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Microwave-assisted reaction of peptide formation by amino acid with phosphate:Exploration of the most possible channels for the origin of life

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Science china chemistry 2006年第4期49卷 351-356页

作者： hu rong1, tian jinping2.& yin yingwu2.3.1. college of chemistry & environment protection engineering, southwest University for {3., chengdu 610041, china 2. TH-UNIS Insight Co., Ltd., Beijing 100085, china 3. Key Laboratory of Bioorganic Phosphorus chemistry & Chemical Biology, Ministry of Education, Department of chemistry, Tsinghua University, Beijing 100084, china 1. college of chemistry & environment {3. engineering Southwest University for Nationalities Chengdu 610041 China 2. TH-UNIS Insight Co. Ltd. Beijing 100085 China 3. Key Laboratory of Bioorganic Phosphorus chemistry & Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 China

Microwave-assisted reaction of peptide formation by amino acids with phosphate was studied. The results showed that the products were a mixture of peptides containing dipeptide, oc- tapeptides and cyclic peptides, which could be obtained in a short time. Polyphosphate was also produced synchronously by the intermolecular condensation of phosphate. The polymerization de- gree reached 99% (pyrophosphate 64%, trimetaphosphate 3.%) after 2 h at 200℃ under microwave irradiation. The intermediates of the mixed anhydrides formed by the intermolecular condensation of phosphates and glycin were determined by ESI-MS. Peptides were also produced by the reaction of amino acids with trimetaphosphate in aqueous solution. The conversion degree of valine reached 46.5% even at room temperature. The cyclic process of peptide formation and phosphate polymeri- zation, regeneration and utilization in amino acids-phosphate system under microwave irradiation was detected and proved. Peptides could be continually formed only by inputting energy into this system. The above recycle may be the most possible process for primitive peptide formation in the origin of life.

关键词： microwave, phosphate, amino acid, peptide, origin of life.

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