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Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study

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International journal of Ophthalmology(English edition) 2024年第9期17卷 1665-1674页

作者： Xue-Lin Wang Xu-jun Zheng Li-juan Zhang jin-Yu hu hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Xu Chen Yi Shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina jiangxi Medical College Shangrao 334000Jiangxi ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiff CF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands

AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)***:Twenty HR patients and 20 healthy controls(HCs)were respectively *** age,gender,and educational background characteristics of the two groups were *** functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF *** operating characteristic(ROC)curve analysis was used to classify the ***,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with ***:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual *** contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR *** results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.

关键词： hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging

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Probing multi-physical process and deformation mechanism of a largescale landslide using integrated dual-source monitoring

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Geoscience Frontiers 2024年第2期15卷 417-432页

作者： hong-hu Zhu Xiao Ye hua-Fu Pei Wei Zhang Gang Cheng Zi-Li Li School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Department of Geotechnical Engineering Dalian University of TechnologyDalian 116024China Civil Structural&Environmental EngineeringSchool of Engineering and ArchitectureUniversity College CorkCorkIreland Department of Civil&Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA 02139-4307United States

The implementation of isolated heterologous monitoring systems for spatially distant borehole deployments often comes with substantial equipment costs,which can limit the effectiveness of geohazard mitigation and georisk management *** address this,we have developed a novel monitoring system that integrates fiber Bragg grating(FBG)and microelectromechanical system(MEMS)techniques to capture soil moisture,temperature,sliding resistance,strain,surface tilt,and deep-seated *** system enables real-time,simultaneous data acquisition and cross-validation analyses,offering a costeffective solution for monitoring critical parameters in geohazard-prone *** successfully applied this integrated monitoring system to the Xinpu landslide,an active super-large landslide located in the Three Gorges Reservoir Area(TGRA)of *** resulting strain profile confirmed the presence of two shallow secondary sliding surfaces at depths of approximately 7 m and 12 m,respectively,in addition to the deep-seated sliding surface at a depth of28 *** lower secondary sliding surface was activated by extreme precipitation,while the upper one was primarily driven by significant changes in reservoir water levels and secondarily triggered by concentrated ***-slide piles have remarkably reinforced the upper moving masses but failed to control the lower *** gap between the pile heads and the soil amplified the rainwater erosion effect,creating a preferential channel for rainwater ***-physical measurements revealed a mixture of seepage-driven and buoyancy-driven behaviors within the *** study offers an integrated dual-source multi-physical monitoring paradigm that enables collaborative management of multiple crucial boreholes on a large-scale landslide,and contributes to the evaluation and improvement of engineering measures in similar geological settings.

关键词： Reservoir landslide Multi-physical process Integrated dual-source monitoring Fiber optic Extreme weather

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燃料电池增程式动力系统能量管理策略研究

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北京理工大学学报 2024年第1期44卷 51-59页

作者：张付军胡博睿张虹北京理工大学机械与车辆学院北京100081

以某款纯电动客车为研究对象,以增加车辆续驶里程为目的,提出燃料电池增程式混合动力系统结构,根据性能指标对动力系统各部件进行匹配计算和选型.提出了开关/功率跟随式能量管理策略,基于Cruise和Simulink分别搭建了整车动力系统模型和... 详细信息

以某款纯电动客车为研究对象,以增加车辆续驶里程为目的,提出燃料电池增程式混合动力系统结构,根据性能指标对动力系统各部件进行匹配计算和选型.提出了开关/功率跟随式能量管理策略,基于Cruise和Simulink分别搭建了整车动力系统模型和燃料电池及能量管理策略模型并进行联合仿真.结果表明,采用文中提出的能量管理策略车辆经济性相对于开关式和能量跟随式两种控制策略分别提高62%和31%,续驶里程相对于该两种控制策略分别提高41%和18%.

关键词：燃料电池增程器动力系统匹配模型搭建联合仿真能量管理充电状态(SOC)

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基于记忆泊车场景的视觉SLAM算法

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华南理工大学学报（自然科学版） 2024年第6期52卷 1-11页

作者：胡习之崔博非王琴刘鸿华南理工大学机械与汽车工程学院广东广州510640

随着自动驾驶技术的发展,视觉同步建图与定位(SLAM)技术受到越来越多的关注。在记忆泊车场景中,需要对停车场场景建立先验地图,待汽车再次驶入相同的停车场时,使用视觉SLAM进行场景建图与定位。为使SLAM所建地图的鲁棒性更好、精度和效... 详细信息

随着自动驾驶技术的发展,视觉同步建图与定位(SLAM)技术受到越来越多的关注。在记忆泊车场景中,需要对停车场场景建立先验地图,待汽车再次驶入相同的停车场时,使用视觉SLAM进行场景建图与定位。为使SLAM所建地图的鲁棒性更好、精度和效率更高,文中首先使用轻量化的深度学习算法改善传统特征提取算法在不同场景下鲁棒性较差的不足,用深度可分离卷积代替普通卷积结构,从而大大提升了特征提取效率;接着基于ResNet网络改进Patch-NetVLAD算法,并在MSLS数据集上对改进的残差网络和原始VGG网络进行重新训练,使用图像检索进行粗定位,挑选出候选图像帧,再通过精定位求解相机位姿,完成全局初始化的重定位;在此基础上,使用改进后的词袋算法重新训练不同停车场场景下的图像,将所有算法移植到OpenVSLAM架构中完成实际场景的建图与定位。实验结果表明,文中设计的视觉SLAM系统能够完成地上停车场、地下停车场以及室外半封闭园区道路等多场景的建图,平均纵向定位误差为8.42 cm,平均横向定位误差为8.30 cm,均达到工程要求。

关键词：同步建图与定位记忆泊车深度学习特征提取图像检索

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High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： Xiao-lin Yang Xia Ling Quan Sun Pin-pin Qiu Kai Xiang jun-feng hong Shu-lin He jie Chen Xin Ding Hai hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

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Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie Xian-Qin Li Cong Dai hui-jun hu hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity wasjoint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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从内嵌到互嵌:失能过程理论体系的中国话语

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西北大学学报（哲学社会科学版） 2024年第1期54卷 110-123页

作者：胡宏伟胡鑫怡中国人民大学公共管理学院北京100872

全球性失能风险的扩散加速了失能过程理论体系的发展,中国正积极参与其中并成为不可或缺的主体力量。本文梳理失能过程理论体系的理论脉络、关键议题以及发展趋势,在此基础上讨论中国情境及其发展方向。研究表明:第一,失能过程理论是联... 详细信息

全球性失能风险的扩散加速了失能过程理论体系的发展,中国正积极参与其中并成为不可或缺的主体力量。本文梳理失能过程理论体系的理论脉络、关键议题以及发展趋势,在此基础上讨论中国情境及其发展方向。研究表明:第一,失能过程理论是联系医学、社会学众多领域与理论的复杂体系,核心涵盖失能过程理论并关涉生命历程、累积劣势等理论;第二,失能过程理论研究囊括概念、技术、诱因、结果和治理五大议题,共同推动了失能过程理论体系的深化与延展;第三,失能过程理论体系呈现从个人问题走向社会建构、从社会排斥走向社会包容、从线性路径走向非线性路径、从诠释主义走向经验主义的四大演变态势,全方位构成了失能过程理论体系的发展脉络;第四,中国作为失能过程理论体系检验与发展的最大场域,历经“内嵌→互嵌”两大阶段,从文化、环境与治理模式多维度,融入孝文化、差序格局、有为政府等中国要素,进一步拓展了失能过程理论体系;第五,下一步应坚持以中国问题为导向、将中国情境融入逻辑链条、寻找适合中国情境假设的技术框架、发现研究问题的中国价值,从而发挥中国话语对全世界失能过程理论体系发展的独特价值。

关键词：老年健康治理失能过程理论体系中国话语

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Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical journal 2024年第11期137卷 1332-1342页

作者： Shujung Hsu Yencheng Chao Yong hu Yang Zhang Weifeng hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and june 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(Pjective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

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World journal of Gastroenterology 2024年第9期30卷 1224-1236页

作者： Hai-Yang Li Lin-Lin Zheng Nan hu Zhi-Hao Wang Chang-Cheng Tao Ya-Ru Wang Yue Liu Zulihumaer Aizimuaji hong-Wei Wang Rui-Qi Zheng Ting Xiao Wei-Qi Rong Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Hernia Surgery Liaocheng Dongcangfu People’s HospitalLiaocheng 252000Shandong ProvinceChina State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND As a critical early event in hepatocellular carcinogenesis,telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma(HCC)patients,and its function in the genesis and treatment of HCC has gained much attention over the past two *** To perform a bibliometric analysis to systematically assess the current state of research on HCC-related *** The Web of Science Core Collection and PubMed were systematically searched to retrieve publications pertaining to HCC/telomerase limited to“articles”and“reviews”published in English.A total of 873 relevant publications related to HCC and telomerase were *** employed the Bibliometrix package in R to extract and analyze the fundamental information of the publications,such as the trends in the publications,citation counts,most prolific or influential writers,and most popular journals;to screen for keywords occurring at high frequency;and to draw collaboration and cluster analysis charts on the basis of coauthorship and *** was utilized to compile and visualize the bibliometric *** A surge of 51 publications on HCC/telomerase research occurred in 2016,the most productive year from 1996 to 2023,accompanied by the peak citation count recorded in *** to December 2023,35226 citations were made to all publications,an average of 46.6 citations to each *** United States received the most citations(n=13531),followed by China(n=7427)and japan(n=5754).In terms of national cooperation,China presented the highest centrality,its strongest bonds being to the United States and *** the 20 academic institutions with the most publications,ten came from China and the rest of Asia,though the University of Paris Cité,Public Assistance-Hospitals of Paris,and the National Institute of Health and Medical Research(INSERM)were the most *** for individual contributions,Hisatomi H,Kaneko S,and Ide T were the three most prolific a

关键词： Telomerase Bibliometric analysis Telomerase reverse transcriptase Prognosis Treatment Hepatocellular carcinoma

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Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory

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journal of Central South University 2024年第7期31卷 2341-2364页

作者： LI Liang CHEN jia-jun ZHAO Lian-heng HE Ke-pei hu Shi-hong LI hua-long School of Civil Engineering Central South UniversityChangsha 410075China Key Laboratory of Heavy-haul Railway Engineering Structure Ministry of EducationCentral South UniversityChangsha 410075China hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Central South UniversityChangsha 410075China

Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety ***,previous theoretical studies on the range of blasting-induced cracks often ignore the impact of the in-situ stress,especially that of the intermediate principal *** particle displacement−crack radius relationship was established in this paper by utilizing the blasthole cavity expansion equation,and theoretical analytical formulas of the stress−displacement relationship and the crack radius were derived with unified strength theory to accurately assess the range of cracks in deep surrounding rock under a blasting *** analysis showed that the crushing zone size was positively correlated with in-situ stress,intermediate principal stress,and detonation pressure,whereas negatively correlated with Poisson ratio and decoupling *** dilatancy angle-crushing zone size relationship exhibited nonmonotonic *** relationships in the crushing zone and the fracture zone exhibited opposite trends under the influence of only in-situ stress or intermediate principal *** the in-situ stress increased from 0 to 70 MPa,the rate of change in the crack range and the attenuation rate of the peak vibration velocity gradually slowed.

关键词： deep drilling and blasting cracks in surrounding rock unified strength theory intermediate principle stress in-situ stress cavity expansion dilatancy characteristics

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