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Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu Jun-wei Lv Cai-Yun Ma Xiao-Hui Ma Dong Xing hou-Sheng Ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinical Medical College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the application and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from May 2018 to January *** were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,Ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal carcinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum carbohydrate antigen 19-9 Serum carbohydrate antigen 125

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Bioinspired Double-stranded Yarn with Alternating Hydrophobic/Hydrophilic Patterns for High-efficiency Fog Collection

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Chinese Journal of Polymer Science 2024年第7期42卷 968-975,I0008页

作者： Lan-Lan hou Meng-Na Qiu Ya-Qiong Wang Tong-Hua Bai zhi-Min Cui Jing-Chong Liu Ying-Qun Qi Nü Wang Yong Li Yong Zhao Beijing Institute of Graphic Communication Beijing102600China Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100191China Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Beijing Key Laboratory for Bioengineering and Sensing TechnologyDaxing Research InstituteSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China

Efforts to develop innovative water harvesting strategies offer powerful solutions to alleviate the water crisis,especially in remote and arid *** by the hydrophobic/hydrophilic pattern of desert beetles and water self-propulsion property of spider silks,a double-strand hydrophobic PVDF-HFP/hydrophilic PAN nanofibers yarn is proposed by electrospinning and twisting *** double-strand cooperation approach allows for water deposition on hydrophobic PVDF-HFP segment and transport under the asymmetric capillary driving force of hydrophilic PAN segment,thus speeded up the aggregation and growth of *** effects of the composition and the diameter ratio of the two primary yarns were studied and optimized for boosting fog collection *** double-strand anisotropic yarn not only provide an effective method for water harvesting,but also hold the potential to inspire innovative design concepts for fog collection materials in challenging environments.

关键词： Fog collection Wettability Electrospinning Nanofibers Spider silk

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A preliminary site selection system for underground hydrogen storage in salt caverns and its application in Pingdingshan,China

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Deep Underground Science and Engineering 2024年第1期3卷 117-128页

作者： Liangchao Huang Yanli Fang Zhengmeng hou Yachen Xie Lin Wu Jiashun Luo Qichen Wang Yilin Guo wei Sun Sino‐German Research Institute of Carbon Neutralization and Green Development Zhengzhou UniversityZhengzhouChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany Research Centre of Energy Storage Technologies Clausthal University of TechnologyGoslarGermany Sino‐German Energy Research Center Sichuan UniversityChengduChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunmingChina

Large‐scale underground hydrogen storage(UHS)provides a promising method for increasing the role of hydrogen in the process of carbon neutrality and energy *** all the existing storage deposits,salt caverns are recognized as ideal sites for pure hydrogen *** and optimization of site selection for hydrogen storage facilities in salt caverns have become significant *** this article,the software CiteSpace is used to analyze and filter hot topics in published *** on a detailed classification and analysis,a“four‐factor”model for the site selection of salt cavern hydrogen storage is proposed,encompassing the dynamic demands of hydrogen energy,geological,hydrological,and ground factors of salt ***,20 basic indicators for comprehensive suitability grading of the target site were screened using the analytic hierarchy process and expert survey methods were adopted,which provided a preliminary site selection system for salt cavern hydrogen ***,the developed system was applied for the evaluation of salt cavern hydrogen storage sites in the salt mines of Pingdingshan City,Henan Province,thereby confirming its rationality and *** research provides a feasible method and theoretical basis for the site selection of UHS in salt caverns in China.

关键词： analytic hierarchy process(AHP) evaluation index hydrogen storage salt cavern site selection

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Electron-deficient ZnO induced by heterointerface engineering as the dominant active component to boost CO_(2)-to-formate conversion

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Carbon Energy 2024年第5期6卷 127-136页

作者： Qing Qin Zijian Li Yingzheng Zhang Haeseong Jang Li Zhai Liqiang hou Xiaoqian wei Zhe Wang Min Gyu Kim Shangguo Liu Xien Liu College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoChina Department of Chemistry City University of Hong KongHong Kong SARChina Department of Advanced Materials Engineering Chung-Ang UniversityAnseong-siGyeonggi-doRepublic of Korea Beamline Research Division Pohang Accelerator Laboratory(PAL)PohangRepublic of Korea

Electrocatalytic CO_(2)-to-formate conversion is considered an economically viable *** general,Zn-based nanomaterials are well-known to be highly efficient electrocatalysts for the conversion of CO_(2) to CO,but seldom do they exhibit excellent selectivity toward *** this article,we demonstrate that a heterointerface catalyst ZnO/ZnSnO3 with nanosheet morphology shows enhanced selectivity with a maximum Faradaic efficiency(FE)of 86%at−0.9 V versus reversible hydrogen electrode and larger current density for the conversion of CO_(2) to formate than pristine ZnO and *** particular,the FEs of the C1 products(CO+HCOO−)exceed 98%over the potential *** experimental measurements combined with theoretical calculations revealed that the ZnO in ZnO/ZnSnO3 heterojunction delivers the valence electron depletion and accordingly optimizes Zn d-band center,which results in moderate Zn-O hybridization of HCOO*and weakened Zn-C hybridization of competing COOH*,thus greatly boosting the HCOOH *** study highlights the importance of charge redistribution in catalysts on the selectivity of electrochemical CO_(2) reduction.

关键词： charge redistribution CO_(2)reduction reaction electrocatalyst heterointerfaces selectivity

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带电Top-pion介子产生过程的研究

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河南师范大学学报（自然科学版） 2012年第3期40卷 60-61,91页

作者：侯志伟李霞郭鹏河南工业大学理学院郑州450001 解放军信息工程大学理学院郑州450001 中原工学院理学院郑州450007

在顶色辅助的人工色(TC2)模型框架下,研究了带电的top-pion介子Πt-在光子对撞机上的产生过程γγ→t■Πt-.研究表明该过程的产生截面随质心能量的增加而增加,在TC2模型合理的参数空间内,其产生截面可达几十个fb的量级,在未来的高能直... 详细信息

在顶色辅助的人工色(TC2)模型框架下,研究了带电的top-pion介子Πt-在光子对撞机上的产生过程γγ→t■Πt-.研究表明该过程的产生截面随质心能量的增加而增加,在TC2模型合理的参数空间内,其产生截面可达几十个fb的量级,在未来的高能直线对撞机上可产生足够多的可观测事例.另外,由于存在味改变的Πt-c■耦合,通过衰变道Πt-→c■探测Πt-背景比较干净,所以通过此过程可在将来的高能直线对撞机上实验中探测到的明显信号.

关键词： TC2模型产生截面 top-pion介子

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Tailored energy absorption for a novel auxetic honeycomb structure under large deformation

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 63-80页

作者： Xiuhui hou Bin Wang Zichen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710129China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

In comparison to conventional hexagonal honeycomb structures,auxetic metamaterials with re-entrant configurations have exhibited superior mechanical properties in terms of energy *** further enhance the energy absorption capacity of these materials,a novel re-entrant honeycomb configuration,named novel auxetic re-entrant honeycomb(NARH),is developed by incorporating“”-shaped cell walls into the conventional auxetic re-entrant honeycomb(ARH).Two analytical models for the plateau stress are formulated to consider the plastic deformation of NARH during quasi-static compression and the dynamic impact using the linear momentum ***-static compression tests on 3D printed NARH honeycomb specimens and finite element simulations are performed to verify the effectiveness of the theoretical *** exhibits higher plateau stresses compared with ARH during compression,which can be attributed to the presence of more plastic hinges formed in *** hinges,the embedded parts with inclined cell walls,not only improve stability by forming stable triangles during compression but also enhance the energy absorption capacity.A parametric study is conducted to analyze the effect of impact velocity,thickness,and incline angle of cell walls on *** simulations demonstrate higher sensitivity of the mechanical properties to impact velocity and cell wall *** ribs to the“”-shaped cell walls in NARH further reduces the initial peak force during dynamic crushing while maintaining high energy *** research provides valuable guidelines for the design of energy absorption metamaterials.

关键词： absorption walls shaped

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Multidimensional coupled structure-activity relationship models for replacement of SF_(6)

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High Voltage 2024年第2期9卷 484-494页

作者： Mi Zhang Hua hou Baoshan Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhanChina

Computational screening of single gases to replace SF_(6)for electrical insulation has been challenged by the difficulty in combining various mutually exclusive properties especially for dielectric performance with liquefaction and environmental *** reveal the inherent correlations between dielectric strength(Er),boiling point(Tb),and global warming potential(GWP)of dielectric materials,a coupled structure-activity relationship(CSAR)model has been proposed for the first *** means of the generic descriptors,as deduced from the electrostatic potentials,and the specific descriptors,as introduced from the respective microscopic mechanisms,the complex interdependence between Er,Tb,and GWP of the insulation gases is quantitatively characterised by the 3-D coupling *** coupling mechanism for the right balance of properties is uncovered in terms of the first-principle *** CSAR model outperforms the previous SAR models in predicting Er,Tb,and GWP simultaneously in a self-consistent *** importantly,the concept of CSAR could be extended readily to any multidimensional macroscopic *** replacement compounds have been identified tentatively to be the promising candidates to replace SF_(6)using the CSAR model.

关键词： properties. dielectric insulation

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mRNA medicine:Recent progresses in chemical modification,design,and engineering

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Nano Research 2024年第10期17卷 9015-9030页

作者： Xiaowen hou Jinjun Shi Yuling Xiao Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Center for Nanomedicine and Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Messenger RNA(mRNA)is a type of RNA that carries genetic information from DNA to the ribosome,where it is translated into *** has emerged as a powerful platform for development of new types of medicine,especially after the clinical approval of COVID-19 mRNA *** modification and nanoparticle delivery have contributed to this success significantly by improving mRNA stability,reducing its immunogenicity,protecting it from enzymatic degradation,and enhancing cellular uptake and endosomal ***,substantial progresses have been made in new modification chemistries,sequence design,and structural engineering to generate more stable and efficient next-generation *** innovations could further facilitate the clinical translation of mRNA therapies and *** that numerous review articles have been published on mRNA nanoparticle delivery and biomedical applications over the last few years,we herein focus on overviewing recent advances in mRNA chemical modification,mRNA sequence optimization,and mRNA engineering(e.g.,circular RNA and multitailed mRNA),with the aim of providing new perspectives on the development of more effective and safer mRNA medicines.

关键词： mRNA self-amplifying RNA circular RNA multitailed mRNA chemical modification machine learning

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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1147-1164页

作者： Yan Guo Pan Xiang Xiaojiao Sun wei Liu Jiafeng Zhou Bin Yin Lin hou Boqin Qiang Huiliang Li Pengcheng Shu Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of Common Mechanism Research for Major Diseases Beijing 100005China Wolfson Institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Chinese Institute for Brain Research Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules to selectively activate downstream ***,we identified that DOK6,a member of the Dok(downstream of tyrosine kinases)family,is required for the maintenance of peripheral axons,and that loss of Dok6 can cause typical peripheral neuropathy symptoms in mice,manifested as impaired sensory,abnormal posture,paw deformities,blocked nerve conduction,and ***,Dok6 is highly expressed in peripheral neurons but not in Schwann cells,and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding,axon destruction,and hindered retrograde axonal ***,DOK6 acts as an adaptor protein for selectivitymediated neurotrophic signal transduction and retrograde transport for TrkC and Ret but not for TrkA and ***6 interacts with certain proteins in the trafficking machinery and controls their phosphorylation,including MAP1B,Tau and Dynein for axonal transport,and specifically activates the downstream ERK1/2 kinase pathway to maintain axonal survival and *** finding provides new clues to potential insights into the pathogenesis and treatment of hereditary peripheral neuropathies and other degenerative diseases.

关键词： impaired restrain peripheral

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Synergistic anionic/zwitterionic mixed surfactant system with high emulsification efficiency for enhanced oil recovery in low permeability reservoirs

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Petroleum Science 2024年第2期21卷 936-950页

作者： Hai-Rong Wu Rong Tan Shi-Ping Hong Qiong Zhou Bang-Yu Liu Jia-wei Chang Tian-Fang Luan Ning Kang Ji-Rui hou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Gas Production Plant 5 of PetroChina Changqing Oilfield Company PetroChinaXi'an710000ShaanxiChina College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Kazakh-British Technical University Almaty050000Kazakhstan

Emulsification is one of the important mechanisms of surfactant flooding. To improve oil recovery for low permeability reservoirs, a highly efficient emulsification oil flooding system consisting of anionic surfactant sodium alkyl glucosyl hydroxypropyl sulfonate(APGSHS) and zwitterionic surfactant octadecyl betaine(BS-18) is proposed. The performance of APGSHS/BS-18 mixed surfactant system was evaluated in terms of interfacial tension, emulsification capability, emulsion size and distribution, wettability alteration, temperature-resistance and salt-resistance. The emulsification speed was used to evaluate the emulsification ability of surfactant systems, and the results show that mixed surfactant systems can completely emulsify the crude oil into emulsions droplets even under low energy conditions. Meanwhile,the system exhibits good temperature and salt resistance. Finally, the best oil recovery of 25.45% is achieved for low permeability core by the mixed surfactant system with a total concentration of 0.3 wt%while the molar ratio of APGSHS:BS-18 is 4:6. The current study indicates that the anionic/zwitterionic mixed surfactant system can improve the oil flooding efficiency and is potential candidate for application in low permeability reservoirs.

关键词： Anionic/zwitterionic mixed surfactant system Emulsification Synergistic effect Low permeability reservoir Enhanced oil recovery

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