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Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis

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World Journal of Gastroenterology 2015年第14期21卷 4365-4372页

作者： qi-Bin Song qi Wang Wei-Guo hu Department of Oncology Renmin Hospital of Wuhan University

AIM: To investigate the correlation between Kirsten rat sarcoma viral oncogene homolog(KRAS) status and the therapeutic effects of anti-epidermal growth factor receptor(EGFR) monoclonal antibodies(Mo Abs) in metastatic colorectal cancer(m CRC).METHODS: Randomized controlled trials(RCTs) were identified and the association between KRAS mutation and clinical outcome in m CRC patients treated with anti-EGFR Mo Abs was *** RCTs wereincluded in this ***-free survival and overall survival were used to assess the strength of the relationship between KRAS mutation and clinical ***: In first-line treatment, survival benefit was confined to patients with wild-type *** regimens and angiogenesis inhibitor treatment influenced the results of the *** KRAS m CRC patients did not seem to benefit from oxaliplatin-based chemotherapy(PFS: HR = 0.88, 95%CI: 0.70-1.10; OS: HR = 0.93, 95%CI: 0.82-1.04).Clinical benefit in m CRC patients was limited to therapeutic regimens which included anti-EGFR Mo Abs and fluorouracil-based therapy(PFS: HR = 0.77, 95%CI: 0.69-0.86; OS: HR = 0.85, 95%CI: 0.75-0.95).When anti-EGFR Mo Abs were used as second- or further-line treatment, clinical benefit was still confined to patients with wild-type ***: KRAS status is a potential predictive marker of clinical benefit due to anti-EGFR Mo Ab therapy in m CRC patients.

关键词： Colorectal neoplasm Kirsten rat sarcoma viral onco

Special issue on application of Al in steelmaking and ferrous materials

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Journal of Iron and Steel Research International 2023年第5期30卷 849-850页

作者： Wangzhong Mu Jie Sun Hong-hui Wu shun-hu Zhang Department of Materials Science and Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Beijing Advanced Innovation Center for Materials Genome Engineering Innovation Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

It is well known that metallurgy is one of the key industries for national economic ***,state-ofthe-art information technologies,like artificial intelligence(AI),industrial big data,etc.,are of vital importance for economic and social development to meet the intelligentization of metallurgical processes and to promote intelligent *** techniques are also boosting the transformation and upgrading of traditional manufacturing ***-based intelligent manufacturing process,integrating the technologies of advanced manufacturing and the new generation of informatics,is a new opportunity for further innovation and development of global metallurgical industries.

关键词： integrating boosting intelligent

Stress Wave Propagation Analysis on Vortex-Induced Vibration of Marine Risers

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China Ocean Engineering 2017年第1期31卷 30-36页

作者： LI hua-jun WANG Chao LIU Fu-shun hu Sau-Lon James Shandong Provincial Key Lab of Ocean Engineering Ocean University of China Department of Ocean Engineering University of Rhode Island

To analyze the stress wave propagation associated with the vortex-induced vibration（VIV） of a marine riser, this paper employed a multi-signal complex exponential method. This method is an extension of the classical Prony＇s method which decomposes a complicated signal into a number of complex exponential components. Because the proposed method processes multiple signals simultaneously, it can estimate the “global” dominating frequencies（poles） shared by those *** complex amplitude（residues） corresponding to the estimated frequencies for those signals is also obtained in the process. As the signals were collected at different locations along the axial direction of a marine riser, the phenomena of the stress wave propagation could be analyzed through the obtained residues of those signals. The Norwegian Deepwater Program（NDP） high mode test data were utilized in the numerical studies, including data sets in both the in-line（IL） and cross-flow（CF） directions. It was found that the most dominant component in the IL direction has its stress wave propagation along the riser being dominated by a standing wave, while that in the CF direction dominated by a traveling wave.

关键词： Vortex exponential utilized reconstructed riser directions interpolation dominated residues processed

Preparation and characterization of high-performance ZrB2-SiC-Cf composites sintered at 1450 ℃

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Journal of Advanced Ceramics 2017年第2期6卷 110-119页

作者： Wenhu HONG Kaixuan GUI Ping hu Xinghong ZHANG shun DONG China Academy of Launch Vehicle Technology Beijing 100000 China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of Technology Harbin 150001 China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of Technology Harbin 150001 ChinaKey Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of SciencesHefei 230031 China

ZrB2-SiC-Cf composites containing 20-50 vol％ short carbon fibers were hot pressed at low sintering temperature (1450 ℃) using nanosized ZrB2 powders,in which the fiber degradation was effectively *** strain-to-failure values of such composites increased with increasing fiber content,and the value for the composite with 50 vol％ Cf was even more than 3 times higher than that of the composite with 20 vol％ ***,the composite exhibited non-brittle fracture mode when the fiber content was above 30 vol％,and the thermal shock critical temperature difference of the composite with 30 vol％ Cf was up to 727 ℃,revealing excellent thermal shock resistance of this ***,ZrB2-Sic-Cf composites displayed good oxidation resistance when the fiber content was below 40 vol％,suggesting that this method provides a promising way for preparation of high-performance ZrB2-SiC-Cf composites at low temperature.

关键词： ceramics fibers microstructure thermal shock resistance oxidation resistance

A β-type TiNbZr alloy with low modulus and high strength for biomedical applications

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Progress in Natural Science:Materials International 2014年第2期24卷 157-162页

作者： qingkun Meng shun Guo qing Liu Liang hu Xinqing Zhao School of Materials Science and Engineering Beihang University Institute for Advanced Materials Jiangsu University

The effect of thermo-mechanical treatment on the mechanical properties of a novel β-type Ti–36Nb–5Zr(wt%) alloy has been *** solution treated alloy consists of β and α″ phases and exhibits a two-stage yielding with a low yield stress(around 100 MPa). After cold rolling at a reduction of 87.5% and subsequent annealing treatment at 698 K for 25 min, a fine microstructure with nanosized α precipitates distributed in small β grains as well as high density of dislocations was obtained to achieve a yield strength of 720 MPa and a ultimate tensile strength of 860 MPa. In spite of the formation of α precipitates, the β-stabilizers are not enriched in the parent β matrix due to the short duration and low temperature of the thermal treatment, resulting in a low chemical stability of β phase. The low stability of β phase and the small volume fraction of α precipitates produce a low Young’s modulus of 48 GPa. Such an excellent combination of low elastic modulus and high strength in mechanical properties indicates great potential for biomedical applications.

关键词： β-type Ti alloy Ti–Nb–Zr Chemical stabilization Young’s modulus Biomedical

Space experimental investigation on thermocapillary migration of bubbles

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Science China(Physics,Mechanics & Astronomy) 2008年第7期51卷 894-904页

作者： CUI HaiLiang hu Liang DUAN Li KANG qi hu WenRui National Microgravity Laboratory Institute of MechanicsChinese Academy of SciencesBeijing 100080China

Results from a space experiment on bubble thermocapillary migration conducted on board the Chinese 22nd recoverable satellite were presented. Considering the temperature field in the cell was disturbed by the accumulated bubbles, the temperature gradient was corrected firstly with the help of the temperature measurement data at six points and numerical simulation. Marangoni number (Ma) of single bubble migrating in the space experiment ranged from 98.04 to 9288, exceeding that in the previous experiment data. The experiment data including the track and the velocity of two bubble thermocapillary migration showed that a smaller bubble would move slower as it was passed by a larger one, and the smaller one would even rest in a short time when the size ratio was large enough.

关键词： bubble thermocapillary migration microgravity interaction

THE HYDRODYNAMIC CHARACTERISTICS OF FREE VARIABLE-PITCH VERTICAL AXIS TIDAL TURBIN

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Journal of Hydrodynamics 2012年第6期24卷 834-839页

作者： ZHANG Xue-weii WANG Shu-qi WANG Feng ZHANG Liang SHENG qi-hu Institute of Ocean Renewable Energy System Harbin Engineering University

The hydrodynamic characteristics of free variable-pitch vertical axis tidal turbine are investigated by combining experimental and numerical simulations. The variations of hydrodynamics are obtained based on testing the kinematics and the dynamics of the turbine under different flow and structural conditions. Through analyzing the movement of the turbine and the characteristics of the flow field by numerical simulations, it is shown how the turbine＇s performance is improved.

关键词： tidal current energy vertical axis variable-pitch turbine hydrodynamic characteristics experiments

One-pot synthesis of concentration and excitation dual-dependency truly full-color photoluminescence carbon dots

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Chinese Chemical Letters 2022年第8期33卷 4116-4120页

作者： Chen Wei shun hu Fuxin Liang Zhining Song Xue Liu Institute of Clean Energy Chemistry Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced MaterialsCollege of ChemistryLiaoning UniversityShenyang 110036China Institute of Polymer Science and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

The paper describes a kind of truly full-color photoluminescence(PL)*** CDs were prepared by using one-pot hydrothermally heating citric acid and formamide at 200℃ for 2 *** CDs have three fluorescent centers at blue,green,and red light *** color was regulated through two means,including changing excitation wavelengths or CDs *** emission maxima changed from blue to red with the increase of excitation wavelengths or CDs *** full-color PL behavior of the CDs was inherited and conserved in the solid polymer matrix,giving multicolor CDs/polymer films and light emitting diodes(LEDs).White-light LED(WLED)with the CIE coordinate approaching to(0.31,0.32)were also achieved.

关键词： Carbon dots Full-color Fluorescent centers Concentration and excitation White-light LEDs

Controllable time delay using slow/fast light in active fiber ring resonators with gain manipulation

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Science China(Physics,Mechanics & Astronomy) 2013年第6期56卷 1085-1089页

作者： XIAO PingPing hu HongWu qi Min College of Physics Science and Engineering Technology Yichun University College of Mathematics and Computer Science Yichun University

We propose to generate controllable time delay using slow/fast light in fiber ring resonators with gain *** dispersion and group delay of active fiber ring resonator can be controlled by manipulating its gain level below the lasing *** of the negative group delay in the undercoupled regime and the positive group delay in the overcoupled regime is theoretically ***,large group delay can be obtained accompanied by signal gain in active ring *** addition,we describe wide bandwidth and large group delay in 4-stage cascaded ring resonators.

关键词： slow and fast light fiber ring resonator loss factor active fiber