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The Grand Canonical Monte Carlo Simulations of Benzene and Propylene in ITQ-1 Zeolite

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Chinese Chemical Letters 2000年第7期11卷 623-626页

作者： Li Li ZHU, Ting jun hou Xiao Jie XU(College of Chemistry and Molecular Engineering, Peking University, Beijing 100871) Coll. of Chem. and Molec. Eng. Peking University Beijing 100871 China

Grand Canonical Monte Carlo (GCMC) simulations have been performed to study the localization and adsorption behavior of benzene and propylene, in purely siliceous MWW zeolite (ITQ-1). By analyzing the locations of benzene and propylene in ITQ-1, it can be deduced that the alkylation of benzene and propylene will mainly happen in 12-MR supercages at the external surface or close to the external surface. The adsorption isotherms of benzene and propylene at 315K and 0 similar to 3.5kPa are predicted, and the results for benzene generally coincide with the trend from the experiments of a series of aromatic compounds.

关键词： Grand Canonical Monte Carlo (GCMC) ITQ-1 adsorption diffusion

TCM-based new drug discovery and development in China

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Chinese Journal of Natural Medicines 2014年第4期12卷 241-250页

作者： WU Wan-Ying hou Jin-jun LONG Hua-Li YANG Wen-Zhi LIANG Jian GUO De-An Shanghai Research Center for Modernization of Traditional Chinese Medicine and National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences

Over the past 30 years, China has significantly improved the drug development environment by establishing a series of policies for the regulation of new drug approval. The regulatory system for new drug evaluation and registration in China was gradually developed in accordance with international standards. The approval and registration of TCM in China became as strict as those of chemical drugs and biological products. In this review, TCM-based new drug discovery and development are introduced according to the TCM classification of nine categories.

关键词： China China Food and Drug Administration(CFDA) Traditional Chinese Medicine Regulatory classification Drug discovery Drug development

Soil Organic Carbon Accumulation Increases Percentage of Soil Olsen-P to Total P at Two 15-Year Mono-Cropping Systems in Northern China

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Journal of Integrative Agriculture 2014年第3期13卷 597-603页

作者： SHEN Pu HE Xin-hua XU Ming-gang ZHANG Hui-min PENG Chang GAO Hong-jun LIU Hua XU Yong-mei QIN Song XIAO hou-jun Key Laboratory of Crop Nutrition and Fertilization Ministry of Agriculture/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences School of Plant Biology University of Western Australia Institute of Agricultural Resources and Environment Jilin Academy of Agricultural Sciences Institute of Soil and Fertilizer Xinjiang Academy of Agricultural Sciences Guizhou Institue of Soil and Fertilizer

Soil organic carbon （SOC） and soil Olsen-P are key soil fertility indexes but information on their relationships is limited particularly under long-term fertilization. We investigated the relationships between SOC and the percentage of soil Olsen-P to total P （PSOPTP） under six different 15-yr （1990-2004） long-term fertilizations at two cropping systems in northern China. These fertilization treatments were （1） unfertilized control （control）; （2） chemical nitrogen （N）; （3） N plus chemical P （NP）; （4） NP plus chemical potassium （NPK）; （5） NPK plus animal manure （NPKM） and （6） high NPKM （hNPKM）. Compared with their initial values in 1989 at both sites, during the 1 lth to 15th fertilization years annual mean SOC contents were significantly increased by 39.4-47.0% and 58.9-93.9% at Gongzhuling, Jilin Province, and Urumqi, Xinjiang, China, under the two NPKM fertilizations, respectively, while no significant changes under the no-P or chemical P fertilization. During the 1 lth to 15th fertilization years, annual mean PSOPTP was respectively increased by 2.6-4.2 and 5.8-14.1 times over the initial values under the two chemical P fertilizations and the two NPKM fertilizations, but was unchanged in their initial levels under the two no-P fertilizations at both sites. Over the 15-yr long-term fertilization SOC significantly positively correlated with PSOPTP （r^2=0.55-0.79, P〈0.01）. We concluded that the combination of chemical P plus manure is an effective way to promote SOC accumulation and the percentage of soil Olsen-P to total P at the two mono-cropping system sites in northern China.

关键词： long-term fertilization phosphorus availability black soil grey desert soil

Glomus tumor in the stomach:Computed tomography and endoscopic ultrasound findings

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World Journal of Gastroenterology 2013年第8期19卷 1327-1329页

作者： Min Tang jun hou Dong Wu Xin-Ye Han Meng-Su Zeng Xiu-Zhong Yao Department of Radiology Zhongshan Hospital of Fudan University Department of Medical Image Shanghai Medical College of Fudan University Department of Pathology Zhongshan Hospital of Fudan University

A 57-year-old man presented with intermittent dull abdominal pain after a period of 1 *** computed tomography(CT) was *** for the endoscopy,the work-up for possible medical causes remained *** open-abdomen,partial surgical excision of the stomach was performed after the unsuccessful endoscopic *** pathology report revealed a glomus tumor of the ***,glomus tumors of the stomach are rare and are almost always ***,the most important current role of imaging associated with the diagnostic approach and therapeutic plan for a glomus tumor is to differentiate it from other gastric submucosal tumors(SMTs).We report this case with representative radiologic findings,including CT and endoscopic ultrasound(EUS) reports,and also correlate them with clinical and pathologic presentations that can help in the early detection and differentiation of gastric SMTs from other *** such,the purpose of this report is to provide a better understanding of relevant CT and EUS *** treatments should be considered carefully according to the imaging results.

关键词： Glomus tumor Stomach Diagnosis Therapy

Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards

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Engineering 2019年第1期5卷 83-97页

作者： Jin-jun hou Jian-Qing Zhang Chang-Liang Yao Rudolf Bauer Ikhlas A. Khan Wan-Ying Wu De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Pharmacognosy Institute of Pharmaceutical Sciences Karl-Franzens-Universitat Graz Graz A-8010 Austria National Center for Natural Products Research School of Pharmacy The University of Mississippi University MS 38677 USA

Traditional Chinese medicines (TCMs), a complex system of natural resources with many diverse components, are widely used as approved medicinal agents in China. Quality control of TCMs is a huge challenge for the government and for testing institutes and is associated with numerous scientific issues. Among these considerations include the following questions: How many components are in TCMs? How can the multiple components in TCMs be comprehensively delineated and subsequently characterized? What is the level and range of these (active) metabolites within these multiple-component TCMs, in order to recommend standards? and What are the qualities required for a marker constituent to be selected, and from a practical perspective, how can these components be assessed with low cost and in a short time? All of these factors require significant and deep thinking in order to understand the individualistic chemistry of TCM in order to develop enhanced TCM quality standards for improved and consistent patient care. In this review, the latest exploratory research in TCM chemistry analytical techniques and methods is summarized in order to begin to develop responses to these scientific issues. Advances in these methods have included multidimensional separation for liquid chromatography–high-resolution mass spectrometry (LC–HRMS), smart triggering data-dependent acquisition of LC–HRMS, target analysis with liquid chromatography–mass spectrometry (LC–MS), supercritical fluid chromatography, and data mining of large mass spectrometry (MS) datasets. In addition, two quality strategies have been introduced in order to save reference standards and the analysis time for a TCM quality standard, including the application of the single standard to determine multi-components (SSDMC) and monomethodheterotrait matrix methods. Finally, a series of future improvements for analytical methods for TCMs are proposed.

关键词： Traditional Chinese medicine Liquid chromatography Mass spectrometry Data-dependent acquisition Chemometrics Untargeted Data mining Quality control

Experimental Study of Overtopping on Sea Dikes and Coastal Flooding Under the Coupled Processes of Tides and Waves

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China Ocean Engineering 2022年第3期36卷 413-426页

作者： LI Yan-ting ZENG Cheng-jie Zhao Yi-han HU Po SUN Tian-ting hou Yi-jun MO Dong-xue WANG Deng-ting School of Civil Engineering Tianjin UniversityTianjin 300350China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China Water Resources Department of Jiangsu Province Nanjing 210029China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean and Climate Dynamics Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Storm surges are cataclysmic natural disasters that occur along the coasts and are usually accompanied by large *** effects of coupled storm surges and waves can pose a significant threat to coastal *** labo-ratory studies on the effects of storm surges and waves on coastal structures have typically utilized steady water levels and constant wave *** indoor simulation of the coupled processes of tides and waves is developed by adding a tide generation system to an existing laboratory wave basin to model continuous dynamic tide levels so that tide generation and wave-making occur synchronously in the *** experimental methods are given,which are applied to further study waves overtopping on artificial sea dikes and coastal flooding evolution under the coupled actions of tides and *** results of the overtopping discharge obtained by the test with a dynamic water level are compared with those obtained from steady water level tests and the existing empirical *** addition,the impacts of ecological coastal shelterbelts and structures on coastal flood processes and distributions are also *** proposed simulation methods provide a new approach for studying the effects of storm surges and waves on coastal *** study also aims to provide a reference for coastal protective engineering.

关键词： storm surge water level variation wave overtopping coastal flooding experimental technique

Current Status and Future Perspective in the Globalization of Traditional Chinese Medicines

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World Journal of Traditional Chinese Medicine 2015年第1期1卷 1-4页

作者： Wan-Ying Wu Wen-Zhi Yang Jin-jun hou De-An Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine and National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences

Globalization of traditional Chinese medicines started around 1996, which was initiated by the Chinese government. However, substantial progress was only achieved in recent years including the adoption of TCM quality monographs in the western pharmacopoeias(United States Pharmacopoeia and European Pharmacopoeia) and registration in main stream drug regulatory agencies such as US Food and Drug Administration(FDA) and European Medicines Agency(EMA). So far, several TCM herbal quality monographs were adopted by the United States Pharmacopoeia including Chinese Salvia, Ganoderma lucidum and Panax notoginseng, etc. Over 45 TCM quality monographs were recorded in the European Pharmacopoeia with 20 more in progress. After the successful registration of the first TCM product named Diao Xin Xue Kang as traditional medicine via the Medicines Evaluation Board of the Netherlands, several other TCM herbal products are in the registration process in several European member states. So far, there has been still not any TCM product authorized as a drug by the FDA regardless of a few TCM products in phase III or phase II clinical trials. This review summarizes the progress made in the globalization of traditional Chinese medicines in recent years and future issues in this regard.

关键词： Globalization Traditional Chinese Medicine(TCM) Quality Monograph Registration regulation

Allograft rejection-related gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 820-828页

作者： Yang LI Hang YAN Wu-jun XUE Pu-xun TIAN Xiao-ming DING Xiao-ming PAN Xin-shun FENG Xiao-hui TIAN He-li XIANG jun hou Department of Renal Transplantation Center of Nephropathy the First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China The two authors contributed equally to this work

Objective： To explore the effects of cytomegalovirus （CMV） infection on rejection-related gene expression in the endothelial cells of renal transplantation recipients. Methods： Endothelial cells （ECs） were cultured and stimulated by a variety of factors： A, normal control group; B, inactivated human cytomegalovirus （HCMV） infection group; C, HCMV infection group; D, HCMV supematant infection group; and E, ganciclovir HCMV group. Expression of intercellular adhesion molecule-1 （ICAM-1） and major histocompability complex （MHC） class I and class II antigens was detected by flow cytometry （FCM） and immuno- histochemistry. Results： We found characteristic CMV-infected ECs in this study. There were no significant differences among groups A, B and D （P〉0.05）. Although the expression levels of ICAM-1 were not significantly different between groups C and E （P〉0.05）, the ICAM-1 expression in these two groups was significantly higher than that in group A （P〈0.05）. ICAM-1 expression was detected in groups C and E, while there was no expression in groups A, B and D. Furthermore, there was no significant difference of ICAM-1 mRNA expression between groups C and E （P〉0.05）. Human leucocyte antigen （HLA）-ABC expression was detected in all the groups, while HLA-DR expression was only detected in groups C and E. There were no significant dif- ferences of HLA-ABC and HLA-DR expression among groups A, B and D （P〉0.05）. However, the HLA-ABC and HLA-DR expression levels in groups C and D were higher than those of the remaining groups previously reported （P〈0.05）. Meanwhile, the HLA-ABC and HLA-DR expression levels in group E were lower than those of group C （P〈0.05）. Conclusion： CMV could up-regulate the expression levels of ICAM-1 and MHC antigens, which was closely related to allograft rejection.

关键词： Renal transplantation Cytomegalovirus (CMV) Rejection Intercellular adhesion molecule-1 (ICAM-1) Major histocompability complex (MHC)

THE EFFECTS OF MONSOONS AND CONNECTIVITY OF SOUTH CHINA SEA ON THE SEASONAL VARIATIONS OF WATER EXCHANGE IN THE LUZON STRAIT

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Journal of Hydrodynamics 2009年第2期21卷 264-270页

作者： ZHAO Wei hou Yi-jun QI Peng LE Ken-tang LI Ming-kui Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China National Meteorological Center Beijing 100081 China

Seasonal variations of water exchange in the Luzon Strait are studied numerically using the improved Princeton Ocean Model （POM） with a consideration of the effects of connectivity of South China Sea （SCS） and monsoons. The numerical simulations are carried out with the strategy of variable grids, coarse grids for the Pacific basin and fine grids for the SCS. It is shown that the Mindoro Strait plays an important role in adjusting the water balance between the Pacific and the SCS. The SCS monsoon in summer seasons hinders the entrance of the Pacific water into the SCS through the Luzon Strait while the SCS monsoon in winter seasons promotes the entrance of Pacific water into the SCS through the Luzon Strait. However, the SCS monsoon does not affect the annual mean Luzon Strait transport, as is mainly determined by the Pacific basin wind.

关键词： numerical experiment Kuroshio Luzon Strait transport seasonal variation