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Recent developments in neuropsychological endophenotypes for schizophrenia: Development of the MATRICS battery, liability syndromes and the near future

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Chinese Science Bulletin 2011年第32期56卷 3385-3393页

作者： STONE William S hsi xiaolu Department of Psychiatry Massachusetts Mental Health Center Division of Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02115-6092 USA MIT Medical Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA

Cognitive deficits are now recognized widely as core features of schizophrenia, and as major contributors to the clinical outcome of the disorder. They are also studied widely as 'endophenotypes', reflecting a growing consensus that schizophrenia is a broader, more multidimensional illness than the diagnostic criteria required for its formal diagnosis. This evolving view of cognition underlies its utilization in recent initiatives for intervention and assessment in schizophrenia. Two of these initiatives are reviewed in this paper. The first focuses on the development and validation of the MATRICS Cognitive Consensus Battery, a standardized battery of neuropsychological tests developed to assess the effectiveness of cognitive enhancing treatments in schizophrenia. A part of this effort includes the identification of performance-based, 'co-primary' measures of functional capacity that are related to cognition, and that are likely to show improvement at least partly as a function of improved cognition. The second initiative involves efforts to utilize neuropsychological deficits in the identification, validation and remediation of a liability syndrome for schizophrenia ('schizotaxia'). The discussion of this effort focuses on the development of a syndrome that is both measurable and meaningful clinically, and that may provide useful intervention targets. The utilization of cognition in both of these initiatives underscores its functional importance in the clinical outcome of schizophrenia. Moreover, it helps to illuminate indicators of liability for schizophrenia that might be amenable to remediation.

关键词：精神分裂症心理测验综合征电池神经稳定责任认知功能

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Visibility graph approach to extreme event series

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Chinese Physics B 2023年第10期32卷 317-327页

作者：张晶陈晓露王海英顾长贵杨会杰 Department of Systems Science University of Shanghai for Science and TechnologyShanghai 200093China Department of Business Wuxi Taihu UniversityWuxi 214064China

An extreme event may lead to serious disaster to a complex *** an extreme event series there exist generally non-trivial patterns covering different time *** on extreme events are currently based upon statistics,where the patterns are merged into *** this paper from extreme event series we constructed extreme value series and extreme interval *** the visibility graph is then adopted to display the patterns formed by the increases/decreases of extreme value or interval faster/slower than the linear *** the fractional Brownian motions,the properties for the constructed networks are the persistence,threshold,and event-type-independent,e.g.,the degree distributions decay exponentially with almost identical speeds,the nodes cluster into modular structures with large and similar modularity degrees,and each specific network has a perfect hierarchical *** the volatilities of four stock markets(NSDQ,SZI,FTSE100,and hsi),the properties for the former three's networks are threshold-and *** with the factional Brownian motions,their degree distributions decay exponentially but with slower speeds,their modularity behaviors are significant but with smaller modularity *** fourth market behaves similar qualitatively but different quantitatively with the three ***,all the transition frequency networks share an identical backbone composed of nine edges and the linked *** universal behaviors give us a framework to describe extreme events from the viewpoint of network.

关键词： extreme events visibility graph

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一种快速实现的偏振光学去雾方法

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激光与光电子学进展 2019年第14期56卷 149-154页

作者：张文飞满忠胜葛筱璐邢飞付圣贵山东理工大学物理与光电工程学院

基于hsi(Hue,Saturation and Intensity)颜色空间提出一种快速偏振光学去雾方法。利用hsi颜色空间中强度与颜色无关的优势,在强度通道中利用偏振光学去雾方法进行去雾处理,然后利用颜色恒常性校正方法对图像的颜色畸变进行校正。该技术... 详细信息

基于hsi(Hue,Saturation and Intensity)颜色空间提出一种快速偏振光学去雾方法。利用hsi颜色空间中强度与颜色无关的优势,在强度通道中利用偏振光学去雾方法进行去雾处理,然后利用颜色恒常性校正方法对图像的颜色畸变进行校正。该技术不仅具有良好的图像细节恢复能力,还有效地提高了偏振光学去雾方法的计算效率。与目前流行的去雾方法进行对比后可知,该技术可以得到更好或者相同的实验效果,但其执行效率更高。所提出的方法在图像实时去雾和视频去雾领域有广阔的应用前景。

关键词：成像系统偏振成像图像增强能见度浑浊介质成像

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