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Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 246-261页

作者： Ai-Yu Nie Zhong-hui Xiao Jia-li Deng Na li li-Yuan Hao Sheng-Hao li Xiao-Yu hu College of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Infection Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are *** cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune *** a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in ***,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor *** To investigate the dual-regulation mechanism of cGAS-STING in *** This review was conducted according to the PRISMA *** study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science *** rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC *** All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 *** removing duplicates,remaining 964 records were ***,55 articles met the inclusion criteria and were included in this *** Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its *** cGAS-STING pathway activation will result in a suppressive tumor microenvironment.

关键词： Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Bifunctional bridging capping layer enables 24.5%efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期68卷 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu Jing li Shucheng Qin Ke hu Xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information EngineeringZhejiang Normal UniversityJinhua 321004China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Developing a bridge capping layer between perovskite and hole transport layer materials(HTMs)in the n-i-p perovskite solar cells(pero-SCs)is an effective approach to modify the morphology of HTMs and passivate the perovskite ***,we select the quinoxaline-based bifunctional passivation agent,quinoxalin-6-yl-methylamine hydrochloride(Qx MACl),as the bridging layer,and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p *** to theπ-πstacking among the common quinoxaline units in the bridge layer and HTM,Qx MACl induces theπ-πstacking of the PBQ12 film and improves the film morphology of HTMs with better ***,Qx MACl can effectively passivate the perovskite surface,and PBQ12 possesses appropriate energy levels and high hole *** pero-SCs based on FAPbI_(3)with PBQ12/Qx MACl treatment showed a higher power conversion efficiency(PCE)of 24.05%and outstanding stability,maintaining 95.4%and 92.1%of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85℃,*** further enhance the PCE of the PBQ12/Qx MACl-based devices,we developed a non-metal ion dopant for the PBQ12 *** trace doping of PBQ12 HTM by the non-metal ion dopant,the PCE of the PBQ12/Qx MACl-based devices reached 25.24%(the calibrated PCE of 24.55%by the National Institute of Metrology,China).

关键词： D-A copolymer hole transport materials bifunctional bridge capping layer passivation perovskite solar cells

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Microplastics enhance the adsorption capacity of zinc oxide nanoparticles:Interactive mechanisms and influence factors

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Journal of Environmental Sciences 2025年第1期147卷 665-676页

作者： Weiping Xiong Min hu Siying He Yuhang Ye Yinping Xiang Haihao Peng Zhaomeng Chen Zhengyong Xu Honglin Zhang Weixiang li Shudian Peng College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China hunan Boke Environmental Engineering Co.Ltd. Hengyang 421099China College of Environmental Protection and Safety Engineering University of South ChinaHengyang 421001China hunan Modern Environmental Technology Co.Ltd. Changsha 410004China

Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous *** on the interaction and joint toxicity of MPs on engineered nanoparticles(ENPs)are exhaustive,but limited research on the effect of MPs on the properties of ENPs in multisolute ***,the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first *** results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on *** polyamide prevented aggregation of ZnONPs by introducing negative charges,whereas virgin polyamide affected ZnONPs with the help of electrostatic ***-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and *** results showed no chemical interaction and electrostatic interactionwas the dominant force between ***,the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic *** study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs,which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on *** also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.

关键词： Microplastics Engineered nanoparticles Adsorption Tetracycline

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Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi lian Kang hu Qiuju li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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Evolutionary Particle Swarm Optimization Algorithm Based on Collective Prediction for Deployment of Base Stations

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Computers, Materials & Continua 2025年第1期82卷 345-369页

作者： Jiaying Shen donglin Zhu Yujia liu Leyi Wang Jialing hu Zhaolong Ouyang Changjun Zhou Taiyong li School of Computer Science and Technology Zhejiang Normal UniversityJinhua321004China School of Future Technologies Jiangxi Institute of Applied Science and TechnologyNanchang330000China School of Computing and Artificial Intelligence Southwestern University of Finance and EconomicsChengdu611130China

The wireless signals emitted by base stations serve as a vital link connecting people in today’s society and have been occupying an increasingly important role in real *** development of the Internet of Things(IoT)relies on the support of base stations,which provide a solid foundation for achieving a more intelligent way of *** a specific area,achieving higher signal coverage with fewer base stations has become an urgent ***,this article focuses on the effective coverage area of base station signals and proposes a novel Evolutionary Particle Swarm Optimization(EPSO)algorithm based on collective prediction,referred to herein as *** a new strategy called neighbor-based evolution prediction(NEP)addresses the issue of premature convergence often encountered by *** also employs a strengthening evolution(SE)strategy to enhance the algorithm’s global search capability and efficiency,ensuring enhanced robustness and a faster convergence speed when solving complex optimization *** better adapt to the actual communication needs of base stations,this article conducts simulation experiments by changing the number of base *** experimental results demonstrate thatunder the conditionof 50 ormore base stations,ECPPSOconsistently achieves the best coverage rate exceeding 95%,peaking at 99.4400%when the number of base stations reaches *** results validate the optimization capability of the ECPPSO algorithm,proving its feasibility and *** ablative experiments and comparisons with other algorithms highlight the advantages of ECPPSO.

关键词： Particle swarm optimization effective coverage area global optimization base station deployment

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Polymer-based smart fibers and textiles for wearable electronics

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Science China(Technological Sciences) 2025年第1期68卷 81-116页

作者： Sanming hu li WANG Zaixian YUAN Kun CHEN Wei PENG Hai YIN Zhijun SHI Guang YANG School of Biomedical Engineering and Imaging Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China College of life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Wuhan Branch of the National Science library Chinese Academy of SciencesWuhan 430071China

Smart fibers and textiles have attracted considerable interest for application in wearable devices because of their advantages of being human-friendly,lightweight,flexible,and *** addition,they are considered to have potential applications in health monitoring,energy management,and human-machine interaction *** and polymer fibers,with excellent mechanical strength,wrinkle resistance,and heat resistance,are widely used to fabricate smart fibers and ***,a comprehensive overview of polymer-based fibers and textiles is ***,we review the design principles of various polymer-based smart textiles,including textile-based sensors,energy capture and storage textiles,and computation and display ***,materials used for preparing polymer-based smart fibers,such as metals,carbon-based materials,and natural and synthetic polymers,particularly conductive polymers,are *** addition,this review summarizes key technologies used for preparing smart fibers and the conventional structures of smart ***,the applications of smart textiles in personal health monitoring,thermal management,energy capture and storage,and computation and displays are ***,the current challenges,limitations,and future trends of smart fibers and textiles are discussed.

关键词： polymers smart fibers smart textiles wearable electronics health management

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Regulating local electron transfer environment of covalent triazine frameworks through F,N co-modification towards optimized oxygen reduction reaction

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Chinese Chemical Letters 2025年第1期36卷 344-348页

作者： Quanyou Guo Yue Yang Tingting hu Hongqi Chu lijun liao Xuepeng Wang Zhenzi li liping Guo Wei Zhou Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Ji’nan 250353China

The high conductivity of electrocatalyst can eliminate the Schottky energy barrier at the interface of heterogeneous phases during an electrocatalytic reaction and accelerate the rapid electron transfer to the catalytic active ***,the electronic conductivity is a vital parameter for oxygen reduction reaction(ORR).Covalent triazine frameworks(CTFs)have shown great potential application as electrocatalysts in ORR with a merit of the diverse building ***,the intrinsic low conductivity and high impedance of CTFs could be significant setbacks in electrocatalytic ***,CTFs were constructed by introducing F and N co-modification for efficient 2e^(-)*** with the pristine CTF,the co-presence of F,N could increase the conductivity obviously by *** a result,F-N-CTF exhibits enhanced catalytic performance of H_(2)O_(2)generation and selectivity towards reaction *** work reveals the importance of conductivity optimization for CTFs and provides guidance for designing high conductivity non-metallic organic semiconductor catalysts for 2e^(-)ORR.

关键词： Covalent triazine frameworks Conductivity Co-modification Electrocatalysis Oxygen reduction reaction

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Aspect-Level Sentiment Analysis of Bi-Graph Convolutional Networks Based on Enhanced Syntactic Structural Information

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Journal of Computer and Communications 2025年第1期13卷 72-89页

作者： Junpeng hu Yegang li School of Computer Science and Technology Shandong University of Technology Zibo China

Aspect-oriented sentiment analysis is a meticulous sentiment analysis task that aims to analyse the sentiment polarity of specific aspects. Most of the current research builds graph convolutional networks based on dependent syntactic trees, which improves the classification performance of the models to some extent. However, the technical limitations of dependent syntactic trees can introduce considerable noise into the model. Meanwhile, it is difficult for a single graph convolutional network to aggregate both semantic and syntactic structural information of nodes, which affects the final sentence classification. To cope with the above problems, this paper proposes a bi-channel graph convolutional network model. The model introduces a phrase structure tree and transforms it into a hierarchical phrase matrix. The adjacency matrix of the dependent syntactic tree and the hierarchical phrase matrix are combined as the initial matrix of the graph convolutional network to enhance the syntactic information. The semantic information feature representations of the sentences are obtained by the graph convolutional network with a multi-head attention mechanism and fused to achieve complementary learning of dual-channel features. Experimental results show that the model performs well and improves the accuracy of sentiment classification on three public benchmark datasets, namely Rest14, Lap14 and Twitter.

关键词： Aspect-Level Sentiment Analysis Sentiment Knowledge Multi-Head Attention Mechanism Graph Convolutional Networks

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Alternative splicing drives the functional diversification of a b HLH transcription factor in the control of growth and drought tolerance in rice

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Science Bulletin 2025年第2期70卷 153-156页

作者： Min Ning Qinyan li Ya Wang Qingmao li Yonghong Tao Fan Zhang Fengyi hu liyu huang Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs School of AgricultureYunnan UniversityKunming 650091China Cereal Crops Research Institute Henan Academy of Agricultural SciencesZhengzhou 450002China Wenshan Academy of Agricultural Sciences Wenshan 663000China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Given the increase in global climate change,reconciling the increasing demand for food production with dwindling water resources poses a formidable *** ensure sustainable rice production and global food security,a thorough exploration of the genetic mechanism that underlies the delicate balance between growth and drought tolerance in rice is *** sessile nature of plants has driven their adaptive evolution,enabling them to regulate gene expression and exhibit physiological and developmental plasticity in response to environmental changes[1].Alternative splicing(AS),a prevalent phenomenon in plants,plays a crucial role in the regulation of posttranscriptional gene expression[2].AS serves as an essential mechanism involved in both developmental processes and stress responses[3–5].

关键词： drought mechanism tolerance

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