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Transurethral dividing vaporesection for the treatment of large volume benign prostatic hyperplasia using 2 micron continuous wave laser

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Chinese Medical Journal 2010年第17期123卷 2370-2374页

作者： SUN Dong-chong YANG Yong WEI Zhi-tao hong bao-fa ZHANG Xu Department of Urology General Hospital of Chinese People's Liberation Army Beijing 100853 China

Background The safety and efficiency of transurethral laser resection of the prostate to treat benign prostatic hyperplasia have been verified. However, this method does still not manage large volume prostates efficiently. To tackle this problem, we have designed a method of ＂transurethral dividing vaporesection of prostate＂ using a 2 micron continuous wave laser. The aim of this study was to evaluate the safety and efficiency of this method in the management of large prostates （〉80 ml）.Methods In this study, 45 cases of benign prostatic hyperplasia with a median prostatic volume of （123.7±26.7） ml （range, 80.2-159.8 ml） were treated by the same surgeon under epidural anesthesia. During the surgery, superapubic catheters were needed, and saline solution was used for irrigation. First, the prostate was divided longitudinally into several parts from the bladder neck to the prostatic apex, and then gradually incised transversely chip by chip. Intraoperative blood transfusion rate, postoperative complications, maximum urinary flow rate, International Prostate Symptom Score and quality of life scores were recorded for statistical analysis using SPSS 16.0 *** Intraoperatively, no transurethral resection syndrome was observed, and no blood transfusions were *** resected prostatic chips were easily flushed out of the bladder through the resectoscope sheath without the use of a morcellator. Median vaporesection time was （95.0±13.2） minutes （range, 75-120 minutes）, and the median retrieved and removed prostatic tissue were （25.2±5.1） g （range, 15.5-34.7 g） and （75.4±16.4） g （range, 43.8-106.1 g）, respectively. Median catheter time and hospital stay were （3.3±0.9） days （range, 3-5 days） and （4.8±1.8） days （range, 3-9 days）, respectively. After a follow-up of 6 to 12 months, two patients had stress urinary incontinence and three had anterior urethral strictures. Satisfactory improvement was seen in maximum urinary flow rate, International Prostate Symptom Sc

关键词： 2 micron continuous wave laser vaporesection benign prostatic hyperplasia

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球囊辅助下治疗肾血管平滑肌脂肪瘤合并下腔静脉瘤栓一例报告并文献复习

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中华外科杂志 2007年第12期45卷 836-838页

作者：杨勇宋勇洪宝发解放军总医院泌尿外科北京100853

目的报道球囊辅助下治疗肾血管平滑肌脂肪瘤伴下腔静脉瘤栓1例,结合文献复习加深对此病的认识。方法 20岁女性患者,术前影像学检查提示右肾巨大肿瘤伴下腔静脉瘤栓,在球囊辅助阻断下行右肾切除及下腔静脉取栓术。结果病理报告为右肾血... 详细信息

目的报道球囊辅助下治疗肾血管平滑肌脂肪瘤伴下腔静脉瘤栓1例,结合文献复习加深对此病的认识。方法 20岁女性患者,术前影像学检查提示右肾巨大肿瘤伴下腔静脉瘤栓,在球囊辅助阻断下行右肾切除及下腔静脉取栓术。结果病理报告为右肾血管平滑肌脂肪瘤,伴下腔静脉瘤栓,长6.5 cm,术后随访1年未见复发。结论球囊辅助阻断下腔静脉可用于治疗肾血管平滑肌脂肪瘤伴下腔静脉瘤栓。

关键词：脂肪瘤肌平滑血管肾瘤栓

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Photoselective vaporization of the prostate in the treatment of benign prostatic hyperplasia

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Chinese Medical Journal 2005年第19期118卷 1610-1614页

作者： FU Wei-jun hong bao-fa YANG Yong CAI Wei GAO Jiang-ping WANG Chun-yang WANG Xiao-xiong Department of Urology General Hospital of People＇s LiberationArmy Beijing 100853 China

Background The treatment of symptomatic benign prostatic hyperplasia （BPH） remains a challenge for most urologic surgeons. We studied a cumulative cohort of patients with symptomatic benign prostatic hyperplasia （BPH） who underwent photoselective vaporization of the prostate （PVP） and evaluated the efficacy and safety of this procedure. Methods A total of 196 patients with lower urinary tract obstruction symptoms secondary to BPH were treated using laser vaporization of the prostate under sacral canal anesthesia at our institutions. The therapeutic results were assessed using following variables ： the safety and efficacy of sacral anesthesia, blood loss, operative time, indwelling catheterization. Preoperative and perioperative parameters were evaluated in the international prostate symptom score （ IPSS）, quality of life score （ QoL）, maximal urinary flow rate （ Qmax）, post-void residual urine volume （PVR） and the change of sexual function. Patients were also assessed for 3-month follow up. Results PVP was performed successfully for all patients. There were 195 patients under sacral anesthesia and 1 patient under epidural anesthesia. Mean operative time was （45.2±18.5 ） minutes. The mean IPSS decreased from （26.6±3.2 ） to （5.6±1.4） and the QoL score decreased from （5.7±0.4） to （ 1.6±0. 5 ）, respectively （ P 〈 0. 05 ）, while mean Qmax increased from （6.7±2.5 ） ml/s preoperatively to （ 19.6± 2.4 ） ml/s, PVR decreased from 158.4 to 25.8 ml, respectively （ P 〈 0.05）. Average catheterization time was （ 1.8±0. 9） days. There was no significant blood loss or fluid absorption during the period of PVP. Complications consisted of transient dysuria in 3 patients （1.5%）, delayed gross hematuria in 5 patients （2. 5% ）, respectively. Significant improvement in clinical outcomes were noted as early as 3 months after PVP treatment. Conclusions PVP is considered as a high satisfaction rate by complication. Hence, PVP is a novel, safe, effective and minimal symptomatic BPH. patient a

关键词： benign prostatic hyperplasia prostatectomy laser surgery

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li Jian-hong Shi Tan Li Wan-Su bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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A surface-modified biodegradable urethral scaffold seeded with urethral epithelial cells

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Chinese Medical Journal 2011年第19期124卷 3087-3092页

作者： FU Wei-jun WANG Zhong-xin LI Gang ZHANG Bing-hong ZHANG Lei HU Kun hong bao-fa WANG Xiao-xiong CUI Fu-zhai ZHANG Xu Department of Urology Chinese People＇s Liberation Army General Hospital Beijing 100853 China Biomaterials Lab School of Materials Science and Engineering Tsinghua University Beijing 100084 China

Background Efficient cell adhesion and proliferation is a central issue in cell-based tissue engineering, which offers great promise for repair of urethral defects or strictures. This study evaluated the adhesion and growth of rabbit uroepithelium on a surface-modified three-dimensional poly-L-lactic acid （PLLA） *** Urethral mucosa were harvested from male New Zealand rabbits and the urothelium were dissociated and then cultured. Immunocytochemistry on cultured uroepithelium for pancytokeratin and uroplakin Ⅱ and TE-7 confirmed pure populations. After in vitro proliferation, cells were seeded onto a surface-modified urethral scaffold with non-knitted filaments. The morphology and viability of the cells were examined by immunohistochemical and fluorescence *** and scanning microscopes were used to document cell growth and *** Three to five days after primary culture, the uroepithelial cells gradually became confluent, assuming a cobblestone pattern. The filaments of the urethral scaffold had excellent biocompatibility and allowed growth of the uroepithelium, without affecting viability. The uroepithelial cells adhered to and grew well on the scaffold. After 3-7 days,the cells grew vigorously and meshes of the scaffold were full of *** The surface-modified urethral scaffold with non-knitted filaments allows the growth of uroepithelium and can serve as a carrier for the tissue engineering of urethra.

关键词： biodegradation urethral scaffold urothelium cell adhesion tissue engineering

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经尿道2μm激光膀胱部分切除术治疗膀胱尿路上皮癌组织病理学分析

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中华外科杂志 2009年第20期47卷 1566-1568页

作者：郭刚杨勇洪宝发张旭周振鸿解放军总医院泌尿外科北京100853 解放军总医院病理科北京100853

目的观察应用2μm激光行经尿道行膀胱部分切除术治疗膀胱肿瘤的组织病理学特点。方法2007年10月至2008年12月采用经尿道膀胱镜行2μm激光膀胱部分切除术治疗54例膀胱肿瘤患者，男性41例，女性13例，年龄27—81岁，平均（66．2±12．4）... 详细信息

目的观察应用2μm激光行经尿道行膀胱部分切除术治疗膀胱肿瘤的组织病理学特点。方法2007年10月至2008年12月采用经尿道膀胱镜行2μm激光膀胱部分切除术治疗54例膀胱肿瘤患者，男性41例，女性13例，年龄27—81岁，平均（66．2±12．4）岁；共有肿瘤65个。术中全层汽化切割瘤体周围膀胱壁至膀胱壁最外层的疏松结缔组织，将切取的全层标本送病理检查。观察术后组织形态学改变。结果54例患者均可耐受手术。术后肿瘤临床分期：T1期42例，T2期12例。术后随访1—14个月，平均8．5个月，复发2例，无原位复发。组织病理学示瘤体及其附着的膀胱黏膜、黏膜下层及全部肌层完整切除，切缘无残留，标本可清楚判定肿瘤分期。术后1周手术创面呈凹陷状，为纤维结缔组织伴慢性炎细胞浸润；术后1个月创面凹陷变浅，并出现移行上皮细胞覆盖，其下为纤维结缔组织；至术后3个月创面凹陷基本消失，黏膜稍苍白；术后6个月观察创面黏膜与周围膀胱壁黏膜基本一致。结论2μm激光治疗膀胱肿瘤可达到膀胱部分切除术的临床效果，肿瘤及萁附着的陪胱壁伞肌．屡可完整切除．所得标本可准确判守肿瘤的临床分期．术后创面恢复良好。

关键词：膀胱肿瘤膀胱镜检查激光病理学

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Photoselective vaporization of the prostate in the treatment of benign prostatic hyperplasia

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中华医学杂志(英文版) 2005年第19期000卷 28-32页

作者： FU Wei-jun,hong bao-fa,YANG Yong,CAI Wei,GAO Jiang-ping,WANG Chun-yang and WANG Xiao-xiong Department of Urology, General Hospital of People’s Liberation Army, Beijing 100853, China Department of Urology General Hospital of People's Liberation Army Beijing 100853 China

Benign prostatic hyperplasia (BPH) is a common disease in aged men. The traditional transurethral resection of the prostate (TURP) has been the best standard procedure in treating BPH for decades. However, the complication morbidity associated with TURP has remained relatively constant at 18%.~1 Recently the photoselective vaporization of the prostate (PVP) with a high powered potassium-titanyl-phosphate (KTP) laser is a rapidly emerging technique and an attractive alternative for the management of obstructive BPH.~2 Early and limited clinical results of PVP have demonstrated minimally invasive techniques and equivalent efficacy and greater safety in comparison with those of TURP.~3 We evaluated our early clinical experience with PVP in the treatment of Chinese *** Wei-jun, hong bao-fa, YANG Yong, CAI Wei, GAO Jiang-ping, WANG Chun-yang and WANG Xiao-xiong

关键词： benign prostatic hyperplasia · prostatectomy · laser surgery

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Modified one-cut circumcision technique by clamp： reports of 2000 cases

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Chinese Medical Journal 2010年第19期123卷 2732-2735页

作者： LI Gang LI Qian FU Wei-jun hong bao-fa LUO Jin XU Fu-qiang CAO Lei KANG Yi-sheng DONG Xin WANG Yan LIU Li ZHANG Xu Department of Urology Anesthesia and Operation Center General Hospital of People's Liberation Army Beijing 100853 China Department of Urology Anesthesia and Operation Center General Hospital of People's Liberation Army Beijing 100853 China Organ Transplant Center 309 Hospital of People's Liberation Army Beijing 100091 China Medical School of Nankai University Tianjin 300071 China Yongzhou People's Hospital Yongzhou Hunan 425006 China

In the western countries, circumcision has been .performed for a long time. However, because of religious and cultural differences, circumcision was rare in China before the 20th century. As a result, penile cancer, accounting for 17% of all cancers, was more *** the introduction of western medicine in the 1920s, especially after the establishment of urology as a separate department, gradually more circumcisions were carried out.

关键词： circumcision, male foreskin phimosis

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经尿道2μm激光膀胱部分切除术治疗膀胱肿瘤的初步探讨

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中华外科杂志 2009年第2期47卷 143-145页

作者：杨勇魏志涛张旭洪宝发郭刚解放军总医院泌尿外科北京100853

目的分析应用经尿道2μm激光行膀胱部分切除术治疗膀胱肿瘤的临床特点。方法采用骶管麻醉，经尿道膀胱镜2μm激光行膀胱部分切除术治疗18例膀胱肿瘤患者，共切除肿瘤21个，肿瘤直径大小1-3em。术中用2μm激光沿肿瘤周围全层切开膀胱壁... 详细信息

目的分析应用经尿道2μm激光行膀胱部分切除术治疗膀胱肿瘤的临床特点。方法采用骶管麻醉，经尿道膀胱镜2μm激光行膀胱部分切除术治疗18例膀胱肿瘤患者，共切除肿瘤21个，肿瘤直径大小1-3em。术中用2μm激光沿肿瘤周围全层切开膀胱壁，在肌层与外层结缔组织之间剥离整块膀胱壁，完整切除肿瘤及其基底部膀胱全肌层标本送病理检查。观察手术时间，术中出血情况，术中及术后并发症，肿瘤病理分期以及术后随访。结果18例患者均可耐受手术，本组患者手术时间5～12min，平均（7．4±3．3）min；术中出血量极少或几乎不出血，无闭孔神经反射，术后亦无继发出血，1例术后出现尿外渗，给予置管引流；术后肿瘤病理分期：T1期15例患者，共18个肿瘤，1、2期：3例患者，共3个肿瘤；术后随访3～6个月，平均4．5个月，无原位复发。结论2μm激光能对膀胱壁全层进行精确的汽化切割，并且可以在肌层与疏松结缔组织之间进行剥离，在膀胱肿瘤治疗中达到膀胱部分切除的目的。

关键词：膀胱肿瘤激光治疗部分切除术

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单克隆抗体在前列腺癌诊断及治疗中的应用

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中国临床康复 2005年第26期9卷 216-218页

作者：高雪松洪宝发周建光解放军总医院泌尿外科北京市100853 解放军军事医学科学院生物工程研究所北京市100850

目的:由于单克隆抗体在治疗肿瘤方面应用广泛,具有特异性、靶向性、亲和力强、不影响周围正常细胞和毒副作用少等优点,探讨其在前列腺癌诊断和治疗中的应用发展。资料来源:应用计算机检索Medline数据库1987-01/2004-11相关单克隆抗体在... 详细信息

目的:由于单克隆抗体在治疗肿瘤方面应用广泛,具有特异性、靶向性、亲和力强、不影响周围正常细胞和毒副作用少等优点,探讨其在前列腺癌诊断和治疗中的应用发展。资料来源:应用计算机检索Medline数据库1987-01/2004-11相关单克隆抗体在前列腺癌诊断和治疗中的文章,检索词“monoclonalantibody,prostatecancer,diagnosis,treatment”,限定文章语言种类为English。资料选择:对资料进行初审,纳入标准:①单克隆抗体在前列腺癌诊断和治疗中的作用及应用的文献。②不排除是否为随机、盲法等论证推荐的文章。排除标准:综述类文献及重复研究。资料提炼:收集到的资料中分别对单克隆抗体对前列腺癌患者放射免疫显像和治疗进行探讨,包括对不同类单克隆抗体的作用进行阐述。共收集到53篇与单克隆抗体在前列腺癌诊断和治疗中应用相关的文章。排除其中研究内容相似的文章,以近5年内发表在较权威杂志者优先。对符合标准的26篇文献进行分析。资料综合:针对单克隆抗体对前列腺癌患者放射免疫显像和治疗研究有的已进入临床试验,有的正在进行动物试验。单克隆抗体在前列腺癌诊断和治疗中的应用在于它能准确的与肿瘤细胞靶抗原位点特异结合。单克隆抗体显像既可以用于淋巴显影,又能区分肿瘤细胞;在前列腺癌治疗中,利用抗体直接与靶细胞结合,通过抗体依赖细胞毒作用、补体依赖细胞毒作用、传递细胞毒药物(放射性同位素和免疫毒素)或封闭肿瘤组织和细胞生长所必需的相关生长因子等来实施。现在,已利用基因工程技术,研究出了针对在肿瘤细胞膜外分布的前列腺特异性膜抗原的人源化单克隆抗体。结论:单克隆抗体10余年来在前列腺癌诊断和治疗中的研究与应用取得了进展,需要在以下方面开展更深入的研究:人抗单克隆抗体技术上的突破;合理的安排抗肿瘤单抗偶联物或免疫偶联物的组合,包括化学药物、毒素、放射性同位素、生物因子和基因等。随着基因工程、蛋白质工程技术的发展及单克隆抗体在临床研究的不断深入,单克隆抗体将在前列腺癌的诊断和治疗中发挥重要的作用。

关键词：前列腺肿瘤抗体,单克隆诊断综述文献人源化单克隆抗体前列腺癌治疗前列腺癌患者前列腺特异性膜抗原 Medline数据库 diagnosis

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