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Fate of organophosphate esters from the Northwestern Pacific to the Southern Ocean:Occurrence,distribution,and fugacity model simulation

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Journal of Environmental Sciences 2024年第3期137卷 347-357页

作者： Tengda Shi Ruijing Li Jie Fu chao hou Hui Gao Guanjie Cheng Haibo Zhang Shuaichen Jin Liang Kong Guangshui Na College of Marine Technology and Environment Dalian Ocean UniversityDalian 116023China Laboratory for coastal marine eco-environment process and carbon sink of Hainan province/Yazhou Bay Innovation Institute Hainan Tropical Ocean UniversitySanya 572022China National Marine Environmental Monitoring Center Dalian 116023China College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai 201306China NCS Testing Technology Co. Ltd.Beijing 10081China

Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in seawater.Two halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross Sea.The model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE sink.Dry and wet deposition dominated the processes involving OPE transfer to seawater.The OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater region.These findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic.

关键词： Organophosphate esters(OPEs) Long-range transport Fugacity model Antarctic Fate

Effects of Traditional Chinese Medicine on the survival of patients with stage Ⅰ gastric cancer and high-risk factors:a real-world retrospective study

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Journal of Traditional Chinese Medicine 2023年第3期43卷 568-573页

作者： hou chao ZHANG Yusen YANG Die LI Yifei ZHANG Xiaochun LIU Yanqing Department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China College of Medicine Yangzhou UniversityYangzhou 225001China the Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine Yangzhou 225001China Oncology Department Yangzhou Hospital of Traditional Chinese MedicineYangzhou 225009China

OBJECTIVE:To investigate the benefits of Traditional Chinese Medicine(TCM) therapy for improving the survival of patients with stage I gastric cancer(GC) and high-risk factors in a real-world setting.METHODS:The clinical data of patients who were diagnosed with stage I GC from March 1,2012 to October 31,2020 were collected.Prognostic analysis was performed to explore the high-risk factors that affected the survival of the patients.A Cox multivariate regression model was used to compare the hazard ratios for the mortality risk of patients,especially those with high-risk factors.Kaplan-Meier survival curve and log-rank test were utilized to assess the survival time.RESULTS:Prognostic analysis demonstrated that female sex,tumor invasion into blood vessels,and Ib stage were independent risk factors.The 1-,3-,and 5-year survival rates of the TCM group vs those of the non-TCM group were 100.0% vs 91.0%,97.6% vs 64.5%,and 81.4% vs 55.5%,respectively.A significant difference in median overall survival(m OS) was found between the two groups(χ2 = 7.670,P = 0.006).Subgroup analysis showed that the m OS of female patients and stage Ib patients in the TCM group were longer than those in the non-TCM group (P ≤ 0.001 and 0.001,respectively).CONCLUSIONS:TCM treatment can improve the survival of patients with stage I GC and high-risk factors.

关键词： stomach neoplasms overall mortality integrative medicine medicine Chinese traditional real-world

Mechanical and acoustic emission characteristics of anhydrite rock under freeze-thaw cycles

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Journal of Mountain Science 2023年第1期20卷 227-241页

作者： ZHANG Chi JIN Xiao-guang hou chao HE Jie School of Civil Engineering Chongqing UniversityChongqing400045China China Railway 14TH Bureau Group Fourth Engineering Corporation Limited Jinan250101China Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education Chongqing UniversityChongqing400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400045China

To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magnetic resonance, scanning electron microscope tests, and uniaxial compression combined with acoustic emission(AE) tests. Results show that with the increase of freeze-thaw processes,the mass, uniaxial compression strength, and elastic modulus of the anhydrite specimens decrease while the porosity and plasticity characteristics increase.For example, after 120 cycles, the uniaxial compression strength and elastic modulus decrease by 46.54% and 60.16%, and the porosity increase by 75%. Combined with the evolution trend of stressstrain curves and the detected events, three stages were labeled to investigate the AE characteristics in freeze-thaw weathered anhydrite rock. It is found that with the increase of freeze-thaw cycles, the proportions of AE counts in stage Ⅰ and stage Ⅱ show a decaying exponential trend. Contrarily, the proportion of AE counts in stage Ⅲ displays an exponential ascending trend. Meanwhile, as the freeze-thaw cycles increase, the low-frequency AE signals increase while the intermediate-frequency AE signals decrease. After 120 cycles, the proportion of low-frequency AE signals increases by 168.95%, and the proportion of intermediate-frequency AE signals reduces by 81.14%. It is concluded that the microtensile cracking events occupy a dominant position during the loading process. With the increase of freeze-thaw cycles, the b value of samples decreases.After 120 cycles, b value decreases by 27.2%, which means that the proportion of cracking events in rocks with small amplitude decreases. Finally, it is proposed that the freeze-thaw damage mechanism of anhydrite is also characterized by the water chemical softening effect.

关键词： Freeze-thaw cycles Anhydrite rock Physical and mechanical properties AE characteristics Damage mechanism

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安徽马鞍山(博望)方言的三个晚起音变

方言 2024年第2期46卷 167-174页

作者：侯超江苏第二师范学院文学院南京安徽大学安徽语言资源保护与研究实验室合肥

苏皖交界地区的马鞍山博望区方言处于吴语和江准官话的交界地带,晚近时期发生了三个特殊音变。其一,为保持[I]、[i]韵在[tç]组声母后的对立,[Ι]韵前的[tç]组声母发生了舌尖化[ts]音变。其二,咸山宕江摄转变为元音韵,咸山摄开口一二等... 详细信息

苏皖交界地区的马鞍山博望区方言处于吴语和江准官话的交界地带,晚近时期发生了三个特殊音变。其一,为保持[I]、[i]韵在[tç]组声母后的对立,[Ι]韵前的[tç]组声母发生了舌尖化[ts]音变。其二,咸山宕江摄转变为元音韵,咸山摄开口一二等字的元音高化引起了蟹止摄韵母的连锁式音变。其三,由于跟官话方言的接触,流摄侯韵的读音[*ei]被[■u]所替换,蟹(止)摄合口字的读音[*ei]/[*uei]也被[■u]/[u■u]所替换。

关键词：安徽省马鞍山(博望) 吴语三个晚起音变

Flexible smart sensing skin for“Fly-by-Feel”morphing aircraft

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Science China(Technological Sciences) 2022年第1期65卷 1-29页

作者： HUANG YongAn ZHU Chen XIONG WenNan WANG Yu JIANG YongGang QIU Lei GUO DongLiang hou chao JIANG Shan YANG ZhaoXi WANG Bo WANG Lu YIN ZhouPing State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Bionic and Micro/Nano/Bio Manufacturing Technology Research Center School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an 710072China The 38th Research Institute of China Electronics Technology Group Corporation Hefei 230088China

Flexible smart sensing skin is a key enabling technology for the future"Fly-by-Feel"control of morphing aircraft.It represents the next-generation skin of aircraft that can exhibit a more powerful sensing function than a conventional one and could be mounted on arbitrary curvilinear surfaces,especially for advanced autonomic,morphing aircraft.Recent significant technical advances in flexible electronics have overcome many historic drawbacks of conventional smart skin,e.g.,only a limited number of discrete block sensors can be integrated due to the inevitable structural damage and heavy guidelines.Herein,we review the key developments in flexible sensors technology and highlight both the state-of-the-art devices and the potential applications for the measurement of aircraft.We begin with the importance of flexible smart skin for morphing aircraft and then expand to the latest progress in various types of flexible sensors.Then we highlight flexible sensors as smart skin to measure aerodynamic parameters and monitor the structural health,and further to achieve the Fly-by-Feel control.Finally,the challenges and opportunities on flexible smart sensing skin are discussed,from the functional design to practical applications.

关键词： flexible electronics smart skin morphing aircraft flexible sensors

Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia

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Science China(Life Sciences) 2011年第3期54卷 235-239页

作者： HAN HongBin XIA ZuoLi CHEN He hou chao LI WeiBo Department of Radiology Peking University Third Hospital Beijing 100191 China Department of Neurology Affiliated Hospital Taishan Medical College Tai'an 271000 China Department of Medical Radiation Physics and Diagnostics Helmholtz Zentrum Miinchen German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany

Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier.However,despite 16 years of research on a number of central nervous system disorders,an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme.Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system.To validate this technique,rats were subjected to a single intracranial (at the caudate nucleus),or intraperitoneal injection,of the compound citicoline,followed two hours later by a permanent middle cerebral artery occlusion (pMCAO).Results showed that 12 h after pMCAO,with 0.0025 g kg-1 citicoline,an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group.These results suggest that given the appropriate injection point,through SDD a pharmacologically effective concentration of citicoline can be administered.

关键词：脑缺血中枢神经系统疾病治疗扩散胞二磷胆碱交货间质路线

浅谈300吨大型转炉检修危险作业的安全管理

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新疆钢铁 2024年第2期 128-130页

作者：赵宇侯超首钢京唐钢铁联合有限责任公司河北唐山063200

冶金企业大型转炉检修复杂多变,参与检修的人员众多,现场交叉作业多,涉及高处、煤气、有限空间、动火等危险作业,特别是部分检修任务进行临时外委施工,进一步加大了检修安全管理的难度。为此,应通过开展危险源辨识和隐患排查治理、加强... 详细信息

冶金企业大型转炉检修复杂多变,参与检修的人员众多,现场交叉作业多,涉及高处、煤气、有限空间、动火等危险作业,特别是部分检修任务进行临时外委施工,进一步加大了检修安全管理的难度。为此,应通过开展危险源辨识和隐患排查治理、加强危险作业安全管控等措施,全面提升大型转炉检修作业的安全管理水平。

关键词：大型转炉检修危险作业

抽水蓄能电站主机房底板精确控界切割技术研究

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工程爆破 2024年第3期30卷 121-127页

作者：毛羽侯超普徐士超李彬顾云程建辉刘迪国网新源山西大同抽水蓄能有限公司山西大同037000 核工业南京建设集团有限公司南京210000

抽水蓄能电站主机房底板爆破开挖时,对其平整度及保留岩体完好度要求很高,传统爆破方法会带来底板开挖边界控制精度差、装药量大、保留岩石损伤严重及环境危害大等问题。为克服上述缺点,提出沿主机房底板水平钻凿炮孔并侧向预切槽,沿切... 详细信息

抽水蓄能电站主机房底板爆破开挖时,对其平整度及保留岩体完好度要求很高,传统爆破方法会带来底板开挖边界控制精度差、装药量大、保留岩石损伤严重及环境危害大等问题。为克服上述缺点,提出沿主机房底板水平钻凿炮孔并侧向预切槽,沿切槽多点双向设置聚能装药进行岩石控界爆破的方法。首先采用数值模拟正交分析方法对工业炸药装填的聚能装药参数进行了优化,然后根据优化结果制作了聚能切割装置并在实地进行了试验。试验结果表明,当炮孔中双向聚能射流控界切割装置的平均线装药密度为150 g/m、孔距0.5 m时,爆破后就可以在炮孔间岩体产生精确的贯穿性裂纹。相较于传统爆破方法,该控界切割爆破方法在保证切割面精确的同时,大幅度地减少了装药量,降低了保留岩体的损伤程度和对周围环境的影响。

关键词：聚能射流抽水蓄能电站主机房底板控界切割聚能装药爆炸破岩

基于JAK2/STAT3通路研究周氏固金消瘤汤含药血清对人肺腺癌A549细胞侵袭迁移能力的影响

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陕西中医 2024年第4期45卷 451-456页

作者：文静王理槐侯超湖南中医药大学第一附属医院湖南长沙410007 深圳市中医院广东深圳518033

目的:探讨周氏固金消瘤汤(ZSGJXLT)含药血清对人肺腺癌A549细胞侵袭迁移能力的影响及其机制。方法:应用健康SD大鼠制备ZSGJXLT含药血清与空白血清,将0%(空白血清)及5%、10%、20%、30%、40%ZSGJXLT含药血清作用于A549细胞,CCK-8法测算细... 详细信息

目的:探讨周氏固金消瘤汤(ZSGJXLT)含药血清对人肺腺癌A549细胞侵袭迁移能力的影响及其机制。方法:应用健康SD大鼠制备ZSGJXLT含药血清与空白血清,将0%(空白血清)及5%、10%、20%、30%、40%ZSGJXLT含药血清作用于A549细胞,CCK-8法测算细胞活性抑制率和半数抑制浓度(IC_(50))。用0%ZSGJXLT(空白对照组)、5%ZSGJXLT(ZSGJXLT低剂量组)、10%ZSGJXLT(ZSGJXLT中剂量组)及20%ZSGJXLT(ZSGJXLT高剂量组)含药血清培养A549细胞,细胞划痕实验及高内涵细胞成像技术观察细胞运动情况;Transwell侵袭及迁移实验观察细胞侵袭及迁移情况;Western blot法检测A549细胞JAK2/STAT3通路相关蛋白表达情况。结果:与空白对照组相比,不同浓度ZSGJXLT含药血清组A549细胞活性受到不同程度的抑制,与时间及浓度呈正相关性,24 h的IC_(50)为25.42%。与空白对照组相比,ZSGJXLT中、高剂量组A549细胞划痕愈合率、细胞移动速度均显著下降(均P<0.05),不同浓度ZSGJXLT含药血清组A549细胞侵袭及迁移数量明显减少(均P<0.05)。与空白对照组比较,ZSGJXLT中、高剂量组A549细胞的p-JAK2、p-STAT3、VEGFA蛋白表达水平显著降低(均P<0.05);不同浓度ZSGJXLT含药血清组MMP-2、MMP-9、N-cadherin蛋白表达有下调趋势,而E-cadherin蛋白表达有上调趋势,呈剂量依赖性,其中ZSGJXLT高剂量组与空白对照组比较差异有统计学意义(均P<0.05)。结论:周氏固金消瘤汤含药血清能抑制A549细胞侵袭迁移能力,其机制可能与调控JAK2/STAT3通路有关。

关键词：肺腺癌A549细胞周氏固金消瘤汤含药血清侵袭迁移 JAK2/STAT3