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扶正驱邪方联合新辅助化疗对三阴性乳腺癌患者肿瘤复发、血清TK1 水平及免疫功能的影响

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广州中医药大学学报 2024年第4期41卷 881-887页

作者：左晓娜谢昱伟刘欣王佳李萌胡志伟沧州中西医结合医院东院区放化疗科河北沧州061012 沧州中西医结合医院骨伤院区重症医学科河北沧州061012 沧州中西医结合医院放化疗六科河北沧州061012

【目的】探究扶正驱邪方联合新辅助化疗对三阴性乳腺癌(TNBC)患者肿瘤复发、血清胸苷激酶1(TK1)水平及免疫功能的影响。【方法】将80例TNBC气阴两虚型患者随机分为联合组和对照组,每组各40例。对照组给予AC-T序贯化疗方案(多柔比星与环... 详细信息

【目的】探究扶正驱邪方联合新辅助化疗对三阴性乳腺癌(TNBC)患者肿瘤复发、血清胸苷激酶1(TK1)水平及免疫功能的影响。【方法】将80例TNBC气阴两虚型患者随机分为联合组和对照组,每组各40例。对照组给予AC-T序贯化疗方案(多柔比星与环磷酰胺联合并序贯多西他赛)治疗,联合组在对照组的基础上加用扶正驱邪方治疗。1个疗程为21 d,连续治疗4个疗程。观察2组患者治疗前后中医证候积分、生活质量Karnofsky功能状态(KPS)评分、肿瘤标志物[糖类抗原125(CA125)、糖类抗原153(CA153)、TK1]水平及T淋巴细胞亚群的变化情况,比较2组患者的临床疗效以及肿瘤的转移、复发情况。【结果】(1)治疗4个疗程后,联合组的总有效率为87.50%(35/40),对照组为67.50%(27/40),组间比较(χ2检验),联合组的疗效明显优于对照组(P<0.05)。(2)治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.05),KPS评分均较治疗前明显升高(P<0.05),且联合组对中医证候积分的降低幅度及对KPS评分的升高幅度均明显优于对照组(P<0.05或P<0.01)。(3)治疗后,2组患者的血清CA125、CA153、TK1水平均较治疗前明显降低(P<0.05),且联合组对血清CA125、CA153、TK1水平的降低幅度均明显优于对照组(P<0.01)。(4)治疗后,2组患者的T细胞CD3+、CD4+水平和CD4+/CD8+比值均较治疗前明显升高(P<0.05),CD8+水平均较治疗前明显降低(P<0.05),且联合组对T细胞CD3+、CD4+水平和CD4+/CD8+比值的升高幅度及对CD8+水平的降低幅度均明显优于对照组(P<0.05或P<0.01)。(5)经过1年的随访调查,联合组的肿瘤复发率和肿瘤转移率分别为7.50%(3/40)和12.50%(5/40),明显低于对照组的25.00%(10/40)和35.00%(14/40),组间比较,差异均有统计学意义(P<0.05)。【结论】扶正驱邪方联合新辅助化疗对于TNBC气阴两虚型患者的治疗效果较好,能有效改善患者的免疫功能,降低血清肿瘤标志物水平,提高患者的生活质量,降低肿瘤复发和转移的发生率。

关键词：扶正驱邪方新辅助化疗三阴性乳腺癌血清胸苷激酶1 生活质量免疫功能

A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

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Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： zhi-wei Shen Shu-Feng hu Chen Zeng wei-Qing Kong Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

Optimization Design for Drum of Prepress Device

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International Journal of Plant Engineering and Management 2014年第1期19卷 46-51页

作者： hu zhi-wei KODAK Electronic Products(Shanghai)Co. Ltd

Structural design for a drum of a CTP device and modal analysis by means of ANSYS workbench have been done to get the first four natural frequencies and vibration *** frequency and maximum deformation of drum as the optimization goal,three kinds of proposals are put forward based on the weak area of the *** means of adjusting static balance and adding thickness,an optimal project 3 is determined the best in the three kinds of *** first natural frequency of the drum optimized is increased by 33.1% than that before optimization,the maximum displacement is reduced by 23.2%.Testing the result of simulation meets image high quality requirements,dynamics analysis and structural optimization are realized.

关键词： prepress optimal design drum modal analysis vibration model natural frequency static balance

新冠疫情期间杭州市CO_(2)浓度变化及成因分析

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中国环境科学 2024年第7期44卷 3563-3572页

作者：陈啸鸣刘硕臧昆鹏林溢陈圆圆胡智伟温军兰文港潘凤梅鲁嫣冉陈丽涵李珊郭朋方双喜浙江工业大学环境学院杭州310014 浙江工业大学浙江碳中和创新研究院浙江省碳减排与碳监测技术国际科技合作基地杭州310014 南京信息工程大学气象灾害预报预警与评估协同创新中心南京210044

以长三角地区典型城市监测站(杭州)为研究对象,对2020年9月~2022年12月的大气CO_(2)数据进行分析,并进行疫情前后对比.结果表明,受新冠疫情影响,杭州城区2021年CO_(2)年平均浓度明显降低,与2019年相比下降了12.7×10^(-6)(2.8%),并且在2... 详细信息

以长三角地区典型城市监测站(杭州)为研究对象,对2020年9月~2022年12月的大气CO_(2)数据进行分析,并进行疫情前后对比.结果表明,受新冠疫情影响,杭州城区2021年CO_(2)年平均浓度明显降低,与2019年相比下降了12.7×10^(-6)(2.8%),并且在2022年实现“零增长”.疫情后的游客等人为活动减少是导致杭州城区夏秋季(5~10月)CO_(2)浓度大幅降低的关键因素.与疫情前相比,疫情后工作日和周末CO_(2)浓度没有明显差异,并且在工作日出行高峰时段CO_(2)浓度没有出现明显上升,这表明疫情后,人为活动和交通排放对杭州大气CO_(2)浓度的贡献大幅降低.72h后向轨迹的聚类分析显示,杭州城区CO_(2)浓度不仅受到本地人为排放的影响,同时也受到人口密集､工业发达地区的污染气团传输的影响.

关键词：二氧化碳新冠疫情城市监测站趋势变化潜在源

自动化顶空平衡-气相色谱法测定京杭运河中溶解甲烷

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中国环境科学 2024年第3期44卷 1507-1514页

作者：温军臧昆鹏潘凤梅申小龙魏康轩兰文港胡智伟陈啸鸣陈炳江李珊鲁嫣冉陈丽涵郭朋方双喜林溢陈圆圆刘硕徐宏辉浙江工业大学环境学院浙江杭州310014 浙江工业大学浙江碳中和创新研究院浙江杭州310014 浙江省气象科学研究所浙江杭州310008

将顶空平衡法和气相色谱仪相结合,通过自主设计和优化测试实现了技术升级,建立了可自动化进样并同步测定水中溶解CH_(4)和CO_(2)浓度的新型气相色谱系统及方法.结果表明,本系统线性范围宽且运行稳定,自动化程度更高,运行成本更低.该系统... 详细信息

将顶空平衡法和气相色谱仪相结合,通过自主设计和优化测试实现了技术升级,建立了可自动化进样并同步测定水中溶解CH_(4)和CO_(2)浓度的新型气相色谱系统及方法.结果表明,本系统线性范围宽且运行稳定,自动化程度更高,运行成本更低.该系统对CH_(4)的测定精密度优于0.16%,准确度优于0.02%,满足水中溶解CH_(4)浓度监测需求.基于本方法,于2022年8月对京杭大运河杭州段水体中溶解CH_(4)开展了试观测研究.结果显示:夏季京杭大运河杭州段水体中溶解CH_(4)浓度平均值为(642.4±423.3)nmol/L,饱和度平均值为(22310±14701)%,水-气界面CH_(4)扩散通量平均值为(548.57±603.70)μmol/(m^(2)·d),是大气CH_(4)的净源.根据该河段的面积,可估算观测期内CH_(4)的日均排放量约为1710mol,相当于大约38.31m^(3)天然气或约82.94kg碳.

关键词：顶空平衡气相色谱京杭大运河甲烷通量

Tetraethylenepentamine-functionalized magnetic mesoporous composites as a novel adsorbent for the removal Cr(Ⅲ)-ethylenediaminetetraacetic acid in complex solution

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Chinese Journal of Chemical Engineering 2024年第4期68卷 16-26页

作者： zhi hu Jiahong Wang Tongtong Sun School of Environmental Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China Shaanxi Key Laboratory of Green Preparation and Functionalization of Inorganic Materials Xi'an 710021China

A novel tetraethylenepentamine(TEPA) functionalized magnetic mesoporous silica adsorbent(FNMs/TEPA) was prepared for the adsorption of Cr(Ⅲ)-ethylenediaminetetraacetic acid(EDTA)from wastewater. The characterization of the prepared adsorbent certified that TEPA was modified onto the magnetic mesoporous silicon(FNMs), while FNMs/TEPA maintained the ordered mesoporous and pristine magnetic properties. The batch adsorption experiments demonstrated that TEPA significantly enhanced the removal capacity of the adsorbent for Cr(Ⅲ)-EDTA. FNMs/TEPA exhibited an excellent adsorption property(13.84 mg·g-1) at p H 4.0. Even in the presence of high concentrations of coexisting ions and organic acids, the adsorption performance of FNMs/TEPA was stable. Experimental characterization and DFT demonstrated that the adsorption of Cr(Ⅲ)-EDTA was ascribed to the electrostatic interaction, hydrogen bonding, and complexation between Cr(Ⅲ)-EDTA and amino groups on the adsorbent surface. The analysis of the independent gradient model(IGM) shows that electrostatic interaction is the main mode of action in the adsorption process. Moreover, FNMs/TEPA demonstrated remarkable reusability in three regeneration cycles. These findings indicated that FNMs/TEPA possessed excellent application prospects in the disposal of wastewater containing Cr(Ⅲ)-EDTA.

关键词： TEPA functionalized magnetic mesoporous silicon Adsorption Cr(III)-EDTA Density functional theory calculations

Tetraphenylethylene dicycle helicates: circularly polarized luminescence and chiral recognition based on emission wavelength change

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Science China Chemistry 2024年第11期67卷 3817-3824页

作者： zhi-Rong Xu Miao-Li Gao Ming hu wei Yu Yan-Song Zheng Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Chiral tetraphenylethylene(TPE) dicycle tetraaldehyde and TPE dicycle tetraacids bearing optically pure groups on the cycles were designed and synthesized. Due to the propeller-like conformation immobilization of TPE unit, this new class of TPE dicycle was resolved into M-and P-enantiomers, which could emit strong circular polarized luminescence(CPL). Interestingly,these TPE helicates displayed exceptional ability of molecule recognition. While the TPE dicycle tetraaldehyde could detect the microscale water in anhydrous tetrahydrofuran, the chiral TPE dicycle tetraacid could display different fluorescent color after interacting with two enantiomers of a wide variety of chiral amines including monoamines, diamines, and aminols, which could be applied to chiral recognition of these chiral amines. Furthermore, the emission wavelength of TPE dicycle tetraacid was found to change linearly with the enantiomer purity of chiral amine from enantiomer excess(ee) percent-100% to +100%, for the first time showing the potential for quantitative chiral analysis of chiral amines based on emission wavelength change. The emission wavelength was affected less by environmental factors than fluorescence intensity, which would enable the chiral analysis based on wavelength change with higher accuracy and repeatability.

关键词： TPE dicycle helicate CPL chiral recognition enantiomer excess analysis emission wavelength change

自拟健脾除积方联合免疫检查点抑制剂治疗对晚期非小细胞肺癌患者的临床疗效及对其外周血管生长因子的影响

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世界中西医结合杂志 2024年第4期19卷 759-763页

作者：李金红蒋玥孟雅楠张振山张志涛胡志伟刘非河北省沧州中西医结合医院放化疗三科河北沧州061000

目的探究自拟健脾除积方联合免疫检查点抑制剂治疗对晚期非小细胞肺癌患者的临床疗效及对其外周血管生长因子的影响。方法选取2021年6月—2022年12月期间河北省沧州中西医结合医院收治的晚期非小细胞肺癌患者70例,按随机数字表法分为... 详细信息

目的探究自拟健脾除积方联合免疫检查点抑制剂治疗对晚期非小细胞肺癌患者的临床疗效及对其外周血管生长因子的影响。方法选取2021年6月—2022年12月期间河北省沧州中西医结合医院收治的晚期非小细胞肺癌患者70例,按随机数字表法分为对照组和治疗组,每组各35例。对照组给予常规化疗方法,采用信迪利单抗联合含铂双药治疗,治疗组在对照组的基础上加用自拟健脾除积方治疗。每21 d(3周)为一个治疗周期,两组患者连续接受2个疗程的药物治疗,观察比较两组患者临床疗效、不良反应情况,治疗前后中医临床证候评分、KPS评分、血管生长因子(Vascular endothelial growth factor,VEGF)水平。结果治疗后治疗组总有效率88.57%(31/35)明显高于对照组65.71%(23/35),差异有统计学意义(P0.05)。治疗组白细胞计数降低、恶心/呕吐发生率明显低于对照组,差异有统计学意义(P<0.05)。结论自拟健脾除积方联合免疫检查点抑制剂治疗晚期非小细胞肺可提高临床治疗效果,改善中医证候评分,提高生活质量,降低外周血血管生长因子含量,且具有相当的安全性,值得推荐使用。

关键词：非小细胞肺癌晚期自拟健脾除积方免疫检查点抑制剂血管生长因子

Effect of lanthanum on inclusions in non-oriented electrical steel slabs

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Journal of Iron and Steel Research International 2024年第7期31卷 1680-1691页

作者： Qiang Ren zhi-yuan hu Yun-xia Liu wei-cheng Zhang Zi-qi Gao Li-feng Zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Research and Development Department Shougang Zhixin Qian'an Electromagnetic Material Co.Ltd.Qian'an 064400HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The effect of lanthanum on the characteristics of inclusions in the slab of non-oriented electrical steels was investigated through industrial trials and thermodynamic *** number,size,and chemical composition of inclusions in the surface,one-quarter of thickness and the center of slabs with and without lanthanum addition were statistically analyzed using an automatic inclusion analysis *** the lanthanum-free slab,inclusions were predominately ***_(2)O_(3),MgO,and AlN as well as a small number of Al_(2)O_(3)-MgO-CaO and *** number densities of oxide inclusions and AlN decreased from the surface to the center of the slab,which was ascribed to the difference in cooling intensity during the continuous *** the steel with lanthanum addition,inclusions were modified into LaAlO_(3) and La_(2)O_(2)S and gradually transformed into dual-phase MgO-La_(2)S3 with an increasing distance from the slab surface due to the reaction between the lanthanum-containing inclusion and the steel *** uneven distribution of oxide inclusions along the thickness of the slab was eliminated in the lanthanum-bearing slab because the dissolved oxygen was remarkably decreased by ***-bearing inclusions were more likely to agglomerate AlN by inducing the heterogeneous nucleation of AlN on their surface,while small-size ***_(2)O_(3) inclusions hardly showed a coarsening effect on the size of AlN.

关键词： Lanthanum-Inclusion Non-oriented electrical steel Aluminum nitride Heterogenous nucleation