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Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients

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Stroke & Vascular Neurology 2024年第1期9卷 18-29页

作者： Yongjie Ma Zihao Song Yinqing Wang jiachen Wang Chuan He Guilin Li Peng Zhang Tao hong Liyong Sun Peng hu Ming Ye hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical University

Background Craniocervical junction(CCj)arteriovenous fistulas(AVFs)are *** current treatment strategies for AVFs with different angioarchitecture need to be *** present study aimed to analyse the correlation between angioarchitecture and clinical characteristics,share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage(SAH)and poor *** A total of 198 consecutive patients with CCj AVFs from our neurosurgical centre were retrospectively *** patients were grouped according to their clinical manifestations,and their baseline clinical characteristics,angioarchitecture,treatment strategies and outcomes were *** The patients’median age was 56 years(IQR 47–62 years).The majority of patients were men with 166(83.8%)*** most common clinical manifestation was SAH(52.0%),followed by venous hypertensive myelopathy(VHM)(45.5%).The most common CCj AVFs type was dural AVF,with 132(63.5%)*** most frequent fistula location was C-1(68.7%)and dural branch of vertebral artery(70.2%)was the most involved arterial feeders for *** most common direction of venous drainage was descending intradural drainage(40.9%),followed by ascending intradural drainage(36.5%).Microsurgery was the most common treatment strategy applied for 151(76.3%)patients,15(7.6%)patients were treated with interventional embolisation only,and 27(13.6%)received both interventional embolisation and microsurgical *** learning curve for microsurgery only was analysed by cumulative summation method,and the turning point was the 70th case,and blood loss in post-group was lower than that in pre-group(p=0.034).At the last follow-up,there were 155(78.3%)patients with favourable outcomes(modified Rankin Scale(mRS)<3).Age≥56(OR 2.038,95%CI 1.039 to 3.998,p=0.038),VHM as the clinical manifestation(OR 4.102,95%CI 2.108 to 7.982,p<0.001)and pretreatment mRS≥3(OR 3.127,95%CI 1.617 to 6.047,p<0

关键词： patients treatment hypertensive

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STING signaling in islet macrophages impairs insulin secretion in obesity

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Science China(Life Sciences) 2024年第2期67卷 345-359页

作者： Ze hong Saihua Chen jing Sun Dan Cheng Hanli Guo jiahao Mei Xiang Zhang Munire Maimaiti Haiping Hao Peng Cao Haiyang hu Chen Wang School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Natural Medicines Department of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China School of Life Sciences Westlake UniversityHangzhou 310012China

The innate immune regulator stimulator of interferon genes(STING)mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines,which promotes the progression of various inflammatory and autoimmune *** immune system plays a critical role in regulating obesity-induced islet dysfunction,whereas the potential effect of STING signaling is not fully ***,we demonstrate that STING is mainly expressed and activated in islet macrophages upon high-fat diet(HFD)***^(-/-)alleviates HFD-induced islet inflammation by inhibiting the expression of pro-inflammatory cytokines and the infiltration of ***,palmitic acid incubation promotes mitochondrial DNA leakage into the cytosol and subsequently activates STING pathway in ***,STING activation in macrophages impairs glucose-stimulated insulin secretion by mediating the engulfment ofβcell insulin secretory *** inhibiting STING activation enhances insulin secretion to control ***,our results reveal a regulatory mechanism in controlling the islet inflammation and insulin secretion in dietinduced obesity and suggest that selective blocking of the STING activation may be a promising strategy for treating type 2 diabetes.

关键词： STING obesity type 2 diabetes insulin macrophages islet

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Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li jia-Wei Tu juan Kong Ling-Ling Yang jian-hong jia Chuan Wang Bin hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

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Rh(Ⅲ)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks

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Chinese Chemical Letters 2024年第8期35卷 270-277页

作者： Shulei hu Yu Zhang Xiong Xie Luhan Li Kaixian Chen hong Liu jiang Wang Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratoty Shanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and ***,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and *** report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular ***-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.

关键词： C-H functionalization Rh(Ⅲ)-catalyzed Alkenylation Cyclic peptides Macrolactamization

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Cationic ordering transition in oxygen-redox layered oxide cathodes

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Carbon Energy 2024年第1期6卷 197-206页

作者： Xinyan Li Ang Gao Qinghua Zhang Hao Yu Pengxiang ji Dongdong Xiao Xuefeng Wang Dong Su Xiaohui Rong Xiqian Yu hong Li Yong-Sheng hu Lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijingChina Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijingChina

Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion ***,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural *** two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering *** find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical ***-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR *** findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes.

关键词： cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries

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Research on perturbation of neutron fluence rate in a closed thermal neutron field due to medium materials

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-11页

作者： Yang, jun-Kai Wang, Ping-Quan hu, Zhi-Meng Li, Fan Zeng, jun-Mei Xiao, Lin Guo, hong-Yu Zhang, jian Gorini, Giuseppe Zhang, hui Chu, Chungming Paul Nanjing Univ Coll Engn & Appl Sci Nanjing 210093 Peoples R China Natl Inst Metrol Beijing 100029 Peoples R China Nanjing Univ Aeronaut & Astronaut Dept Nucl Sci & Technol Nanjing 210093 Peoples R China Univ Milano Bicocca Dept Phys I-20126 Milan Italy

The neutron radiation field has vital applications in areas such as biomedicine, geology, radiation safety, and many others for neutron detection and neutron metrology. Correcting neutron fluence rate perturbation accurately is an important yet challenging problem. This study proposes a correction method that analyzes three physical processes. This method, which transforms the detection process from point detection to area detection, is based on a novel physical model and has been validated through theoretical analyses, experiments, and simulations. According to the average differences between the calculated and experimental results, the new method (1.67%) demonstrated better accuracy than the traditional simulation (2.17%). In a closed thermal neutron radiation field, the detector or strong neutron absorption material significantly perturbs the neutron fluence rate, whereas its impact on the energy spectrum shape and neutron directionality is relatively minor. Furthermore, based on the calculation results of the perturbation rate formula for medium materials with different compositions and sizes, the larger the volume and capture cross section of the medium, the higher the perturbation rate generated in the closed radiation field.

关键词： Perturbation rate Area detection Three-dimensional neutron energy spectrum Closed radiation field INFINITE-PLANE ABSORBERS FLUX PERTURBATIONS SPECTRUM

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VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling

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World journal of Stem Cells 2024年第2期16卷 207-227页

作者： Yun Yuan Xu-Fan Zhang Yu-Chen Li hong-Qing Chen Tian Wen jia-Lian Zheng Zi-Yi Zhao Qiong-Ying hu Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Hepatology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu 610072Sichuan ProvinceChina

BACKGROUND Colorectal cancer stem cells(CCSCs)are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer(CRC)*** are generally accepted to be important sources of CRC and are responsible for the progression,metastasis,and therapeutic resistance of ***,targeting this specific subpopulation has been recognized as a promising strategy for overcoming *** To investigate the effect of VX-509 on CCSCs and elucidate the underlying *** CCSCs were enriched from CRC cell lines by in conditioned serum-free *** blot,Aldefluor,transwell and tumorigenesis assays were performed to verify the phenotypic characteristics of the *** anticancer efficacy of VX-509 was assessed in HCT116 CCSCs and HT29 CCSCs by performing cell viability analysis,colony formation,sphere formation,flow cytometry,and western blotting assessments in vitro and tumor growth,immunohistochemistry and immunofluorescence assessments in *** Compared with parental cells,sphere cells derived from HCT116 and HT29 cells presented increased expression of stem cell transcription factors and stem cell markers and were more potent at promoting migration and tumori-genesis,demonstrating that the CRC sphere cells displayed CSC ***-509 inhibited the tumor malignant biological behavior of CRC-stem-like cells,as indicated by their proliferation,migration and clonality in vitro,and suppressed the tumor of CCSC-derived xenograft tumors in ***,VX-509 suppressed the CSC character-istics of CRC-stem-like cells and inhibited the progression of epithelial-mesenchymal transition(EMT)signaling in *** was identified as the regulatory factor of VX-509 on CRC stem-like cells through analyses of differen-tially expressed genes and CSC-related database ***-509 markedly downregulated the expression of Nodal and its downstream phosphorylated Smad2/3 to inhibit EMT ***,VX-509 rev

关键词： Colorectal cancer stem cells Stemness VX-509 Epithelial-mesenchymal transition Nodal

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ARHGAP4 variants are associated with X-linked early-onset temporal lobe epilepsy

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World journal of Pediatrics 2024年第8期20卷 859-867页

作者： Yuan-Yuan hu Wang Song Zhi-Gang Liu Xing-Guang Ye hong-Wei Zhang Xin Li jun-Xia Luo Peng-Yu Wang jie Wang Xiao-Fei Lin hong-Li Zhu Wei-Ping Liao Bin Li Xu-Qin Chen Department of Neurology Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityChang-gang-dong RoadGuangzhou510260China Epilepsy Center and Neurology Department of Children’s Hospital of Soochow University Suzhou215000JiangsuChina Department of pediatrics Foshan Women and Children HospitalFoshan528000China Children’s Hospital Affiliated to Shandong University Jinan250000ShandongChina Second Hospital of Shandong University Jinan250000China huai’an Maternity&Child Healthcare Hospital Huai’an223001China Institute of Neuroscience of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Chang-gang-dong Road 250Guangzhou510260GuangdongChina

The ARHGAP4 gene(OMIM*300,023),also known as Rho GTPase activating protein 4,encodes a protein that has an essential role in the regulation of small ***4 message RNA(mRNA)is highly expressed during the developing and adult nervous *** the protein level,ARHGAP4 is exclusively present in certain brain regions,such as the mesial temporal lobe,specifically the stratum lucidum of the CA3 region[1].ARHGAP4 enhances the GTPase activity of Rho proteins,which modulate morphological alterations in neuron development and synaptic plasticity by interacting with the actin cytoskeleton[2].

关键词： epilepsy alterations stratum

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带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中的霍金辐射

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物理学报 2024年第2期73卷 104-111页

作者：韩亦文胡成洪云重庆工商大学物理系重庆400067 成都东软学院基础教学学院成都611844

本文研究了带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中出射粒子的量子隧穿辐射过程.其中,将宇宙学参数视为动态变量而不同于之前研究工作中将其视为常数而忽略其贡献.具体地,在计算出射粒子隧穿率时将宇宙学参数引入计算... 详细信息

本文研究了带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中出射粒子的量子隧穿辐射过程.其中,将宇宙学参数视为动态变量而不同于之前研究工作中将其视为常数而忽略其贡献.具体地,在计算出射粒子隧穿率时将宇宙学参数引入计算并将其解释为热力学压强.计算结果表明,出射粒子的隧穿率与粒子出射前后黑洞的贝肯斯坦-霍金熵差成正比,辐射谱偏离了纯热谱,该结果与将宇宙学参数视为常数的情况完全相同.这意味着在扩展相空间中可以得到粒子的隧穿概率,并且隧穿过程不依赖于热力学状参量,这一工作自然地进一步将霍金辐射推广到了带有整体单极Reissner-Nordstrom-AdS黑洞扩展相空间中.结果表明,整体单极子尽管影响粒子的动力学行为和热力学量,但并不影响熵变和隧穿率.

关键词：霍金辐射宇宙学参数热力学压强整体单级

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Safety and Immunogenicity After Primary and Booster Inactivated SARS-Cov-2 Vaccination in Patients with Autoimmune Liver Diseases

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journal of Clinical and Translational Hepatology 2024年第2期12卷 162-171页

作者： Zhiwei Chen Yuting Wang Taiyu He hu Li Ling Ao Qingbo Pan Yingzhi Zhou Qian Zhu Dejuan Xiang Gaoli Zhang Ning Ling Min Chen Peng hu Mingli Peng Dachuan Cai Dazhi Zhang hong Ren Department of Infectious Diseases the Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral Hepatitisthe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Background and Aims:SARS-CoV-2 vaccines-associated autoimmune liver diseases have been reported in several case ***,the safety and immunogenicity after primary and booster inactivated SARS-CoV-2 vaccination in patients with autoimmune liver diseases(AILD)is still ***:Eighty-four patients with AILD were prospectively followed up after the second dose(primary)of inactivated SARS-CoV-2 *** of them received the third dose(booster)of inactivated *** events(AEs),autoimmune activation,and liver inflammation exacerbation after primary and booster vaccination were ***,dynamics of antireceptor-binding-domain IgG(anti-RBD-IgG),neutralizing antibodies(NAbs)and RBD-specific B cells responses were ***:The overall AEs in AILD patients after primary and booster vaccination were 26.2%and 13.3%,*** decrease of C3 level and increase of immunoglobulin light chain K andλlevels were observed in AILD patients after primary vaccination,however,liver inflammation was not exacerbated,even after booster *** the seroprevalence and titers of anti-RBD-IgG and NAbs were decreased over time in AILD patients after primary ***,the antibody titers were significantly elevated after booster vaccination(10-fold in anti-RBD-IgG and 7.4-fold in NAbs,respectively),which was as high as in healthy ***,the inferior antibody response was not enhanced after booster vaccination in patients with *** of atypical memory B cells were inversely related to antibody levels,which indicate that the impaired immune memory was partially restored partly by the booster ***:The well tolerability and enhanced humoral immune response of inactivated vaccine supports an additional booster vaccination in AILD patients without immunosuppressants.

关键词： SARS-CoV-2 Autoimmune liver disease Inactivated SARS-CoV-2 vaccine Safety Antibody responses Memory B cells

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