocean Observing Integration, ocean observing scope has been expanded from the region to the global, therefore the need of large-scale ocean observing system integration has become more and more urgent. Currently, ocean observing systems enabled ocean sensor networks are commonly developed by different organizations using specific technologies and platforms, which brings several challenges in ocean observing instrument （OOI） access and ocean observing system seamless integration. Furthermore, the development of ocean observing systems often suffers from low efficiency due to the complex prograrmning and debugging process. To solve these problems, a novel model, Complex Virtual Instrument （CVI） Model, is proposed. The model provides formal definitions on observing instrument description file, CVI description file, model calculation method, development model and interaction standard. In addition, this model establishes mathematical expressions of two model calculation operations, meanwhile builds the mapping relationship between observing instrument description file and CVI description file. The CVI based on the new model can achieve automatic access to different OOIs, seamless integration and communication for heterogeneous environments, and further implement standardized data access and management for the global unified ocean observing network. Throughout the development, integration and application of such CVI, the rationality and feasibility of the model have been evaluated. The results confirm that the proposed model can effectively implement heterogeneous system integration, improve development efficiency, make full usage of reusable components, reduce development cost, and enhance overall software system quality. We believe that our new model has great significance to promote the large-scale ocean observing system integration.

关键词： ocean observing complex virtual instrument seamless integration model calculation development platform