检索结果-南通市图书馆

天然产物研究与开发 2023年第10期35卷 1659-1668页

作者： hosameldeen mohamed husien 彭伟龙刘明江伯若楠李金贵扬州大学兽医学院江苏省高校动物重要疫病与人畜共患病防控协同中心扬州225009 布尔塔那大学兽医学院 Rufaa 999129

探讨辣木叶多糖(Moringa oleifera leaf polysaccharide,MOLP)对葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎(ulcerative colitis,UC)防治作用及其作用机制。50只BALB/c小鼠随机分为正常对照组(Con组)、模型对照组(DSS组)、MOLP-L(25 mg/kg)、MOLF-M(50 mg/kg)、MOLF-H(100 mg/kg)组,通过饮用4%DSS诱导小鼠UC模型。试验期间每日记录各组小鼠体重情况和疾病活动指数(DAI)变化;ELISA法检测血清中TNF-α、IL-1β、IL-10、HMGB1和结肠组织MPO含量;HE染色观察结肠组织病理学变化;实时荧光定量PCR法检测结肠组织TNF-α、IL-1β、IL-10、HMGB1 mRNA表达水平;蛋白免疫印迹(Western blot)法检测结肠组织中TLR4、MyD88、P65、p-P65、IκBα和p-IκBα的表达;16S rRNA高通量测序探究小鼠肠道菌群的变化。结果显示,与Con组相比,DSS组小鼠一般状况下降,体重减轻,结肠长度缩短,DAI和病理切片损伤评分均显著增加(P<0.001);TNF-α、IL-1β、HMGB1含量和MPO活性显著升高(P<0.001),结肠组织中TLR4、MyD88、p-P65和p-IκBα的蛋白表达水平显著上调(P<0.001)。与DSS组相比,不同剂量MOLP处理组明显改善上述病变和炎性指标,显著提升了IL-10的表达,作用结果具有剂量依赖性;并且MOLP可以改善UC小鼠肠道菌群多样性,恢复菌群平衡。研究结果提示MOLP可以通过抑制炎症反应,调节小鼠肠道菌群多样性、组成和相对丰度进而发挥防治UC的作用。

关键词：辣木叶多糖溃疡性结肠炎炎性因子肠道菌群

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

辣木叶总黄酮对小鼠溃疡性结肠炎防治作用的研究

引用

中国畜牧兽医 2022年第10期49卷 4042-4051页

作者：彭伟龙 hosameldeen mohamed husien 伯若楠刘明江杨海峰李金贵扬州大学兽医学院江苏省高校动物重要疫病与人畜共患病防控协同中心扬州225009 布尔塔那大学兽医学院 Rufaa 999129 江苏农牧科技职业学院泰州225300

【目的】以葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)小鼠为模型,探究辣木叶总黄酮(MOLF)对UC的防治作用。【方法】将50只BALB/c小鼠随机分为5组:对照组、DSS组(模型组)和MOLF-L(25 mg/kg)、MOLF-M(50 mg/kg)、MOLF-H(100 mg/kg)处理组... 详细信息

【目的】以葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)小鼠为模型,探究辣木叶总黄酮(MOLF)对UC的防治作用。【方法】将50只BALB/c小鼠随机分为5组:对照组、DSS组(模型组)和MOLF-L(25 mg/kg)、MOLF-M(50 mg/kg)、MOLF-H(100 mg/kg)处理组,每组10只。小鼠通过饮用4%DSS诱导UC模型,各MOLF处理组灌胃相应剂量药物0.2 mL,对照组和DSS组灌以等体积的生理盐水,每天1次,连续7 d。每天记录各组疾病活动指数(DAI),在末次给药的次日经眼眶静脉丛采血,分离血清测定白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、高迁移率族蛋白B1(HMGB1)和内毒素(LPS)含量;小鼠脱颈处死后取结肠组织进行HE染色观察组织形态、PAS染色观察组织杯状细胞数量变化;实时荧光定量PCR法检测结肠组织中IL-1β、TNF-α、IL-10、HMGB1 mRNA表达水平;免疫荧光法检测肠黏膜闭锁连接蛋白-1(ZO-1)和闭合蛋白(Occludin)表达情况;Western blotting分析凋亡相关蛋白cleaved-caspase 3、Bcl-2、Bax的表达水平。【结果】UC小鼠造模成功,DSS组小鼠体内LPS、炎性因子含量、cleaved-caspase 3和Bax蛋白表达量与对照组相比差异极显著(P<0.01);不同剂量MOLF均可以改善UC小鼠体内炎症状况,尤以MOLF-H组效果最佳:与DSS组相比,DAI评分以及血清中LPS含量极显著降低(P<0.01),小鼠血清和结肠组织中促炎因子IL-1β、TNF-α、HMGB1含量和mRNA表达量均极显著降低(P<0.01),抗炎因子IL-10的表达量极显著升高(P<0.01),且cleaved-caspase 3和Bax的表达量极显著上调,Bcl-2的表达量极显著下调(P<0.01)。此外,MOLF可以改善结肠黏膜水肿、炎性细胞浸润情况,维持杯状细胞数量及其形态,增加ZO-1和Occludin蛋白表达量,且这些作用具有剂量依赖性。【结论】MOLF对DSS诱导的UC具有显著的防治作用,这可能与其抑制炎症并维护肠黏膜屏障的完整性有关。

关键词：辣木叶总黄酮小鼠溃疡性结肠炎炎性因子肠黏膜屏障

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Predicting the Need for ICU Admission in COVID-19 Patients Using XGBoost

引用

Computers, Materials & Continua 2021年第11期69卷 2077-2092页

作者： mohamed Ezz Murtada K.Elbashir hosameldeen Shabana College of Computer and Information Sciences Jouf UniversitySakakaKSA Faculty of Engineering Al Azhar UniversityCairoEgypt Faculty of Mathematical and Computer Sciences University of GeziraWad MadaniSudan Faculty of Medicine Al Azhar UniversityCairoEgypt College of Medicine Shaqra UniversityKSA

It is important to determine early on which patients require ICU admissions in managing COVID-19 especially when medical resources are *** in ICU admissions is associated with negative outcomes such as mortality and ***,early identification of patients with a high risk of respiratory failure can prevent complications,enhance risk stratification,and improve the outcomes of severely-ill hospitalized *** this paper,we develop a model that uses the characteristics and information collected at the time of patients’admissions and during their early period of hospitalization to accurately predict whether they will need ICU *** use the data explained and organized in a window-based manner by the Sírio-Libanês hospital team(published on Kaggle).Preprocessing is applied,including imputation,cleaning,and feature *** the cleaning process,we remove zero-variance,redundant,and/or highly correlated(measured by the Pearson correlation coefficient)*** use Extreme Gradient Boosting(XGBoost)with early stopping as a predictor in our developed *** run the experiment in four stages starting from the features of Window 1 in Stage 1 and then incrementally add the features of Windows 2–4 in Stages 2–4 *** achieve AUCs of 0.73,0.92,0.95,and 0.97 in those four stages.

关键词： COVID-19 ICU admission XGBoost

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Transfer Learning Approach Based on Ultrasound Images for Liver Cancer Detection

引用

Computers, Materials & Continua 2023年第6期75卷 5105-5121页

作者： Murtada K.Elbashir Alshimaa Mahmoud Ayman mohamed Mostafa Eslam Hamouda Meshrif Alruily Sadeem M.Alotaibi hosameldeen Shabana mohamed Ezz College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia Department of Information Systems MCI AcademyCairoEgypt College of Medicine Shaqra UniversityShaqraKSA Faculty of Medicine Al Azhar UniversityCairoEgypt

The convolutional neural network(CNN)is one of the main algorithms that is applied to deep transfer learning for classifying two essential types of liver lesions;Hemangioma and hepatocellular carcinoma(HCC).Ultrasound images,which are commonly available and have low cost and low risk compared to computerized tomography(CT)scan images,will be used as input for the model.A total of 350 ultrasound images belonging to 59 patients are *** number of images with HCC is 202 and 148,*** images were collected from ultrasound ***(28 Hemangiomas patients and 11 HCC patients),the department of radiology,the University of Washington(7 HCC patients),the Atlas of ultrasound Germany(3 HCC patients),and Radiopedia and others(10 HCC patients).The ultrasound images are divided into 225,52,and 73 for training,validation,and testing.A data augmentation technique is used to enhance the validation *** proposed an approach based on ensembles of the best-selected deep transfer models from the on-the-shelf models:VGG16,VGG19,DenseNet,Inception,InceptionResNet,ResNet,and *** tuning both the feature extraction and the classification layers,the best models are *** accuracy is used for model tuning and *** accuracy,sensitivity,specificity and AUROC are used to evaluate the *** experiments are concluded in five *** first stage aims to evaluate the base model performance by training the on-the-shelf *** best accu-racy obtained in the first stage is 83.5%.In the second stage,we augmented the data and retrained the on-the-shelf models with the augmented *** best accuracy we obtained in the second stage was 86.3%.In the third stage,we tuned the feature extraction layers of the on-the-shelf *** best accuracy obtained in the third stage is 89%.In the fourth stage,we fine-tuned the classification layer and obtained an accuracy of 93%as the best *** the fifth stage,we applied the en

关键词： Transfer learning liver lesions ultrasound images and convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental and computational chemical studies on the cationic furanylnicotinamidines as novel corrosion inhibitors in aqueous solutions

引用

Chinese Journal of Chemical Engineering 2020年第2期28卷 477-491页

作者： Abdelaziz S.Fouda mohamed A.Ismail Rabab M.Abou-shahba Walaa A.husien Esraa S.EL-Habab Ashraf S.Abousalem Department of Chemistry Faculty of ScienceEl-Mansoura UniversityEl-Mansoura 35516Egypt Department of Chemistry Faculty of ScienceAl-Azhar UniversityEgypt Quality Control Laboratory Operation DepartmentJOTUNEgypt

The corrosion inhibition action of three newly synthesized furanylnicotinamidine derivatives namely: 6-[5-{4(dimethylamino)phenyl}furan-2-yl]nicotinamidine(MA-1256), 6-[5-(4-chlorophenyl)furan-2-yl]nicotinamidine(MA-1266), and 6-[5-{4-(dimethylamino)phenyl}furan-2-yl]nicotinonitrile(MA-1250) on carbon steel(C-steel) was investigated in 1.0 mol·L-1 HCl solution by weight loss(WL), potentiodynamic polarization(PP), electrochemical impedance spectroscopy(EIS), and electrochemical frequency modulation(EFM)techniques. Morphological analysis was performed on the uninhibited and inhibited C-steel using atomic force microscope(AFM) and Infrared Spectroscopy(ATR-IR) methods. The effect of temperature was studied and discussed. Inspection of experimental results revealed that the inhibition efficiency(IE) increases with the incremental addition of inhibitors and with elevating the temperature of the acid media. The adsorption of furanylnicotinamidine derivatives on C-steel follows Temkin’s isotherm. PP studies indicated that the investigated compounds act as mixed-type inhibitors and showed that p-dimethylaminophenyl furanylnicotinamidine derivative(MA-1256) was the most efficient inhibitor among the other studied derivatives with IE reached(95%)at 21 × 10-6 mol·L-1. MA-1266 is highly soluble in aqueous solution and has non-toxicity profile with LC50 N 37 mg·L-1. Thus, MA-1266 can be a promising green corrosion inhibitor candidate with IE N 91% at 21× 10-6 mol·L-1. The experiments were coupled with computational chemical theories such as quantum chemical and molecular dynamic methods. The experimental results were in good agreement with the computational outputs.

关键词： Acid corrosion C-steel Furanylnicotinamidines Green inhibitor Computational chemical methods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：