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2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌临床分离株分布及耐药性

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中华医院感染学杂志 2024年第5期34卷 658-662页

作者：张绮萍陆锦琪金建文王霄腾侯国新嘉兴市第一医院感控与公共卫生部浙江嘉兴314000 嘉兴市第一医院消化内科浙江嘉兴314000 嘉兴市第一医院肿瘤内科浙江嘉兴314000

目的了解2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌(CRPA)临床分离株的分布特征及耐药情况。方法收集2018年1月1日-2022年12月31日嘉兴市第一医院各临床科室送检标本培养出的铜绿假单胞菌(PA)2358株,进行菌株培养、鉴定及药敏试... 详细信息

目的了解2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌(CRPA)临床分离株的分布特征及耐药情况。方法收集2018年1月1日-2022年12月31日嘉兴市第一医院各临床科室送检标本培养出的铜绿假单胞菌(PA)2358株,进行菌株培养、鉴定及药敏试验,统计并分析CRPA的分布及耐药性。结果 2018-2022年共检出PA2358株,其中CRPA407株,CRPA总检出率为17.26%,5年间CRPA检出率整体呈下降趋势(P<0.05)。CRPA感染主要为60岁以上的老年男性患者、夏季检出率较高。标本来源以痰液为主(75.92%),其次是尿液(5.65%)。科室来源主要是重症医学科(24.32%)、重症康复科(15.48%)和呼吸内科(15.23%)。CRPA对亚胺培南和美罗培南总耐药率高达96.32%和79.04%,对多数头孢菌素类、β-内酰胺类和喹诺酮类耐药率高于45%,对阿米卡星、庆大霉素较为敏感,耐药率在12%以下;对哌拉西林/他唑巴坦耐药率呈上升趋势(P<0.05),对阿米卡星、庆大霉素、环丙沙星耐药率呈下降趋势(P<0.05)。结论医院应加强对易感人群、重点科室CRPA的耐药性监测,加强病原学标本送检和抗菌药物临床应用管理,采取有效的防控措施,防止CRPA的医院流行和播散。

关键词：碳青霉烯类铜绿假单胞菌临床分布抗菌药物耐药性多重耐药

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Deep learning for joint channel estimation and feedback in massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 83-93页

作者： Jiajia guo Tong Chen Shi Jin Geoffrey Ye Li xin Wang Xiaolin hou National Mobile Communications Research Laboratory Southeast UniversityNanjing210096China Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZUK DOCOMO Beijing Communications Laboratories Co. LtdBeijingChina

The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base ***,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive *** this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO *** networks are constructed to perform estimation and feedback explicitly and *** explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network *** module is also designed to generate data-bearing *** results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.

关键词： Channel estimation CSI feedback Deep learning Massive MIMO FDD

Metal-organic-framework-derived copper-based catalyst for multicomponent C-S coupling reaction

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Chinese Journal of Chemical Engineering 2024年第6期70卷 1-8页

作者： Lixin Chen Hui Zhang Linxi hou xin Ge Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Department of Materials-Oriented Chemical Engineering School of Chemical EngineeringFuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

Copper-based metal-organic frameworks(Cu-MOFs)are a promising multiphase catalyst for catalyzing C-S coupling reactions by virtue of their diverse structures and ***,the unpleasant odor and instability of the organosulfur,as well as the mass-transfer resistance that exists in multiphase catalysis,have often limited the catalytic application of Cu-MOFs in C-S coupling *** this paper,a Cu-MOFs catalyst modified by cetyltrimethylammonium bromide(CTAB)was designed to enhance mass transfer by increasing the adsorption of organic substrates using the long alkanes of ***,elemental sulfur was used to replace organosulfur to achieve a highly efficient and atom-economical multicomponent C-S coupling reaction.

关键词： Design Copper-based metal-organic frameworks (Cu-MOFs) Adsorption C-S coupling reaction Multiphase reaction

Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

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World Journal of Diabetes 2024年第4期15卷 735-757页

作者： Jing Gao Ying Zou Xiao-Yu Lv Li Chen xin-guo hou Department of Endocrinology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Institute of Endocrine and Metabolic Diseases Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Endocrine and Metabolic Diseases Shandong Province Medicine&HealthJinan 250012Shandong ProvinceChina Department of Endocrinology Jinan Clinical Research Center for Endocrine and Metabolic DiseaseJinan 250012Shandong ProvinceChina

BACKGROUND The cognitive impairment in type 2 diabetes mellitus(T2DM)is a multifaceted and advancing state that requires further exploration to fully ***-roinflammation is considered to be one of the main mechanisms and the immune system has played a vital role in the progression of the *** To identify and validate the immune-related genes in the hippocampus associated with T2DM-related cognitive *** To identify differentially expressed genes(DEGs)between T2DM and controls,we used data from the Gene Expression Omnibus database *** identify T2DM module genes,we used Weighted Gene Co-Expression Network *** the genes were subject to Gene Set Enrichment ***-protein interaction network construction and machine learning were utilized to identify three hub *** cell infiltration analysis was *** three hub genes were validated in GSE152539 via receiver operating characteristic curve *** experiments including reverse transcription quantitative real-time PCR,Western blotting and immunohistochemistry were conducted both in vivo and in *** identify potential drugs associated with hub genes,we used the Comparative Toxicogenomics Database(CTD).RESULTS A total of 576 DEGs were identified using *** taking the intersection of DEGs,T2DM module genes,and immune-related genes,a total of 59 genes associated with the immune system were ***,machine learning was utilized to identify three hub genes(H2-T24,Rac3,and Tfrc).The hub genes were associated with a variety of immune *** three hub genes were validated in *** experiments were conducted at the mRNA and protein levels both in vivo and in vitro,consistent with the bioinformatics ***,11 potential drugs associated with RAC3 and TFRC were identified based on the *** Immune-related genes that differ in expression in the hippocampus are closely linked to microgli

关键词： Bioinformatics analysis Type 2 diabetes mellitus Cognitive impairment Hippocampus Immune Microglia

Composition operators on weighted Bergman spaces induced by doubling weights

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Science China Mathematics 2024年第7期67卷 1571-1598页

作者： xin guo Maofa Wang School of Mathematics and Statistics Wuhan UniversityWuhan430072China

Given a doubling weightωon the unit disk D,let A_(ω)^(p) be the space of all the holomorphic functions f,where∥f∥A_(ω)^(p):=(∫_(D)|f(z)|_(p)ω(z)dA(z))^(1/p)<∞.We completely characterize the topological connectedness of the set of composition operators on A_(ω)^(p).As an application,we construct an interesting example which reveals that two composition operators on A_(α)^(p) in the same path component may fail to have a compact difference and give a negative answer to the Shapiro-Sundberg question in the(standard)weighted Bergman *** addition,we completely describe the central compactness of any finite linear combinations of composition operators on A_(ω)^(p) in three terms:a Julia-Carathéodory-type function-theoretic characterization,a power-type characterization,and a Carleson-type measure-theoretic characterization.

关键词： composition operator linear combination linearly connected weighted Bergman space doubling weight

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Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： Peng Chen Yi Liu guo-xin Sun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. However,no attempt was done to explore As methylation and volatilization under non-fooded conditions. Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. However, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/L) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p H in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation

Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： Shuai-Bin Hua Tian Jin xin guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

Two thin middle-crust low-velocity zones imaged in the Chuan-Dian region of southeastern Tibetan Plateau and their tectonic implications

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Science China Earth Sciences 2024年第5期67卷 1675-1686页

作者： Long LI xin WANG Guangbing hou Yuan LING Yinshuang AI Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

Intracrustal low-velocity zones(LVZs)indicate a mechanically weak crust and are widely observed in the southeast margin of the Tibetan ***,their spatial distributions and formation mechanisms remain *** investigate their distribution and detailed morphology of the LVZs in the southeastern Tibetan Plateau,here we used teleseismic events and continuous waveform data recorded by 40 broadband seismic stations newly deployed in the Sichuan-Yunnan region from December 2018 to October 2020.A total of 12,924 high-quality P-wave receiver functions and 5–40 s fundamental Rayleigh surface wave phase velocity dispersion curves from ambient noise cross-correlation functions were *** Swave velocity model at a depth interval of 0–100 km in the study area was inverted by using the trans-dimensional Markov chain Monte Carlo strategy to jointly invert the complementary data of the receiver function waveform and Rayleigh surface wave phase velocity *** results show that there are two separate LVZs(~3.5 km/s)surrounding the rigid Daliangshan subblock at crustal depths of approximately 30–40 km,providing new constraints on the geometry of the LVZs in our study *** two LVZs obtained in this study may represent the middle crustal flow channels,through which the material in the center of the Tibetan Plateau extrudes to its southeast *** by the rigid Sichuan Basin and the spindle-like Daliangshan subblock,the material continues to flow southward through the mechanically weak middle crustal channels surrounding the Daliangshan *** addition,the existence of thin LVZs in the middle crust plays an important role in understanding the decoupling between the upper and lower crust in the study *** also provides new constraint on the complex tectonic deformation process of the southeastern margin of the Tibetan Plateau caused by the collision and compression of the Indian and the Eurasian plates.

关键词： Southeastern Tibetan Plateau Joint inversion Intracrustal low-velocity zone Mid-crustal channel flow

Spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice in multiple dimensions during 1979 to 2020

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Acta Oceanologica Sinica 2024年第3期43卷 102-114页

作者： Yu guo Xiaoli Wang He Xu Xiyong hou CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China

Arctic sea ice is broadly regarded as an indicator and amplifier of global climate *** rapid changes in Arctic sea ice have been widely ***,the spatiotemporal changes in the horizontal and vertical dimensions of Arctic sea ice and its asymmetry during the melt and freeze seasons are rarely quantified simultaneously based on multiple sources of the same long time *** this study,the spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice were investigated from both the horizontal and vertical dimensions during 1979–2020 based on remote sensing and assimilation *** results indicated that Arctic sea ice was declining at a remarkably high rate of–5.4×10^(4) km^(2)/a in sea ice area(SIA)and–2.2 cm/a in sea ice thickness(SIT)during 1979 to 2020,and the reduction of SIA and SIT was the largest in summer and the smallest in ***,compared with other sub-regions,SIA showed a sharper declining trend in the Barents Sea,Kara Sea,and East Siberian Sea,while SIT presented a larger downward trend in the northern Canadian Archipelago,northern Greenland,and the East Siberian *** to the seasonal trend of sea ice on sub-region scale,the reduction rate of SIA exhibited an apparent spatial heterogeneity among seasons,especially in summer and winter,i.e.,the sub-regions linked to the open ocean exhibited a higher decline rate in winter;however,the other sub-regions blocked by the coastlines presented a greater decline rate in *** SIT,the sub-regions such as the Beaufort Sea,East Siberian Sea,Chukchi Sea,Central Arctic,and Canadian Archipelago always showed a higher downward rate in all ***,a striking freeze-thaw asymmetry of Arctic sea ice was also *** sea ice changes in different dimensions,sea ice over most regions in the Arctic showed an early retreat and rapid advance in the horizontal dimension but late melting and gradual freezing in the vertical *** amount of sea ice me

关键词： Arctic sea ice sea ice area sea ice thickness spatiotemporal variation freeze-thaw asymmetry