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基于X射线光谱测定法分析氚深度的模拟研究

光谱学与光谱分析 2011年第3期31卷 831-834页

作者：胡广春张伟光中国工程物理研究院核物理与化学研究所四川绵阳621900

氚是一种重要的聚变材料,在军事和民用方面都有广泛的用途,氚在薄膜靶中的浓度和深度研究是一项重要的课题。文章建立了氚β射线诱发X射线光谱的模拟方法,分析了氚β射线诱发X射线光谱与氚的浓度和深度分布的关系,研究表明氚在薄膜靶中... 详细信息

氚是一种重要的聚变材料,在军事和民用方面都有广泛的用途,氚在薄膜靶中的浓度和深度研究是一项重要的课题。文章建立了氚β射线诱发X射线光谱的模拟方法,分析了氚β射线诱发X射线光谱与氚的浓度和深度分布的关系,研究表明氚在薄膜靶中浓度和深度分布与测定光谱存在对应关系,这为利用X光谱反解氚含量和深度分布奠定了基础。

关键词：氚深度分布氚含量轫致辐射数值模拟

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控制棒棒位测量系统中两极板电容传感器设计

原子能科学技术 2017年第12期51卷 2352-2356页

作者：胡广薄涵亮清华大学核能与新能源技术研究院北京100084

控制棒棒位测量对于反应堆运行与安全至关重要。针对NHR-200反应堆控制棒棒位测量系统,引入基于电容传感器的控制棒棒位测量方法。设计出一种两极板电容传感器,通过分析极板面积、干扰电容以及屏蔽方式的影响,进行仿真计算与优化。分析... 详细信息

控制棒棒位测量对于反应堆运行与安全至关重要。针对NHR-200反应堆控制棒棒位测量系统,引入基于电容传感器的控制棒棒位测量方法。设计出一种两极板电容传感器,通过分析极板面积、干扰电容以及屏蔽方式的影响,进行仿真计算与优化。分析结果表明,计算结果与试验结果吻合较好,该传感器能进行控制棒棒位的准确测量,有较好的适应能力和应用前景。

关键词：电容传感器控制棒棒位两电极有限元方法

Review and prospect on the botryoidal structures from the Sinian Dengying Formation,Sichuan Basin,China

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Petroleum 2017年第2期3卷 190-196页

作者： Chengbo Lian Guanxiong Ren Fang Qu Xiucheng Tan Ling Li Wei Zeng guang hu Hong Liu School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500SichuanChina Department of Sedimentology and Hydrocarbon Accumulation PetroChina Key Laboratory of Carbonate ReservoirSouthwest Petroleum UniversityChengdu610500SichuanChina

Fabric of carbonate rock is the important foundation and one of main research contents for study on carbonate sedimentology,and has always been the attention of the academic *** structures from the Sinian Dengying Formation in the Sichuan Basin is a kind of special carbonate fabric,the fabric is named after the shape of a *** this paper,from four aspects of the research status,the definition of the botryoidal structures and the related terms,the construction characteristics of the botryoidal structures,the component of the botryoidal structures,geochemical characteristics and the genesis of the botryoidal structures are *** points out the current research issues of botryoidal structures from the Sinian Dengying Formation in the Sichuan Basin,and put forward that future research should focus on the accurate analysis of its internal construction,precipitation mechanism of the major components,and the construction mechanism of botryoidal structures.

关键词： Botryoidal structures Construction Lamina Genesis

Spatially resolved metabolomics visualizes heterogeneous distribution of metabolites in lung tissue and the anti-pulmonary fibrosis effect of Prismatomeris connate extract

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Journal of Pharmaceutical Analysis 2024年第9期14卷 1330-1346页

作者： Haiyan Jiang Bowen Zheng guang hu Lian Kuang Tianyu Zhou Sizheng Li Xinyi Chen Chuangjun Li Dongming Zhang Jinlan Zhang Zengyan Yang Jiuming He Hongtao Jin New Drug Safety Evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China School of Biomedical Sciences Hunan UniversityChangsha410082China College of Pharmacy Shaanxi University of Traditional Chinese MedicineXianyangShaanxi712046China guangxi International Zhuang Medicine Hospital Nanning530201China Key Laboratory for Safety Research and Evaluation of Innovative Drug National Medical Products AdministrationBeijing102206China Beijing Union-Genius Pharmaceutical Technology Development Co. Ltd.Beijing100176China

Pulmonary fibrosis (PF) is a chronic progressive end-stage lung disease. However, the mechanisms underlying the progression of this disease remain elusive. Presently, clinically employed drugs are scarce for the treatment of PF. Hence, there is an urgent need for developing novel drugs to address such diseases. Our study found for the first time that a natural source of Prismatomeris connata Y. Z. Ruan (huang Gen, HG) ethyl acetate extract (HG-2) had a significant anti-PF effect by inhibiting the expression of the transforming growth factor beta 1/suppressor of mothers against decapentaplegic (TGF-β1/Smad) pathway. Network pharmacological analysis suggested that HG-2 had effects on tyrosine kinase phosphorylation, cellular response to reactive oxygen species, and extracellular matrix (ECM) disassembly. Moreover, mass spectrometry imaging (MSI) was used to visualize the heterogeneous distribution of endogenous metabolites in lung tissue and reveal the anti-PF metabolic mechanism of HG-2, which was related to arginine biosynthesis and alanine, asparate and glutamate metabolism, the downregulation of arachidonic acid metabolism, and the upregulation of glycerophospholipid metabolism. In conclusion, we elaborated on the relationship between metabolite distribution and the progression of PF, constructed the regulatory metabolic network of HG-2, and discovered the multi-target therapeutic effect of HG-2, which might be conducive to the development of new drugs for PF.

关键词： Spatially resolved metabolomics Mass spectrometry imaging Network pharmacology Pulmonary fibrosis Prismatomeris connate extract

The Hydration of Blended Cement at Low W/B Ratio

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Journal of Wuhan University of Technology(Materials Science) 2003年第4期18卷 72-75页

作者：胡曙光 Wuhan University of Technology

The hydration process,hydration product and hydration heat of blended cement paste mixed with mineral admixture and expansive agent at low W/B ratio are studied by XRD,thermo analysis,and calorimetry instrument,and they were compared with those of pure cement *** results show that pure cement and blended cement at low W/B ratio have the same types of hydration products,but their respective amounts of hydration products of various blended cements at same ages and the variation law of the amount of same hydration products with ages are different;The joint effect of tumefaction of gel-ettringite due to water absorption and the expansive pressure on the pore and rift caused by the crystalloid ettringite is the impetus of the volume expansion of cement paste,and the former effect is much greater than the latter one.

关键词： hydration blended cement low W/B ratio expansion mechanism

Prognostic and survival analysis of 837 Chinese colorectal cancer patients

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World Journal of Gastroenterology 2013年第17期19卷 2650-2659页

作者： Ying Yuan Mo-Dan Li Han-guang hu Cai-Xia Dong Jia-Qi Chen Xiao-Fen Li Jing-Jing Li Hong Shen Department of Medical Oncology 2nd Hospital of Zhejiang University College of Medicine

AIM:To develop a prognostic model to predict survival of patients with colorectal cancer (CRC). METHODS:Survival data of 837 CRC patients undergoing surgery between 1996 and 2006 were collected and analyzed by univariate analysis and Cox proportional hazard regression model to reveal the prognostic factors for CRC. All data were recorded using a standard data form and analyzed using SPSS version 18.0 (SPSS, Chicago, IL, United States). Survival curves were calculated by the Kaplan-Meier method. The log rank test was used to assess differences in survival. Univariate hazard ratios and significant and independent predictors of disease-specific survival and were identified by Cox proportional hazard analysis. The stepwise procedure was set to a threshold of 0.05. Statistical significance was defined asP < 0.05. RESULTS:The survival rate was 74% at 3 years and 68% at 5 years. The results of univariate analysis suggested age, preoperative obstruction, serum carcinoembryonic antigen level at diagnosis, status of resection, tumor size, histological grade, pathological type, lymphovascular invasion, invasion of adjacent organs, and tumor node metastasis (TNM) staging were positive prognostic factors (P < 0.05). Lymph node ratio (LNR) was also a strong prognostic factor in stage Ⅲ CRC (P < 0.0001). We divided 341 stage Ⅲ patients into three groups according to LNR values (LNR1, LNR ≤ 0.33, n = 211; LNR2, LNR 0.34-0.66, n = 76; and LNR3, LNR ≥ 0.67, n = 54). Univariate analysis showed a significant statistical difference in 3-year survival among these groups:LNR1, 73%; LNR2, 55%; and LNR3, 42% (P < 0.0001). The multivariate analysis results showed that histological grade, depth of bowel wall invasion, and number of metastatic lymph nodes were the most important prognostic factors for CRC if we did not consider the interaction of the TNM staging system (P < 0.05). When the TNM staging was taken into account, histological grade lost its statistical significance, while the speci

关键词： Colorectal cancer Prognostic factors Cox proportional hazard regression Lymph node ratio

Effects of perioperative managements on ocular surface microbiota in intravitreal injection patients

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 248-254页

作者： Ya-guang hu Qiong Wu Tian-hui Li Fang Sui Ming Zhang Zhen Zhang Rui Shi Na hui Li Qin Li Li Department of Ophthalmology the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Northwest Women and Children's HospitalXi'an 710061Shaanxi ProvinceChina Key Laboratory of Biomedical Information Engineering Ministry of EducationXi'an 710049Shaanxi ProvinceChina Department of Biomedical Engineering School of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049Shaanxi ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Xi'an huaxia Eye Hospital Xi'an 710061Shaanxi ProvinceChina

AIM:To investigate the effects of on ocular surface microbiota in patients who received intravitreal ***:Samples of ocular surface microbiota were obtained from 41 eyes of 41 patients who visited the Department of *** were separated for three *** A did not receive perioperative managements or intravitreal *** B1 received only once and B2 received more than *** operating room,the samples were collected on the ocular *** taxonomic units(OTUs) clustering and alpha/beta diversity analysis was *** microbial 16S rRNA from samples were analyzed using the Hi Seq 2500 ***:Alpha diversity did not differ in each group,and beta diversity differed in the B2 *** diversity showed a significant difference between Group A and B2(P=0.048).With the perioperative managements before intravitreal injection,the composition and relative abundance were *** 10 microbiota on phylum and genus level,and then microbiota notably changed at genus level were ***-negative bacteria were varied ***,Proteus was not found in Groups A and B1,but it was appeared after the patients received perioperative management and intravitreal injections in Group ***:With the perioperative managements,the balance of microbiota on the ocular surface is destroyed,and relative composition and abundance of microbiota on the ocular surface is obviously *** clinical doctors should pay more attention on the consequence of perioperative managements before intravitreal injection.

关键词： microbiota perioperative managements ocular surface intravitreal injection high-throughput sequencing

虚拟环境商标保护问题研究 --基于典型案例的分析

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河南师范大学学报（哲学社会科学版） 2024年第1期51卷 61-67页

作者：胡光河南师范大学法学院河南新乡453007

近期美国、欧盟等多起涉及虚拟商品和NFTs商标侵权的典型案例表明,需要通过对虚拟商品和NFTs进行商标意义上的详细商品/服务分类和精准描述,用以明显区分与其形成对应关系的实物商品和虚拟商品。对于侵权行为的认定则必须关注所在虚拟... 详细信息

近期美国、欧盟等多起涉及虚拟商品和NFTs商标侵权的典型案例表明,需要通过对虚拟商品和NFTs进行商标意义上的详细商品/服务分类和精准描述,用以明显区分与其形成对应关系的实物商品和虚拟商品。对于侵权行为的认定则必须关注所在虚拟场景与现实世界的相似度、市场行为的融合度以及由此对消费者造成的对商品来源的认知影响等要素。对侵权行为的抗辩,基于NFTs可能具有金融、权证和艺术品的多重属性,有必要结合具体的案例,只有在能够证明用于铸造的底层内容具有艺术性并且不会造成混淆,或者单纯地用于权属证明而不是实现金融目的的情况下,才可以适用“合理使用”或者“权利用尽”原则。

关键词：虚拟环境商标典型案例

Efficacy of wet-lab training versus surgical-simulator training on performance of ophthalmology residents during chopping in cataract surgery

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 366-370页

作者： Ya-guang hu Qiu-Ping Liu Ning Gao Chang-Rui Wu Jian Zhang Li Qin Jing-Ming Li Department of Ophtalmology the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvniceChina Department of Ophthalmology Shaanxi People's HospitalXi'an 710068Shaanxi ProvinceChina

AIM: To analyze whether wet-lab training(WLT) or surgical-simulator training(SST) is better for ophthalmology residents to master the chopping ***: Sixty ophthalmology residents(in their second year) and three cataract surgeons participated in the study. The residents were randomly separated into two groups, WLT group and SST group. The residents in WLT group were asked to perform 10 trials of chopping using pig eyes and scored by the surgeons, and then they performed and scored using simulator for one time. The residents in SST group underwent 10 trials of chopping using simulator, and the simulator scored each trail. Then, this group were asked to perform the chopping using pig eyes and scored by the surgeons. At last, we investigated the residents’ satisfaction about the ***: The demographic characteristics had no significant differences between the two groups. Recorded by the simulator, the residents in SST group got significantly higher overall score(83.90±1.31) than WLT group(78.73±1.92, P=0.03). And the residents in SST group got less corner area injured, and they spend less time than WLT group(P<0.05). Moreover, the residents in WLT group used more ultrasonic energy value than SST group(P=0.03). However, scored by the surgeons, the residents in two groups got nearly the same overall score. The residents in WLT group performed better on the frequencies of posterior capsule torn and incisional stress(P=0.03, 0.008, respectively). In the survey, the residents in two groups held the same opinion that the training was helpful and they strongly recommended this training. And all of them enjoyed the training, and enjoyed being randomized in their own group. However, with respect to the realistic character, the residents thought that WLT was better than SST(P<0.001).CONCLUSION: Both of the Eyesi surgical-stimulator and the wet-lab improve the residents’ chopping ability and each has its own advantages. The combination of the two training w

关键词： chopping in cataract simulator wet-lab