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Promoted catalytic property of Cu/SSZ-13 by introducing a minority of Mn for NO removal from diesel engine exhaust

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Chinese Journal of Chemical Engineering 2024年第7期71卷 172-182页

作者： Runnong Yang Wuyuan Liu Zhaoying Wang Ming sun Guangying fu Zihan Gao Wenjian Jiao Rui Li Lin Yu Guangdong Provincial Laboratory of chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China Guangdong Engineering Technology Research Center of Modern Fine Chemical Engineering School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006China Key Laboratory of Bioinorganic and Synthetic chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Testing and Certification Business department China Automotive Technology and Research Center Company LimitedWuhan 430056China Guangdong Foran Technology Company Limited Foshan 528000China

The Cu-exchanged SSZ-13 with the small-pore chabazite framework is considered as a highly efficient catalyst for selective catalytic reduction of NO with NH_(3)(NH_(3)-SCR).In order to further improve the catalytic property,a series of Mn ion-assisted Cu/SSZ-13 powder catalysts were prepared by co-exchange method and stepwise exchange *** is found that the NH_(3)-SCR activity,N_(2) selectivity,hydrothermal stability and sulfur resistance of Cu/SSZ-13 are promoted by introducing a minority of Mn(0.15%to 0.23%(mass))through co-exchange *** results reveal that the Cu,Mn co-exchange enables the higher amounts of Cu^(2+)active sites,the abundant medium strong and strong acid,the optimized ratio of Lewis acid to Brønsted acid etc.,which are required for a good NH_(3)-SCR catalytic property over broad temperature range and under harsh working ***,a monolithic catalyst was prepared by impregnating a cordierite ceramic support into the coating slurry containing the optimized CuMn/SSZ-13 *** diesel engine bench tests show that Cu,Mn co-exchange gives the monolith catalyst a better catalytic property than commercial *** work provides an important guidance for the rational design of secondary-ion-assisted zeolites applied in NH_(3)-SCR.

关键词： MnCu/SSZ-13 Co-exchange Zeolite Catalysis Selective catalytic reduction

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

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Bone Research 2024年第2期12卷 438-452页

作者： Bowen fu Jianlin Shen Xuenong Zou Nian sun Ze Zhang Zengping Liu Canjun Zeng Huan Liu Wenhua Huang Guangdong Medical Innovation Platform for Translation of 3D Printing Application The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Digital Medicine and BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510145 GuangdongChina department of Foot and Ankle Surgery Center for Orthopedic SurgeryThe Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina department of Orthopedics Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Central Laboratory Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080 GuangdongChina Nanfang Hospital Southern Medical UniversityGuangzhou 510515 GuangdongChina Guangzhou Blood Center Guangzhou 510095 GuangdongChina department of Orthopedics The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000 SichuanChina

Extracellular matrix(ECM)stiffening is a typical characteristic of cartilage aging,which is a quintessential feature of knee osteoarthritis(KOA).However,little is known about how ECM stiffening affects chondrocytes and other molecules *** study mimicked the physiological and pathological stiffness of human cartilage using polydimethylsiloxane(PDMS)*** demonstrated that epigenetic Parkin regulation by histone deacetylase 3(HDAC3)represents a new mechanosensitive mechanism by which the stiffness matrix affected chondrocyte *** found that ECM stiffening accelerated cultured chondrocyte senescence in vitro,while the stiffness ECM downregulated HDAC3,prompting Parkin acetylation to activate excessive mitophagy and accelerating chondrocyte senescence and osteoarthritis(OA)in ***,intra-articular injection with an HDAC3-expressing adeno-associated virus restored the young phenotype of the aged chondrocytes stimulated by ECM stiffening and alleviated OA in *** findings indicated that changes in the mechanical ECM properties initiated pathogenic mechanotransduction signals,promoted the Parkin acetylation and hyperactivated mitophagy,and damaged chondrocyte *** results may provide new insights into chondrocyte regulation by the mechanical properties of ECM,suggesting that the modification of the physical ECM properties may be a potential OA treatment strategy.

关键词： chondrocyte osteoarthritis stiffness

First-principle study of interaction of H2 and H2O molecules with （ZnO）_n（n=3-6） ring clusters

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Progress in Natural Science:Materials International 2010年第1期20卷 30-37页

作者： Hua-peng CHEN~1,Jian-ning DING~(2,3),Ning-yi YUAN~2,Xiu-qin WANG~2,Cheng-lung CHEN~4,Duan WENG~(1*) 1.department of Materials Science and Engineering,Tsinghua Universtiy,Beijing 100084,China 2.Center for Low-dimensional Materials,Micro-nano Devices and System, Jiangsu Polytechnic university,Changzhou 213164,China 3.Key Laboratory of New Energy Source,Changzhou 213164,China 4.department of chemistry,national sun yat-sen university,kaohsiung 80424,taiwan,China department of Materials Science and Engineering Tsinghua Universtiy Beijing 100084 China Center for Low-dimensional Materials Micro-nano Devices and System Jiangsu Polytechnic University Changzhou 213164 China Key Laboratory of New Energy Source Changzhou 213164 China department of chemistry National Sun Yat-sen University Kaohsiung 80424 Taiwan China

A density functional calculation was performed to investigate the impact of hydrogen and water molecules on zinc oxide clusters（ZnO）n=3-6…X,where X=H2and *** calculated binding energies were corrected for the basis set superposition error （BSSE）.The structural parameters and chemical hardness were calculated for the complexes of zinc oxide clusters and guest *** strength values of the interaction between the clusters and the guest molecules were analyzed based on the topological properties of atoms in molecules（AIM）theory of *** stereo electronic interactions inside the ZnO clusters were analyzed in detail using the natural bond orbital（NBO）analysis.

关键词： density functional theory zinc oxide clusters atoms in molecules

Metallomics:An integrated biometal science

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Science China chemistry 2009年第12期52卷 2055-2070页

作者： GE RuiGuang1,2 & sun HongZhe1 1 department of chemistry and Open Laboratory of Chemical Biology,The university of Hong Kong,Hong Kong,China 2 Laboratory of Integrative Biology,College of Life Sciences,sun yat-sen university,Guangzhou 510006,China department of chemistry and Open Laboratory of Chemical Biology The University of Hong Kong Hong Kong China Laboratory of Integrative Biology College of Life Sciences Sun Yat-Sen University Guangzhou China

Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics,metalloproteins,metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes,similar to genomes and proteomes in genomics and proteomics,respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods,particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation,chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma,ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry,or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins,probing of relationships between structure and function of metal-loproteins,and study of clinically used metallodrugs will be selectively outlined,along with their advantages and limitations.

关键词： metallomics metallome metallodrug metalloprotein chemical speciation

Spatial calculating analysis model research of land-use change in urban fringe districts

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Science China(Technological Sciences) 2008年第S1期51卷 186-194页

作者： ZHANG XinChang,PAN Qiong,WANG ZhongYang & CHEN XinXiang department of Remote sensing and GIS Engineering,sun yat-sen university,Guangzhou 510275,China department of Remote sensing and GIS Engineering Sun Yat-sen University Guangzhou China

The spatial calculating analysis model is based on GIS overlay. It compartmental-izes the research district land into three spatial parts: unchanged part,converted part and increased part. By this method we can evaluate the numerical model and dynamic degree model for existing calculating changing speed of land-use. fur-thermore the paper raises reviving the calculating analysis model of spatial infor-mation in order to predict the dynamic changing level of all sorts of land. More concretely speaking,the model is mainly to know the changing area and changing speed (increased or decreased) of different land classifications from the micro-cosmic angle and to clearly show the spatial distribution and spatio-temporal law for changing urban lands. We discover why the situation has taken place by com-bining social and economic conditions. The result indicates that the calculating analysis model of spatial information can derive more accurate procedure of spatial transference and increase of all kinds of land from the microcosmic angle. By this model and technology,we can make the research of spatio-temporal structure evolution in land-use be more systematical and deeper. The result will benefit the planning management of urban land-use of developed districts in China in the fu-ture.

关键词： land-use dynamic change calculating analysis model

A New Conductivity Detector for Capillary Electrophoresis

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Chinese Chemical Letters 2000年第5期11卷 439-442页

作者： Zuan Guang CHEN Jin Yuan MO Tian Yao XIE Li Shi WANG Xiao Yun YANG Kong ZHANG Min Sheng ZHANG (department of chemistry. sun yat-sen university of Medical Sciences. Guangzhou 510089 College of chemistry and Chemical Engineering. Zhongshan university. department of chemistry Sun Yat-sen Univ. of Med. Sciences Guangzhou 510089 China Coll. of Chem. and Chem. Engineering Zhongshan University Guangzhou 510275 China First Attached Hospital Sun Yat-sen Univ. of Med. Sciences Guangzhou 510080 China

A new conductivity detector for capillary electrophoresis consisting of an electrochemical cell and a conductive meter was developed. In the cell, the microelectrode and capillaryd were inserted through the cell wall and fixed by screws and sealing ring, the ends of microelectrode: and capillary were located by a guide with two cross holes. LOD for K+ was 1.5 x 10(-5) mol/L.

关键词： capillary electrophoresis conductivity detector

Precise immobilization of metal single atoms into a porphyrinic metal-organic framework for an efficient alkene hydrosilylation

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Nano Research 2024年第7期17卷 5914-5921页

作者： Chun-Ying Chen Qi-Jie Mo fu-Zhen Li Hai-Li Song Li Zhang MOE Laboratory of Bioinorganic and Synthetic chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510006China

Alkene hydrosilylation is one of the most concise and atom-economical methods to synthesize organosilicon ***,we reported the precise immobilization of metal single atoms(M-SAs;M=Ru,Rh,Ir,Pd,Pt,and Au)into a porphyrinic metalorganic framework(MOF)of PCN-222(PCN=porous coordination network),and then applied the resultant MOF composites of M-SAs@PCN-222 to alkene *** solvent-free conditions,Pt-SAs@PCN-222 displayed an especially high catalytic efficiency with the turnover frequency up to 119 s−1 and the maximum turnover number of 906,250 at room *** and theoretical studies revealed that there existed strong interactions between Pt-SAs@PCN-222 and the substrates,which helped to condense the substrates in the cavities of the porous *** density functional theory calculations and molecular dynamics simulations disclosed that PCN-222 could transfer electrons to Pt-SAs to enhance the silane oxidative addition and drive the reaction to proceed smoothly via Chalk–Harrod pathway.

关键词： alkene hydrosilylation single atom catalysts metal-organic frameworks precision chemistry synergistic catalysis

FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo

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Acta Pharmacologica Sinica 2007年第6期28卷 913-920页

作者： Wen-jing DENG~2,Xiao-qiang YANG~2,Yong-ju LIANG~2,Li-ming CHEN~2,Yan-yan YAN~2,Xin-tao SHUAI~3,Li-wu fu~(2,4)~2 State Key Laboratory of Oncology in Southern China Cancer Center,sun yat-sen university,Guangzhou 510060,China ~3 School ofchemistry and Chemical Engineering of sun yat-sen university,Guangzhou 510275,China State Key Laboratory of Oncology in Southern China Cancer Center Sun Yat-Sen University Guangzhou China School of chemistry and Chemical Engineering of sun yat-sen university Guangzhou China

Aim:FG020326,a novel imidazole derivative,is a potent multidrug-resistance(MDR) modulator in vitro and in ***,FG020326 is ***-FG020326 is a FG020326-1oaded nanoparticle formed with diblock copolymers ofpoly (ethylene glycol)-block-poly (D,L-lactic acid) (PEG:PDLLA,PEDLLA) thatcan solubilize *** work was intended to evaluate the pharmacody-namics of PEDLLA-FG020326 on reversing MDR in vitro and in ***:Cytotoxicity was determined by tetrazolium *** intracellular accumulationand efflux of doxorubicin (Dox) were detected by fluorescence *** function of P-glycoprotein was examined by Rhodamine 123 (Rh123) accumu-lation detected by flow *** KBv200 cell xenograft model was estab-lished to investigate the effect of PEDLLA-FG020326 on reversing MDR in ***:PEDLLA-FG020326 and FG020326 exhibited 56.4-and 35.9-fold activityin reversing KBv200 cells to vincristine (VCR) resistance,respectively and 14.98-and 7.64-fold to Dox resistance,***-FG020326 was much stron-ger than FG020326,resulting in the increase of Dox and Rh 123 accumulation andthe decrease of intracellular Dox extrusion in KBv200 ***,PEDLLA-FG020326 exhibited more powerful activity than FG020326 in enhancing the effectof VCR against KBv200 cell xenografts in nude mice,but did not appear more ***:The pharmacodynamics of FG020326 was improved by incorporatingit into a micellar nanoparticle formed with PEG-block-PDLLA copolymers.

关键词： FG020326 micellar nanoparticle multidrug resistance xenografts

functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-Cheng Lu Hai-Yang Jing Shen Qian sun-Wook Moon Guang-fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China university of Chinese Academy of Sciences Beijing 100049China department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China university of Science and Technology of China HefeiAnhui 230027China department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory