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Clinical study of inflammatory factors in sputum induced early after lung volume reduction surgery

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Chinese Medical Journal 2008年第18期121卷 1796-1799页

作者： MIAO Jin-bai hou sheng-cai LI Hui HU Bin WANG Tian-you Department of Thoracic Surgery Beijing Chaoyang Hospital Capital Medical University the Institute of Beijing Respiratory Medicine Beijing 100020 China Department of Thoracic Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Background The aim of this study was to prospectively study the changes in neutrophil elastase （NE）, fibroblast growth factor 9 （Fgf9）, matrix metalloproteinase-9 （MMP-9）, tissue inhibitor of metalloproteinase 1 （TIMP-1） in sputum induced during the early period after lung volume reduction surgery （LVRS）. Methods From April to October 2005, ten consecutive patients with chronic obstructive pulmonary disease （COPD） underwent LVRS. Ten non-small cell lung cancer patients （stage II-Illa） received Iobectomy as a control group. The induced sputum was collected from both groups at six different times （two weeks before operation and postoperatively at 1, 2, 4, 6 and 10 days）. The level of NE, Fgf9, MMP-9 and TIMP-1 were measured using enzyme-linked immunosorbent assay. Results The pulmonary function （FEV~%） and arterial blood gases （PaO2 and PaCO2） were significantly different belween the groups. There were no significant differences in age, ejection fraction （EF）, and operation duration, but hemoglobin in the LVRS group was statistically higher than in the controls. At certain times, there were significant differences in NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 （P 〈0.05） but not in Fgf9 between the two groups. The levels of NE and TIMP-1 were maximal at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 4 days postoperatively in the LVRS group. In the control group, maximal levels of NE and TIMP-1 occurred at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 1 day postoperatively. Ten days after surgery, all values of the control group were not significantly different from the baseline. In the LVRS group, the levels were significantly different from the pre-operative values （P 〈0.05） apart from TIMP-1. Conclusion The levels of NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 of the LVRS group were different from those of the control group. The time course of these chanties may be related to LVRS and the underlying process of COPD.

关键词： pulmonary surgical procedures chronic obstructive pulmonary disease inflammation mediators

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小兴安岭白桦林降水转化过程元素特征分析

北京林业大学学报 2015年第2期37卷 59-66页

作者：盛后财蔡体久琚存勇东北林业大学林学院

为了探究小兴安岭白桦林生态系统在降水转化过程中养分循环及养分平衡的变化特征,采用生态系统野外长期定位观测和采样的方法,并利用ICP发射光谱分析仪对小兴安岭白桦林穿透雨、树干径流以及林外雨中的K、Ca、Si、Mg和Mn共5种养分元素... 详细信息

为了探究小兴安岭白桦林生态系统在降水转化过程中养分循环及养分平衡的变化特征,采用生态系统野外长期定位观测和采样的方法,并利用ICP发射光谱分析仪对小兴安岭白桦林穿透雨、树干径流以及林外雨中的K、Ca、Si、Mg和Mn共5种养分元素进行了测定,结合白桦林对大气降雨的截留再分配比例,计算了白桦林内各元素的输入量,结果表明:1)大气降雨中各养分元素年均质量浓度Ca为最高(10.807 mg/L),Mn最低(0.069 mg/L),其排序为Ca>K>Si>Mg>Mn;大气降雨中养分输入量排序与养分年均质量浓度有相同排序规律;2)穿透雨与树干径流中的各元素年均质量浓度规律一致,均为Ca>K>Mg>Si>Mn;与大气降雨相比,穿透雨和树干径流中养分元素的年均浓度均有不同幅度的增长;3)大气降雨中除Ca元素外,其他元素的变异系数均大于1,其中K的变异系数最大(1.514),Ca的变异系数最小(0.827);白桦林穿透雨、树干径流中Mg元素变异系数均为最大,分别为0.989和0.827,最小变异系数分别为Si(0.46)和Mn(0.459);与大气降雨相比,穿透雨和树干径流中各养分元素的变异系数均小于降雨中该元素的变异系数;4)白桦林各元素年净输入量为K>Mg>Si>Mn>Ca,且Ca元素的年净输入量为负值。

关键词：大气降雨白桦林穿透雨树干径流元素特征养分输入

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一种新型变壁厚涡旋型线的构建理论

吉林大学学报（工学版） 2020年第5期50卷 1627-1634页

作者：侯才生刘涛郭李先兰州理工大学机电工程学院兰州730050

在深入研究涡旋压缩机型线构造方式的基础上,提出了一种利用Frenet活动标架构建涡旋型线的新方法,利用该方法构建了一种新型的变壁厚涡旋型线,并建立了该型线的基本几何理论,详细推导了工作腔容积。在此基础上引入了压缩比、面积利用系... 详细信息

在深入研究涡旋压缩机型线构造方式的基础上,提出了一种利用Frenet活动标架构建涡旋型线的新方法,利用该方法构建了一种新型的变壁厚涡旋型线,并建立了该型线的基本几何理论,详细推导了工作腔容积。在此基础上引入了压缩比、面积利用系数、轴向气体力和切向气体力4个性能指标,对其性能进行评估。结果表明:在相同几何参数条件下,与传统的变壁厚涡旋型线相比,新型变壁厚涡旋型线的各项性能均较优,不但压缩比和面积利用系数分别提高了7.15%和4.84%,而且所受的轴向气体力和切向气体力也明显较小。可见,采用新型的变壁厚涡旋型线有助于进一步提高涡旋压缩机的性能。

关键词：机械设计涡旋压缩机 Frenet活动标架变壁厚涡旋型线几何理论性能指标气体力

大兴安岭山地樟子松天然林土壤水分物理性质及水源涵养功能研究

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水土保持学报 2011年第2期25卷 87-91,96页

作者：李奕满秀玲蔡体久盛后财东北林业大学林学院哈尔滨150040

对大兴安岭山地樟子松天然林土壤水分物理性质及水源涵养能力进行研究,结果表明,0-20 cm土层土壤含水量、土壤毛管孔隙度、总孔隙度、枯落物蓄积量和蓄水量均表现为：坡下〉坡中〉坡上,土壤含水量变化范围为278.71~377.98 g/kg,平均值为... 详细信息

对大兴安岭山地樟子松天然林土壤水分物理性质及水源涵养能力进行研究,结果表明,0-20 cm土层土壤含水量、土壤毛管孔隙度、总孔隙度、枯落物蓄积量和蓄水量均表现为：坡下〉坡中〉坡上,土壤含水量变化范围为278.71~377.98 g/kg,平均值为327.67 g/kg;整个坡面土壤毛管孔隙和总孔隙度平均值分别为29.08%和53.15%;枯落物蓄积量和最大蓄水量分别为16.72,53.24 t/hm2。0-20 cm土层土壤容重随坡位降低有减小趋势,其平均值为0.84 g/cm3。土壤非毛管孔隙、土壤毛管蓄水量、有效蓄水量、最大蓄水量均表现为：坡下〉坡上〉坡中。整个坡面平均毛管蓄水量、有效蓄水量和最大蓄水量分别为625.90,499.05,1 130.29 t/hm2。樟子松天然林林地蓄水能力也表现为：坡下〉坡上〉坡中,坡下为1 358.51 t/hm2,坡上为1 102.09 t/hm2,坡中为1 058.85 t/hm2,平均蓄水量为1 183.54 t/hm2。由此可见,山地樟子松天然林蓄水能力受坡度和坡位影响较大。

关键词：大兴安岭樟子松天然林坡位土壤孔隙度蓄水量

Short- and long-term outcomes of lung volume reduction surgery

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Chinese Medical Journal 2006年第9期119卷 769-773页

作者： LI Tong hou sheng-cai LI Hui HU Bin MIAO Jin-bai ZHANG Zhen-kui WANG Yang FU Yi-li YOU Bin Department of Thoracic Surgery Beijing Chaoyang Hospital Capital University of Medical Sciences Beijing 100020 China

In 1957, Brantigan applied lung volume reduction surgery （LVRS） to the treatment of emphysema. In 1995, Cooper reused this operation and obtained remarkable benefit in patients with chronic obstructive pulmonary disease （COPD）. Although there are still some doubts about the effect of LVRS, in the past 10 years, a lot of clinical information approved that LVRS can give benefit to more than 70% of COPD patients. At present, a series of researches in long-term investigation and function evaluation such as NETT have got elementary affirmative conclusion about some disputative problems.

关键词： chronic obstructive pulmonary disease lung volume reduction surgery early-term result long-term result

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人工落叶松林降雨截留再分配及其水化学特征

水土保持学报 2009年第2期23卷 79-83,89页

作者：盛后财蔡体久朱道光石福臣东北林业大学林学院黑龙江哈尔滨150040 黑龙江省科学院自然资源研究所黑龙江哈尔滨150040 南开大学生命科学学院天津300071

以凉水国家级自然保护区内的人工落叶松林为研究对象,对其林冠截留再分配和水化学特征变化进行了系统研究,结果表明:(1)一个生长季内(4-9月),人工落叶松林林冠总截留量为109.19 mm,占同期降雨量21.71%,穿透雨量为393.39 mm,占同期降雨量... 详细信息

以凉水国家级自然保护区内的人工落叶松林为研究对象,对其林冠截留再分配和水化学特征变化进行了系统研究,结果表明:(1)一个生长季内(4-9月),人工落叶松林林冠总截留量为109.19 mm,占同期降雨量21.71%,穿透雨量为393.39 mm,占同期降雨量的78.20%;树干茎流量为0.47 mm,占同期降雨量的0.093%;(2)按照各养分元素月平均浓度排序,林外雨为:Ca>K>Mg>Si>Mn>Na>Fe,穿透雨为:Ca>K>Si>Na>Mg>Fe>Mn,树干茎流为:Ca>Na>Mg>Si>K>Mn>Fe,且不同样品按照养分元素浓度稳定度排序为:树干茎流>穿透雨>林外雨;(3)人工落叶松林养分元素净输入排序为:K>Mg>Mn>Na>Fe>Ca>Si,净输入量依次为22.339,2.920,0.856,-0.216,-0.260,-1.280,-2.478 kg/hm2,其中,穿透雨占人工落叶松林(穿透雨+树干茎流)元素输入量的98.23%,树干茎流占1.77%。

关键词：人工落叶松林林冠截留穿透雨树干茎流养分输入

大兴安岭地区天然樟子松林降雪截留及积雪特征

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水土保持学报 2014年第5期28卷 124-128页

作者：李奕蔡体久盛后财俞正祥东北林业大学林学院哈尔滨150040

为研究大兴安岭地区不同林分组成天然樟子松林降雪截留及积雪特征,选择黑龙江漠河森林生态系统定位站研究区内3种不同林分组成类型樟子松林为研究对象,对其降雪截留、积雪厚度、雪水当量及雪密度进行测量。通过对14场降雪的观测分析,结... 详细信息

为研究大兴安岭地区不同林分组成天然樟子松林降雪截留及积雪特征,选择黑龙江漠河森林生态系统定位站研究区内3种不同林分组成类型樟子松林为研究对象,对其降雪截留、积雪厚度、雪水当量及雪密度进行测量。通过对14场降雪的观测分析,结果表明：在整个观测期内,类型Ⅰ的林冠截雪量最大,其值为16.4mm,占同期降雪量的23.66%。不同林分组成类型对林内积雪厚度和雪水当量均有显著影响（P〈0.05）,其中类型Ⅲ内积雪厚度和雪水当量最高,分别达到37.00cm和79.3mm。在3种林分组成类型樟子松林中,积雪雪水当量和雪密度均表现为10-20cm〉20-30cm〉0-10cm。不同林分组成类型樟子松林对林内积雪雪水当量有影响,但对雪密度无显著影响（P〉0.05）,其积雪雪密度范围在0.217~0.226g/cm3之间。相比于林外空地积雪的保存率（36.04%）来看,类型Ⅲ的保存效率最高,达到57.99%,类型Ⅱ次之,为53.86%;类型Ⅰ最低,仅为50.92%。由此可见,森林具有保存积雪的效应。

关键词：大兴安岭樟子松降雪截留积雪

以奥运会为契机建立重大活动医疗保障的长效机制

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中华医院管理杂志 2009年第6期25卷 421-424页

作者：闫勇胡燕生侯生才首都医科大学附属北京朝阳医院北京100020

在北京奥运会定点医院的医疗保障过程中，北京朝阳医院在组织管理体系的建设、医务人员服务效果的保障、服务体系的有效衔接、医疗服务质量的实时改进、信息的全面管理和应急救治系统的建设等方面取得一定的经验和体会，并将其转化为长... 详细信息

在北京奥运会定点医院的医疗保障过程中，北京朝阳医院在组织管理体系的建设、医务人员服务效果的保障、服务体系的有效衔接、医疗服务质量的实时改进、信息的全面管理和应急救治系统的建设等方面取得一定的经验和体会，并将其转化为长效机制，促使医院管理水平得以提高，对今后重大活动的医疗保障将产生深远影响。

关键词：奥运会医疗保障重大活动长效机制

Donor MHC gene to mitigate rejection of transplantation in recipient mice

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Chinese Medical Journal 2011年第24期124卷 4279-4285页

作者： LI Tong YAN Jun TAN Jia-li LU Yue-ping hou sheng-cai LI Shen-tao XU Qing TONG Xue-hong DING Jie ZHANG Zhi-tai LI Hui Department of Thoracic Surgery Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Cardiae Surgery Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Experimental Centre Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Department of Orthodontics School of Stomatology FourthMilitary Medical University Xi＇an Shaanxi 710032 China Department of Molecular Biology Capital Medical University Beijing 100069 China Department of Thoracic Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Donor organ rejection continues to be a significant problem for patients receiving transplants. We therefore tested whether transferring a donor＇s major histocompatibility complex （MHC） gene to the recipient would mitigate the rejection of transplanted hearts in mice. Methods H-2K^kgene from donor mice was amplified using nested polymerase chain reaction （PCR） and ligated into a mammalian expression vector, which was then transfected into thymus ground mass cells collected from the recipients. Clones stably expressing the transgene were then injected into the recipients＇ thymus visualized using ultrasound. Control mice were administered cells previously transfected with empty vector. Following heart transplantation, cardiac activity was monitored electrocardiographically. Recipient thymus cells were tested for MHC antigenicity using flow cytometry and spleen cells were subjected to mixed lymphocyte culture tests. Finally, the transplanted hearts were sectioned, stained and examined under light microscopy. Results Southern analysis following nested PCR revealed clear expression of H-2K^ gene. Following transplantation, electrocardiosignals were detectable highly significantly longer in recipients administered thymal cells expressing donor H-2K^ than in those receiving control cells. Flow cytometric analysis using an anti-H-2K^ antibody confirmed its expression in H-2K^ treated recipients but not in control mice. Mixed lymphocyte cultures containing H-2K^ treated cells showed significantly less proliferation than those containing control cells. Hearts from control mice showed substantially greater lymphocyte infiltration than those from H-2K^ treated mice and large areas of necrosis. Conclusion Rejection of transplanted hearts can be mitigated substantially by introducing the donor＇s MHC into the recipient.

关键词： major histocompatibility complex transplantation gene transference tolerance