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骨癌痛大鼠脊髓背角pCREB表达的变化

中国疼痛医学杂志 2010年第5期16卷 285-288页

作者：胡计嬅杨建平刘磊李彩芳姚明苏州大学附属第一医院麻醉科苏州215006 嘉兴医学院附属第一医院麻醉科嘉兴314000

目的：观察脊髓背角磷酸化环磷酸腺苷反应元件结合蛋白（pCREB,phosphorylated cAMP re-sponse element binding protein）在骨癌痛大鼠中的表达变化,探讨其在骨癌痛中枢敏化中的作用。方法：雌性SD大鼠32只,随机分为4组（n=8）,分别为... 详细信息

目的：观察脊髓背角磷酸化环磷酸腺苷反应元件结合蛋白（pCREB,phosphorylated cAMP re-sponse element binding protein）在骨癌痛大鼠中的表达变化,探讨其在骨癌痛中枢敏化中的作用。方法：雌性SD大鼠32只,随机分为4组（n=8）,分别为对照组,骨癌痛6d、12d、18d组。对照组和骨癌痛各组分别于左胫骨上端注射Hank＇s液和Walker256肿瘤细胞5μl。分别于术前（基础值）、术后6d、12d、18d测定机械性痛阈值。对照组于术后18d,其余三组在各时点测定机械性痛阈值后立即处死大鼠,取L4~L6脊髓组织,采用免疫组化法计数pCREB免疫反应阳性细胞数量。结果：骨癌痛术后6d、12d、18d组机械性痛阈值进行性下降（P〈0.01）,对照组差异无统计学意义（P〉0.05）;与对照组比较,骨癌痛术后6d、12d、18d组脊髓pCREB免疫反应阳性细胞数逐渐增多（P〈0.01）。结论：骨癌痛大鼠脊髓背角pCREB表达的增加,可能是产生中枢敏化的机制之一。

关键词：骨癌痛磷酸化CREB 脊髓中枢敏化

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半薄切片技术实践探讨

黑龙江科学 2014年第10期5卷 44-45页

作者：胡基华李晶张淑梅孟力强曹旭黑龙江省科学院微生物研究所哈尔滨150020 黑龙江省科学院高技术研究所哈尔滨150010

半薄切片的制备是一种常用制样手段,图像清晰度、分辨率远优于石蜡切片,视野大于超薄切片,有利于获得高质量的光镜图像,同时也是电镜超薄切片技术中一种有效的定位方法。尽管一些关键技术如固定、切片、染色有其特点和难点,但是已经成... 详细信息

半薄切片的制备是一种常用制样手段,图像清晰度、分辨率远优于石蜡切片,视野大于超薄切片,有利于获得高质量的光镜图像,同时也是电镜超薄切片技术中一种有效的定位方法。尽管一些关键技术如固定、切片、染色有其特点和难点,但是已经成为现在结构观察中不可缺少的手段之一,在电镜观察中发挥着越来越大的作用和优势。本文从固定液的选择、切片的制备、脱树脂和染色几个方面进行探讨,为找到最好的制片方法提供参考。

关键词：电镜超微结构固定液树脂包埋染色

维普期刊数据库博看期刊

Multi-scale traffic vehicle detection based on faster ReCNN with NAS optimization and feature enrichment

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Defence Technology（防务技术） 2021年第4期17卷 1542-1554页

作者： ji-qing Luo hu-sheng Fang Fa-ming Shao Yue Zhong Xia hua Department of Mechanical Engineering College of Field EngineeringArmy Engineering University of PLANanjing210007China

It well known that vehicle detection is an important component of the field of object ***,the environment of vehicle detection is particularly sophisticated in practical *** is comparatively difficult to detect vehicles of various scales in traffic scene images,because the vehicles partially obscured by green belts,roadblocks or other vehicles,as well as influence of some low illumination *** this paper,we present a model based on Faster ReCNN with NAS optimization and feature enrichment to realize the effective detection of multi-scale vehicle targets in traffic ***,we proposed a Retinex-based image adaptive correction algorithm(RIAC)to enhance the traffic images in the dataset to reduce the influence of shadow and illumination,and improve the image ***,in order to improve the feature expression of the backbone network,we conducted Neural Architecture Search(NAS)on the backbone network used for feature extraction of Faster ReCNN to generate the optimal cross-layer connection to extract multi-layer features more ***,we used the object Feature Enrichment that combines the multi-layer feature information and the context information of the last layer after cross-layer connection to enrich the information of vehicle targets,and improve the robustness of the model for challenging targets such as small scale and severe *** the implementation of the model,K-means clustering algorithm was used to select the suitable anchor size for our dataset to improve the convergence speed of the *** model has been trained and tested on the UN-DETRAC dataset,and the obtained results indicate that our method has art-of-state detection performance.

关键词： Neural architecture search Feature enrichment Faster R-CNN Retinex-based image adaptive correction algorithm K-means UN-DETRAC

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蚓激酶的临床应用

职业与健康 2017年第20期33卷 2867-2869页

作者：金茜张波令狐金卿李华刚罗稼戟胡明华遵义师范学院化学化工学院贵州遵义563006 遵义师范学院工学院贵州遵义563006

蚓激酶是从赤子爱胜蚓中提取的一种具有纤溶活力的丝氨酸蛋白酶,它可直接激活并溶解纤维蛋白原,广泛应用于抗肿瘤、溶栓、中风、冠心病、心肺功能不全、糖尿病合并循环障碍及肾病综合征等多种疾病的治疗。文章主要是对与其相关的临床应... 详细信息

蚓激酶是从赤子爱胜蚓中提取的一种具有纤溶活力的丝氨酸蛋白酶,它可直接激活并溶解纤维蛋白原,广泛应用于抗肿瘤、溶栓、中风、冠心病、心肺功能不全、糖尿病合并循环障碍及肾病综合征等多种疾病的治疗。文章主要是对与其相关的临床应用予以综述,以期能有助于今后对蚓激酶的进一步研究开发和利用。

关键词：蚯蚓蚓激酶临床应用缺血性脑中风肺心病

Horizontal Velocity of Variable Gauge Rolling:Theory and Finite Elements Simulation

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Journal of Iron and Steel Research International 2013年第10期20卷 10-16页

作者： ZHANG Guang-ji LIU Xiang-hua hu Xian-lei ZHI Ying State Key Laboratory of Rolling and Automation Northeastern University

Within the production chain of longitudinal profiled （LP） plates and tailor rolled blanks （TRB）, variable gauge roiling （VGR） represents the vital important forming stage, in which shape and properties are tailored to sat- isfy customers＇ requirements. It is of vital importance to reveal the relationship between work-piece horizontal veloci- ty and roll vertical velocity during VGR, which is not only a key point to understand the deformation law, but also an important content for setting VGR process parameters. It is proved that the simplified assumption of equal dis- charge per second condition （EDSC） breaks down during VGR. Due to this reason the differential equation of the work-piece horizontal velocity （VGR-V） is performed by keeping the material volume constant. To attain a compre- hensive understanding of this underlying process in detail, numerical approaches based on finite elements method have been performed by utilizing the Abaqus Explicit. Rolling experiment is carried out which indicates that the nu- merical result coincides with the expel＇imental result well. A fine spatial discretization of work-piece is essential for special emphasis has to be put on detecting different horizontal velocity of work-piece cross section, often leading to a hundred thousand degrees of freedom even for plane strain calculations. The data obtained by using Abaqus Explicit coincide with the results determined by theory. A theoretical basis on deformation parameters and mechanical param- eters during VGR process is provided.

关键词： variable gauge rolling horizontal velocity non-linear finite element analysis

Site Occupation of Nb in γ-TiAI:Beyond the Point Defect Gas Approximation

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Acta Metallurgica Sinica(English Letters) 2019年第12期32卷 1511-1520页

作者： Wei Diao Li-hua Ye Zong-Wei ji Rui Yang Qing-Miao hu Institute of Metal Research Chinese Academy of SciencesWenhua Road 72Shenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaJinzhai Road 96Hefei 230026China University of Chinese Academy of Sciences Yuquan Road 19ABeijing 100049China

Microalloying is an effective approach to improve the mechanical properties of γ-TiAl intermetallic *** about the site occupancy of the ternary alloying element in the crystal lattice ofγ-TiAl is highly demanded in order to understand the physics underlying the alloying *** first-principle methods-based thermodynamic models for the determination of the site occupancy were based on the point defect gas approximation with the interaction between the point defects *** the present work,we include the point defect interaction energy in the thermodynamic model,which allows us to predict the site occupancy of the ternary alloying element inγ-TiAl beyond the point defect gas *** model is applied to theγ-TiAl-Nb *** show that,at low temperature,the site occupancy of Nb atoms depends on the composition of the alloy:Nb atoms occupy the A1 sublattice for the Ti-rich alloy but occupy Ti sublattice for the Al-rich *** fraction of Nb atoms occupying A1 sublattice in the Ti-rich alloy decreases drastically,whereas the fraction of Nb atoms on the Ti sublattice in the Al-rich alloy decreases slightly with increasing *** high temperature,Nb atoms occupy dominantly the Ti sublattice for both the Ti-rich and Al-rich *** interaction between the point defects makes the Ti sublattice more favorable for the Nb atoms to occupy.

关键词： Site preference Titanium aluminides Special quasi-random structures First principles method

Coupling effect of the conductivities of Li ions and electrons by introducing LLTO@C fibers in the LiNi0.8Co0.15Al0.05O2 cathode

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 305-316页

作者： Hao-yang Wang Xue Cheng Xiao-feng Li ji-min Pan Jun-hua hu School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China State Center for International Cooperation on Designer Low-carbon&Environmental Materials(CDLCEM) Zhengzhou UniversityZhengzhou 450001China Zhengzhou Materials Genome Institute(ZMGI) Xingyang 450100China

To probe the coupling effect of the electron and Li ion conductivities in Ni-rich layered materials(LiNi0.8Co0.15Al0.05O2,NCA),lithium lanthanum titanate(LLTO)nanofiber and carbon-coated LLTO fiber(LLTO@C)materials were introduced to polyvinylidene difluoride in a *** enhancement of the conductivity was indicated by the suppressed impedance and *** 1 and 5 C,the cathodes with coupling conductive paths had a more stable cycling *** coupling mechanism was analyzed based on the chemical state and structure evolution of NCA after cycling for 200 cycles at 5 *** the pristine cathode,the propagation of lattice damaged regions,which consist of high-density edge-dislocation walls,destroyed the bulk integrity of *** addition,the formation of a rock-salt phase on the surface of NCA caused a capacity *** contrast,in the LLTO@C modified cathode,although the formation of dislocation-driven atomic lattice broken regions and cation mixing occurred,they were limited to a scale of several atoms,which retarded the generation of the rock-salt phase and resulted in a pre-eminent capacity *** NiO phase“pitting”occurred.A mechanism based on the synergistic transport of Li ions and electrons was proposed.

关键词： Ni-rich cathode coupling mechanism dislocation wall coaxial structure cation mixing

Quantitative deformation measurements and analysis of the ferrite-austenite banded structure in a 2205 duplex stainless steel at 250 ℃

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Chinese Physics B 2018年第3期27卷 487-493页

作者： ji-hua Liu School of Mechanical Engineering Tianjin UniversityTianjin 300354China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin UniversityTianjin 300354China

The deformation process of the microstructure in 2205 duplex stainless steel(DSS)under thermo-mechanical coupling at 250℃was investigated using digital image correlation(DIC).A thermal tension test of duplex stainless steel(2205DSS)with a banded structure was carded out to observe the initial deformation of the *** was found that inhomogeneous strain fields occurred primarily in *** maximum normal strain in austenite was almost pos-itive,while that in ferrite was almost *** addition,a thermal cyclic-loading test was conducted,and the strain field was characterized by *** heterogeneities were induced after 400 cycles,which spread within the austenite and at the phase boundaries with the load *** high tensile-strain regions were always located adjacent to regions of intense compressive *** on the strain matrix sum *** number,we found that hardening occurred in the early cycles followed by softening.

关键词： thermo-mechanical coupling duplex stainless steel digital image correlation(DIC)

Pancharatnam Phase of a Mesoscopic Coupled Circuit

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Communications in Theoretical Physics 2005年第3X期44卷 555-558页

作者： ji Ying-hua LIU Qing LUO Hai-Mei hu Ju-Ju Department of Physics Jiangxi Normal University Nanchang 330027 China

We derive a formula of the nonadiabatic noncyclic Pancharatnam phase for a mesoscopic circuit with coupled inductors and capacitors. It shows that, because of coupling effect, the circuit is in squeezed quantum state initially, and the time evolution of Pancharatnam phase exhibits an oscillation in a complex way. Especially we find that when the capacity of the coupled capacitors is larger than that of other ones in the circuit, with the variation of time Pancharatnam phase becomes nearly periodic square-wave, which perhaps can provide a new approach for the realization of quantum logic gate.

关键词： mesoscopic coupled circuits Pancharatnam phase oscillation