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Journal of Energy Chemistry 2020年第12期29卷 7-13页

作者： Qin Chang honggang Chen Jun Yuan Yunbin hu Jiefeng Hai Wei Liu Fangfang Cai Juan Hong Xuxian Xiao Yingping Zou College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083HunanChina Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004GuangxiChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina

The versatility and flexibility of organic photoelectric materials endow organic photovoltaic cells fine function modulation and huge commercial potential. In this work, a new noncovalent fused-ring small molecule acceptor(SMA) BID-4 F has been synthesized for high-efficient organic solar cells(OSCs). BID-4 F consists of a diflurobenzothiadiazole(DFBT) core, ladder-like indacenodithiophene(IDT) spacers, and dicyanoindanone electron-withdrawing end groups, which are supposed to be conformationally interlocked by noncovalent interactions, leading to good molecular planarity. In addition, compact solid state stacking was revealed by UV–vis–NIR absorption spectrum. The optimized PM6:BID-4 F based device delivers an eminent power conversion efficiency(PCE) of 12.30% with a high open-circuit voltage(Voc) of 0.92 V and a high fill factor(FF) of 74.3%. Most importantly, the PCE and FF are among one of the highest values reported for the OSCs based on the unfused-ring SMAs. Overall, our work demonstrates that the unfused ring central framework with high molecular planarity through noncovalent interactions provides a good strategy to construct highly efficient SMAs.

关键词： Diflurobenzothiadiazole core Noncovalently fused small molecule acceptor High efficiency High fill factor

A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma

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Chinese Medical Journal 2014年第24期127卷 4171-4176页

作者： Qian honggang Wei Meng Qiu hu Wu Jianhui Liu Bonan Lyu Ang Liu Qiao Li Chengpeng Leng Jiahua Department of Hepato-Pancreato-Biliary Surgery Peking University School of Oncology Beijing Cancer Hospital Beijing 100142 China

Background The management of Barcelona Clinic Liver Cancer （BCLC） stage B hepatocellular carcinoma （HCC） is controversial due to the early recurrence after curative hepatectomy, and many variables were related to the prognosis. The purpose of this study was to predict the tumor recurrence in early postoperative period of the patients with BCLC stage B HCC. Methods From January 2004 to January 2012, 104 patients with BCLC stage B HCC underwent hepatectomy. Clinicopathological factors and follow-up data were statistically analyzed to establish a predicting scoring system. Results The overall survival rates for one, three, and five years were 69.2%, 52.7%, and 42.3%, and the disease-free survival rates for one, three, and five years were 52.9%, 47.3%, and 37.5%, respectively. The multiple factors analysis showed that the micro-vessel invasion, lymph nodes metastasis, multiple lesions, and the high expression of HMGB1 were independent factors （P 〈0.05）. A scoring system was established to predict the early recurrence within one year after the surgery for BCLC stage B HCC, according to the analysis results with a specificity of 85.1% and a sensitivity of 80.3%. Conclusion Variant clinicopathological factors were associated with early postoperative recurrence for BCLC stage B HCC and recurrence early after hepatectomy was more likely in patients with a higher score of the scoring system.

关键词： hepatocellular carcinoma hepatectomy postoperative recurrence high mobility group box 1 protein

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抗肿瘤多肽蜂毒素的固相合成

药学实践杂志 2014年第1期32卷 51-52页

作者：李文娟李任武吴茂诚王傅喆秦丽萍李柏胡宏岗烟台大学药学院山东烟台264005 第二军医大学药学院有机化学教研室上海200433 第二军医大学长海医院中医系上海200433

目的合成具有抗肿瘤活性的二十六肽蜂毒素。方法采用Fmoc固相逐步化学合成,确立了以Wang树脂为固相载体,HOBt/DCC为缩合剂的合成工艺。结果通过本法能够顺利合成得到二十六肽蜂毒素,收率达32%。结论该合成方法具有可行性强、操作简便、... 详细信息

目的合成具有抗肿瘤活性的二十六肽蜂毒素。方法采用Fmoc固相逐步化学合成,确立了以Wang树脂为固相载体,HOBt/DCC为缩合剂的合成工艺。结果通过本法能够顺利合成得到二十六肽蜂毒素,收率达32%。结论该合成方法具有可行性强、操作简便、总收率高等特点,适用于长链多肽的合成。

关键词：蜂毒素固相合成逐步缩合

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中美研究生教育和培养的差异

中国医药科学 2013年第5期3卷 160-161页

作者：俞世冲孙青龑柴晓云胡宏岗赵庆杰汪亭邹燕吴秋业第二军医大学药学院上海200433

通过在美国韦恩州立大学的考察学习,主要对研究生教育的过程培养进行比较,对我国的研究生教育提出宝贵意见和建议,对提高我们的研究生培养质量具有重要的现实和实际意义。

关键词：高等教育研究生教育研究生培养

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如何提高药学本科专业有机化学课堂效果

中国医药科学 2013年第9期3卷 150-150,165页

作者：俞世冲柴晓云胡宏岗赵庆杰汪亭邹燕孙青 王小燕吴秋业第二军医大学药学院上海200433

通过精选教学内容、互动提问式教学、多种教学手段结合等方式来提高有机化学课堂效果,完成教学大纲内容,以此来达到教学目的,增强学生对有机化学的学习兴趣。

关键词：药学专业有机化学课堂效果

Acupotomy ameliorates subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis by regulating bone morphogenetic protein 2-Smad1 pathway

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中医杂志:英文版 2023年第4期43卷 734-743页

作者： Chen Xilin GUO Yan LU Juan QIN Luxue hu Tingyao ZENG Xin WANG Xinyue ZHANG Anran ZhuANG Yuxin ZHONG honggang GUO Changqing School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Acupuncture and Moxibustion Department Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical UniversityBeijing 100010China Shenzhen Hospital of Southern Medical University Shenzhen 518000China Institute of Bone Injury China Academy of Chinese Medical SciencesBeijing 100010China

OBJECTIVE:To investigate the effects of acupotomy on the subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis(KOA).METHODS:The rabbits were divided into blank control,model,acupotomy and electroacupuncture(EA)groups,with 12 rabbits in *** Videman's method was used to prepare KOA *** acupotomy and EA group were given indicated intervention for 3 *** behavior of rabbits in each group was ***,cartilage–subchondral bone units were obtained and morphological changes were observed by optical microscope and micro computed *** test was used to detect the mechanical properties of subchondral bone,Western blot and real-time polymerase chain reaction(RT-PCR)were applied to detect the expression of bone morphogenetic protein 2-Smad1(BMP2-Smad1)pathway in subchondral ***:Compared with the control group,rabbits in the KOA group showed lameness,knee pain,and cartilage degradation;the subchondral bone showed active resorption,the mechanical properties decreased significantly and the BMP2-Smad1 pathway downregulated *** acupotomy and EA intervention could increase the thickness of trabecular bone(***),the bone volume fraction(BV/TV)and the thickness of subchondral bone plate,reduce the separation of trabecular bone(***),improve the maximum load and elastic modulus of subchondral bone,and effectively delay cartilage degeneration in KOA *** process may be achieved through upregulation the related proteins of BMP2-Smad1 *** maximum load and elastic modulus of subchondral bone in the acupotomy group were slightly better than those in the EA ***:Acupotomy could effectively protect cartilage by inhibiting abnormal bone resorption and improving mechanical properties of subchondral bone thorough the related proteins of BMP2-Smad1 pathway in KOA rabbits.

关键词： acupuncture therapy osteoarthritis knee subchondral bone mechanical properties bone morphogenetic protein 2 Smad1 protein

A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair

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Neural Regeneration Research 2014年第10期9卷 1041-1046页

作者： Dong Wang Xijun huang Guo Fu Liqiang Gu Xiaolin Liu honggang Wang Jun hu Jianhua Yi Xiaofeng Niu Qingtang Zhu Department of Orthopedics and Microsurgery the First Affiliated Hospital of Sun Yat-Sen University

Current research on bone marrow stem cell transplantation and autologous or xenogenic nerve transplantation for peripheral nerve regeneration has mainly focused on the repair of peripher-al nerve defects in rodents. In this study, we established a standardized experimental model of radial nerve defects in primates and evaluated the effect of repair on peripheral nerve injury. We repaired 2.5-cm lesions in the radial nerve of rhesus monkeys by transplantation of autografts, acellular allografts, or acellular allografts seeded with autologous bone marrow stem cells. Five months after surgery, regenerated nerve tissue was assessed for function, electrophysiology, and histomorphometry. Postoperative functional recovery was evaluated by the wrist-extension test. Compared with the simple autografts, the acellular allografts and allografts seeded with bone marrow stem cells facilitated remarkable recovery of the wrist-extension functions in the rhesus monkeys. This functional improvement was coupled with radial nerve distal axon growth, a higher percentage of neuron survival, increased nerve fiber density and diameter, increased myelin sheath thickness, and increased nerve conduction velocities and peak amplitudes of compound motor action potentials. Furthermore, the quality of nerve regeneration in the bone marrow stem cells-laden allografts group was comparable to that achieved with autografts. The wrist-extension test is a simple behavioral method for objective quantification of peripheral nerve regeneration.

关键词： nerve regeneration peripheral nerve injury rhesus monkeys bone marrow stem cells allogeneic nerve transplantation wrist-extension test electrophysiology neurological function NSFC grant neural regeneration

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浅析电量电价对抽水蓄能电站运营效益的影响

水电与抽水蓄能 2018年第5期4卷 91-95,77页

作者：董阳伟王璞胡宏刚国网新源控股有限公司技术中心北京市100161 国家电网有限公司北京市100031

本文在分析抽水蓄能电站运营效益构成因素的基础上,就抽水蓄能机组的运行策略、电量电价如何影响抽水蓄能电站运营效益进行研究与分析,为将来抽水蓄能电站机组运行和经济效益的实现提供技术与经济参考。

关键词：电量电价影响抽水蓄能电站效益

金属有机框架(MOFs)材料在防腐涂层中的应用研究进展

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涂料工业 2024年第2期54卷 72-79,88页

作者：曹皓孙宏刚杨建军张静元杨琳娜陈万军胡文霞陈永福西南技术工程研究所重庆400039 重庆市环境腐蚀与防护工程技术研究中心重庆400039

有机涂层在固化过程或长期使用中会出现裂纹、微孔等局部缺陷,导致有机涂层的预期防腐效果大大降低。近年来,金属有机框架(MOFs)涂层在构建高效耐用的金属防护材料方面展现出巨大的潜力。介绍了MOFs材料的结构特点和近年研究进展,从4个... 详细信息

有机涂层在固化过程或长期使用中会出现裂纹、微孔等局部缺陷,导致有机涂层的预期防腐效果大大降低。近年来,金属有机框架(MOFs)涂层在构建高效耐用的金属防护材料方面展现出巨大的潜力。介绍了MOFs材料的结构特点和近年研究进展,从4个方面阐述了其在涂层中的防腐机理:通过MOFs的特殊结构改性纳米填料提高涂层抗渗透性、MOFs缓蚀剂阻止金属腐蚀、MOFs自修复材料弥补涂层缺陷、通过MOFs结构特性构建超疏水涂层。以上基于MOFs的复合防腐涂层已表现出巨大的研究潜力和商业价值,但MOFs涂层材料的大规模商业化应用,仍需在环保、低成本、产品稳定等多个方面做出努力。

关键词： MOFs 防腐涂层缓蚀剂自修复超疏水研究进展

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71℃试验法寿命外推结果的影响因素分析

装备环境工程 2024年第4期21卷 35-39页

作者：李芳张鹏辉王红刚谢明伟彭钺胡伟陕西应用物理化学研究所瞬态化学效应与控制全国重点实验室西安710061

目的研究71℃试验法用于火工品贮存寿命外推结果的准确性。方法采用对比分析的方法,对美军标和国军标中71℃试验法的寿命影响因素进行分析。结果加速模型、试验条件和外推温度取值对火工品的寿命外推结果均有影响。结论71℃试验法评估... 详细信息

目的研究71℃试验法用于火工品贮存寿命外推结果的准确性。方法采用对比分析的方法,对美军标和国军标中71℃试验法的寿命影响因素进行分析。结果加速模型、试验条件和外推温度取值对火工品的寿命外推结果均有影响。结论71℃试验法评估结果的准确性取决于使用场景是否正确,试验条件设置是否合理,贮存环境温度取值是否准确,并提出了71℃试验法的使用建议。

关键词：火工品 71℃试验法贮存寿命加速模型寿命外推

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