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Changes in lumbosacral spinal nerve roots on diffusion tensor imaging in spinal stenosis

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Neural Regeneration Research 2015年第11期10卷 1860-1864页

作者： Zhong-jun hou Yong Huang Zi-wen Fan Xin-chun Li Bing-yi Cao Department of Radiology the Second Affiliated Hospital of Guangzhou Medical University Department of Orthopedics the Second Affiliated Hospital of Guangzhou Medical University Department of Radiology the First Affiliated Hospital of Guangzhou Medical University

Lumbosacral degenerative disc disease is a common cause of lower back and leg pain. Conventional T1-weighted imaging（T1WI） and T2-weighted imaging（T2WI） scans are commonly used to image spinal cord degeneration. However, these modalities are unable to image the entire lumbosacral spinal nerve roots. Thus, in the present study, we assessed the potential of diffusion tensor imaging（DTI） for quantitative assessment of compressed lumbosacral spinal nerve roots. Subjects were 20 young healthy volunteers and 31 patients with lumbosacral stenosis. T2 WI showed that the residual dural sac area was less than two-thirds that of the corresponding normal area in patients from L3 to S1 stenosis. On T1 WI and T2 WI, 74 lumbosacral spinal nerve roots from 31 patients showed compression changes. DTI showed thinning and distortion in 36 lumbosacral spinal nerve roots（49%） and abruption in 17 lumbosacral spinal nerve roots（23%）. Moreover, fractional anisotropy values were reduced in the lumbosacral spinal nerve roots of patients with lumbosacral stenosis. These findings suggest that DTI can objectively and quantitatively evaluate the severity of lumbosacral spinal nerve root compression.

关键词： nerve regeneration magnetic resonance imaging diffusion tensor imaging lumbosacralarea degeneration nerve root fractional anisotropy neural regeneration

The electromagnetic and gravitational-wave radiations of X-ray transient CDF-S XT2

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Research in Astronomy and Astrophysics 2021年第2期21卷 180-186页

作者： hou-jun Lü Yong Yuan Lin Lan Bin-Bin Zhang Jin-Hang Zou En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210093China Space Science and Technology Hebei Normal UniversityShijiazhuang 050000China

Binary neutron star(NS)mergers may result in remnants of supra-massive or even stable NS,which have been supported indirectly by observed X-ray plateau of some gamma-ray burst(GRB)***,Xue et al.(2019)discovered an X-ray transient CDF-S XT2 that is powered by a magnetar from merger of double NS via X-ray plateau and following stepper ***,the decay slope after the plateau emission is slightly larger than the theoretical value of spin-down in electromagnetic(EM)dominated by losing its rotation *** this paper,we assume that the feature of X-ray emission is caused by a supra-massive magnetar central engine for surviving thousands of seconds to collapse into a black *** this scenario,we present the comparisons of the X-ray plateau luminosity,break time,and the parameters of magnetar between CDF-S XT2 and other short GRBs with internal plateau *** adopting the collapse time to constrain the equation of state(EOS),we find that three EOSs(GM1,DD2,and DDME2)are consistent with the observational *** the other hand,if the most released rotation energy of magnetar is dominated by GW radiation,we also constrain the upper limit of ellipticity of NS for given EOS,and its range is[0.32-1.3]×10^(-3).Its GW signal cannot be detected by Advanced LIGO or even for more sensitive Einstein Telescope in the future.

关键词： stars magnetars

Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum

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Chinese Journal of Natural Medicines 2019年第12期17卷 963-969页

作者： HUANG Guang-Hui LEI Chun ZHU Ke-Xin LI Jing-Ya LI Jia hou Ai-jun School of Pharmacy State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 201203China National Center for Drug Screening State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron *** 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtures by chiral *** structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD *** 1 a/1 b,2 a/2 b,3 b,4 a/4 b,and 5 a/5 b were new meroterpenoids with different polycyclic *** enantiomeric pairs(2 a/2 b and 3 a/3 b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1 B(PTP1 B)in vitro.

关键词： Rhododendron fastigiatum Meroterpenoid enantiomers Protein tyrosine phosphatase 1B

I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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China Foundry 2024年第3期21卷 239-247页

作者： Ming-jun hou Hao Dong Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research Institute Chongqing 400039China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

Dynamic responses of K-type and inverted-K-type jacket support structures for offshore wind-turbines

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Journal of Central South University 2017年第4期24卷 947-956页

作者： LIAO Ying-di GUO Meng-yuan WANG Na hou Li-jun CHEN Da Key Laboratory of Coastal Disaster and Defence Ministry of Education (Hohai University) Nanjing 210098 China College of Harbor Coastal and Offshore Engineering Hohai University Nanjing 210098 China

The jacket structure has become more popular as the offshore wind-turbine support structure. K-type and inverted-K-type jacket support structures have superior potential due to their fewer joints and lower cost of manufacture and installation. A numerical study was presented on the dynamic responses of K-type and inverted-K-type jacket support structures subjected to different kinds of dynamic load. The results show that the inverted-K-type jacket structure has higher natural frequencies than the K-type. The wave force spectrum response shows that the maximum displacement of the K-type jacket structure is larger than that of the inverted-K-type. The time-history responses under wind and wave-current load indicate that the inverted-K-type jacket structure shows smaller displacement and stress compared with the K-type, and presents different stress concentration phenomena. The dynamic responses reveal that the inverted-K-type of jacket support structure has greater stiffness and superior mechanical properties, and thus is more applicable in the offshore area with relatively deep water.

关键词： jacket support structure K-type inverted-K-type foundation dynamic responses

The atomic path for constructing single-helical superstructure of AuCu bimetallic nanoclusters

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Aggregate 2023年第3期4卷 169-174页

作者： Ancheng Tang Xiao Cai Yong Liu jun hou Xu Liu Mingyang Chen Yan Zhu Key Lab of Mesoscopic Chemistry of MOE and Jiangsu Key Lab of Vehicle Emissions Control School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina Center for Green Innovation School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingChina

Single-helical or double-helical structures are common in living *** assembly has been found in the artificial nanoparticles,but how they do so remains poorly ***,we exploit atomically precise Au_(6)Cu_(6)bimetallic nanoparticles(or called nanoclusters)as building blocks to construct a single-helical Au_(12)Cu_(12)superstructure in an operative path,thereby providing access to currently elusive mechanistic *** propose that the thermodynamically viable linearto-bent process at a couple of Au_(6)Cu_(6)nanoclusters imparted by the organic ligands seems to be critical for the helical-nanostructured arrangement of Au_(12)Cu_(12).This study could help to offer a new design rule for the exquisitely helical structure assembled from the artificial nanoparticles.

关键词： assembly atomic structure AuCu helical structure nanocluster

Two New Gallotannins from Pistacia weinmannifolia

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Chinese Chemical Letters 2000年第1期11卷 53-56页

作者： Ai jun hou Li Yan PENG Yan Ze LIU Zhong Wen LIN Han Dong SUN Laboratory of phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Department of Phytochemistry Henan College of Traditional Chinese MedicieZhengzhou 450003

Two new gallotannins, pistafolins A (1) and B (2), were isolated from the leaf extract of Pistacia weinmannifolia. Their structures were determined by spectral methods.

关键词： Pistacia weinmannifolia Anacardiaceae gallotannin pistafolin A pistafolin B

Selenocysteine antagonizes oxygen glucose deprivation-induced damage to hippocampal neurons

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Neural Regeneration Research 2018年第8期13卷 1433-1439页

作者： Xian-jun Wang Mei-Hong Wang Xiao-Ting Fu Ya-jun hou Wang Chen Da-Chen Tian Su-Yun Bai Xiao-Yan Fu Department of Neurology People's Hospital of Linyi Linyi Shandong Province China Department of Neurology People's Hospital of Yishui Linyi Shandong Province China School of Basic Medicine Taishan Medical University Taian Shandong Province China

Designing and/or searching for novel antioxidants against oxygen glucose effective strategy for the treatment of human isdlemic stroke. Selenium is deprivation （OGD）-induced oxidative damage represents an an essential trace dement, which is beneficial in the chemo- prevention and chemotherapy of cerebral ischemic stroke. The underlying mechanisms for its therapeutic effects, however, are not well documented. Selenocysteine （SeC） is a selenium-containing amino acid with neuroprotective potential. Studies have shown that SeC can reduce irradiation-induced DNA apoptosis by reducing DNA damage. In this study, the in vitro protective potential and mechanism of action of SeC against OGD-induced apoptosis and neurotoxicity were evaluated in HT22 mouse hippocampal neurons. We cultured HT22 cells in a glucose-free medium containing 2 mM Na2S402, which formed an OGD environment, for 90 minutes. Findings from MTT, flow cytometry and TUNEL staining showed obvious cytotoxicity and apoptosis in HT22 cells in the OGD condition. The activation of Caspa se-7 and Caspase-9 further revealed that OGD-induced apoptosis of HT22 cells was mainly achieved by triggering a mitochondrial-medi- ated pathway. Moreover, the OGD condition also induced serious DNA damage through the accumulation of reactive oxygen species and superoxide anions. However, SeC pre-treatment for 6 hours effectively inhibited OGD-induced cytotoxicity and apoptosis in HT22 cells by inhibiting reactive oxygen species-mediated oxidative damage. Our findings provide evidence that SeC has the potential to suppress OGD-induced oxidative damage and apoptosis in hippocampal neurons.

关键词： selenium selenocysteine ischemic stroke oxygen glucose deprivation hippocampal neuron mitochondria reaction oxygen species superoxide anion oxidative damage apoptosis

A Testing Method for Web Services Composition Based on Data-Flow

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Wuhan University Journal of Natural Sciences 2008年第4期13卷 455-460页

作者： hou jun XU Baowen XU Lei WANG Di XU junling School of Computer Science and Engineering SoutheastUniversity Nanjing 211189 Jiangsu China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China

This paper proposes a method of data-flow testing for Web services composition. Firstly, to facilitate data flow analysis and constraints collecting, the existing model representation of business process execution language （BPEL） is modified in company with the analysis of data dependency and an exact representation of dead path elimination （DPE） is proposed, which over-comes the difficulties brought to dataflow analysis. Then defining and using information based on data flow rules is collected by parsing BPEL and Web services description language （WSDL） documents and the def-use annotated control flow graph is created. Based on this model, data-flow anomalies which indicate potential errors can be discovered by traversing the paths of graph, and all-du-paths used in dynamic data flow testing for Web services composition are automatically generated, then testers can design the test cases according to the collected constraints for each path selected.

关键词： Web services composition business process execution language (BPEL) Web services description language (WSDL) data flow all-du-path