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CYp24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells

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World Journal of Gastroenterology 2013年第17期19卷 2621-2628页

作者： János p Kósa péter horváth János Wlfling Dóra Kovács Bernadett Balla péter Mátyus Evelin horváth Gábor Speer István Takács Zsolt Nagy Henrik horváth péter Lakatos 1 st Department of Internal Medicine Semmelweis University Department of Organic Chemistry University of Szeged Department of Organic Chemistry Semmelweis University

AIM:the effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYp24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYp24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. the aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome p450 component of CYp24A1 activity. MEthODS:We examined the expression of CYp24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYp24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYp24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their Cp24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYp24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYp24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:these findings demonstrate that the selective inhibition of CYp24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC.

关键词： Colorectal cancer CYp24A1 inhibition Vitamin D3 Tetralone derivatives Caco-2 cell culture

Information schema constructs for defining warehouse databases of genotypes and phenotypes of system manifestation features

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 862-884页

作者： Shahab pOURTALEBI Imre horváth Faculty of Industrial Design Engineering Delft University of Technology

Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. the novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. the main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. they increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.

关键词： Cyber-physical systems Software toolbox pre-embodiment design System manifestation features(SMFs) Warehouses Database schemata SMF genotypes SMF phenotypes SMF instances Information schema constructs

NORMALLY DISTRIBUTED pROBABILITY MEASURE ON thE METRIC SpACE OF NORMS

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Acta Mathematica Scientia 2013年第5期33卷 1231-1242页

作者： Á.G.horvÁth Department of Geometry Mathematical Institute Budapest University of Technology and Economics

In this paper we propose a method to construct probability measures on the space of convex bodies. For this purpose, first, we introduce the notion of thinness of a body. then we show the existence of a measure with the property that its pushforward by the thinness function is a probability measure of truncated normal distribution. Finally, we improve this method to find a measure satisfying some important properties in geometric measure theory.

关键词： Hausdorff metric Borel Dirac Haar and Lebesgue-measure space of convex bodies metric space of norms

Algorithm fusion to improve detection of lung cancer on chest radiographs

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International Journal of Intelligent Computing and Cybernetics 2012年第1期5卷 111-144页

作者： Gergely Orbán Gábor horváth Department of Measurement and Information Systems Budapest University of Technology and EconomicsBudapestHungary Intelligent Systems Research Group Budapest University of Technology and EconomicsBudapestHungary

purpose-the purpose of this paper is to show an efficient method for the detection of signs of early lung *** image processing algorithms are presented for different types of lesions,and a scheme is proposed for the combination of ***/methodology/approach-A computer aided detection(CAD)scheme was developed for detection of lung *** enables different lesion enhancer algorithms,sensitive to specific lesion subtypes,to be used *** image processing algorithms are presented for the detection of small nodules,large ones,and infiltrated *** outputs are merged,the false detection rate is reduced with four separated support vector machine(SVM)*** classifier input comes from a feature selection algorithm selecting from various textural and geometric features.A total of 761 images were used for testing,including the database of the Japanese Society of Radiological Technology(JSRT).Findings-the fusion of algorithms reduced false positives on average by 0.6 per image,while the sensitivity remained 80 per *** the JSRT database the system managed to find 60.2 per cent of lesions at an average of 2.0 false positives per *** effect of using different result evaluation criteria was tested and a difference as high as 4 percentage points in sensitivity was *** system was compared to other published ***/value-the study described in the paper proves the usefulness of lesion enhancement decomposition,while proposing a scheme for the fusion of ***,a new algorithm is introduced for the detection of infiltrated areas,possible signs of lung cancer,neglected by previous solutions.

关键词： programming and algorithm theory Image processing Cancer Radiography Medical diagnosis Lung nodule Infiltrated area Chest radiograph Lung cancer Early detection

Revealing the topological phase diagram of ZrTe_(5) using the complex strain fields of microbubbles

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npj Computational Materials 2022年第1期8卷 1685-1691页

作者： Zoltán Tajkov Dániel Nagy Konrád Kandrai János Koltai LászlóOroszlány péter Süle Zsolt Ehorváth péter Vancsó Levente Tapasztó péter Nemes-Incze Centre for Energy Research Institute of Technical Physics and Materials Science1121BudapestHungary Department of physics of Complex Systems ELTE Eötvös Loránd University1117BudapestHungary ELTE Eötvös Loránd University Department of Biological Physics1117BudapestHungary Budapest University of Technology and Economics 1111BudapestHungary

Topological materials host robust properties,unaffected by microscopic perturbations,owing to the global topological properties of the bulk electron *** in which the topological invariant can be changed by easily tuning external parameters are especially sought *** pentatelluride(ZrTe_(5))is one of a few experimentally available materials that reside close to the boundary of a topological phase transition,allowing the switching of its invariant by mechanical ***,we unambiguously identify a topological insulator–metal transition as a function of strain,by a combination of ab initio calculations and direct measurements of the local charge *** model quantitatively describes the response to complex strain patterns found in bubbles of few layer ZrTe_(5) without fitting parameters,reproducing the mechanical deformation-dependent closing of the band gap observed using scanning tunneling *** calculate the topological phase diagram of ZrTe_(5) and identify the phase at equilibrium,enabling the design of device architectures,which exploit the topological switching characteristics of the system.

关键词： density topological invariant

Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： Santiago RUIZ-ARENAS Zoltán RUSáK Imre horváth Ricardo MEJí-GUTIERREZ Faculty of Industrial Design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de Diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. there is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

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复杂技术系统中基础研究的初步分类(英文)

Journal of Zhejiang University-Science A(Applied physics & Engineering) 2015年第9期16卷 681-705页

作者： Imre horváth Faculty of Industrial Design Engineering Delft University of Technology2628 CE Delft the Netherlands

目的:对于复杂技术系统,给出不同研究领域的初步分类,并找出一些研究关注的问题。创新点:提出了一种推理方法,将复杂技术系统的研究领域分为三类。方法:1.对相关的学术刊物进行直觉探索;2.对领域和子领域研究给出基于证据的分类规范;3.... 详细信息

目的:对于复杂技术系统,给出不同研究领域的初步分类,并找出一些研究关注的问题。创新点:提出了一种推理方法,将复杂技术系统的研究领域分为三类。方法:1.对相关的学术刊物进行直觉探索;2.对领域和子领域研究给出基于证据的分类规范;3.对基于相关学术刊物的控制给出的分类进行提炼与验证。结论:复杂技术系统的研究领域分为三类,分别为:(1)智能化类,包括哲学、本体和认识论;(2)实现类,包括方法论和复杂技术系统的创建;(3)影响类,包括表现和价值学。

关键词：基础研究复杂技术系统初步分类研究范畴与领域

Groundwater uptake of different surface cover and its consequences in great Hungarian plain

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Ecological processes 2017年第1期6卷 408-416页

作者： Zoltán Gribovszki péter Kalicz Kitti Balog András Szabó Tibor Tóth péter Csáfordi Mohamed Metwaly Sándor Szalai Institute of Geomatics and Civil Engineering University of SopronSopronHungary Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural ResearchHungarian Academy of SciencesBudapestHungary Forest Research Institute National Agricultural Research and Innovation CentreBudapestHungary Archaeology Department College of Tourism and ArchaeologyKing Saud UniversityRiyadhSaudi Arabia National Research Institute of Astronomy and Geophysics(NRIAG) CairoEgypt MTA CSFK GGI SopronHungary

Introduction:Forest cover in Hungary has increased from 1.1 to 2.0 million hectares during the last *** EU(European Union)promotes further afforestation;thus,15,000–18,000 ha are being forested each year,mainly in the Hungarian Great *** terms of species used for afforestation,poplar plantations are preferred over native oak *** groundwater uptake of trees can be a significant water balance element of forested areas in shallow groundwater environments within the Hungarian Great *** can cause water table depressions and subsurface salt accumulation in areas with negative water *** study examined the hydrological impact of forest cover in the Hungarian Great *** the framework of this research,climatic water balance,water table depth and salinity,subsoil layering,tree species and stand age were analysed as influencing *** paper compares the effect which an oak forest,a poplar plantation and a pasture have on groundwater uptake and salt ***:the water table level was roughly 0.4–0.5 m lower beneath the oak forest and the poplar plantation than it was beneath the *** groundwater use was 1.5–2 times higher than that of *** uptake of oak forest was greater than that of poplar plantation during the monitoring *** accumulation,which shows water use in the longer run,was slightly higher for poplar in deeper ***:the greater amount of groundwater used by trees does not lead to a higher salt uptake as only a slight accumulation of salt was measured beneath the ***,hybrid poplar was slightly less favourable than native oak when considering salinization ***,even greater groundwater uptake by trees over longer timescales could cause more significant salt accumulation under pronounced drought conditions due to climate change.

关键词： Groundwater recharge/water budget Evapotranspiration Diurnal fluctuation Forest cover Salinization

Catheter-directed thrombolysis in inflammatory bowel diseases:Report of a case

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World Journal of Gastroenterology 2012年第34期18卷 4791-4793页

作者： péter Ilonczai Judit Tóth László Tóth István Altorjay Zoltán Boda Károly palatka Division of Haemostasis 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Euromedic Diagnostics Hungary Ltd. Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Department of pathology Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Division of Gastroenterology 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary

In patients with inflammatory bowel diseases (IBD) the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. the TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. the application of antico-agulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. the control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. this case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.

关键词： Inflammatory bowel disease Crohn's dis-ease thromboembolism Catheter-directed thromboly-sis Gastrointestinal haemorrhage