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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 302-319页

作者： Chang-feng LI Yi-rang YUAN huai-ling SONG School of Economics Shandong UniversityJinan 250100China Institute of Mathematics Shandong UniversityJinan 250100China College of Mathematics and Econometrics Hunan UniversityChangsha 410082China

In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical *** important factors,heat and magnetic influences are *** mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical *** influences of magnetic fields are supposed to be weak,and the strength is parallel to the *** elliptic equation is treated by a block-centered method,and the law of conservation is *** computational accuracy is improved one *** equations are convection-dominated,thus are approximated by upwind block-centered *** difference can eliminate numerical dispersion and nonphysical *** diffusion is approximated by the block-centered difference,while the convection term is treated by upwind ***,the unknowns and adjoint functions are computed at the same *** characters play important roles in numerical computations of conductor device *** the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is *** a composite numerical method is shown for solving this problem.

关键词： three-dimensional conductor device problem with heat and magnetic influences upwind blockcentered differences elemental conservation of mass numerical analysis

Application of transgenic mice to the molecular pathogenesis of cataract

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1929-1948页

作者： yue Zhang Xiao-Ya Chen Yu-Zhu hu Xiao Zhang Shun-Fei Zheng Shan-Shan hu Mudanjiang Medical University Mudanjiang 157011Heilongjiang ProvinceChina Department of Ophthalmology Hongqi Hospital of Mudanjiang Medical UniversityMudanjiang 157011Heilongjiang ProvinceChina

One of the most prevalent disorders that cause blindness worldwide is cataract,and its essence is the visual disorder caused by the opacity of the *** significant degree of variation in cataracts and the fact that a variety of factors can impact a patient’s lens transparency make it especially crucial to investigate the pathogenesis of cataracts at the molecular *** has been found that more than 60 genes are linked to the formation of cataracts,and the construction of a transgenic mouse model of cataract similar to the selection of human lens clouding due to a variety of causes has become an important means of studying the pathogenesis of ***,the research on the application of transgenic mice to the molecular pathogenesis of cataracts will be the main topic of this review of the literature.

关键词： transgenic mice cataract lens

Perinatal outcomes of frozen-thawed embryo transfer following blastocyst-stage embryo transfer compared to those of cleavage-stage embryo transfer:analysis of 9408 singleton newborns using propensity score analysis

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Reproductive and Developmental Medicine 2024年第2期8卷 67-74页

作者： hu-Cen Zhong Qi Wan Yu-Ling hu Tian Li Li-Juan huang Mao Wang Xin-yue hu Meng-Di Wang Zhao-hui Zhong School of Public Health Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaChongqing 400016China Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengdu 610041China Sichuan Jinxin Xinan Women and Children’s Hospital Chengdu 610041 SichuanChina Department of Reproductive Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of Public Health Research Center for Medical and Social DevelopmentChongqing Medical UniversityChongqing 400016China

Objective:Regarding frozen-thawed embryo transfer(FET),there is limited consensus on whether extending embryo culture from the cleavage stage to the blastocyst stage affects perinatal *** study aimed to compare perinatal outcomes of singletons between blastocyst-stage embryo transfer(BT)and cleavage-stage embryo transfer(CT)in ***:A total of 9408 FET cycles that met the inclusion criteria were included in this retrospective cohort study between 2019 and ***-stage embryo transfers were performed in the BT group,and cleavage-stage embryo transfers were performed in the CT *** logistic regression analyses were performed,as well as propensity score matching(PSM)to adjust for ***:After PSM,a higher risk of pre-term birth(PTB;odds ratio[OR]:1.23,95%confidence interval[CI]:1.00-1.50,P=0.048)and being large for gestational age(LGA;OR:1.16,95%CI:1.00-1.35,P=0.050)was observed in the BT group compared to that in the CT *** stratified PSM,in the subgroup under 35 years of age,only an increased risk of LGA was observed in the BT group compared to the CT *** outcomes in the double-embryo transfer subgroup were similar to those in the unstratified ***,in the subgroup beyond 35 years of age and the single embryo transfer subgroup,perinatal outcomes were not statistically different between the BT and CT groups(P>0.05).Conclusions:In FET,prolonged embryo culture to the blastocyst stage increased the risk of PTB and LGA in single ***,stratified analysis based on age and the number of transferred embryos yielded different results,necessitating further mechanistic studies.

关键词： Frozen-thawed embryo transfer Blastocyst Cleavage stage Perinatal outcomes Pre-term birth Large for gestational age Small for gestational age

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong LIANG Qi MEI Li-yan LIANG You-bang WANG Mao-jie CHEN Xiu-min huANG Qing-chun WEN Ze-huai huANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： Shi-Hao Guan Wen-Jing hu Xin-Yu Wang yue-Xia Gu De-hua Zhou Department of Plastic Surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Gastrointestinal Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

Elite Dung Beetle Optimization Algorithm for Multi-UAV Cooperative Search in Mountainous Environments

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Journal of Bionic Engineering 2024年第4期21卷 1677-1694页

作者： Xiaoyong Zhang Wei yue The College of Marine Electrical Engineering Dalian Maritime UniversityDalian116026China

This paper aims to address the problem of multi-UAV cooperative search for multiple targets in a mountainous environment,considering the constraints of UAV dynamics and prior environmental ***,using the target probability distribution map,two strategies of information fusion and information diffusion are employed to solve the problem of environmental information inconsistency caused by different UAVs searching different areas,thereby improving the coordination of UAV ***,the task region is decomposed into several high-value sub-regions by using data clustering *** on this,a hierarchical search strategy is proposed,which allows precise or rough search in different probability areas by adjusting the altitude of the aircraft,thereby improving the search ***,the Elite Dung Beetle Optimization Algorithm(EDBOA)is proposed based on bionics by accurately simulating the social behavior of dung beetles to plan paths that satisfy the UAV dynamics constraints and adapt to the mountainous terrain,where the mountain is considered as an obstacle to be ***,the objective function for path optimization is formulated by considering factors such as coverage within the task region,smoothness of the search path,and path *** effectiveness and superiority of the proposed schemes are verified by the simulation.

关键词： Mountainous environment Multi-UAV cooperative search Environment information consistency Elite dung beetle optimization algorithm(EDBOA) Path planning

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng Si yue-yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

A Comprehensive Review of Thermal Performance Improvement of High-Temperature Heat Pipes

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Journal of Thermal Science 2024年第2期33卷 625-647页

作者： CHEN Qihan ZHOU Jingzhi ZHOU Guohui CHENG Keyong huai Xiulan WEI Gaosheng School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing100096China Nanjing Institute of Future Energy System Nanjing211135China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China

Energy efficiency issues are being focused on the growing concern of global warming and environmental *** high-temperature heat pipe(HTHP) is an effective and environmental-friendly heat transfer device employed in many industries,including solar power generation,high-temperature flue gas waste heat recovery,industrial furnaces,nuclear industries,and *** a critical factor in HTHPs,thermal performance is mainly introduced in the entire *** date,most reviews have been published concerning one or several application ***,to the best of authors' knowledge,it is hard to find a review discussing how to improve the thermal performance of HTHPs ***,the impact on the performance of three main components of HTHPs over the past 30 years is introduced:the working fluid,the HTHP structure,and the wick ***,it is a considerable review of the optimal operating conditions for each direction,and we expect this paper contribute to improving the thermal performance of ***,current numerical simulations and theoretical research on the heat transfer limit of HTHPs are *** significant hypotheses used in numerical simulations and the present theoretical studies are compiled ***,some potential future directions and tentative suggestions for HTHP research are put forward.

关键词： high-temperature heat pipe review alkali metal heat pipe thermal performance

Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

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World Journal of Clinical Cases 2024年第6期12卷 1063-1075页

作者： hua Bai Hong-Mei Zeng Qi-Fang Zhang yue-Zhi hu Fei-Fei Deng Department of Neurology The Third Affiliated Hospital of Guizhou Medical University in ChinaDuyun 558099Guizhou ProvinceChina Department of Neurology Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Key Laboratory of Medical Molecular Biology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social *** quality of life and prognosis of AD patients have attracted much *** role of chronic immune inflammation in the pathogenesis of AD is becoming more and more *** To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in *** A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November *** cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other *** logistic regression analysis was used to determine independent prog-nostic *** modified Rankin scale(mRS)was used to determine whether the prognosis was *** correlation between drug treatment and prognostic mRS score was tested by the rank sum *** Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD *** logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of *** number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T

关键词： Alzheimer’s disease Cellular immunity Prognosis T lymphocytes Magnetic resonance spectroscopy

Self-fertilization in a gonochoristic fish yellow catfish

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Aquaculture and Fisheries 2024年第2期9卷 234-244页

作者： yue Yu Ziyi Lu Min Chen Ya Liu Yang Ding Chenhao hu Zhigang Shen College of Fisheries Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural AffairsWuhan430070China Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of EducationWuhan430070China Engineering Technology Research Center for Fish Breeding and Culture in hubei Province Wuhan430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt of Ministry of Education Huazhong Agricultural UniversityWuhan430070China hubei huangyouyuan Fishery Development Limited Company Wuhan430070China

Sex control techniques are in great demand for aquaculture because of the huge benefits of mono-sex *** a previous study on yellow catfish(Tachysurus fulvidraco),intersex individuals were produced by administrating 17α-methyltestosterone(MT)or aromatase inhibitor letrozole(LZ).The ovarian and testicular portions of intersexual gonads developed well and were completely separated,arousing our interest in producing self-fertilizable fish and clone-like fish *** this study,yellow catfish fry were treated with a combination of MT and LZ at a low dose(5 mg kg^(-1)MT,300 mg kg^(-1)LZ)at a low water temperature(27.0℃,mixed sex-producing temperature,LL group)and a high temperature(33.5◦C,male-producing temperature,HL group),and with a high dose(10 mg kg^(-1) MT,600 mg kg^(-1) LZ)at a low water temperature(LH group),during 12-65 days post-hatching,the critical period of sex *** XX and XY intersex were produced with different percentages at the same time through co-treatment with MT and LZ,with or without the help of male-producing *** highest percentage of XY intersex(53%in XY,36%in XX and XY)and XX intersex(47%in XX,25%in XX and XY)was produced in LH and HL groups,*** of gonadal morphology,histology,and sperm dynamic analysis indicate that some XX and XY intersex individuals were capable of self-fertilization through artificial *** reproductive performance of these intersex individuals was then investigated by injecting spawning agents,dissecting gonads,and artificially fertilizing eggs with their own *** XX,XY,and YY genotypic individuals were produced by the self-fertilization of XY intersex *** present study successfully produced high percentages of XX and XY intersex and conducted self-fertilization by mating the eggs and sperm of a single intersex ***-fertilization in fish will show great potential in aquaculture genetics and breeding,for example,generating high

关键词： Sex differentiation Self-fertilization Sex reversal Mono-sex Clone