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基于JAK2/STAT3通路研究周氏固金消瘤汤含药血清对人肺腺癌A549细胞侵袭迁移能力的影响

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陕西中医 2024年第4期45卷 451-456页

作者：文静王理槐侯超湖南中医药大学第一附属医院湖南长沙410007 深圳市中医院广东深圳518033

目的:探讨周氏固金消瘤汤(ZSGJXLT)含药血清对人肺腺癌A549细胞侵袭迁移能力的影响及其机制。方法:应用健康SD大鼠制备ZSGJXLT含药血清与空白血清,将0%(空白血清)及5%、10%、20%、30%、40%ZSGJXLT含药血清作用于A549细胞,CCK-8法测算细... 详细信息

目的:探讨周氏固金消瘤汤(ZSGJXLT)含药血清对人肺腺癌A549细胞侵袭迁移能力的影响及其机制。方法:应用健康SD大鼠制备ZSGJXLT含药血清与空白血清,将0%(空白血清)及5%、10%、20%、30%、40%ZSGJXLT含药血清作用于A549细胞,CCK-8法测算细胞活性抑制率和半数抑制浓度(IC_(50))。用0%ZSGJXLT(空白对照组)、5%ZSGJXLT(ZSGJXLT低剂量组)、10%ZSGJXLT(ZSGJXLT中剂量组)及20%ZSGJXLT(ZSGJXLT高剂量组)含药血清培养A549细胞,细胞划痕实验及高内涵细胞成像技术观察细胞运动情况;Transwell侵袭及迁移实验观察细胞侵袭及迁移情况;Western blot法检测A549细胞JAK2/STAT3通路相关蛋白表达情况。结果:与空白对照组相比,不同浓度ZSGJXLT含药血清组A549细胞活性受到不同程度的抑制,与时间及浓度呈正相关性,24 h的IC_(50)为25.42%。与空白对照组相比,ZSGJXLT中、高剂量组A549细胞划痕愈合率、细胞移动速度均显著下降(均P<0.05),不同浓度ZSGJXLT含药血清组A549细胞侵袭及迁移数量明显减少(均P<0.05)。与空白对照组比较,ZSGJXLT中、高剂量组A549细胞的p-JAK2、p-STAT3、VEGFA蛋白表达水平显著降低(均P<0.05);不同浓度ZSGJXLT含药血清组MMP-2、MMP-9、N-cadherin蛋白表达有下调趋势,而E-cadherin蛋白表达有上调趋势,呈剂量依赖性,其中ZSGJXLT高剂量组与空白对照组比较差异有统计学意义(均P<0.05)。结论:周氏固金消瘤汤含药血清能抑制A549细胞侵袭迁移能力,其机制可能与调控JAK2/STAT3通路有关。

关键词：肺腺癌A549细胞周氏固金消瘤汤含药血清侵袭迁移 JAK2/STAT3

基于自然灾害综合风险普查成果的城市防灾减灾一张图关键技术研究

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测绘与空间地理信息 2024年第6期47卷 72-76页

作者：严涵忻静侯超上海市测绘院上海200063 自然资源部超大城市自然资源时空分析应用重点实验室上海200063

第一次全国自然灾害综合风险普查为城市应急管理提供了数据支撑,也对整合多方面灾害风险数据以建设综合风险数据库、深化普查成果应用、实现城市防灾减灾一张图的构建提出了新的要求。本文以国务院灾险普查办关于自然灾害综合风险数据... 详细信息

第一次全国自然灾害综合风险普查为城市应急管理提供了数据支撑,也对整合多方面灾害风险数据以建设综合风险数据库、深化普查成果应用、实现城市防灾减灾一张图的构建提出了新的要求。本文以国务院灾险普查办关于自然灾害综合风险数据库和灾险普查成果应用的相关文件为指导,在研究与防灾减灾相关的灾害风险全要素数据基础上,从综合数据收集、处理、建库、更新方法的数据管理体系,和线上线下相结合的可视化方法等层面进行了城市防灾减灾一张图构建涉及的关键技术研究,并以城镇房屋建筑灾害风险数据为例,开展了应用实例的设计与实现。

关键词：自然灾害综合风险普查防灾减灾空间数据可视化

基于帕累托最优效率模型的轨道交通沿线公交线路运行效率评价

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科学技术与工程 2024年第22期24卷 9569-9576页

作者：徐玉萍周金赛张津杭侯明超华东交通大学交通运输工程学院南昌330013

通过建立公交运行效率评价模型,确定轨道交通沿线待优化线路,为两网融合奠定理论基础。首先通过定性定量法筛选出与轨道交通关联度大且有研究意义公交线路,其次以公交线网自身合理性、两网之间协同关系等数据构建评价体系,最后采用帕累... 详细信息

通过建立公交运行效率评价模型,确定轨道交通沿线待优化线路,为两网融合奠定理论基础。首先通过定性定量法筛选出与轨道交通关联度大且有研究意义公交线路,其次以公交线网自身合理性、两网之间协同关系等数据构建评价体系,最后采用帕累托最优交叉效率模型,求解沿线公交线路运行效率。以南昌市1号线为例,筛选出沿线25条公交线路并进行实证分析。结果表明:帕累托最优交叉效率模型的评分更容易被所有的决策单元(decision-making units,DUMs)接受;数据分析得出南昌公交线网自身合理性较好,但在两网协同关系方面,可优化线路走向、调整线路重复系数等加强其协同性。最后基于两者的帕累托交叉效率均值,将25条公交线路划分为4种案例,为公共交通系统的管理者和决策者提供了更实用和有价值的观点。

关键词：公共交通公交线网帕累托最优运行效率线路优化

φ40 mm孔径下爆炸应力波衰减特性试验研究

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工程爆破 2024年第2期30卷 27-33页

作者：毛羽侯超普徐士超周俊杰陈作彬李飞陈顺禄刘迪国网新源山西大同抽水蓄能有限公司山西大同037000 核工业南京建设集团有限公司南京211102

为了研究爆炸应力波在基岩中的传播和衰减规律,利用不同标号的混凝土代替不同等级围岩,对φ40 mm孔径下不同装药结构的工况进行爆破试验。通过制作及预埋PVDF薄膜传感器,测量6种装药结构下不同距离处的爆炸应力峰值,探究不同药量、不同... 详细信息

为了研究爆炸应力波在基岩中的传播和衰减规律,利用不同标号的混凝土代替不同等级围岩,对φ40 mm孔径下不同装药结构的工况进行爆破试验。通过制作及预埋PVDF薄膜传感器,测量6种装药结构下不同距离处的爆炸应力峰值,探究不同药量、不同岩石性质对爆炸应力波传播的影响。通过试验得到了C20、C30、C40混凝土试件在试验所涉及的范围内爆炸应力波随传播距离衰减的指数关系式。试验结果表明随着介质波阻抗的增大,该介质内部的爆炸应力波衰减系数会增大的规律,同时也验证了利用PVDF传感器测量混凝土内部的爆炸应力峰值这一方法是可行的,测试数据是可靠的,对后续不同岩土介质下的应力衰减规律研究和工程应用有一定的指导意义。

关键词：爆炸应力波爆破试验混凝土试件 PVDF传感器

Experimental studies on the pore structure and mechanical properties of anhydrite rock under freeze-thaw cycles

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第3期14卷 781-797页

作者： chao hou Xiaoguang Jin Jie He Hanlin Li School of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education Chongqing UniversityChongqing400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400045China

To study the deterioration mechanisms of anhydrite rock under the freeze-thaw weathering process,the physico-mechanical characteristics and microstructure evolutions of anhydrite samples were determined by a series of laboratory ***,a descriptive-behavioral model was used to measure the integrity loss in anhydrite samples caused by cyclic ***,the freeze-thaw damage mechanisms of anhydrite rock were revealed from the macro and micro *** results show that the pore size of the anhydrite rock is mainly concentrated in the range of 0.001-10μ*** the number of freeze-thaw cycles increases,there is a growth in the proportion of macropores and ***,the proportion of micropores shows a declining *** relations of the uniaxial compressive strength,triaxial compressive strength,cohesion,and elastic modulus versus freeze-thaw cycles can be fitted by a decreasing exponential function,while the internal friction angle is basically unchanged with freezethaw *** the increase of confining pressure,the disintegration rates of the compressive strength and the elastic modulus decrease,and the corresponding half-life values increase,which reveals that the increase of confining pressures could inhibit freeze-thaw damage to ***,it has been proven that the water chemical softening mechanism plays an essential role in the freeze-thaw damage to anhydrite ***,it is concluded that the freeze-thaw weathering process significantly influences the macroscopic and microscopic damages of anhydrite rock.

关键词： Anhydrite rock Freeze-thaw cycles Physico-mechanical characteristics Microstructure evolution Deterioration mechanisms

Uncover the mystery of interfacial interactions in immiscible composites by spectroscopic microscopy:A case study with W-Cu

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Journal of Materials Science & Technology 2022年第31期126卷 106-115页

作者： Zhi Zhao Fawei Tang chao hou Xintao Huang Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaBeijing University of TechnologyBeijing 100124China

Characterizing immiscible metallic composites with electron microscopy and X-ray spectroscopy is the classic way of obtaining their structural and physical ***,such a combination lacks abil-ity to tell the interfacial interactions at grain *** we demonstrate a novel strategy to un-cover the mystery of interfacial interactions in such systems by spectroscopic *** morpho-logical and spectral data of samples were simultaneously recorded and analyzed,which reveals critical information regarding interfacial electronic *** W-Cu as a model,we experimentally quanti-fied its connectivity and unambiguously identified conditional bonding between W and ***,we chemically reconstructed the specific W-Cu boundary that possessed the strongest interactions and inves-tigated its atomic *** mechanism of W-Cu bonding was proposed and verified by first-principle *** above methodology holds great promise to serve as a universal approach in achieving in-depth understanding of immiscible composites.

关键词： Metal-matrix composites Interface Physical properties Spectroscopic microscopy Interfacial bonding

indfulness Meditation for Primary Headache Pain： A Meta-Analysis

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Chinese Medical Journal 2018年第7期131卷 829-838页

作者： Qiang Gu Jin-chao hou Xiang-Ming Fang School of Medicine Zhejiang University Hangzhou Zhejiang 210029 China Department of Anesthesiology School of Medicine The First Affiliated Hospital Zhejiang University Hangzhou Zhejiang 210029 China

Background： Several studies have reported that mindfulness meditation has a potential effect in controlling headaches, such as migraine and tension-type headache; however, its role remains controversial. This review assessed the evidence regarding the effects of mindfulness meditation for primary headache pain. Methods： Only English databases （PubMed, Cochrane Central Register of Controlled Trials [the Cochrane Library], PsyclNFO, Psychology and behavioral science collection, PsyArticles, Web of Science, and Scopus） were searched from their inception to November 2016 with the keywords （＂meditation＂ or ＂mindfulness＂ or ＂vipassana＂ or ＂dzogchen＂ or ＂zen＂ or ＂integrative body-mind training＂ or ＂IBMT＂ or ＂mindfulness-based stress reduction＂ or ＂MBSR＂ or ＂＇mindfulness-based cognitive therapy＂ or ＂MBCT＂ and ＂Headache＂ or ＂Head pain＂ or ＂Cephalodynia＂ or ＂Cephalalgia＂ or ＂Hemicrania＂ or ＂Migraine＂）. Titles, abstracts, and full-text articles were screened against study inclusion criteria： controlled trials of structured meditation programs for adult patients with primary headache pain. The quality of studies included in the meta-analysis was assessed with the Yates Quality Rating Scale. The meta-analysis was conducted with Revman 5.3. Results： Ten randomized controlled trials and one controlled clinical trial with a combined study population of 315 patients were included in the study. When compared to control group data, mindfulness meditation induced significant improvement in pain intensity （standardized mean difference, -0.89; 95% confidence interval, 1.63 to 0.15; P - 0.02） and headache frequency （-0.67; - 1.24 to -0.10; P - 0.02）. In a subgroup analysis of different meditation forms, mindfulness-based stress reduction displayed a significant positive influence on pain intensity （P 〈 0.000）. Moreover, 8-week intervention had a significant positive effect （P 〈 0.000）. Conclusions： Mindfulness meditation may reduce pain intensity and is a promising treatment option tbr pa

关键词： Headache Pain Meta-Analysis Mindfulness Meditation

Mechanical and acoustic emission characteristics of anhydrite rock under freeze-thaw cycles

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Journal of Mountain Science 2023年第1期20卷 227-241页

作者： ZHANG Chi JIN Xiao-guang hou chao HE Jie School of Civil Engineering Chongqing UniversityChongqing400045China China Railway 14TH Bureau Group Fourth Engineering Corporation Limited Jinan250101China Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education Chongqing UniversityChongqing400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400045China

To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magnetic resonance, scanning electron microscope tests, and uniaxial compression combined with acoustic emission(AE) tests. Results show that with the increase of freeze-thaw processes,the mass, uniaxial compression strength, and elastic modulus of the anhydrite specimens decrease while the porosity and plasticity characteristics *** example, after 120 cycles, the uniaxial compression strength and elastic modulus decrease by 46.54% and 60.16%, and the porosity increase by 75%. Combined with the evolution trend of stressstrain curves and the detected events, three stages were labeled to investigate the AE characteristics in freeze-thaw weathered anhydrite rock. It is found that with the increase of freeze-thaw cycles, the proportions of AE counts in stage Ⅰ and stage Ⅱ show a decaying exponential trend. Contrarily, the proportion of AE counts in stage Ⅲ displays an exponential ascending trend. Meanwhile, as the freeze-thaw cycles increase, the low-frequency AE signals increase while the intermediate-frequency AE signals decrease. After 120 cycles, the proportion of low-frequency AE signals increases by 168.95%, and the proportion of intermediate-frequency AE signals reduces by 81.14%. It is concluded that the microtensile cracking events occupy a dominant position during the loading process. With the increase of freeze-thaw cycles, the b value of samples *** 120 cycles, b value decreases by 27.2%, which means that the proportion of cracking events in rocks with small amplitude decreases. Finally, it is proposed that the freeze-thaw damage mechanism of anhydrite is also characterized by the water chemical softening effect.

关键词： Freeze-thaw cycles Anhydrite rock Physical and mechanical properties AE characteristics Damage mechanism

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基于深度学习网络的非侵入式负荷分解方法

计算机仿真 2024年第2期41卷 137-140,445页

作者：侯林超朱武汤德清上海电力大学电子与信息工程学院上海200092

负荷特征的选取能够在很大程度上描述用电设备的电气特征,选择合适的负荷特征是影响负荷分解优劣的关键条件之一,提出基于深度学习网络的非侵入式负荷分解方法。选取有功功率、无功功率和V-I轨迹图作为负荷特征项并获取相关特征,构建GA... 详细信息

负荷特征的选取能够在很大程度上描述用电设备的电气特征,选择合适的负荷特征是影响负荷分解优劣的关键条件之一,提出基于深度学习网络的非侵入式负荷分解方法。选取有功功率、无功功率和V-I轨迹图作为负荷特征项并获取相关特征,构建GA-BP神经网络和卷积神经网络并加以训练。提取非侵入式负荷的高级特征,并将特征提取结果融合为复合特征。将融合后的复合特征输入至经过训练的GA-BP神经网络用于负荷分解,实现非侵入式负荷分解。实验结果表明,所提方法的绝对误差均值、均方根误差较小,召回率较大,通过特征处理有效提升了负荷分解效果。

关键词：非侵入式负荷分解轨迹图神经网络遗传算法卷积神经网络