检索结果-南通市图书馆

Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第12期8卷 5954-5969页

作者： Daoyuan Xie Yaomei Tian die hu Yuanda Wang Yuling Yang Bailing Zhou Rui Zhang Zhixiang Ren Mohan Liu Jie Xu Chunyan Dong Binyan Zhao Li Yang Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China College of Bioengineering Sichuan University of Science&EngineeringZigong 643000China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610212China

Despite the remarkable success of immune checkpoint inhibitors(ICIs),primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment(TME).Oncolytic viruses(OVs)can overcome the immunosuppressive TME and promote systemic antitumor immunity in *** OVs armed with ICIs would likely have improved effectiveness as a cancer *** to the diverse immune cell landscapes among different types of tumors,we rationally and precisely generated three recombinant oncolytic adenoviruses(OAds):OAd-SIRPα-Fc,OAd-Siglec10-Fc and *** viruses were designed to locally deliver SIRPα-Fc,Siglec10-Fc or TIGIT-Fc fusion proteins recognizing CD47,CD24 or CD155,respectively,in the TME to achieve enhanced antitumor *** results suggested that OAd-SIRPα-Fc and OAd-Siglec10-Fc both showed outstanding efficacy in tumor suppression of macrophage-dominated tumors,while OAd-TIGIT-Fc showed the best antitumor immunity in CD8+T-cell-dominated ***,the recombinant OAds activated an inflammatory immune response and generated long-term antitumor *** addition,the combination of OAd-Siglec10-Fc with anti-PD-1 significantly enhanced the antitumor effect in a 4T1 tumor model by remodeling the *** summary,rationally designed OAds expressing ICIs tailored to the immune cell landscape in the TME can precisely achieve tumor-specific immunotherapy of cancer.

关键词： immunity expressing landscape

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轻盈的力量——论传统京剧中的怪力乱神

戏剧（中央戏剧学院学报） 2009年第3期 97-102页

作者：胡叠中国戏曲学院

传统京剧和当代新编京剧,从题材的选择和处理上看,区别最大的是前者有许多"怪力乱神"的成分,使传统京剧中浪漫主义的倾向较为明显,演剧风格呈现出轻盈、跳脱、机智、生动的特点。京剧艺术中,民间文化的传统不容忽视。这些怪力乱神的内容... 详细信息

传统京剧和当代新编京剧,从题材的选择和处理上看,区别最大的是前者有许多"怪力乱神"的成分,使传统京剧中浪漫主义的倾向较为明显,演剧风格呈现出轻盈、跳脱、机智、生动的特点。京剧艺术中,民间文化的传统不容忽视。这些怪力乱神的内容,正是京剧民间文化传统的具体体现之一。

关键词：京剧艺术神鬼戏民间文化

在线全文

学校读者我要写书评

暂无评论

论“国剧运动”的文化保守主义立场

戏剧（中央戏剧学院学报） 2005年第2期 5-15页

作者：胡叠中央戏剧学院戏剧文学系

“国剧运动”作为一个特殊社会文化现象,在中国话剧还处于起步阶段的1920年代出现,有其偶然性和必然性。它对东西方戏剧的理性思考和对未来中国戏剧形态的构想,与当时社会文化思潮的“主流”显得格格不入,但却在几十年后成为当代话剧探... 详细信息

“国剧运动”作为一个特殊社会文化现象,在中国话剧还处于起步阶段的1920年代出现,有其偶然性和必然性。它对东西方戏剧的理性思考和对未来中国戏剧形态的构想,与当时社会文化思潮的“主流”显得格格不入,但却在几十年后成为当代话剧探索的方向之一。“国剧运动”的先驱大多属于文化保守主义者,他们对“国剧”理论的创建,不仅在于对中国传统文化的承继,更与特定的历史文化背景下的价值选择有密切关联。

关键词： ·国剧运动文化保守主义闻一多余上沅

“有隔有通”:宗白华关于建筑空间的美学理论

在线全文

学校读者我要写书评

暂无评论

湖南师范大学社会科学学报 2021年第3期50卷 144-151页

作者：胡谍北京大学哲学系北京100871

宗白华用“有隔有通”概括中国古代建筑艺术的空间观念,“有隔有通”的意思是说,中国古代建筑是隔出空间的艺术,同时它又追求空间的内外交通。宗白华有关隔的理论源自德国美学与建筑思想,有关通的观念从中国古典美学和艺术哲学中转化提... 详细信息

宗白华用“有隔有通”概括中国古代建筑艺术的空间观念,“有隔有通”的意思是说,中国古代建筑是隔出空间的艺术,同时它又追求空间的内外交通。宗白华有关隔的理论源自德国美学与建筑思想,有关通的观念从中国古典美学和艺术哲学中转化提炼而来。可以说,“有隔有通”融合了中西美学和建筑理论,是中西学术共同推进的产物。更重要的是,“有隔有通”的空间观体现了“时空合一”的观念,从“有隔有通”与“时空合一”的观念看,中国古代建筑与西方现代建筑存在相似性。这种相似表明,中国古代建筑艺术同时也是世界的和现代的,对“世界美学”的建构有重要价值。宗白华提出“有隔有通”的空间理论,目的是建构将来的“世界美学”。

关键词：宗白华空间有隔有通时空合一世界美学

Researches of Street Greening Landscape Based on Plant Diversity Investigation in Jingzhou

在线全文

学校读者我要写书评

暂无评论

Journal of Landscape Research 2021年第2期13卷 65-68,73页

作者： huANG Yingying TIAN Mengna hu die College of Horticulture and Gardening Yangtze UniversityJingzhouHubei 434025China

Street greening effectively embodies the ecological and landscape functions of plants,and is of great significance to regional maintenance and ecological *** this study,an evaluation system was constructed based on plant diversity,and typical sampling method was used to study the landscape and evaluate the ecological function of main roads in Jingzhou *** results showed that:①the average species richness of the 14 plot roads was 2,and the average Shannon-Wiener diversity index (H’) and average Pielou evenness index (Jsw) were 0.892 and 0.911,respectively;due to single street landscape and high homogeneity of landscape,there is a lack of landscape characteristics in Jingzhou;②the ecological functions of five streets were compared:shading > dust fall > humidity elimination > noise reduction > temperature reduction;street greening has significant shading effect and certain dust retention *** investigation and research will provide reference and improvement suggestions for street greening construction in Jingzhou City in the future.

关键词： Landscape effect Plant diversity Ecological function

西湖凹陷平湖构造带平湖组砂岩储层特征及其主控因素

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石油与天然气地质 2013年第2期34卷 185-191页

作者：胡明毅沈娇胡蝶长江大学地球科学学院湖北武汉430100 长江大学油气资源与勘探技术教育部重点实验室湖北武汉430100

以岩心和铸体薄片观察为基础,结合扫描电镜、储层物性、压汞及试采等综合资料分析,对西湖凹陷平湖构造带平湖组砂岩储层发育特征进行了研究。结果表明,该区平湖组储层岩石类型以长石质石英砂岩为主,颗粒分选和磨圆度较好,成分成熟度中等... 详细信息

以岩心和铸体薄片观察为基础,结合扫描电镜、储层物性、压汞及试采等综合资料分析,对西湖凹陷平湖构造带平湖组砂岩储层发育特征进行了研究。结果表明,该区平湖组储层岩石类型以长石质石英砂岩为主,颗粒分选和磨圆度较好,成分成熟度中等,结构成熟度高;储层物性表现为低孔、低渗和中孔、中渗的特征,孔、渗相关性好;孔隙类型主要发育有粒间溶孔和剩余原生粒间孔,喉道类型以缩颈型喉道、片状喉道、弯片状喉道为主,孔、喉组合以中孔、粗喉为主。在此基础上,从沉积相、成岩作用和异常超压等方面对该区储层发育主控因素进行了分析。综合研究表明,沉积相是该区储层发育的主控因素之一,其中三角洲平原分支河道砂体物性最好,其次为三角洲前缘水下分流河道砂体;压实作用和胶结作用导致该区储层物性变差,溶蚀作用则有助于形成次生孔隙空间,并大大改善储层物性;异常超压对研究区储层有建设性影响,可以在一定程度上使原生孔隙得以保存,并促进早期碳酸盐胶结物的溶解,形成粒间溶孔,改善储层物性。

关键词：异常超压沉积相成岩作用储层特征平湖组平湖构造带西湖凹陷

The role of brevican regulation in the antidepressant effects of electroacupuncture in a chronic stress rat model

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2024年第4期11卷 513-521页

作者： Cong Gai Zhenyu Guo Kai Guo Shixin Yang Yi Zhang huimin Zhu Feifei Kan Hongmei Sun die hu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective:To investigate the mechanism of electroacupuncture(EA)for treating depression and to explore the role of brevican in the medial prefrontal cortex(mPFC)in modulating stress susceptibility and the antidepressant effects of EA in ***:Twenty-four SpragueeDawley(SD)rats were equally divided into three groups:green fluo-rescent protein(GFP)+control,GFP+chronic unpredicted mild stress(CUMS),and short-hairpin RNA targeting on brevican(shBcan)+*** 24 SD rats were equally divided into CUMS+GFP,CUMS+GFP+EA,and CUMS+shBcan+EA *** tests were conducted to assess depression-like *** blot analysis was used to evaluate the expression of brevican,aggrecan,GLuA1,and PSD95 in mPFC ***:Behavioral parameter evaluation show that rats in the shBcan+CUMS group exhibited a significantly reduced sucrose preference(P=0.0002)and increased immobility time(P=0.0011)compared to those in rats in the GFP+CUMS *** blotting showed that brevican expression was significantly downregulated in the PrL of the shBcan+CUMS group compared with that in the GFP+CUMS group(P=0.0192).Furthermore,compared to the CUMS+GFP+EA group,the CUMS+shBcan+EA group exhibited a significantly decreased sucrose preference(P=0.0334),increased immobility time(P=0.0465),and increased latency to food(P=0.0261).In the CUMS+shBcan+EA group,the EA-induced brevican and PSD95 overexpression was reversed,compared with that in the CUMS+GFP+EA group(P=0.0454 and P=0.0198,respectively).Conclusion:EA exerts its antidepressant effects through the modulation of brevican expression in *** findings highlight the important role for brevican in stress susceptibility,which could be a potential target for treating depression.

关键词： Depression Electroacupuncture Brevican Perineuronal nets Plasticity

Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第12期36卷 1524-1537页

作者： Yu Zhang Jian Song Xu-Zhong He Jian Xiong Rong Xue Jia-Hao Ge Shi-Yu Lu die hu Guo-Xing Zhang Guang-Yin Xu Lin-hui Wang Department of Physiology and Neurobiology Medical College of Soochow UniversitySuzhou 215123China Institute of Medical Biotechnology Suzhou Vocational Health CollegeSuzhou 215009China Institute of Neuroscience Soochow UniversitySuzhou 215123China

Following intrathecal injection of fluorescent tracers,ex vivo imaging of brain vibratome slices has been widely used to study the glymphatic system in the rodent *** penetration into the brain is usually quantified by image-processing,even though this approach requires much time and manual ***,we illustrate a simple protocol for the quantitative determination of glymphatic activity using *** specific time-points following intracisternal or intrastriatal injection of fluorescent tracers,certain brain regions and the spinal cord were harvested and tracers were extracted from the *** intensity of tracers was analyzed spectrophotometrically and their concentrations were quantified from standard *** this approach,the regional and dynamic delivery of subarachnoid CSF tracers into the brain parenchyma was assessed,and the clearance of tracers from the brain was also ***,the impairment of glymphatic influx in the brains of old mice was confirmed using our *** method is more accurate and efficient than the imaging approach in terms of the quantitative determination of glymphatic activity,and this will be useful in preclinical studies.

关键词： Glymphatic system Cerebrospinal fluid Fluorescent tracer Spectrophotofluorometry

走下神坛的美国亚当——论《边境三部曲》对西部牛仔形象的重构

在线全文

学校读者我要写书评

暂无评论

烟台大学学报（哲学社会科学版） 2015年第2期28卷 82-88页

作者：胡蝶同济大学外国语学院上海200092

麦卡锡是美国当代最重要的小说家之一,其重要作品《边境三部曲》中体现出西部神话对小说创作的重要影响。虽然麦卡锡采用了西部小说的传统写作符码和许多经典情节,然而他是通过建构"反神话"话语的方式、从西部神话的内部对其进行揭示和... 详细信息

麦卡锡是美国当代最重要的小说家之一,其重要作品《边境三部曲》中体现出西部神话对小说创作的重要影响。虽然麦卡锡采用了西部小说的传统写作符码和许多经典情节,然而他是通过建构"反神话"话语的方式、从西部神话的内部对其进行揭示和解构。在《边境三部曲》中,麦卡锡秉承后现代解构神话的一贯思想,将神人般的牛仔英雄重构成为一个个在凡间生活的既困顿流离又孤独迷惘的常人和凡人形象,揭露出美国亚当们背后隐藏的个人主义和帝国主义的意识形态,从而将美国亚当们拉下了神坛,也在更深层次上解构了美国西部神话。

关键词：麦卡锡边境三部曲美国亚当人物重构