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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 646-652页

作者： Xuan Liu ming Liu Meng Ji Bo Ma Yu-Cen hou Xin-Yue Yao Qiao-Chu Cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** EMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were ***:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(P<0.05)in ***,the migration of RPE cells in the BMP-6 siRNA group was also significantly ***-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of E-cadherin(P<0.05).Overexpression of BMP-6 inhibited the migration of RPE cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(P<0.05).CONCLUSION:BMP-6 prevents the EMT in RPE cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

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中国入侵昆虫预防与控制研究进展

应用昆虫学报 2020年第2期57卷 244-258页

作者：彭露万方浩侯有明福建农林大学闽台作物有害生物生态防控国家重点实验室福州350002 福建省昆虫生态重点实验室福州350002 中国农业科学院深圳农业基因组研究所深圳518120 中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100193

在全球经济一体化、农业结构调整以及全球气候变化等因素的影响下,我国正面临着严峻的生物入侵问题。外来入侵昆虫是我国生物入侵的重要组成部分,阐明其传入至成灾的发生过程与机制,研发快速高效的防控技术体系具有重要意义。本文综述了... 详细信息

在全球经济一体化、农业结构调整以及全球气候变化等因素的影响下,我国正面临着严峻的生物入侵问题。外来入侵昆虫是我国生物入侵的重要组成部分,阐明其传入至成灾的发生过程与机制,研发快速高效的防控技术体系具有重要意义。本文综述了近20年来我国在外来入侵昆虫的生物学特性、种群遗传分化、种间互作与生态适应方面取得的重要研究成果,以及在入侵昆虫早期快速检测、田间监测与高效防控技术的研发与应用方面取得的进展,并提出入侵昆虫学科未来发展的方向与思路。旨在为进一步分析新时代背景下入侵昆虫的发生机制奠定基础,对丰富和完善入侵昆虫可持续控制的策略和措施也具有指导意义。

关键词：生物入侵遗传分化种间互作生态适应预防控制

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不同寄主搭配对小菜蛾生殖的影响效应

湖北农业科学 2017年第8期56卷 1480-1482,1493页

作者：黄斌侯有明福建农林大学植物保护学院/福建省昆虫生态重点实验室/农业部闽台作物有害生物综合治理重点实验室福州350002

在实验室条件下,设菜心/花菜、菜心/芥菜、菜心、芥菜、花菜5种处理,比较放虫5 d后,每种处理小菜蛾(Plutella xyllostella)的产卵量。在5 d内,菜心/芥菜组合上的小菜蛾总产卵量显著低于除花菜单作外其他处理的总产卵量,菜心/芥菜组合上... 详细信息

在实验室条件下,设菜心/花菜、菜心/芥菜、菜心、芥菜、花菜5种处理,比较放虫5 d后,每种处理小菜蛾(Plutella xyllostella)的产卵量。在5 d内,菜心/芥菜组合上的小菜蛾总产卵量显著低于除花菜单作外其他处理的总产卵量,菜心/芥菜组合上的小菜蛾分别产于菜心与芥菜上的卵量间无显著差异,表现为干扰效应;而菜心/花菜组合上的小菜蛾总产卵量与菜心以及芥菜单植间无显著差异,且显著高于花菜单植与菜心/芥菜组合,在产卵量分布上,小菜蛾产于菜心上的卵量显著高于产在花菜上的,表现为陷阱效应,即不同的寄主搭配对小菜蛾表现出不同的影响效应。

关键词：小菜蛾(Plutella xyllostella) 不同寄主陷阱效应干扰效应繁殖

A novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite oxide with surface doping of Y and its application in Pd-only three-way catalyst

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Rare Metals 2024年第2期43卷 749-757页

作者： Zheng Zhao Wei-Xin Zhao Yong-Qi Zhang Mei-Sheng Cui Yong-Ke hou Dong-ming Chen Juan-Yu Yang Zong-Yu Feng Xiao-Wei Huang National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.GRINM Group Corporation LimitedBeijing100088China Griem Hi-Tech Co.Ltd. Langfang065000China Rare Earth Functional Materials(Xiong’an)Innovation Venter Co.Ltd. Baoding071700China

The ceria-zirconia compound oxide-supported noble metal Pd(Pd@CZ)is widely used in three-way ***,the surface structure of CZ plays an important role in catalytic activity of ***,how to regulate the surface structure of CZ and clarify the structure–activity relationship is still a *** this paper,a strategy is proposed to develop high activity Pd@CZ nanocatalysts by tuning Y doping sites in *** precipitate-deposition method is developed to prepare the novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite with surface doping of Y(CZ-Y-S).In addition,the Pd@CZ-Y-S(Pd supported on CZ-Y-S)exhibits superior catalytic activity for HC,CO,and NO oxide,wherein,for CO and C_(3)H_(6) oxidation,the low-temperature activity of Pd@CZ-Y-S is still 20%higher than that of Pd@CZ-Y-B(Y bulk doping)and commercial Pd@CZ after 1000℃/4 h *** effect mechanism is further studied by density functional theory(DFT)*** with Pd@CZ-Y-B,Pd@CZ-Y-S shows the lower CO oxide reaction energy barriers due to the weaker adsorption strength of *** Y surface doping strategy could provide valuable insights for the development of highly efficient Pd@CZ catalyst with extensive applications.

关键词： Rare earth Ceria-zirconia-supported Pd Surface doping Experiment and theory Catalytic application

Electronic-scale assessment of high-temperature oxidation mechanisms in a novel Fe-based alloy

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Journal of Iron and Steel Research International 2024年第4期31卷 982-997页

作者： Wei-di Luo Ting-ping hou Xuan Liang Dong Zhang Heng-fu Lin Yu Li Tian-liang Zhao Cheng-yang Hu Serhii Yershov Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy.Wuhan University of Science and Technology.Wuhan 430081 HubeiChina Hubei Province Key Laboratory of Systems Science in Meallurgial Process Wuhan University of Science and Technology.Wuhan 430081.Hubei.China International Research Institute for Steel Technology Wuhan University of Science and Technology.Wuhan 430081.HubeiChina Collaborative Innovation Center for Advanced Steels w uhan University of Science and Technology.Wuhan 430081.HuleiChina

The development of alloys with high antioxidation performance is limited by the ambiguous details of the oxidation ***,based on the structures of internal oxides detected by high-resolution transmission electron microscopy,a hybrid method combining first-principles calculation,climb image nudged elastic band method and quasi-harmonic Debye model has been implemented to explain the oxidation mechanism with an emphasis on the origin of delamination and *** results showed that the delamination of oxides corresponds to the acceleration of diffusion of Cr element caused by lamellar *** reduction in the cracking occurrence at high temperature mainly results from the smaller bulk modulus of ***,the stronger chemical bonds promoted by lamellar structures also correspond to the higher crackingresistance.

关键词： Oxidation Crystal structure Diffusion Cracking-First-principles calculation

Tailored energy absorption for a novel auxetic honeycomb structure under large deformation

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 63-80页

作者： Xiuhui hou Bin Wang Zichen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710129China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

In comparison to conventional hexagonal honeycomb structures,auxetic metamaterials with re-entrant configurations have exhibited superior mechanical properties in terms of energy *** further enhance the energy absorption capacity of these materials,a novel re-entrant honeycomb configuration,named novel auxetic re-entrant honeycomb(NARH),is developed by incorporating“”-shaped cell walls into the conventional auxetic re-entrant honeycomb(ARH).Two analytical models for the plateau stress are formulated to consider the plastic deformation of NARH during quasi-static compression and the dynamic impact using the linear momentum ***-static compression tests on 3D printed NARH honeycomb specimens and finite element simulations are performed to verify the effectiveness of the theoretical *** exhibits higher plateau stresses compared with ARH during compression,which can be attributed to the presence of more plastic hinges formed in *** hinges,the embedded parts with inclined cell walls,not only improve stability by forming stable triangles during compression but also enhance the energy absorption capacity.A parametric study is conducted to analyze the effect of impact velocity,thickness,and incline angle of cell walls on *** simulations demonstrate higher sensitivity of the mechanical properties to impact velocity and cell wall *** ribs to the“”-shaped cell walls in NARH further reduces the initial peak force during dynamic crushing while maintaining high energy *** research provides valuable guidelines for the design of energy absorption metamaterials.

关键词： absorption walls shaped

Multidimensional coupled structure-activity relationship models for replacement of SF_(6)

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High Voltage 2024年第2期9卷 484-494页

作者： Mi Zhang Hua hou Baoshan Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhanChina

Computational screening of single gases to replace SF_(6)for electrical insulation has been challenged by the difficulty in combining various mutually exclusive properties especially for dielectric performance with liquefaction and environmental *** reveal the inherent correlations between dielectric strength(Er),boiling point(Tb),and global warming potential(GWP)of dielectric materials,a coupled structure-activity relationship(CSAR)model has been proposed for the first *** means of the generic descriptors,as deduced from the electrostatic potentials,and the specific descriptors,as introduced from the respective microscopic mechanisms,the complex interdependence between Er,Tb,and GWP of the insulation gases is quantitatively characterised by the 3-D coupling *** coupling mechanism for the right balance of properties is uncovered in terms of the first-principle *** CSAR model outperforms the previous SAR models in predicting Er,Tb,and GWP simultaneously in a self-consistent *** importantly,the concept of CSAR could be extended readily to any multidimensional macroscopic *** replacement compounds have been identified tentatively to be the promising candidates to replace SF_(6)using the CSAR model.

关键词： properties. dielectric insulation

mRNA medicine:Recent progresses in chemical modification,design,and engineering

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Nano Research 2024年第10期17卷 9015-9030页

作者： Xiaowen hou Jinjun Shi Yuling Xiao Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Center for Nanomedicine and Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Messenger RNA(mRNA)is a type of RNA that carries genetic information from DNA to the ribosome,where it is translated into *** has emerged as a powerful platform for development of new types of medicine,especially after the clinical approval of COVID-19 mRNA *** modification and nanoparticle delivery have contributed to this success significantly by improving mRNA stability,reducing its immunogenicity,protecting it from enzymatic degradation,and enhancing cellular uptake and endosomal ***,substantial progresses have been made in new modification chemistries,sequence design,and structural engineering to generate more stable and efficient next-generation *** innovations could further facilitate the clinical translation of mRNA therapies and *** that numerous review articles have been published on mRNA nanoparticle delivery and biomedical applications over the last few years,we herein focus on overviewing recent advances in mRNA chemical modification,mRNA sequence optimization,and mRNA engineering(e.g.,circular RNA and multitailed mRNA),with the aim of providing new perspectives on the development of more effective and safer mRNA medicines.

关键词： mRNA self-amplifying RNA circular RNA multitailed mRNA chemical modification machine learning

Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

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Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang Ching-Heng Lin ming-Ju Wu Yi-Hsing Chen Kuo-Cheng Chang Chung-Wei hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of Medical Research Taichung Veterans General HospitalTaichungTaiwan Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research *** with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December *** HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival *** In total,8310 patients with SLE and 16620 patients without SLE were *** general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in *** multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with *** with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,phould be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely