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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： hu Wei Qiong ZHOU Wei Guang ZHOU Guang Wei LIAO jia Xi SHI jia Xing XIE FengYang LI Shou Heng WANG Yong FENG Xian hong GU Xiu Li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

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Property evolution and service life prediction of novel metallic materials for future lunar bases

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Rare Metals 2024年第10期43卷 5318-5331页

作者： Sen-Kuan Meng Rui-Song Zhu hong-Liang Zheng Tong Gao Shi-Hao jiang Wen-Hao Wang Shu-Hao Zhang Zi-Yuan Zhao Xuan Ge Wei-Min Wang Li-Na hu Zheng Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University Department of Chemistry and Bioscience Aalborg University

While lunar bases have been a focus of development in recent years, the complex and extreme environment of the lunar surface remains a considerable challenge for lunar exploration. Unlike those on Earth,lunar day and night temperature variations cause the properties of materials, especially metallic materials, to evolve in completely different manners. In this study, we investigated the property evolution of nine typical highperformance metallic materials using laboratory simulations of the extremely long-period lunar temperature environment. While lunation treatment improves the properties of all metallic materials, the microscopic mechanisms vary for amorphous and crystalline alloys with different structures. The treatment reduces both the loosely packed regions and heterogeneity in amorphous alloys while causing significant phase changes in crystalline alloys. Furthermore, a conservative prediction of the service life of metallic materials on lunar bases is provided based on analyzing microplastic events, followed by the practical material selection recommendations in various lunar application scenarios.

关键词： Lunar exploration Metallic glass Metallic material Property evolution

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Mode coupling with Fabry-Perot modes in photonic crystal slabs

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Chinese Physics B 2024年第8期33卷 90-94页

作者：秦恳胡鹏刘杰向红韩德专 Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China School of Science Chongqing Key Laboratory of New Energy Storage Materials and DevicesChongqing University of TechnologyChongqing 400054China

Fabry–Perot(FP)modes are a class of fundamental resonances in photonic crystal(PhC)*** to their low quality factors,FP modes are frequently considered as background fields with their resonance nature being ***,FP modes can play important roles in some phenomena,as exemplified by their coupling with guided resonance(GR)modes to achieve bound states in the continuum(BIC).Here,we further demonstrate the genuine resonance mode capability of FP modes PhC ***,we utilize temporal coupled-mode theory to obtain the transmittance of a PhC slab based on the FP ***,we construct exceptional points(EPs)in both momentum and parameter spaces through the coupling of FP and GR ***,we identify a Fermi arc connecting two EPs and discuss the far-field polarization *** work elucidates that the widespread FPs in PhC slabs can serve as genuine resonant modes,facilitating the realization of desired functionalities through mode coupling.

关键词： Fabry–Perot mode photonic crystal slab mode coupling exceptional point

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Grain size effect on the assembly quality of micro-scaled barrel formed by microforming

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Advances in Manufacturing 2024年第1期12卷 19-32页

作者： Dien hu jieyichen Fang Feng Zeng Ming-Wang Fu Department of Mechanical Engineering Research Institute of Advanced ManufacturingThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Xiamen Yulong Machinery Co.Ltd. Xiamen361023FujianPeople’s Republic of China

In this research,a method employing micro-extrusion was designed to produce the micro-scaled barrel-shaped parts with complex geometrical features to study the feasibility of the proposed microforming method and its grain size effect on the formability of the complicated internal features in terms of deformation behavior,material evolution,accuracy of dimensions and final components *** results reveal that the deformation behavior is highly affected by grain size and becomes unpredictable with increased grain *** addition,assembly parameters including feature dimension,tolerance and coaxiality also vary with grain size,and the variation of grain size needs to be accommodated by different assembly types,viz.,clearance fit or transition *** the microstructural evolution aspect,it was identified there were two dead zones and four shear bands,and the formation of these deformation zones was barely affected by the variation in grain *** bulges,cracks,and fracture induced voids were observed on the surface of the final components,tailoring the microstructure of the working material with finer grains could significantly avoid these *** study advances the understanding of forming microparts by extrusion processes and provides guidance for microforming of similar microparts.

关键词： Microformed part Size effect Extrusion Microstructural evolution Dimensions Assembly accuracy

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Au(111)表面WS_(2)成核控制的理论研究

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物理学报 2024年第13期73卷 111-120页

作者：胡艺山袁清红华东师范大学精密光谱科学与技术国家重点实验室上海200241

二维二硫化钨(WS_(2))作为一种具有层依赖的电子和光电特性的半导体材料,在光电器件领域展现出极具潜力的应用前景.当前,晶圆级单层WS_(2)薄膜的制备是推动其在先进晶体管和集成电路中应用的关键挑战.化学气相沉积(CVD)能够实现大尺寸... 详细信息

二维二硫化钨(WS_(2))作为一种具有层依赖的电子和光电特性的半导体材料,在光电器件领域展现出极具潜力的应用前景.当前,晶圆级单层WS_(2)薄膜的制备是推动其在先进晶体管和集成电路中应用的关键挑战.化学气相沉积(CVD)能够实现大尺寸、高质量的单层WS_(2)薄膜合成,但其生长过程的复杂性导致了WS_(2)生长效率低,质量参差不齐.为指导实验上减少WS_(2)晶界,提高薄膜质量以增强其电子性能和机械稳定性,本文基于第一性原理的理论计算,深入探讨了WS_(2)在CVD生长过程中的成核机制.通过引入化学势这一变量,分析了不同实验条件下WS_(2)的生长能量曲线,发现调整前驱体钨源和硫源的温度或压强能有效控制WS_(2)的成核速率.特别是当钨源温度为1250 K时,成核速率达到最大,而提高硫源温度或降低硫源压强则能降低成核速率,从而提高单层WS_(2)的结晶度和均匀性.这些理论计算结果为实验中根据需求精确调整成核速率提供了坚实的理论依据,并为如何通过优化实验参数来提高单层WS_(2)薄膜的结晶度和均匀性提供了理论指导,有望推动WS_(2)材料在各类高性能电子器件中的应用发展,对未来材料科学和工业应用具有重要意义.

关键词：第一性原理计算生长机制化学气相沉积二维二硫化钨

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New sustainable polymers with on-demand depolymerization property

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Science China Chemistry 2024年第9期67卷 2803-2841页

作者： Yangyang Sun Zesheng An Yanshan Gao Rongrong hu Ye Liu hua Lu Xiao-Bing Lu Xuan Pang Anjun Qin Yong Shen Youhua Tao Yu-Zhong Wang junpeng Wang Gang Wu Guang-Peng Wu Tie-Qi Xu Xing-hong Zhang Yuetao Zhang Zhenbiao Zhang jian-Bo Zhu Miao hong Zhibo Li State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China State Key Laboratory Base of Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsDalian University of TechnologyDalian 116024China Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)College of ChemistryState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610064China School of Polymer Science and Polymer Engineering the University of AkronAkronOH 44325USA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State and Local joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

To combat the crisis of today's synthetic polymers arising from unsustainable production and disposal,it is essential for the synthetic polymer community to reshape the current polymer industry with sustainable *** an emerging class of sustainable polymers,the development of chemically depolymerizable polymers(CDPs),which can undergo closed-loop depolymerization/repolymerization cycles to reproduce virgin polymers without the loss of properties from recovered monomers,offers an ideal solution to preserve finite natural resources,provides a feasible solution to the end-of-life issue of polymer waste,and thereby establishes a circular materials ***,two grand key challenges have been encountered in the establishment of practically useful CDPs:how to balance polymerization and depolymerization ability and how to unify conflicted depolymerizability and physical ***,this critical review article presents our vision for summarizing feasible strategies to overcome the above two significant challenges and the design principles for constructing an ideal CDP by highlighting selected major progress made in this rapidly expanding field.

关键词： chemically depolymerizable polymers sustainable polymers depolymerization monomer recovery degradation plastics

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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang hong-Wei Tao Feng-Chan Wang Ping Han Na Liu Guo-jing Zhao Hai-Bo hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFjT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFjT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFjT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFjT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFjT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFjT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFjT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2 phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFjT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

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Genus-specific secondary metabolome in Allokutzneria and Kibdelosporangium

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Synthetic and Systems Biotechnology 2024年第3期9卷 381-390页

作者： Man-jing Ma Wen-Chao Yu huai-Ying Sun Bing-Cheng Dong Gang-Ao hu Zhen-Yi Zhou Yi hua Buddha Bahadur Basnet Yan-Lei Yu hong Wang Bin Wei College of Pharmaceutical Science&Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang Key Laboratory of GreenLow-Carbonand Efficient Development of Marine Fishery ResourcesZhejiang University of TechnologyHangzhou 310014China Central Department of Biotechnology Trihuvan UniversityKathmanduNepal

Rare actinomycete genera are highly recognized as a promising source of structurally diverse and bioactive natural *** these genera,Allokutzneria and Kibdelosporangium are two phylogenetically closely related and have been reported to encode some valuable biosynthetic enzymes and secondary ***,there is currently no relevant systematic research available to outline the linkage of genomic and metabolomics for specific secondary metabolites in these two promising *** this study,we first investi-gated the genus-specific secondary metabolic potential in Allokutzneria and Kibdelosporangium by comparing the diversity and novelty of their secondary metabolite biosynthetic gene clusters(BGCs).The specific secondary metabolites produced by two representative strains of these genera were comprehensively investigated using untargeted metabolomics *** findings unveiled that the majority(95.4%)of the gene cluster families(GCFs)encoded by Allokutzneria and Kibdelosporangium were genus-specific,including NRPS GCFs encoding *** untargeted metabolomics analysis revealed that the metabolic profiles of two representative strains exhibit extensive specificity,with the culture medium having a big impact on the metabolic ***,an MS-cluster featuring a series of hydroxamate-type siderophores was identified from Allokutzneria albata jCM 9917,with two of them,including a novel one(N-deoxy arthrobactin A),being experimentally *** present study offers valuable insights for the targeted discovery of genus-specific natural products from microorganisms.

关键词： Genus-specific secondary metabolism Allokutzneria Kibdelosporangium Genome mining Untargeted metabolomics Siderophore

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水力压裂延迟活化断层的多场耦合数值模拟研究——以加拿大福克斯溪地区诱发地震为例

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地震学报 2024年第3期46卷 394-412页

作者：冷虹胡隽成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 成都理工大学数学地质四川省重点实验室成都610059 牛津大学地球科学系英国牛津OX13AN

加拿大西部盆地的福克斯溪(Fox Creek)页岩气开采区自压裂开采以来,地震频度急剧增加,引发工业界和科学界的广泛关注。目前一些典型诱发地震案例的断层活化动力学机制尚未完全厘清。本文以2014年初福克斯溪地区Duvernay地层附近发生的... 详细信息

加拿大西部盆地的福克斯溪(Fox Creek)页岩气开采区自压裂开采以来,地震频度急剧增加,引发工业界和科学界的广泛关注。目前一些典型诱发地震案例的断层活化动力学机制尚未完全厘清。本文以2014年初福克斯溪地区Duvernay地层附近发生的地震群及构造为研究对象,开展地下断层受流体扰动而活化的多场耦合数值模拟研究。文中重点讨论的1号平台附近发生的诱发地震主要沿着两个较为清晰的发震断层发生,最大震级M_(W)3.9事件发生于压裂井下方约1 km处的结晶基底内,并具有典型的延迟触发特点。本文就上述断层的滞后活化现象开展数值模拟研究。首先,基于PKN裂缝扩展模型计算并验证注入流体的应力扰动输入项,根据地震数据识别出断层的具体位置,结合地层和构造信息建立二维地质模型;然后,耦合固体力学、流体渗流定律和断层活化理论搭建多孔弹性介质内的断层活化数值仿真模型;最后,采用有限元方法数值模拟水力压裂活化断层的全过程,通过计算库仑应力改变量(ΔCFS)的值来观测断层活化前后的流固耦合场和应力应变场的演化特征。结果表明,经过5天注水和15天扩散的流体作用,西断层附近的ΔCFS持续增加,验证西断层延迟活化的主要成因是流体逐渐扩散累积到结晶基底并改变了其应力状态。此外,模拟结果表明东断层的存在使得西断层更容易活化。断层位错产生的正ΔCFS区域与诱发地震发生位置高度吻合。本文的数值模拟研究重现了水力压裂活化断层的物理过程,相关机制的正演分析若能事先开展,将可能为地震危害性预测提供科学依据。

关键词：多场耦合数值模拟断层延迟活化库仑应力水力压裂诱发地震

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Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International journal of Ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： Yu-Wen Liu Shu-jia Guo jia-Ni Li Yu-Ting Zhang Wei-jie Ouyang Yu-Qian Wang Cai-hong huang Yi Liao jiaoyue hu Zuguo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire

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