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Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

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Chinese Chemical Letters 2015年第3期26卷 334-338页

作者： Yan Wu Wei-Qi Chen Yu-Qing Zhao hu-Ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of EducationYanbian University College of Pharmacy Department of Chemistry Fudan University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow *** antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT *** 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.

关键词： antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate

生活饮用水中乙草胺的固相萃取-气相色谱-质谱联用测定法

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环境与健康杂志 2024年第3期41卷 263-265页

作者：胡宁恩戴胡票李小东郑三燕温州市疾病预防控制中心(温州市卫生监督所)理化检验所浙江325100

目的建立生活饮用水中乙草胺的固相萃取(SPE)-气相色谱-质谱(GC-MS)联用测定法。方法生活饮用水经全自动固相萃取系统进行萃取,洗脱液浓缩至1.0 ml,用气相色谱-质谱联用仪测定,内标法定量。通过实验优化进样流速、进样体积和洗脱流速,... 详细信息

目的建立生活饮用水中乙草胺的固相萃取(SPE)-气相色谱-质谱(GC-MS)联用测定法。方法生活饮用水经全自动固相萃取系统进行萃取,洗脱液浓缩至1.0 ml,用气相色谱-质谱联用仪测定,内标法定量。通过实验优化进样流速、进样体积和洗脱流速,从检出限、精密度、准确度及加标样品的测定结果评价本方法的分析效果。结果乙草胺在10~250μg/L范围内有良好的线性关系,相关系数为0.9995;乙草胺的检出限为0.0062μg/L,定量下限为0.025μg/L;内标法所得加标回收率分别为95.2%~99.8%,RSD为1.3%~1.6%。结论该方法具有较高的精密度和准确度,且目标峰和内标分离度好,适用于生活饮用水中乙草胺的检测。

关键词：固相萃取气相色谱-质谱乙草胺生活饮用水

Synthesis Process of MgO-CaO Clinkers and Surface Modification

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China's Refractories 2014年第3期23卷 35-39页

作者： hu piao WANG Jing YU Lingyan Sinosteel Luoyang Institute of Refractories Research Co. Ltd.

The MgO - CaO clinkers were prepared by light burnt and calcining Yanfeag dolomite （〈 0. 088 and 〈 0. 045 mm） , and then were modified via hydration carhonation technology. Th, e synthesis conditions including particle size of the starting materials, the light burnt and calcining temperatures were optimized. The morphology of the modified clinkers surface was observed via SEM, the growth pattern and crystal morphology of the modifled layer and the hydration resistance of the clinkers u,ere researched. The results show that ：（1） the suitable light burnt temperature is 850 ℃ ; （2） the suitable cal- cining temperature is 1 650 ℃; （ 3 ） after hydration carbonation, a dense and uniform CaCO3 layer with a certain thickness is jormed on the surface of the clinkers; prolonging the modtfieation duration can obviously en- hance the hydration resistance of the clinkers; particle size plays an important role in the formation and growth of CaCO3 on the surface.

关键词： dolomite synthesized periclase- lime calcining tempera- modifiealion

Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives

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Chinese Chemical Letters 2009年第2期20卷 175-177页

作者： Ting Ting Li Ling Zhang Zhe Shan Quan Hai Bo Zhu hu Ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of Education Yanbian University College of Pharmacy Yanji 133000 China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

In an attempt to search for more potent positive inotropic agents, a series of 1-（benzylamino）-3-（4,5-dihydro[ 1,2,4]trizaolo[4,3- a]quinolin-7-yloxy）propan-2-ol derivatives was synthesized in four steps using 6-hydroxy-3,4-dihydro-2（1H）-quinolinone as a starting material, and their positive inotropic activities were evaluated by measuring the coronary blood flow （CBF） and the left ventricular pressure （LVP） followed by calculating the rate of pressure development （dp/dtmax values） in the preparation of rat Langendorff＇s heart. Three compounds （5d, 5g, 5j） showed favorable activities, among which 5g was shown the most potent with dp/dtmax value of 9.7% and CBF value of 17.8% at a concentration of 1×10^-5 mol/L in our in vitro study.

关键词： 3,4-Dihydrotrizaolo[4,3-a]quinoline Positive inotropic activity Synthesis

Influence of Temperature Conditions on Dynamic Young’s Modulus Testing

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China's Refractories 2019年第3期28卷 19-21页

作者： SONG Yanyan hu piao LI Ruhang LI Xiaorui Sinosteel Luoyang Institute of Refractories Research Co. Ltd.

The Young’s modulus was measured at high temperatures by impulse excitation of vibration method,and the effects of heating rate,holding time and temperature cycle on the test results were *** results show that the heating rate has obvious effect on the high temperature Young’s modulus of the green body,but has no obvious effect on that of the sintered products;the holding time of the heating process has no regular effect on the Young’s modulus,and the effect varies with the different products at a certain temperature;the method can also be used to test the Young’s modulus during cooling process.

关键词： dynamic Young’s modulus heating rate holding time temperature cycle

Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents

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Chinese Chemical Letters 2017年第8期28卷 1737-1742页

作者： Tian-Yi Zhang Chao Li Yu-Shun Tian Jia-Jun Li Liang-Peng Sun Chang-Ji Zheng hu-Ri piao Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules Ministry of EducationYanbian University College of PharmacyYanji133000China Department of Pharmacy Jilin Medical UniversityJilin 132013China

A series of 1,4-dihydro-1,3,5-triazine derivatives were designed and synthesized and their antibacterial and antifungal activities were evaluated. Most of the synthesized compounds showed potent inhibition of several Gram-positive bacterial strains（including multidrug-resistant clinical isolates） and Gramnegative bacterial strains, with minimum inhibitory concentrations（MICs） in the range of 2.1–181.2 mmol/L. Compounds 7a and 7c presented the most potent inhibitory activities against Grampositive bacteria（e.g., Staphylococcus aureus 4220）, Gram-negative bacteria（e.g., Escherichia coli 1924）,and the fungus Candida albicans 7535, with MICs of 2.1 or 4.1 mmol/L. Especially, compound 7a was the most potent, with an MIC of 2.1 mmol/L against four multidrug-resistant, Gram-positive bacterial *** cytotoxic activity of the compound 7a, 7c and 7f was assessed in HepG2 cells, and the results suggest that 1,4-dihydro-1,3,5-triazine derivatives bearing a 6-benzyloxynaphthalen moiety are interesting scaffolds for the development of novel antibacterial agents.

关键词： Antibacterial activitis Antifungal activities Cytotoxicity Minimal inhibitory concentration 1 4-Dihydro-1 3 5-triazine

Main Influencing Factors on Service Life of High Chrome Refractories for Coal Water Slurry Gasifiers

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China's Refractories 2017年第2期26卷 31-34页

作者： hu piao WANG Jing GENG Kerning WANG Han TAN Qinghua SHI Pengkun YIN Hongji Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang 471039China

The main characteristics of high chrome refractories for coal water slurry gasifiers were introduced. The damage mechanism of the refractories was analyzed by observing the microstructure of the used high chrome refra... 详细信息

关键词： coal water slurry gasifier high chrome re-fractories characteristics damage mechanism servicelife

Acyldesilylation of 5-Trimethylsilyl-2-furancarboxaldehyde

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Chinese Chemical Letters 1999年第1期10卷 11-12页

作者： hu Ri piao Zhe Shan QUAN Kouji NAKAYAMA Akira TANAKA(School of Pharmacy，Yanbian University，Yanji，133000)(Faculty of Pharmaceutical Sciences，Josai University,Saitama，Japan 350-02) School of Pharmacy Yanbian University Yanji 133000 China Faculty of Pharmaceutical Sciences Josai University Saitama 350-02 Japan

Acyldesilylation of 5-trimethylsilyl-2-furancarboxaldehyde with acyl chlorides was investigated and the unexpected 5-acyl-2-dichloromethylfuran were obtained as main products. The expected 5-acyl-2-furancarboxaldehyde... 详细信息

关键词： 2-acyl-5-dichloromethylfuran 5-acyl-2-furancarboxaldehyde 5-trimethyisilyl-2-furancarboxaldehyde acyldesilylation

Ancient mitochondrial genome depicts sheep maternal dispersal and migration in Eastern Asia

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Journal of Genetics and Genomics 2024年第1期51卷 87-95页

作者： Liu Yang Xing Zhang Yaning hu piao Zhu hua Li Zhenyu Peng Hai Xiang Xinying Zhou Xingbo Zhao National Engineering Laboratory for Animal Breeding Key Laboratory of AnimalGeneticsBreeding and ReproductionMinistry of Agriculture and Rural AffairsCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanGuangdong 528225China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China Key Laboratory of Vertebrate Evolution and human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

Sheep have been one of the most important groups of animals since ancient ***,the knowledge of their migration routes and genetic relationships is still poorly *** investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 *** combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern *** least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 ***,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.

关键词： Sheep Ancient DNA Eastern Asia Mitochondrial genome Migration Altai