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Risk factors for acute kidney injury following coronary artery bypass graft surgery in a Chinese population and development of a prediction model

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Journal of Geriatric Cardiology 2021年第9期18卷 711-719页

作者： Yang LI Xue-Jian hou Tao-Shuai LIU Shi-Jun XU Zhu-Hui HUANG Peng-yun YAN Xiao-yu XU Ran DONG Department of Cardiac Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of pharmacy Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Acute kidney injury(AKI)after coronary artery bypass graft(CABG)surgery is associated with significant morbidity and *** retrospective study aimed to establish a risk score for postoperative AKI in a Chinese *** A total of 1138 patients undergoing CABG were collected from September 2018 to May 2020 and divided into a derivation and validation *** was defined according to the Kidney Disease Improving Global Outcomes(KDIGO)*** logistic regression analysis was used to determine the independent predictors of AKI,and the predictive ability of the model was determined using a receiver operating characteristic(ROC)*** The incidence of cardiac surgery–associated acute kidney injury(CSA-AKI)was 24.17%,and 0.53%of AKI patients required dialysis(AKI-D).Among the derivation cohort,multivariable logistic regression showed that age≥70 years,body mass index(BMI)≥25 kg/m2,estimated glomerular filtration rate(eGFR)≤60 mL/min per 1.73 m2,ejection fraction(EF)≤45%,use of statins,red blood cell transfusion,use of adrenaline,intra-aortic balloon pump(IABP)implantation,postoperative low cardiac output syndrome(LCOS)and reoperation for bleeding were independent *** predictive model was scored from 0 to32 points with three risk *** AKI frequencies were as follows:0-8 points(15.9%),9-17 points(36.5%)and≥18 points(90.4%).The area under of the ROC curve was 0.730(95%CI:0.691-0.768)in the derivation *** predictive index had good discrimination in the validation cohort,with an area under the curve of 0.735(95%CI:0.655-0.815).The model was well calibrated according to the Hosmer-Lemeshow test(P=0.372).CONCLUSION The performance of the prediction model was valid and accurate in predicting KDIGO-AKI after CABG surgery in Chinese patients,and could improve the early prognosis and clinical interventions.

关键词： AKI red Risk factors for acute kidney injury following coronary artery bypass graft surgery in a Chinese population and development of a prediction model

304不锈钢在电力火灾下的力学性能与组织演变特性

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金属功能材料 2024年第2期31卷 93-99页

作者：刘晓圣聂京凯陈国宏韩钰侯东田一姬军国网智能电网研究院有限公司先进输电技术全国重点实验室北京102209 国网智能电网研究院有限公司电工新材料研究所北京102209 国网安徽省电力有限公司安徽合肥230009

对电力火灾场景不同热输入条件下304不锈钢力学性能及微观组织开展研究,分析了最高火灾温度下与不同冷却条件下304不锈钢材料力学性能与组织演变的关联关系。结果表明:在相同温度下,保温时间对304不锈钢的力学性能影响不大;而随着温度升... 详细信息

对电力火灾场景不同热输入条件下304不锈钢力学性能及微观组织开展研究,分析了最高火灾温度下与不同冷却条件下304不锈钢材料力学性能与组织演变的关联关系。结果表明:在相同温度下,保温时间对304不锈钢的力学性能影响不大;而随着温度升高,流动应力明显降低,304不锈钢的抗拉强度、屈服强度呈线性减小,1 100℃时分别降低至34.5和13 MPa,断后伸长率呈线性增加,1 100℃时增加到132%;在1 100℃,保温时间低于30 min时,以多个晶粒合并成一个大晶粒的方式逐渐长大,保温时间大于30 min后,大晶粒内部开始出现退火孪晶,晶粒和组织不再发生转变;冷却条件对304不锈钢整体力学性能影响不大,不同过火条件下抗拉强度与室温相比变化率不大于5%,屈服强度在室温至1 000℃范围下变化率不大于10%,1 100℃时,空冷及水冷条件下屈服强度分别降至81%和86%,主要归因于1 100℃时晶粒明显长大,平均晶粒尺寸达到86.1μm。

关键词：电力火灾 304不锈钢微观组织抗拉强度屈服强度断后伸长率

维奈克拉联合阿扎胞苷治疗不耐受强化疗的初治老年急性髓系白血病的临床疗效

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内科理论与实践 2024年第2期19卷 89-94页

作者：赵慧瑾金震张赟翔吴敏郑宇吴文沈扬陈秋生李军民陈瑜上海交通大学医学院附属瑞金医院血液科、上海血液学研究所、医学基因组学国家重点实验室转化医学国家重大科技基础设施(上海) 上海200025

目的:总结35例不耐受强化疗的初治老年急性髓系白血病(acute myeloid leukemia,AML)的临床特点,评估维奈克拉(venetoclax,VEN)联合阿扎胞苷(azacytidine,AZA)的疗效及安全性。方法:纳入本院2021年2月至2022年3月间诊断的35例不耐受强化... 详细信息

目的:总结35例不耐受强化疗的初治老年急性髓系白血病(acute myeloid leukemia,AML)的临床特点,评估维奈克拉(venetoclax,VEN)联合阿扎胞苷(azacytidine,AZA)的疗效及安全性。方法:纳入本院2021年2月至2022年3月间诊断的35例不耐受强化疗的初治老年AML患者,接受VEN+AZA诱导治疗,回顾性分析其临床特征、VEN+AZA诱导的缓解情况及治疗安全性。结果:患者中位年龄68岁,继发AML 9例。所有患者均完成骨髓细胞遗传学及分子生物学评估,其中低危患者10例,中危12例,高危13例。常见的基因突变为DNA甲基转移酶3A(DNA methyltransferase 3A,DNMT3A)(11例)、异柠檬酸脱氢酶1/2(isocitrate dehydrogenase 1/2,IDH1/2)(11例)、TET癌基因家族成员2(ten⁃eleven translocation 2,TET2)(9例)、核仁磷酸蛋白1(nucleophosmin 1,NPM1)(8例)、Fms⁃样酪氨酸激酶3⁃内部串联重复(Fms⁃related tyrosine kinase 3⁃internal tandem duplication,FLT3⁃ITD)(6例)。总完全缓解(complete remission,CR)率65.7%(23例),NPM1、FLT3⁃ITD、IDH1/2突变患者CR率分别为87.5%、66.7%、72.7%。CR患者中总微小残留病变(minimal residual disease,MRD)阴性率73.9%。中位随访时间10.1个月,中位无事件生存(event⁃free survival,EFS)期11.3个月。缓解患者中,相比于MRD阳性患者,MRD阴性患者EFS及总生存(overall survival,OS)期更长(P<0.05)。早期死亡率5.7%,治疗过程中最常见的不良反应为血液学毒性(3~4级中性粒细胞减少31.4%、3~4级血小板减少25.7%、中性粒细胞减少性发热48.6%)及肺部感染(17.1%)。结论:VEN+AZA在不耐受强化疗的初治老年AML中治疗的总缓解率较高。NPM1突变可能提示更高缓解率。MRD转阴患者EFS期及OS期较MRD阳性患者延长,死亡风险下降。VEN+AZA是目前不能耐受强化疗的初治老年AML重要的治疗选择之一。

关键词：急性髓系白血病老年诱导治疗不耐受强化化疗临床疗效

The effect of hierarchical single-crystal ZSM-5 zeolites with different Si/Al ratios on its pore structure and catalytic performance

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 269-278页

作者： yuexin hou Xiaoyun Li Minghui Sun Chaofan Li Syed ul Hasnain Bakhtiar Kunhao Lei Shen yu Zhao Wang Zhiyi Hu Lihua Chen Bao-Lian Su Laboratory of Living Materials at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Material for Architectures Wuhan University of TechnologyWuhan 430070China Laboratory of Inorganic Materials Chemistry(CMI) University of NamurB-5000 NamurBelgium Nanostructure Research Centre(NRC) Wuhan University of TechnologyWuhan 430070China Clare Hall University of CambridgeCambridgeCB39ALUK

Hierarchical single-crystal ZSM-5 zeolites with different Si/Al ratios(Hier-ZSM-5-x,where x=50,100,150 and 200)were synthesized using an ordered mesoporous carbon-silica composite as hard ***-ZSM-5-x exhibits improved mass transport properties,excellent mechanical and hydrothermal stability,and higher catalytic activity than commercial bulk zeolites in the benzyl alcohol self-etherification *** show that a decrease in the Si/Al ratio in hierarchical single-crystal ZSM-5 zeolites leads to a significant increase in the acidity and the density of micropores,which increases the final catalytic *** effect of porous hierarchy on the diffusion of active sites and the final catalytic activity was also studied by comparing the catalytic conversion after selectively designed poisoned acid *** poisoned Hier-ZSM-5-x shows much higher catalytic conversion than the poisoned commercial ZSM-5 zeolite,which indicates that the numerous intracrystalline mesopores significantly reduce the diffusion path of the reactant,leading to the faster diffusion inside the zeolite to contact with the acid sites in the micropores predominating in ZSM-5 *** study can be extended to develop a series of hierarchical single-crystal zeolites with expected catalytic performance.

关键词： hierarchical zeolites single crystalline interconnected pores improved diffusion performance benzyl alcohol self-etherification reaction

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基于美与逻辑的精装石材饰面排版深化实践

建筑技术 2024年第12期55卷 1438-1441页

作者：杨希赵振鑫姚锦岚郝铭君李雨田北京建工集团有限责任公司北京100055

剧院建筑内装墙面的效果在整体设计效果中有着举足轻重的地位,其中大面积的墙顶地饰面排版就是尤为重要的一部分,排版深化是顺利施工的重要前置工作,有逻辑地排布板块与点位是实现整体效果的金钥匙,整体效果的美不拘泥于视觉或形式而源... 详细信息

剧院建筑内装墙面的效果在整体设计效果中有着举足轻重的地位,其中大面积的墙顶地饰面排版就是尤为重要的一部分,排版深化是顺利施工的重要前置工作,有逻辑地排布板块与点位是实现整体效果的金钥匙,整体效果的美不拘泥于视觉或形式而源于逻辑与功能的平衡协调,过程中一步步地推敲,并在逻辑性的基础上不与功能实现相冲突,践行“比例、对位、适用”的艺术法则,最终实现“基于文化,材料消失,留下建筑”。

关键词：剧场建筑精装石材饰面排版逻辑美

Clinical Observation of Shuanghuang Shengbai Granule(双黄升白颗粒) on Prevention and Treatment of Myelosuppression Caused by Chemotherapy in Cancer Patients

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Chinese Journal of Integrative Medicine 2017年第2期23卷 105-109页

作者： WANG Li-fang XU zhen-ye WANG Zhong-qi ZHANG Ming YAN Gui-ying hou An-ji DENG Hai-bin WU Ji ZHAO Xiao-zhen XIANG Yi yu Lei Department of Oncology Longhua Hospital Shanghai University of Traditional Chinese Medicine Department of Integrated Medicine Shanghai Chest Hospital Department of Oncology Shanghai Punan Hospital of Pudong New District Department of Oncology Shanghai Seventh People's Hospital

Objective： To study the efficacy and safety of Shuanghuang Shengbai Granule（双黄升白颗粒, SSG）, a traditional Chinese herbal medicine, on myelosuppression of cancer patients caused by chemotherapy. Methods： A total of 330 patients were randomly assigned to the treatment group（220 cases, analysed 209 cases） and the control group（110 cases, analysed 102 cases） with a 2：1 ratio by envelope method. The patients in the treatment group at the first day of chemotherapy started to take SSG for 14 days, while the patients in the control group took Leucogon Tablets. The changes of the blood routine, clinical symptoms and immune function in both groups were observed for safety and efficacy evaluation. Results： At the 7th day of chemotherapy, the white blood cells（WBCs） level in the treatment group was significantly higher than that in the control group（P〈0.05）. After treatment, the WBCs rate in the normal range accounted for 50.2% in the treatment group, the myelosuppression of WBCs and neutrophil were mainly grade Ⅰ, while 8.1% and 5.7% of patients emerged grade Ⅲ and grade Ⅳ myelosuppression, respectively. The incidence of myelosuppression of the treatment group was significantly lower than that of the control group（P〈0.05）. The total effective rate of Chinese medicine syndrome in the treatment group was significantly higher than that in the control group（84.2% vs. 72.5%, P〈0.05）. The immune cell levels in both groups were maintained in the normal range. Compared with that before treatment, the levels of CD3~＋ and CD4~＋ cells were significantly increased in the treatment group after treatment（P〈0.05）. The discrepancy of CD3~＋ and CD4~＋ cell activity before and after treatment in both groups were significantly different（P〈0.05）. No obvious adverse event occurred in both groups. Conclusion： SSG had a protection effect on bone marrow suppression, and alleviated the clinical symptoms together with clinical safety.

关键词： Shuanghuang Shengbai Granule malignant tumor chemotherapy myelosuppression Chinese medicine

Out-of-pocket payments and economic consequences from tuberculosis care in eastern China:income inequality

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Infectious Diseases of Poverty 2020年第1期9卷 26-35页

作者： Yan Liu Cai-Hong Xu Xiao-Mo Wang zhen-yu Wang Yan-Hong Wang Hui Zhang Li Wang Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Critical Care Medicine The Second People’s Hospital of Shenzhen&First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China National Center for Tuberculosis Control and Prevention China Center for Disease ControlBeijing 100226China

Background:Despite the availability of free tuberculosis(TB)diagnosis and treatment,TB care still generates substantial costs that push people into *** investigated out-of-pocket(OOP)payments for TB care and assessed the resulting economic burden and economic consequences for those with varying levels of household income in eastern ***:A cross-sectional study was conducted among TB patients in the national TB programme networks in eastern ***-related direct OOP costs,time loss,and coping strategies were investigated across households in different economic *** of Variance was used to examine the differences in various costs,and Kruskal-Wallis tests were used to compare the difference in total costs as a percentage of annual household ***:Among 435 patients,the mean OOP total costs of TB care were USD *** the lower-income quartile,OOP payments were lower,but costs as a percentage of reported annual household income were *** costs and costs prior to treatment accounted for 66.4 and 48.9%of the total costs,*** lower the household income was,the higher the proportion of medical costs to total costs before TB treatment,but the lower the proportion of medical costs patients spent in the intensive *** care caused 25.8%of TB-affected households to fall below the poverty line and caused the poverty gap(PG)to increase by United States Dollar(USD)*** in the poorest households had the highest poverty headcount ratio(70.2%)and PG(USD 236.1),but those in moderately poor households had the largest increase in the poverty headcount ratio(36.2%)and PG(USD 177.8)due to TB *** from poor households were more likely to borrow money to cope with the costs of TB care;however,there were fewer social consequences,except for food insecurity,in poor ***:Medical and pretreatment costs lead to high costs of TB care,especially among patients from the poorest *** is nec

关键词： Out-of-pocket payment Tuberculosis Impoverishment Coping strategy Eastern China

Schisandrin B exerts anticancer effects on human gastric cancer cells through ROS-mediated MAPK,STAT3,and NF-κB pathways

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BIOCELL 2023年第1期47卷 195-204页

作者： TIANZHU LI yu ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO WENSHUANG hou YINGHUA LUO CHENGHAO JIN Department of Molecular Biology College of Basic Medical ScienceChifeng UniversityChifeng024000China Department of Biochemistry and Molecular Biology College of Life Science and TechnologyHeilongjiang Bayi Agricultural UniversityDaqing163319China Department of Grass Science College of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing163319China National Coarse Cereals Engineering Research Center Daqing163319China

Schisandrin B(Sch B)is a monomer with anti-cancer and anti-inflammatory effects,which are isolated from the plant Schisandra chinensis(Turcz)*** investigated the anti-gastric cancer(GC)effects of Sch B and its underlying molecular *** Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell ***/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch *** blotting was used to evaluate the effects of Sch B on downstream apoptotic *** DCFH-DA fluorescent probe was used to assess the regulatory effects of Sch B on reactive oxygen species(ROS)levels and related signaling pathways in GC *** results showed that Sch B could regulate the phosphorylation level of mitogen-activated protein kinase(MAPK)by upregulating ROS accumulation in gastric cancer cells,and then reduce the expression of nuclear factor kappa B(NF-κB)and phosphorylated transcription 3(p-STAT3).In addition,Sch B downregulated the cell cycle proteins cyclin-dependent kinase 2/4/6 and cyclin D1/E,and arrested cells in the G0/G1 ***,it also inhibited cell migration,which was reversed with Nacetylcysteine *** summary,Sch B has killing effects on GC cells by upregulating the production of intracellular ROS and regulating the MAPK/STAT3/NF-κB signaling pathway,leading to the migration arrest and apoptosis of GC cells.

关键词： Schisandrin B Gastric cancer Reactive oxygen species Apoptosis Migration Cell cycle

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氮苯基丙二硫酯化合物的合成与表征

广州化工 2024年第15期52卷 166-167,172页

作者：马书修崔晁瑜甘贞洁刘文博河南工程学院化工与印染工程学院河南郑州451191

详细介绍了一种探究性的有机化学综合实验的设计,一种氮苯基丙二硫酯化合物的设计合成与表征。实验利用苯胺,甲醛水溶液与硫代乙酸为原料,在乙醇溶液中,通过“一锅法”得到氮苯基丙二硫酯化合物,并对产物结构进行简要的分析归纳。本实... 详细信息

详细介绍了一种探究性的有机化学综合实验的设计,一种氮苯基丙二硫酯化合物的设计合成与表征。实验利用苯胺,甲醛水溶液与硫代乙酸为原料,在乙醇溶液中,通过“一锅法”得到氮苯基丙二硫酯化合物,并对产物结构进行简要的分析归纳。本实验主要针对化学化工专业类学生在有机化学实验中理论联系实践不足的问题,让学生从探究性的有机化学实验中提高分析与总结的综合能力。

关键词：苯胺硫代乙酸氮苯基丙二硫酯硫酯化合物