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science China(Technological sciences) 2022年第5期65卷 1160-1168页

作者： CHEN GuoYin GUO Ying hsiao s.benjamin HOU Kai ZHU MeiFang state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Department of Chemistry Stony Brook UniversityNew York11794USA

In recent years,conductive hydrogels have become a promising candidate for application in fields such as tissue engineering and flexible electronic devices because of their conductivity,soft and wet ***,the preparation of tough and uniformly conductive hydrogels remains challenging because conductive nanofillers tend to aggregate during hydrogel ***,a hydrophilic polymer assistant dispersion strategy is proposed to fabricate a tough,conductive composite hydrogel with doublenetwork based on well-dispersed carbon nanotubes(CNTs).In particular,A@T_(2.0)/polyacrylamide(PAM)hydrogels showed a tensile strength of 332.9 kPa,elongation of 584.6%,Young’s modulus of 91.5 kPa,and conductivity of 2.765 s m^(-1),and a demonstration was performed to show the strain sensing for health monitoring and *** showed that the fabricated conductive hydrogels offer promising and broad insights in the field of wearable sensors for health monitoring,innovative electronics,and human-machine interactions.

关键词： alginate carbon nanotubes conductive hydrogel tough force sensing

Preparation and surface Modification of High-Density Chitosan/Functionalized Multi-walled Carbon Nanotubes Hollow Fibers

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Journal of Donghua University(English Edition) 2015年第4期32卷 602-608页

作者：邵梅玲杜盼杨庆 hsiao benjamin s College of Material science and Engineering Donghua University

Functionalized multi-walled carbon nanotubes( fMWNTs) were prepared with chitosan via controlled surface deposition and crosslinking process and scanning electron microscopy( sEM),Fourier translation infrared spectroscopy( FT-IR) and Xray diffraction( XRD) are used to character properties. A novel high-density chitosan( HCs) was dissolved in f-MWNTs dispersed dilute acetic acid with a maximal concentration of 5. 8%. The hollow fibers can be made by extruding the solution into a dilute alkali solution through a wet-spinning process and the tensile properties of the materials were evaluated by universal tester. The surface property of fibers,pretreated by Helium( He) and the following grafted with gelatin was evaluated with X-ray photoelectron spectroscopy( XPs).As the hollow fibers were intended for neural tissue engineering,its suitability was evaluated in vitro using rat schwann cells( RsC96) as model cells. The cells attachment,proliferation and morphology,were studied by various microscopic techniques. Based on the results,the gelatin grafted HCs / f-MWNTs hollow fibers could be used as a potential cell carrier in neural tissue engineering.

关键词： chitosan multi-walled carbon nanotubes(MWNTs) hollow fibers wet-spinning cold plasma treatment biocompatibility

Electrospun Nanofibrous Adsorption Membranes for Wastewater Treatment:Mechanical strength Enhancement

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Chemical Research in Chinese Universities 2021年第3期37卷 355-365页

作者： XIN Rui MA Hongyang shyam Venkateswaran benjamin s.hsiao state Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Department of Chemistry Stony Brook UniversityStony BrookNY117943400USA

Functional nanofibrous membranes fabricated by electrospinning technology have attracted much attention in the removal of heavy metal ions from contaminated *** high specific surface area,high porosity and ease of functionality create an enhanced throughput and high adsorption capacity of the nanofibrous ***,the relatively poor mechanical properties of the membrane with a non-woven nanofibrous structure are one of the major concerns,which can limit the applications in wastewater *** strategies and methodologies were explored to address the problems and were reviewed in this work,highlighting the possibilities of overcoming the poor mechanical properties of the nanofibrous membrane and to ensure the recyclability and reusability of the membrane during the adsorption process.

关键词： Electrospun nanofibrous membrane Mechanical property Heavy metal ion Wastewater treatment

spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg school of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALs2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions sPAsT spastin

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Enhancing Dehydration Performance of Isopropanol by Introducing Intermediate Layer into sodium Alginate Nanofibrous Composite Pervaporation Membrane

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Advanced Fiber Materials 2019年第2期1卷 137-151页

作者： Peiyun Li Cheng Cheng Ke shen Tonghui Zhang Xuefen Wang benjamin s.hsiao state Key Lab for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620People’s Republic of China Department of Chemistry Stony Brook UniversityStony BrookNY 11794USA

A novel three-tier composite membrane based on highly porous nanofibrous substrate was demonstrated for efficient iso-propanol dehydration by ***,polyethyleneimine(PEI)modified graphene oxide(GO)sheets were vacuum-assistant assembled onto porous electrospun polyacrylonitrile(PAN)nanofibrous substrate to achieve a smooth,hydrophilic and compact PEI-GO intermediate *** introduction of PEI chains endowed GO interlayer with sufficient interaction for bonding adjacent GO nanosheets to enhance stability in water/isopropanol mixture and also with the ascended inter-lamellar space to improve the water-sorption ability due to the abundant active amino *** from PEI-GO layer,a defect-free sodium alginate(sA)skin layer could be facilely manufactured with elaborately controlled thickness as thin as possible in order to reduce mass transfer resistant and enhance permeability ***,the interlayer would also contribute to enhance interfacial adhesion to promote the structure integrity of three-tier thin-film nanofibrous composite(TFNC)membrane in pervaporation dehydration *** fine-tuning of membrane preparation process,the sA/PEI(75)-GO-60/PAN TFNC membrane exhibited competitive pervaporation performance with the permeate flux of 2009 g/m2 h and the separation factor of 1276 operated at 70°C for dehydration of 90 wt%isopropanol *** unique three-tier composite membrane structure suggested an effective and facile approach to design novel membrane structure for further improvement of pervaporation performance.

关键词： Polyethyleneimine modified graphene oxide Intermediate layer Thin-film nanofibrous composite membrane Pervaporation membrane

MOLECULAR AND sUPRAMOLECULAR ORDERING IN CONFINED ENVIRONMENTs

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Chinese Journal of Polymer science 2000年第4期18卷 287-300页

作者： stephen Z.D.Cheng Bret H.Calhoun Roderic P.Quirk benjamin s.hsiao Maurice Morton Institute and Department of Polymer science The University of Akron Akron Ohio 44325-3909 USAMaurice Morton Institute and Department of Polymer Science The University of Akron Akron Ohio 44325-3909 USAMaurice Morton Institute and Department of Polymer Science The University of Akron Akron Ohio 44325-3909 USADepartment of ChemistryThe State University of New York at Stony Brook Stony Brook New York 11794-3400 USA

Crystal and phase morphologies and structures determined by self-organization of crystalline-amorphous diblockcopolymers, crystallization of the crystallizable blocks, and vitrification of the amorphous blocks are reviewed through asystematic study on a series of poly(ethylene oxide)-b-polystyrene (PEO-b-Ps) diblock copolymers. On the base ofcompetitions among these three processes, molecular and supramolecular ordering in confined environments can beinvestigated. In a concentration-fluctuation-induced disordered (D_(CF)) diblock copolymer, the competition between crystalli-zation of the PEO blocks and vitrification of the Ps blocks is momtored by time-resolved simultaneous small angle X-rayscattering (sAXs) and wide angle X-ray diffraction (WAXD) techniques. In the case of T_cs-rich), the crystallization of thePEO blocks is observed to be confined within the bicontinuous D_(CF) phase due to the rapid vitrification of the Ps-rich *** crystallization rate, crystal melting behavior, and crystallinity results further confirm the competition betweencrystallization and vitrification at different temperatures. In an ordered lamellar PEO-b-Ps diblock copolymer, the crystalli-zation of the PEO blocks is completely confined within the ordered lamellae due to rapid vitrification of the Ps layers asobserved by time-resolved sAXs and WAXD experiments. From the combined two-dimensional sAXs and WAXDmeasurements, the crystal orientation within the confined lamellar geometry is found parallel to the lamellar surface normalwhen it is isothermally crystallized at 35℃. In an ordered cylindrical PEO-b-Ps sample, the crystallization of the PEO blocksis also observed to be confined within the ordered cylinders because of rapid vitrification of the Ps matrix. The crystalorientation within the confined cylinders is found perpendicular to the cylinder axis as it is crystallized at 35℃.

关键词： Poly(ethylene oxide)-b-polystyrene diblock copolymer Molecular ordering, supramolecular ordering, Confined environment

Evolution of Morphology and structure During Crystallization and Melting in syndiotactic Polypropylene

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应用化学 2001年第5期18卷 280-288页

作者： Zhi-Gang WANG benjamin s.hsiao Charles C.HAN state University of New York at stony Brook Department of ChemistryStony BrookNY 11794-3400 Polymers Division and Center for Neutron Research National Institute of Standards and TechnologyGaithersburgMD 20899

structure and morphology development during isothermal crystallization and subsequent melting of syndiotactic polypropylene(sPP) was studied by time-resolved simultaneous small-angle X-ray scattering(sAXs) and wide-angle X-ray diffraction(WAXD) methods with synchrotron radiation and differential scanning calorimetry(DsC). The time and temperature dependent parameters such as long period, L , crystal lamellar thickness, l c, amorphous layer thickness, l a, scattering invariant, Q , crystallinity, X c, lateral crystal sizes, L 200 and L 020 , and unit cell parameters a and b were extracted from sAXs and WAXD profiles. Decreasing long period and crystal thickness indicate that thinner secondary crystal lamellae are formed. The decreases in unit cell parameters a and b during isothermal crystallization process suggest that crystal perfection takes place. The changes in the morphological parameters (the invariant, Q , crystallinity, X c, long period, L , and the crystal thickness, l c) during subsequent melting were found to follow a two-stage melting process, corresponding to the dual endotherm behavior in the DsC scan. We conclude that the dual melting peaks are due to the melting of secondary and primary lamellae(first peak) and the subsequent recrystallization-melting process(second peak). Additional minor endothermic peak located at the lowest temperature was also detected and might be related to melting of secondary, thinner and defective lamellae. WAXD showed that during melting, thermal expansion was greater along the b axis than that along the a axis.

关键词：间规聚丙烯结晶熔化晶体结构 DCs sAXs WAXD