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The Effectiveness of a Chronic Obstructive Pulmonary Disease Computer Game as a Learning Tool for Nursing Students

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Open Journal of Nursing 2015年第7期5卷 605-612页

作者： Sing-ling tsai Sinkuo Chai Kai-hsiang Chuang Fu Jen Catholic University Taiwan Department of Health Services Management China Medical University Taichung Taiwan Lunghwa University of Science and Technology Taiwan

Simulation games that are close to actual clinical situations can assist students in the learning process and, through the active presentation of subject material, help them acquire necessary knowledge. The aims of this study were to develop a computer game focused on caring for patients with chronic obstructive pulmonary disease (COPD) in the outpatient clinic and to evaluate the nursing students’ change in knowledge and their satisfaction score after they played this computer game. This study had a randomized pre-/post-control experimental design. How to assess and care for patients with dyspnea episodes, the use of inhalants, the effects of weather changes, and breathing exercises for patients with COPD were the key content elements of the computer game developed by the study team. The COPD care knowledge test and satisfaction questionnaire were the evaluation instruments. Sixty-eight junior nursing students participated in this study. Of these 68 participants, 35 were randomly assigned to the control group and 33 were randomly assigned to the experimental group. Each group finished the pretest, then played the game for 20 minutes, and then did the post-test questionnaire. The results of this study determined that the COPD care knowledge score was significantly improved after playing the game in the experimental group (t = 2.24, P linic. Important suggestions were to add reflection session after playing the computer game and to modify the fluency of the operation procedures. The experience and results of this study could apply not only to the teaching strategy for nursing students, but also for further developing a game for patient education.

关键词： Computer Game Student Nurse Teaching Strategy Outpatient Clinic Pre-/Post-Control Experimental Design

Interface structure between epitaxial NiSi2 and Si

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International Journal of Minerals,Metallurgy and Materials 2006年第6期13卷 558-563页

作者： Wen-Jauh Chen Ting-Kan tsai Hsun-Heng tsai Shu-Huei Hsieh Graduate Institute of Materials Engineering Pingtung University of Science and Technology 1 PingtungChina Taipei Department of Materials Engineering Formosa UniversityYunlin China Taipei Department of Biosystems Engineering Pingtung University of Science and Technology 1Pingtung China Taipei

The interface structure between the Si and NiSi2 epitaxially grown on the ( 112 ) Si substrate was studied using high resolution transmission electron microscopy and computer image simulation. The results showed that the interface between Si and NiSi2 epitaxially grown on the ( 112 ) Si substrate has six different types: type A NiSi2 ( 111 )/( 111 ) Si, type A NiSi2 (001)/(001) Si, type B NiSi2 (111 )/(111 ) Si, type B NiSi2 ( 112 )/(112 ) Si, type B NiSi2 ( 221)/(001) Si, and type B NiSi2 (114 )/(110 ) Si. And there are one or more different atomic structures for one type of interface.

关键词： nickel silicide interface high resolution image simulation atomic structure

State synchronization in process-oriented chaincode

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Frontiers of Computer Science 2019年第6期13卷 1166-1181页

作者： Lian YU Wei-Tek tsai School of Software&Microelectronics Peking UniversityBeijing 102600China State Key Laboratory of Software Development Environment School of Computer Science&EngineeringBeihang UniversityBeijing 100191China Comp. Info.and Dec.Systems EngineeringArizona State UniversityTempeAZ 85287USA

Business processes often involve operational processes,contracts,and *** modeling of such processes must address regulation monitoring and enforcement and maintain a reliable history of data for *** study proposes modeling business processes as chaincode(CC)on permissioned blockchains(BCs).The challenges encountered by the proposed approach are state synchronizations among distributed nodes(called authnodes)and realtime *** study separates CC executions from the state management of multiple BCs and demonstrates the validity of the proposed approach with a payment authorization system at a Chinese bank.

关键词： blockchains state synchronization chaincode permissioned blockchains concurrent block building

城市产业结构如何影响流动人口的定居意愿——基于结构方程模型的实证研究

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江苏师范大学学报（哲学社会科学版） 2024年第1期50卷 83-98,124页

作者：蔡果兰吕林旺中央民族大学理学院北京100081

在经济高质量发展的大背景下,产业结构转型升级正在持续进行,如何提高流动人口的定居意愿、实现以人为核心的新型城镇化是学界广泛关注的话题。然而现有针对定居意愿的研究多局限于收入、心理等个人属性,忽略了产业结构等客观因素对定... 详细信息

在经济高质量发展的大背景下,产业结构转型升级正在持续进行,如何提高流动人口的定居意愿、实现以人为核心的新型城镇化是学界广泛关注的话题。然而现有针对定居意愿的研究多局限于收入、心理等个人属性,忽略了产业结构等客观因素对定居意愿的制约与塑造。通过多群组结构方程模型,从理论和实证两方面研究了城市产业结构对流动人口定居意愿的路径和机制。研究发现,个人就业质量和心理认同作为中介变量,解释了产业结构对定居意愿所产生的较强的间接影响;流动人口所从事的行业类型在该影响路径中具有显著的调节效应;不同产业的流动人口在定居意愿的影响路径上存在显著差异,第二产业群体更关注就业质量,第三产业群体则近似相同的受到心理认同和就业质量的影响。基于此,本文提出制定差异化的政策,提供符合产业需求的就业机会,增强流动人口心理认同的建设,进而推动当地的城镇化和市民化进程。

关键词：流动人口定居意愿产业结构就业质量结构方程模型

p73β inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73α

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World Journal of Gastroenterology 2002年第6期8卷 1094-1097页

作者： tsai-Ping Li State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

AIM: p73, as a novel member of a family of p53-related transcription factors, shares redundant functions with p53, such as the abilities of inducing apoptosis and suppressing growth. It is well known that p53 can repress HBV expression and transcription efficiently. The aim of this paper is to investigate the transcriptional effect of p73α and p73β on hepatitis B virus (HBV) and to understand the correlation between HBV and ***: To construct an x-gene inactivated HBV plasmid which was cotransfected with p73α or p73β expression vectors into HepG2 cells. After transiently transfecticn, HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) were detected by ELISA. Viral transcripts synthesized by HBV were evaluated by Northern blotting analysis. The activities of HBV regulatory elements, including enhancer Ⅰ/X promoter (ENI/Xp) and enhancer Ⅱ/core promoter (ENⅡ/Cp) were monitored by luciferase ***: Both p73α and p73β could repress HBsAg and HBeAg expression by downregulating the ENⅠ/Xp and ENⅡ/Cp activities. But p73β exerted stronger inhibition on the activity of ENI/Xp than p73α, resulting in much lower level of viral transcripts and the antigens ***: p73β as a novel member of p53 family can efficiently inhibit HBV transcription mainly through downregulating the activities of the HBV ENI/Xp regulatory elements.

关键词： B肝病毒 I增强子 X启动子转录活性 p73β 抑制作用 p73α

Fault tolerant two-step quantum secure direct communication protocol against collective noises

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Science China(Physics,Mechanics & Astronomy) 2011年第3期54卷 496-501页

作者： tsai ChiaWei HWANG Tzonelih Department of Computer Science and Information Engineering National Cheng Kung University

This work proposes two fault tolerant quantum secure direct communication （QSDC） protocols which are robust against two kinds of collective noises： the collective-dephasing noises and the collective-rotation noises, respectively. The two QSDC protocols are constructed from four-qubit DF states which consist of two logical qubits. The receiver simply performs two Bell state measurements （rather than four-qubit joint measurements） to obtain the secret message. The protocols have qubit efficiency twice that of the other corresponding fault tolerant QSDC protocols. Furthermore, the proposed protocols are free from Trojan horse attacks.

关键词： collective noise quantum secure direct communication quantum cryptography

Coagulation factor Ⅶ gene polymorphisms are not associated with the occurrence or the survival of hepatocellular carcinoma:a report of 37 cases

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Cancer Biology & Medicine 2018年第3期15卷 275-281页

作者： Chih-Che lin Chun-Hsien Wu Li-Yu Chen Ming-Chao tsai Ahmed M.Elsarawy Kuang-Tzu Huang Liver Transplantation Center Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Hepato-Gastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Objective: Coagulation factor VII(FVII) triggers the extrinsic pathway of blood coagulation. In our previous study, we showed that FVII plays an important role in tumorigenesis of hepatocellular carcinoma(HCC). However, the role of FVII polymorphism in HCC is still unknown. The present study aimed to investigate the relationship between HCC carcinogenesis and single nucleotide polymorphism of ***: Thirty-seven HCC patients and 30 healthy donors were recruited in this study. Four common FVII gene polymorphisms– a decanucleotide insertion at position –323(–323 ins10-bp), a G to T substitution at position –401(–401 G/T), a G to A substitution at position –402(–402 G/A), and a T to C substitution at position –122(–122 T/C) – were analyzed by sequencing or commercialized assays using genomic DNA isolated from blood samples. Clinicopathological parameters between control and HCC subjects were compared according to the specific ***: The most common nucleotide variation was –402 G/A. However, no statistically significant difference was observed between healthy controls and HCC subjects for all four polymorphisms in terms of genotype distribution and allele frequencies,indicating that these polymorphisms may not affect HCC tumorigenesis. Furthermore, no association was found between–402 G/A polymorphisms and tumor stage, recurrence, and overall ***: Our results indicate that FVII polymorphisms may not be a key factor that clinically impact tumorigenesis and outcomes of HCC, although further investigations should be conducted to confirm our findings.

关键词： Factor Ⅶ gene polymorphism liver hepatocellular cancer survival

Impact of Cross-Strait Trade Liberalization:A Computable General Equilibrium Analysis

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China & World Economy 2009年第6期17卷 106-122页

作者： Kun-Ming Chen Meng-Chia tsai Chia-Ching lin Chaw-Hsia Tu the Department of International Business National Chengchi University National Chengchi University Nanhua University Chung Hua Institution for Economic Research

This paper applies a computable general equilibrium model to investigate the potential economic effects of trade liberalization across the Taiwan Strait. Our simulation results reveal that cross-Strait trade liberalization will have significant positive impacts on external trade, domestic investment and real GDP for the economies in this area in general and in Taiwan in particular. Furthermore, the negative impact from the formation of a free trade arrangement between Taiwan and Chinese Mainland on Hong Kong seems to be rather small. These results suggest that cross-Strait trade liberalization is very likely to bring about a win-win situation for the economies in this area.

关键词： cross-Strait free trade area free trade arrangement trade liberalization

Metabolic biomarkers and long-term blood pressure variability in military young male adults

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World Journal of Clinical Cases 2020年第11期8卷 2246-2254页

作者： Yu-Kai lin Pang-Yen Liu Chia-Hao Fan Kun-Zhe tsai Yen-Po lin Ju-Mi Lee Jiunn-Tay Lee Gen-Min lin Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan Departments of Neurology Tri-Service General Hospitaland Graduate Institute of Medical SciencesNational Defense Medical CenterTaipei 114Taiwan Department of Medicine Tri-Service General Hospital and National Defense Medical CenterTaipei 114Taiwan Department of Critical Care Medicine Taipei Tzu-Chi General HospitalNew Taipei City 231Taiwan Department of Preventive Medicine Eulji College of MedicineDaejeon 34824South Korea Department of Preventive Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

BACKGROUND Metabolic syndrome is a cluster of cardiovascular risk factors, including central obesity, high blood pressure, elevated plasma glucose, reduced high-density lipoprotein and elevated triglyceride *** To investigate the relationship between metabolic biomarkers and long-term blood pressure variability(BPV) in young *** A cohort of 1112 healthy military males aged 18-40 years from the cardiorespiratory fitness and hospitalization events in armed forces study in eastern Taiwan was prospectively included. The following metabolic biomarkers were used: Waist circumference, serum uric acid(SUA), triglycerides, high density lipoprotein, triglycerides, and fasting glycose. BPV was assessed by average real variability(ARV) and standard deviation(SD) across 4 clinic visits during the study period(2012-14, 2014-15, 2015-16, and 2016-18). Multivariable linear regression analysis was used to determine the association after adjusting for age, body mass index, systolic and diastolic blood pressure(SBP and DBP),lipid profiles, physical activity, alcohol intake and tobacco smoking *** In the unadjusted model, waist circumference was significantly and positively correlated with ARVDBP and SDDBP [β(standard errors) = 0.16(0.049) and 0.22(0.065), respectively], as was SUA [β = 0.022(0.009) and 0.038(0.012),respectively]. High-density lipoprotein was negatively correlated with ARVSBP [β=-0.13(0.063)]. There were no associations with the other metabolic *** contrast, only SUA was significantly correlated with SDSBP and SDDBP [β = 0.019(0.011) and 0.027(0.010), respectively] in the adjusted *** Our findings showed that of traditional metabolic biomarkers, SUA had the strongest positive correlation with long-term systolic and diastolic BPV in young male adults, and the clinical relevance needs further investigation.

关键词： Blood pressure variability Metabolic syndrome Serum uric acid Young males