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High-performance Bi_(2)S_(3)/ZnO photoanode enabled by interfacial engineering with oxyanion for efficient photoelectrochemical water oxidation

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Nano Research 2024年第7期17卷 5996-6005页

作者： Ying-Chu Chen Hsiang-yu Jui Yichen Feng yun-Hsiang Lu yu-Kuei hsu Department of Chemical Engineering&Biotechnology "National Taipei University of Technology"No.1Sec.3Zhong-Xiao E.Rd.Da'an Dist.Taipei City 10608TaiwanChina Department of Opto-Electronic Engineering "National Dong Hwa University"No.1Sec.2Da Hsueh RoadShoufengHualien 97401TaiwanChina China-UK Low Carbon College Shanghai Jiao Tong UniversityNo.3Yinlian RoadLingangShanghai 201306China

In the present contribution,we demonstrate that the sluggish kinetics of oxygen evolution reaction(OER)over the bismuth sulfide(Bi_(2)S_(3))photoanode,which severely restricts its photoelectrochemical activity,is markedly accelerated by employing a sulfatecontaining ***-principle calculation points to the spontaneous adsorption of sulfate(SO_(4)^(2−))on Bi_(2)S_(3)and its capacity of stabilizing the OER intermediates through hydrogen bonding,which is further reinforced by increasing the local density of states near the Fermi level of Bi_(2)S_(3).Meanwhile,the electron transfer is also promoted to synergistically render the ratedetermining step(from O*to OOH*)of OER over Bi_(2)S_(3)kinetically *** but not least,benefitting from such enhanced OER activity and efficient charge separation resulted from depositing Bi_(2)S_(3)on the zinc oxide nanorods(ZnO NRs),forming a core–shell heterojunction,its photocurrent density achieves 8.61 mA·cm^(−2)at 1.23 VRHE,far surpassing those reported for additional Bi_(2)S_(3)-based and several state-of-the-art photoanodes in the literature and further exceeding their theoretical *** great promise of the Bi_(2)S_(3)/ZnO NRs is in view of such outperformance,the superior Faradaic yield of oxygen of more than~80%and the outstanding half-cell applied bias photon-to-current efficiency of~1%well corroborated.

关键词： photoelectrochemical water oxidation oxyanion adsorption electronic structure regulation oxygen evolution reaction(OER)intermediates stabilization Bi_(2)S_(3)

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-hsu Pan Hui-yu Huang Chieh-Hsi Wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung hsu Yencheng chao Yong Hu Yang Zhang Weifeng Hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P<0.001).Median overall survival was 20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

Concurrent occurrence of adenocarcinoma and urothelial carcinoma of the prostate gland:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5952-5959页

作者： Jhe yuan hsu Yi Sheng Lin Li Hua Huang Tang Yi Tsao chao yu hsu Yen Chuan Ou Min Che Tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan Department of Pathology Tungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan

BACKGROUND Adenocarcinoma is the most common subtype of prostate *** urothelial carcinoma(UC)typically originates from the prostatic *** concurrent occurrence of adenocarcinoma and UC of the prostate gland is *** SUMMARY We present the case of an 82-year-old male patient with simultaneous adenocarcinoma and UC of the prostate *** patient underwent a transrectal ultrasound-guided biopsy,and the pathology test revealed ***,transurethral laser prostatectomy was performed,and the pathology test indicated adenocarcinoma of the prostate with a Gleason score of 3+4 and highgrade ***,the patient was treated with androgen deprivation therapy,systemic chemotherapy,and *** resonance imaging performed during follow-up revealed a prostate tumor classified as cT2cN1M0,stage ***,the patient underwent robotic-assisted radical prostatectomy and bilateral pelvic lymph node *** final pathology test of the prostate gland revealed acinar-type adenocarcinoma,Gleason pattern 4+3,pT2N0M0,and high-grade *** patient regularly presented to the clinic for postoperative follow-up *** did not experience any urinary *** According to our literature review,this is the first reported case of coexisting adenocarcinoma and UC of the prostate gland.

关键词： Adenocarcinoma Urothelial carcinoma Prostate Coexist Case report

A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong JIA Yiran LUO Bing XU Li-Ta hsu Renbiao WU Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary Division of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics Engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-Sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

Understanding pediatric surgical needs in North Korea: a modeling analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 47-53页

作者： Phillip J hsu Sangchul Yoon Kee B Park University of Michigan Ann ArborMichiganUSA Department of Global Health and Social Medicine Harvard Medical SchoolBostonMassachusettsUSA Department of Medical Humanitiesand Social Sciences Yonsei University SeoulSouth Korea

Background Sixty-five percent of children worldwide lack access to surgical care,the majority of whom live in low-income and middle-income countries(LMiCs).Developing surgical infrastructure requires information on surgical need;however,this information is often limited in *** Korea(Democratic People's Republic of Korea,DPRK)has a low amount of publicly available ***,we analyzed available modeled data to understand the causes of pediatric deaths due to conditions treatable with surgery in *** We used World Bank data and models from the Institute for Health Metrics and Evaluation to identify causes of pediatric deaths affecting pediatric patients(age<20 years).We compared mortality of disease between DPRK and countries with similar economic *** Between 1990 and 2019,the number of overall pediatric deaths has *** 2019,32.2%of allpediatric deaths in DPRK were caused by surgical *** leading categories of surgical conditions were injuries(53.9%),congenital conditions(34.2%),tumors(8.8%),and abdominal conditions(3.2%).DPRK has a lower relative rate of pediatric deaths compared with other LMICs with similar gross domestic product per ***,it has a higher relative rate of pediatric deaths due to conditions requiring treatment with *** injuries contribute significantly to the high rate of pediatric deaths in *** Although DPRK may be allocating overall resources toward pediatric healthcare more efficiently than economic peers,DPRK may benefit from improvement in pediatric surgical *** availability of data and close international collaboration could be potential solutions to bridge this gap.

关键词： pediatric surgical injuries

High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu Yin-hsuan Chang Chin-Lin hsu Sheng-Yi Chen Gow-Chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

Hypermethylation of the ALOX12 and CBS promoters in osteoporosis:Potential biomarkers for early diagnosis

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Genes & Diseases 2024年第1期11卷 30-33页

作者： Shang Guo yue Wu Weekai Chia Peichun hsu Hongwei Wang yunliang Wang Biao Zhong Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200023China Institute of Translational Medicine Shanghai General HospitalShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025China The University of Chicago Department of MedicineChicagoIL 60637USA Department of Neurology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China

As a bone-confined chronic degenerative disorder,the progression of osteoporosis is characterized by abnormal crosstalk between osteoblasts and osteoclasts,leading to an imbalance of bone remodeling in adults.1 Several studies reported that arachidonic acid ester 12 lipoxygenase(ALOX12)acts as a regulator in bone genesis by participating in the activation of the peroxisome proliferatoractivated receptor(PPARG)pathway through its reaction product.

关键词： osteoporosis diagnosis remodeling

Mirrorless MEMS imaging:a nonlinear vibrational approach utilizing aerosol-jetted PZT-actuated fiber MEMS scanner for microscale illumination

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Microsystems & Nanoengineering 2024年第1期10卷 175-192页

作者： Wei-Chih Wang Ming-Yao Li Kuan-Chang Peng Yi-Feng hsu Benjamin Estroff Pao-yun Yen David Schipf Wen-Jong Wu Department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Institute of NanoEngineering and Microsystems National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Department of Mechanical Engineering University of WashingtonSeattleWA 98195USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA Department of Engineering Science and Ocean Engineering National Taiwan UniversityTaiwanChina

This study introduces a novel image capture and lighting techniques using a cutting-edge hybrid MEMS scanner system designed for compact microscopic *** scanner comprises a tapered optical fiber waveguide and innovative aerosol-jet printed PZT(lead zirconate titanate)bimorph push-pull actuators on a stainless-steel substrate,effectively addressing issues that are commonly associated with PZT on silicon substrates such as fracture and layer *** leveraging nonlinear vibration,the scanner achieves a spiral scan pattern from a single signal input,in addition to the expected two-dimensional scanning and target illumination from two phase-shifted *** capability is further enhanced by a novel process to taper the optical fiber,which reduces illumination scattering and tunes the fiber to the resonant frequencies of the *** precisely tapered tip enables large fields of view while maintaining independent 2-axis scanning through one-degree-of-freedom *** validation showcases the successful generation of a spiral scan pattern with a 60μm diameter scan area and a 10 Hz frame rate,effectively reconstructing scanned images of 5μm lines,cross patterns(15μm in length with a 5μm gap),and structures of a Psychodidae wing.

关键词： steel fiber scanner