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儿童食管支架的研究进展

上海交通大学学报（医学版） 2019年第1期39卷 99-101页

作者：胡涵博孙锟上海交通大学医学院附属新华医院小儿心内科上海200092

良性食管狭窄是目前临床上常见的儿童食管疾病,其常用的治疗方式为球囊扩张术。根据病变的复杂程度,患儿往往需经历多次食管扩张术,较为痛苦。食管支架因具有更加持久的支撑效果,为治疗儿童食管狭窄提供了新的选择,但诸如胸痛、再狭窄... 详细信息

良性食管狭窄是目前临床上常见的儿童食管疾病,其常用的治疗方式为球囊扩张术。根据病变的复杂程度,患儿往往需经历多次食管扩张术,较为痛苦。食管支架因具有更加持久的支撑效果,为治疗儿童食管狭窄提供了新的选择,但诸如胸痛、再狭窄、支架移位等并发症却限制了其临床应用。该文对儿童食管支架的研究现状及临床应用进行了综述。

关键词：食管支架儿童良性食管狭窄

Role and mechanism of ORM in adipose tissue fibrosis and insulin resistance in obese mice

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中国药理学与毒理学杂志 2019年第10期 786-787页

作者： WANG Peng-yuan QIN Zhen ZhanG Yu FENG Jia-yi hu bo-han WEI Jie SU Ding-feng SUN Yang LIU Xia Department of Pharmacology School of Pharmacy Second Military Medical University Department of Clinical Pharmacy School of Pharmacy Second Military Medical University

OBJECTIVE During the development of obesity, adipose tissue fibrosis occurs as a hallmark of adipose tissue dysfunction, leading to metabolic dysfunction such as insulin resistance. We previously reported adipokine orosomucoid（ORM） could be a negative feedback signal in energy homeostasis, and its level was significantly elevated in response to obese state. Here we aimed to explore the role of ORM in adipose tissue fibrosis and insulin resistance during obesity, and its possible mechanism. METHODS MRI was used to assess the distribution of fat and the fat or lean mass in ORM1 knockout mice. HE staining, masson staining, qPCR, and Western blotting were used to assess the fibrosis status of mice. And we used glucose tolerance test（GTT） and insulin tolerance test（ITT） to evaluate the regulation of blood glucose and insulin sensitivity in mice. Leptin receptor-deficient db/db mice and high fat diet-induced obese mice were used as obese models. 3 T3-L1 cells were used in vitro. RESULTS ORM1-deficient mice exhibited an obese phenotype with adipose tissue fibrosis and insulin resistance. The m RNA and protein levels of the fibrogenic genes encoding Col1a1, Col3a1, Col6a3 and ECM regulators MMP-2, MMP-13, MMP-14 TIMP-1,TIMP-2, and TIMP-3 in ORM1-deficient mice were significantly increased. GTT and ITT showed abnormal glucose tolerance and insulin resistance in ORM1-deficient ***, exogenous administration of ORM attenuated excessive expression of type Ⅵ collagen, MMP-13 and TIMP-1 induced by adipose fibrosis in obese db/db（lep Rdeficient） mice. GTT and ITT showed ORM treatment improved insulin resistance in db/db mice. Moreover,ORM synergized with insulin to activate Akt in adipose tissue of db/db mice. Further studies found that ORM could bind to C-C chemikine receptor 5（CCR5） and ORM improves insulin resistance in high fat diet-induced obese mice, which could be blocked by maraviroc, an antagonist against CCR5. In addition, the effect of ORM in synergy with insul

关键词： ORM adipose tissue fibrosis insulin resistance CCR5

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适用于云取证的证据数据完整性评估方法

华中科技大学学报（自然科学版） 2016年第11期44卷 82-86,96页

作者：胡波韩臻黄伟庆孙德刚北京交通大学计算机与信息技术学院北京100044 中国科学院信息工程研究所北京100093

针对证据数据完整性的问题,指出证据数据完整性评估的意义和重要性.通过考察信息系统在物理环境、网络传输、主机与系统、应用程序、管理和时间这六个方面对于证据数据完整性的影响和作用,提出了一种评估证据数据完整性的框架.运用数据... 详细信息

针对证据数据完整性的问题,指出证据数据完整性评估的意义和重要性.通过考察信息系统在物理环境、网络传输、主机与系统、应用程序、管理和时间这六个方面对于证据数据完整性的影响和作用,提出了一种评估证据数据完整性的框架.运用数据融合方法对评价结果进行量化,通过分别对传统终端取证方法和面向云的取证方法的实例进行评估与量化,证实了该框架对证据数据完整性评估具有切实有效的指导作用及可操作性,结果表明使用传统终端取证工具所获取证据数据的不确定性在云环境下是传统终端取证的5倍.

关键词：云取证数据完整性评估框架数字调查数据融合

Role of Acute Phase Protein ORM in A Mice Model of Ischemic Stroke

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神经药理学报 2019年第4期 34-35页

作者： WAN Jing-jing WANG Peng-yuan ZhanG Yu hu bo-han SUN Yang XU Dong-ping LIU Xia Department of Pharmacology School of PharmacySecond Military Medical University

Objective:The only FDA-approved treatment for acute ischemic stroke is tissue plasminogen activator,and the discovery of novel therapeutic targets is critical. Here,we found ORM,an acute phase protein mainly produced by the liver,might act as a treatment candidate for ischemic stroke. Our aim is to explore the role and underlying mechanism of ORM in ischemic stroke. Methods:Ischemic stroke was set up by middle cerebral artery occlusion( MCAO) in mice. Brain microvascular endothelial cells( bEnd.3) were exposed to oxygen-glucose-deprivation(OGD) for 4 h and then treated with 10 μg·mL-1 of ORM for another 4 h. Purified ORM was injected via tail vein 0.5 h before,immediately,or 1 h,3 h,4.5 h and 6 h after MCAO in C57 BL/6 mice,and infarct size was detected 24 h after surgery by TCC staining. ORM subtypes were determined by real-time PCR,and also pro-inflammatory factors,including IL-1β,IL-6 and TNF-α,24 h after surgery. Cerebrovascular permeability was evaluated by Evans blue staining and immunofluorescence. Briefly,22 h after MCAO,2% Evans Blue dye( 0.1 mL·g-1) was injected via the tail vein. 2 h later,the brain was rapidly harvested,detecting Evans blue staining and immunofluorescence results. Blood-brain barrier-associated proteins expression of ZO-1,claudin-5,occludin VE-cadherin and caveolin-1 were detected by immunoblotting. Oxidative stress was clarified by ELISA. Cell apoptosis and caspase-3 activity were detected by ELISA,TUNEL and flowcytometry. Results:The results showed that ORM2 is the dominant subtype in mice normal brain tissue. After middle cerebral artery occlusion( MCAO),the level of ORM2 is significantly increased in the ischemic penumbra compared to the contralateral normal brain tissue,while ORM1 knockout did not affect infarct size. Exogenous ORM could significantly decrease infarct size and neurological deficit score. Inspiringly,the best administration timepoint was at 4.5 h and 6 h after MCAO. ORM treatment could significantly reduce the area o

关键词： ORM ischemic stroke blood-brain barrier inflammation oxidative stress apoptosis

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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直接空冷凝汽器三维流场特性的数值分析

动力工程 2007年第4期27卷 592-595页

作者：胡汉波李隆键张义华崔文智重庆大学动力工程学院重庆400044

对A字形布置的单排管直接空冷凝汽器单元进行了分析,建立了凝汽器单元内三维流动的物理数学模型,并利用Fluent求解器进行了相应的数值计算。分析了不同运行工况(风机转速、风机叶片安装角)以及环境因素(横向风速度、环境温度)对凝汽器... 详细信息

对A字形布置的单排管直接空冷凝汽器单元进行了分析,建立了凝汽器单元内三维流动的物理数学模型,并利用Fluent求解器进行了相应的数值计算。分析了不同运行工况(风机转速、风机叶片安装角)以及环境因素(横向风速度、环境温度)对凝汽器单元流场特性的影响规律,为直接空冷凝汽器设计和优化提供科学依据。

关键词：能源与动力工程直接空冷凝汽器流场特性数值模拟

Anomaly monitoring and early warning of electric moped charging device with infrared image

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Optoelectronics Letters 2025年第3期 136-141页

作者： LI Jiamin han bo JIANG Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices, such as sockets,interfaces, and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this, a temperature detection method based on infrared image processing has been proposed:utilizing the median filtering algorithm to denoise the original infrared image, then applying an image segmentation algorithm to divide the image.

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Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng Su Yanfang huang Bingbing Liu hu Sun Shuzhen Yang Guihong han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy