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Efficacy of rapid antigen self-testing for SARS-CoV-2 screening:Real-world evidence from a prospective cohort study

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Genes & Diseases 2024年第5期11卷 88-90页

作者： Yaoyue hu Bin peng Jie Fan Zhu Yang Jianjiang Xue Quanxin Long Jie Xia Yuan hu Xuefei Cai Li Zhou Ailong huang School of Public Health Chongqing Medical UniversityChongqing 400016China The Second Affiliated Hospital of Chongqing Medical University Chongqing 400016China Clinical Laboratory University-Town Hospital of Chongqing Medical UniversityChongqing 401331China Key Laboratory of Molecular Biology on Infectious Diseases Designated by the Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

Antigen rapid diagnostic tests(Ag-RDTs)have been considered and implemented as an important diagnostic and screening tool to identify SARS-CoV-2 infections in community settings.1 Ag-RDTs are less sensitive,particularly in asymptomatic populations,compared with laboratorybased viral nucleic acid amplification tests(NAATs)such as reverse transcription polymerase chain reaction(RT-PCR).2 However,taking into account the facts that Ag-RDTs are effective for identifying most contagious individuals,they are faster and less expensive than RT-PCR,as well as that RT-PCR could produce positive results for weeks to months after the infection,2 WHO recommends Ag-RDTs be offered as COVID-19 self-testing for screening purposes in addition to professionally administered testing services regardless of the community transmission level.

关键词： testing faster rapid

Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-Yan hu Yan-Ling WANG Zhen-Xing FAN Xi-peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

Measurements of Total Reaction Cross Section for Light Nuclei and Evidence for the Anomalous Nuclear Structure in ^(15)C

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Chinese Physics Letters 2000年第9期17卷 655-657页

作者： FANG De-Qing SHEN Wen-Qing FENG Jun CAI Xiang-Zhou WANG Jian-song SU Qian-Min ZHANG hu-Yong hu peng-yun MA Yu-Gang Zhu Yong-tai LI Song-Lin WU He-Yu GOU Quan-bu JIN Gen-Ming ZHAN Wen-Long GUO Zhong-Yan XIAO Guo-Qing Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Modern Physics Chinese Academy of SciencesLanzhuo 730000

Measurements of the total reaction cross section for^(12-16)C,^(14-17)N and^(16-18)O on carbon target at intermediate energies were performed on RIBLL of HIRFL.A larger enhancement ofσR for^(15)C was observed than that for its *** analysis of these data indicates possible existence of an anomalous nuclear structure in^(15)C.A new quantity was suggested as the criterion to distinguish anomalous structure nuclei from normal nuclei.

关键词： criterion structure neighbor

Experimental investigation on indoor daylight environment of building with Cadmium Telluride photovoltaic window

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Energy and Built Environment 2024年第3期5卷 404-413页

作者： Yilin hu Qingwen Xue Haobo Wang peng Zou Jinming Yang Shikeng Chen Yuanda Cheng State Key Laboratory of Green Building in Western China Xian University of Architecture&TechnologyXianChina College of Civil Engineering Taiyuan University of TechnologyTaiyuanChina

Photovoltaic(PV)windows have received more and more attention in recent years since their active energy-saving *** the surface covered with solar cell modules,the indoor daylight environment of PV windows is obviously different with clear glass ***,despite many scholars have studied the indoor daylight environment of PV windows,there few investigations study it from the perspective of human subjective visual *** this paper,the indoor daylight environment and human visual comfort of building with Cadmium Telluride Photovoltaic(CdTe-PV)window were ***,the parameters of indoor daylight environment and subjective questionnaires in rooms with CdTe-PV window and clear glass window were analyzed *** the basis of this,combined with indoor working surface illuminance and results of subjective questionnaires,the daylight illuminance threshold of human visual comfort was investigated by the method of Mean Bias Degree(MBD).Finally,an evaluation model for indoor daylight environment of buildings with CdTe-PV window was developed by Fuzzy Comprehensive Evaluation *** results showed that the working surface illuminance of CdTe-PV window was lower than that of clear glass room,the CCT of different windows room had a minor gap and the CdTe-PV window room was closer to the recommended range that was *** for CRI,both the CdTe-PV window room and the clear glass room could meet the visual comfort requirements of office ***,it was found that the requirement of human visual comfort was met when indoor working surface illuminance varies between 500-2200lx in the room with CdTe-PV *** last,according to the comprehensive evaluation model proposed in this paper,it was found that the indoor daylight environment of buildings with CdTe-PV window was excellent in the present experiment.

关键词： Cadmium Telluride photovoltaic(CdTe-PV)window Daylight environment human visual comfort Fuzzy comprehensive evaluation method

Smart beam via electrically addressing the dye-doped and polymer-stabilized cholesteric liquid crystals

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Chinese Optics Letters 2024年第5期22卷 111-116页

作者：彭程徐春庭胡伟 College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China

Smart beams play a vital role in modern intelligent vehicles and have recently attracted significant attention.A spatial light modulator with high optical efficiency,low cost,and compact size is crucial for designing smart ***,we mix cholesteric liquid crystals with dichroic black dye and a *** UV polymerization,the sample exhibits a low driving voltage of 26 V,a high transmittance of over 70%,and an On-off ratio over 280,thanks to the joint contribution of both the absorption and the scattering effect.A smart beam device is demonstrated by electrically addressing the dye-doped and polymer-stabilized cholesteric liquid crystal with pixelated *** patterns with arbitrary designs are projected *** switching time reaches several tens of *** strategy brings new designs to intelligent vehicles and may also inspire applications in public information displays,advertising,and even AR/VR displays.

关键词： cholesteric liquid crystal spatial light modulation smart beam dye guest-host effect

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting

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Frontiers in Energy 2024年第3期18卷 378-389页

作者： Zhao-ting SHANG Tang-ming LI Bing-qian hu Min LIU Wang-ting LU Fan YU yun ZHENG Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education College of Optoelectronic Materials and TechnologyJianghan UniversityWuhan 430056China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada

The use of two-dimensional(2D)layered metal-organic frameworks(MOFs)as self-sacrificial templates has been proven to be a successful method to create high-efficiency Selenium(Se)-containing electrocatalysts for overall water ***,two strategies are then utilized to introduce Se element into the Co–Fe MOF,one being the etching of as-prepared MOF by SeO_(2) solution,and the other,the replacing of SCN−with SeCN−as the construction *** electrochemical activity of the pristine 2D MOF and their calcinated derivatives for catalyzing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is evaluated and further *** is found that the effect of introducing Se on improving electrochemical catalytic activity is significant for the HER ***,the calcinated derivative in the replacing method exhibits an overpotential of 235 mV for HER and 270 mV for OER at a current density of 10 mA/*** comparing the two methods of introducing Se element into MOF,similar electrocatalytic activity can be achieved on the their calcinated *** high electrochemical performance of 2D CoFe-MOF derivatives may be resulted from the unique 2D hierarchical porous structure and strong synergistic effect between different components in the material.

关键词： 2D MOF selenium(Se)-containing materials hydrogen evolution reaction(HER) oxygen evolution reaction(OER)

Potential modifying effect of grip strength on the association between glycated hemoglobin(HbA1c)and all-cause mortality in older adults with type 2 diabetes:Evidence from UK Biobank

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Chinese Medical Journal 2024年第12期137卷 1501-1503页

作者： Jingyi Lu Yaxin Wang yun Shen Yifei Mo Xiaojing Ma Gang hu Jian Zhou Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Key Laboratory of Diabetes MellitusShanghai 200233China Shanghai Diabetes Institute Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Pennington Biomedical Research Center Baton RougeLA 70808USA

To the Editor:Frailty status represents one of the core determinants for the individualization of glycated hemoglobin(HbA1c)targets in the elderly ***,the most validated tools to quantify frailty,which are complex and involve multiple dimensions of assessment,are rarely used in the clinical practice of diabetes ***,a simple and practical metric for the evaluation of frailty is *** strength is an easily measurable,objective,and reproducible metric for assessing frailty status.[1]It is correlated with overall muscle strength and has been reported to be signicantly related to important health outcomes both in the general population[2,3]and in patients with diabetes.[4]Therefore,grip strength could be a useful marker for patient strati-cation in diabetes *** this context,this study aimed to examine the associations between HbA1c and all-cause mortality across categories of grip strength,as a measure of frailty status,in older adults with type 2 diabetes in the UK *** researches had applied to access the UK Biobank database with the application approval number of 82812.

关键词： diabetes mortality strength

Experimental Study on Vortex-Induced Vibration of Rough Risers with Coupling Interference Effect Under Side-by-Side Arrangement

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China Ocean Engineering 2024年第1期38卷 18-28页

作者： hu Ze-bo LIU Zhen LI peng GUO Hai-yan WANG Shu-bing REN Xiao-hui HOU Hao WANG Ye-shuo College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China CHEC Dredging Co. LtdShanghai 200136China

A vortex-induced vibration(VIV)experiment of rough risers with coupling interference effect under a side-by-side arrangement was carried out in a wave-current combined *** roughness of the riser was characterized by arranging different specifications of surface attachments on the surface of the *** risers with three different roughnesses were arranged side by side with smooth risers to explore the VIV response of the riser under the combined action of roughness and interference effect,and to reveal the coupling mechanism between roughness and interference *** experimental results show that,compared with that of a smooth riser,the VIV of a rough riser under the coupling interference effect has a wider"lock-in"region,and the displacement decreases more significantly at a high reduced velocity,which is more likely to excite higher-order modes and frequency *** addition,the displacement response and frequency response of the smooth riser are not significantly affected by wake interference from the rough riser,which is caused by the decrease of the wake region due to the delay of the boundary layer separation point of the rough riser.

关键词： marine riser vortex-induced vibration side-by-side arrangement roughness interference effect

Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： Xin Lin Xin Lu yun-He Zhao Yi-Bei Wang Ru-Ge Niu Xiao-hu Chen Department of Cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CIN).Methods:CIN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CIN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CIN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CIN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP