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左旋黄皮酰胺抑制去血清所致神经细胞凋亡及其相关机制的研究

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中药新药与临床药理 2009年第1期20卷 1-4页

作者：胡金凤宁娜薛薇张均田陈乃宏中国医学科学院药物研究所北京100050

目的观察中药成分左旋黄皮酰胺对去血清所致PC12细胞损伤的保护作用及其机制。方法采用形态学观察及MTT法检测左旋黄皮酰胺对去血清所致PC12细胞存活的影响;采用流式细胞术检测左旋黄皮酰胺对PC12细胞凋亡的影响;采用Western blotting... 详细信息

目的观察中药成分左旋黄皮酰胺对去血清所致PC12细胞损伤的保护作用及其机制。方法采用形态学观察及MTT法检测左旋黄皮酰胺对去血清所致PC12细胞存活的影响;采用流式细胞术检测左旋黄皮酰胺对PC12细胞凋亡的影响;采用Western blotting及共聚焦显微镜检测左旋黄皮酰胺对GSK-3β、Bcl-2、Bax表达的影响。结果左旋黄皮酰胺1,10μmol/L剂量组可以通过抑制去血清所致PC12细胞的凋亡而增加细胞的存活率,其机制是抑制GSK-3β的表达并增加Bcl-2/Bax的比值。结论左旋黄皮酰胺可能是通过抑制神经细胞损伤而改善学习记忆障碍。

关键词：左旋黄皮酰胺去血清 PC12细胞凋亡

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云南甘草化学成分的研究(Ⅰ)

天然产物研究与开发 1994年第4期6卷 6-8页

作者：胡金锋叶仲林沈凤嘉兰州大学化学系兰州730000 自贡晨光化工研究院

自云南甘草(Glycyrrhiza yunnanensis)根中分离出13个化合物,本文报道其中两个化合物的结构鉴定。经化学方法和光谱解析,鉴定为甲基化美迪紫檀素(Ⅰ)和5-羟基-7-甲氧基二氢黄酮(Ⅱ),后者命名为云甘宁。Ⅰ和Ⅱ在甘草属植物中均未见文献报... 详细信息

自云南甘草(Glycyrrhiza yunnanensis)根中分离出13个化合物,本文报道其中两个化合物的结构鉴定。经化学方法和光谱解析,鉴定为甲基化美迪紫檀素(Ⅰ)和5-羟基-7-甲氧基二氢黄酮(Ⅱ),后者命名为云甘宁。Ⅰ和Ⅱ在甘草属植物中均未见文献报道,是首次从该植物中获得。

关键词：云南甘草化学成分甘草

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基于D型光纤探针的高灵敏折射率传感器

传感技术学报 2019年第7期32卷 986-990页

作者：梁红勤刘彬刘娟张平胡金凤廖云程蔡旭辉南昌航空大学无损检测与光电传感技术及应用国家地方联合工程实验室

提出并实现了一种表面粗糙D形光纤探针结构的消逝场传感器,通过自主搭建简易的光纤侧面抛磨装置,得到表面粗糙的D型光纤,将其一端镀上银膜作为反射镜面,得到D型光纤探针。对D型光纤探针进行传输损耗的折射率传感特性检测,发现当被测溶... 详细信息

提出并实现了一种表面粗糙D形光纤探针结构的消逝场传感器,通过自主搭建简易的光纤侧面抛磨装置,得到表面粗糙的D型光纤,将其一端镀上银膜作为反射镜面,得到D型光纤探针。对D型光纤探针进行传输损耗的折射率传感特性检测,发现当被测溶液折射率变化时,会因消逝场与被测溶液之间作用的不同而引起能量吸收的不同,进而使接收到的光功率发生显著的变化。实验测得传感器折射率灵敏度为64.93 dB/RIU,线性相关系数高达99.53%,检测精度可达0.000 06。该传感结构在医疗检测、生物化学和环境监测等领域都有着广泛的应用。

关键词：光纤传感器 D型光纤探针侧面抛磨消逝场

A functional cathode sodium compensation agent for stable sodium-ion batteries

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Green Energy & Environment 2025年第1期10卷 173-182页

作者： Wei Wu Zhenglin hu Zhengfei Zhao Aoxuan Wang Jiayan Luo Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Shanghai Jiao Tong University Shaoxing Research Institute of Renewable Energy and Molecular Engineering Shaoxing312000China

Hard carbon(HC)is widely used in sodium-ion batteries(SIBs),but its performance has always been limited by lowinitial Coulombic efficiency(ICE)and cycling *** compensation agent is a favorable strategy to make up for the loss of active sodium ions consumed *** it lacks agent that effectively decomposes to increase the active sodium ions as well as regulate carbon defects for decreasing the irreversible sodium ions ***,we propose 1,2-dihydroxybenzene Na salt(NaDB)as a cathode compensation agent with high specific capacity(347.9 mAh g^(-1)),lower desodiation potential(2.4–2.8 V)and high utilization(99%).Meanwhile,its byproduct could functionalize HC with more C]O groups and promote its reversible ***,the presodiation hard carbon(pHC)anode exhibits highly reversible capacity of 204.7 mAh g^(-1) with 98%retention at 5 C rate over 1000 ***,with 5 wt%NaDB initially coated on the Na3V2(PO4)3(NVP)cathode,the capacity retention of NVP t NaDBjHC cell could increase from 22%to 89%after 1000 cycles at 1 C *** work provides a new avenue to improve reversible capacity and cycling performance of SIBs through designing functional cathode compensation agent.

关键词： Hard carbon ICE Cathode compensation agent Reversible capacity Stability

Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei Zhu Di LI Xing hu Liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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马克思主义哲学与坐标

辽宁工学院学报（社会科学版） 2000年第4期2卷 3-6页

作者：胡金凤李延军辽宁工学院辽宁锦州121001

马克思主义哲学研究的一个重要方法 ,是把物质的联系和运动用哲学的时空坐标贯穿在一起 ,组成一个概念范畴的网络 ,就是把存在与意识、自然与思维、物质与精神看成是三个联系和运动的大圆圈 ,运用这个坐标 ,我们就会对马克思主义哲学对... 详细信息

马克思主义哲学研究的一个重要方法 ,是把物质的联系和运动用哲学的时空坐标贯穿在一起 ,组成一个概念范畴的网络 ,就是把存在与意识、自然与思维、物质与精神看成是三个联系和运动的大圆圈 ,运用这个坐标 ,我们就会对马克思主义哲学对象、哲学基本问题和马克思主义的一些基本规律等问题有一个更深刻的认识。

关键词：马克思主义哲学坐标社会实践

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity