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单细胞转录组测序技术在结核病研究中的应用

中国防痨杂志 2025年第3期47卷 362-368页

作者：石红雨张国良肖国辉西南医科大学附属医院感染性疾病科泸州646000 深圳市第三人民医院/国家感染病临床医学研究中心深圳518112

结核病是结核分枝杆菌感染引起的全球死亡率最高的传染病之一,严重威胁公共卫生。目前,对于结核分枝杆菌感染宿主后引起的细胞免疫应答机制还不是很清晰。单细胞转录组测序技术能在单个细胞的分辨率上揭示病理过程中的细胞异质性,可以... 详细信息

结核病是结核分枝杆菌感染引起的全球死亡率最高的传染病之一,严重威胁公共卫生。目前,对于结核分枝杆菌感染宿主后引起的细胞免疫应答机制还不是很清晰。单细胞转录组测序技术能在单个细胞的分辨率上揭示病理过程中的细胞异质性,可以帮助研究人员更好地理解结核病的发病机制,并为靶向药物研发、新型诊断标志物及疫苗研发提供有力支持。本文综述了该技术在结核病致病机制的探究、在不同临床样本中细胞亚群异质性的分析,以及免疫微环境揭示等方面的应用,并探讨该技术的局限性、未来的挑战,展望了其在结核病研究中潜在的应用方向。

关键词：结核 RNA 免疫,细胞单细胞转录组测序

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Hierarchical self-assembled structure and frictional response of phthalocyanine molecules

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Friction 2023年第3期11卷 354-368页

作者： Yijun QIAO Jian SONG hongyu shi Hongdong WANG shizhu WEN Yuhong LIU State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China School of Mechatronic Engineering Shanghai University Shanghai 200444China

Solid evidence is needed to demonstrate the effect of molecular orientation and structure on the frictional property of boundary *** this work,the frictional properties of phthalocyanine self-assembled monolayers(SAMs)with face-on(aromatic cores parallel to the substrate)and edge-on(aromatic cores stand on the substrate)orientations have been compared and the in situ structural variation of edge-on SAMs under frictional shear has been revealed by atomic force microscope(AFM).Face-on oriented SAMs show lower adhesion,lower friction,and stronger wear resistance,compared with edge-on oriented *** structures of edge-on oriented SAMs have been revealed by frictional topography,which are consisted of nanoscale columns,micron-scale stripes,and centimeter-scale *** column structure deforms under increasing load force,leading to a stepwise friction force curve and a transition among three friction states(ordered friction,collapsed friction,and worn friction).The structural deformation depends on both the order degree and anisotropic stiffness of *** in phthalocyanine SAMs show a larger stiffness when shearing against molecular plane than shearing along the molecular *** presented study on the interfacial structure and frictional mechanism promisingly supports the designing of novel boundary lubricants and their application in engineering.

关键词： hierarchical assembly molecular orientation frictional mechanism phthalocyanine

Weak interaction between CH_3SO and HOCl: Hydrogen bond, chlorine bond and oxygen bond

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Chinese Science Bulletin 2009年第17期54卷 3014-3022页

作者： LI ZhiFeng LI hongyu LIU YanZhi shi XiaoNing TANG HuiAn College of Life Science and Chemistry Tianshui Normal University Tianshui 741001 China

B3lyp/6-311++g** and mp2/6-311++g** calculations were used to analyze the interaction between CH3SO and HOCl. Nine (complex A: S1A-S9A) and five (complex B: S4B-S7B and S10B) minima were localized on the potential energy surface of CH3SO…HOCl complexes at b3lyp/6-311++g** and mp2/ 6-311++g** computational levels, respectively. The AIM and NBO theories were also applied to explain the nature of the complexes. Bonding energy of complexes A and B corrected with BSSE falls in the ranges of -0.4―-41.4 kJ·mol-1 and -6.9―-35.8 kJ·mol-1 at mp2/6-311++g** level, respectively. The re- sults show that a novel oxygen bond complex (S6) exists in the system, besides hydrogen bond and chlorine bond. Especially, S6B-F, S6B-Br and S7B are blue shifted complexes compared with red shifted S6A, because the electron transfer occurs between LP1(S8) and σ*(O5-Cl7), resulting in the increase of O5-Cl7 and the decrease of vibrational frequency. The complex of S10B has characteristics of both red shift and blue shift.

关键词：弱相互作用次氯酸氢键氧误差校正电子转移振动频率复合物

New Chaotic Image Encryption Algorithm Based on Cross-Mapping

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Wuhan University Journal of Natural Sciences 2012年第6期17卷 461-467页

作者： TONG Xiaojun LIU Yang ZHANG Miao shi hongyu School of Computer Science and Technology Harbin Institute of TechnologyWeihai 264209ShandongChina

Chaotic cryptography has been applied to image encryption;however,only the traditional low-dimensional chaotic systems has been widely analyzed or deciphered,which does not show satisfied security and *** solve this problem,a new algorithm based on cross-chaos map has been created in this *** image pixels are scrambled under control of high-dimensional chaotic sequence,which is generated by cross chaotic *** image pixels are substituted by ciphertext feedback *** can relate encryption required parameters with plaintext and can make a plaintext byte affect more ciphertext *** by theoretical analysis and experimental results,the algorithm has higher complex degree and has passed SP800-22 pseudo-random number standard tests,and it has high encryption speed,high security,*** can be widely applied in the field of image encryption.

关键词： chaos image encryption cross chaotic map cross-scrambling substitute

Electric field controlled superlubricity of fullerene-based host–guest assembly

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Nano Research 2023年第1期16卷 583-588页

作者： Shanchao Tan hongyu shi Xin Du Kunpeng Wang Haijun Xu Junhua Wan Ke Deng Qingdao Zeng Yuhong Liu State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China College of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and ChemicalsNanjing Forestry UniversityNanjing 210037China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal UniversityHangzhou 310012China Center of Materials Science and Optoelectonics Engineering University of Chinese Academy of SciencesBeijing 100049China

Controlling friction by the electric field is a promising way to improve the tribological performance of a variety of movable mechanical *** this work,the assembly structure and microscale superlubricity of a host–guest assembly are effectively controlled by the electric *** the help of the scanning tunneling microscopy(STM)technique,the host–guest assembly structures constructed by the co-assembly of fullerene derivative(Fluorene-C60)with macrocycles(4B2A and 3B2A)are explicitly *** with density functional theory(DFT),the distinct different assembly behaviors of fullerene derivatives are revealed at different probe biases,which is attributed to the molecular polarity of the fullerene *** the control on the adsorption behavior,the friction coefficient of host–guest assembly is demonstrated to be controllable in the electric field by using atomic force microscopy(AFM).At positive probe bias,the friction coefficient of the host–guest assembly is significantly reduced and achieves superlubricity(μmin=0.0049).The efforts not only help us gain insight into the host–guest assembly mechanism controlled by the electric field,but also promote the further application of fullerene in micro-electro-mechanical systems(MEMS).

关键词： superlubricity electric field friction control fullerene derivative host-guest assembly

Influence of functional groups on the self-assembly of liquid crystals

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Chinese Chemical Letters 2021年第3期32卷 1149-1152页

作者： Shanchao Tan Jiayu Tao Wendi Luo Hao Jiang Yuhong Liu Haijun Xu Qjngdao Zeng hongyu shi State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Laboratory of Theoretical and Computational Nanoscience CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectonics Engineering University of Chinese Academy of SciencesBeijing 100049China Sino-Danish Center for Education and Research University of Chinese Academy of SciencesBeijing 100190China

Functional groups in the molecule play an important role in the molecular o rganization *** reveal the influence of functional groups on the self-assembly at interface,herein,the self-assembly structures of three liquid crystal molecules,which only differ in the functional groups,are explicitly characterized by using scanning tunneling microscopy(STM).The high-resolution STM images demonstrate the difference between the supramolecular assembly structures of three liquid crystal molecules,which attribute to the hydrogen bonding interaction andπ-πstacking interaction between different functional *** density functional theory(DFT)results also confirm the influence of these functional groups on the *** effort on the self-assembly of liquid crystal molecules at interface could enhance the understanding of the supramolecular assembly mechanism and benefit the further application of liquid crystals.

关键词： Self-assembly Liquid crystal Functional group Hydrogen bond π-πStacking interaction

An annually laminated stalagmite from the eastern Qinghai-Tibetan Plateau provides evidence of climate instability during the early MIS5e in the Asian summer monsoon

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Science China Earth Sciences 2023年第5期66卷 1147-1164页

作者： Tao GAO Pingzhong ZHANG Hai CHENG Leilei ZHANG Xinhu LI hongyu shi Wei JIA Youfeng NING Hanying LI R.Lawrence EDWARDS Key Laboratory of Mineral Resources in Western China(Gansu Province)and School of Earth Sciences Lanzhou UniversityLanzhou730000China Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an710054China Department of Earth Sciences University of MinnesotaMinneapolis55455USA

The Marine Isotope Stage(MIS5e)is characterized by a warmer climate than that of the pre-industrial period,and serves as an analog for the Current Warm Period(CWP).However,uncertainties persist regarding its climatic ***,we retrieved a stalagmite(WXB075)from Wanxiang Cave in the eastern Qinghai-Tibetan Plateau,and employed abs-olute^(230)Th dating and relative annual layer data to establish a high-precision chronological framework for reconstructing the history of the Asian summer monsoon(ASM)and environmental evolution during early MIS5e with multiple *** findings indicate that the annually laminated stalagmite was formed during Cooling Event 27(C27).The deposition of WXB075 experienced a hiatus(~125.58 ka BP)due to a significant cooling event in the North Atlantic,which may be linked to the unstable climate in the Northern ***,the impact of meltwater discharge in high northern latitudes results in a two-phase evolution of the ASM,i.e.,an initial weaker stage followed by a gradual increase(with exception of deposition hiatus).The climatic instability of ASM is generally characterized by a quasi-60 year cycle that affects vegetation conditions,biological productivity,and karst hydroclimate ***,the increase in meltwater and decrease in temperature in the Northern Hemisphere have led to a weakened ASM and subsequent reduction in ***,vegetation degradation above the cave has occurred along with a slowdown of karst *** vegetation conditions,organic matter content,and wet/drought of the karst hydroclimate were affected by both the large-scale monsoon circulation and local environment during extreme weakening(strengthening)of the monsoon when high-frequency climatic events of ASM occurred.A comparison ofδ^(18)O records between early MIS5e and the past 2000 years reveals that the climate during early MIS5e differed significantly from that of CWP,Medieval Warm Period(MWP),and Dark Age Co

关键词： Eastern Qinghai-Tibetan Plateau Climate instability Wanxiang Cave stalagmite Asian summer monsoon Environmental response Deposition hiatus

Cross-polarization suppression in C-shaped microstrip patch antenna employing anisotropic dielectrics

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Journal of Advanced Dielectrics 2017年第4期7卷 29-33页

作者： hongyu shi shitao Zhu Jianxing Li Anxue Zhang Zhuo Xu School of Electronic and Information Engineering Xi'an Jiaotong University Xi'anShaanxi 710049P.R.China Electronic Materials Research Laboratory and the Key Laboratory of the Ministry of Education Xi'an Jiaotong University Xi'anShaanxi 710049P.R.China

An anisotropic dielectric realized by layered ceramic structures was adopted to design a low cross-polarization C-shaped patch *** anisotropic dielectric performs as a substrate and can cause additional cross-polarized fields which are able to cancel the cross-polarized fields generated by the C-shaped patch itself,and then reduce the cross-polarization *** to the C-shaped patch antenna with an isotropic substrate,the cross-polarization of the proposed antenna is suppressed by more than 15 dB with a little gain enhancement at 2.4 *** anisotropic dielectric has a little impact on the direction of the C-shaped patch *** gain of the proposed C-shaped patch antenna is 6.8 dB with a cross-polarization of28 dB.

关键词： Anisotropic dielectrics layered ceramic structures low cross-polarization patch antennas

Research Status and Key Technologies of Geo-Electromagnetic Magnetic Induction Sensor

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Journal of Harbin Institute of Technology(New Series) 2017年第4期24卷 38-49页

作者： Yanzhang Wang Yunxia Wan Chen Chen hongyu shi Jun Lin Defu Cheng Key Laboratory of Geo-Exploration Instrumentation Ministry of EducationJilin University College of Instrumentation & Electrical Engineering Jilin University

According to different applications,the performance parameters of the several Geo-Electromagnetic Magnetic Induction Sensors( GEMISs) which are the most representative in the world are compared. After discussing the several key technologies for improving the performance of GEMISs,the main conclusions are as follows: the application bandwidth can be expanded by adopting flux negative feedback( 1 m Hz-10 k Hz);"laminated"core structure is useful for suppressing eddy current loss; the effective permeability of the core has increased observably after adding flux concentrators to the two ends of the core; the chopper amplifier is a useful method to suppress 1/f noise for reducing the GEMIS's output noise; the indoor calibration scheme based on"long straight solenoid"proposed to obtain sensor sensitivity. Accordingly,the problem how to reduce the noise of GEMIS is urgent need to be solved,which will improve the performance of GEMIS. And there is plenty of work requires further study on parameters ' optimization of coil and core. In the future,miniaturization,intelligence and three-axis measurement are the development directions of GEMIS.

关键词： GEMIS key technologies flux negative feedback “Laminated” corestructure flux concentrators