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Ginsenoside Rg1 ameliorates bloodebrain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3493-3507页

作者： Kefeng Zhai hong Duan Wei Wang Siyu zhao Ghulam Jilany Khan Mengting Wang Yuhan Zhang Kiran Thakur Xuemei Fang Chao Wu Jianbo Xiao zhaojun Wei Suzhou Engineering Research Center of Natural Medicine and Functional Food School of Biological and Food EngineeringSuzhou UniversitySuzhou 234000China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Department of Analytical Chemistry and Food Science Faculty of Food Science and TechnologyUniversity of Vigo-Ourense CampusOurense E-32004Spain School of Biological and Food Engineering Anhui Polytechnic UniversityWuhu 241000China Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(guangxi Normal University) Guilin 541004China Department of Pharmacology and Therapeutics Faculty of PharmacyUniversity of Central PunjabLahore 54000Pakistan

During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic *** levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and bloodebrain barrier(BBB)permeability,reduce nerve apoptosis,restore neural function and ameliorate *** evaluated the role of macrophage derived exosomes-miR-21(M-Exos-miR-21)in disrupting BBB,deteriorating TBI,and Rg1 ***-1β-induced macrophages(ⅡA)-Exos-miR-21 can activate NF-kB signaling pathway and induce the expressions of MMP-1,-3 and-9 and downregulate the levels of tight junction proteins(TJPs)deteriorating the ***1 reduced miR-21-5 p content in ⅡA-Exos(RⅡA-Exos).The interaction of NMIIAe HSP90 controlled the release of Exos-miR-21,this interaction was restricted by ***1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain,enhancing TIMP3 protein expression,MMPs proteolysis,and restricting TJPs degradation thus protected the BBB ***,Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease.

关键词： Traumatic brain injury Exosome MiRNA-21 Bloodebrain barrier Ginsenoside Rg1 Nonmuscle myosinⅡA

玉米赤霉烯酮结构类似物在免疫亲和柱柱容量实时监测中的应用

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食品安全质量检测学报 2025年第3期16卷 25-34页

作者：吴子尧马海灵吴光杰赵佳莹王李平刘仁荣江西科技师范大学生命科学学院南昌330000

目的探索一种可以在检测过程中实时监测玉米赤霉烯酮(zearalenone,ZEN)免疫亲和柱柱容量的方法。方法将两种ZEN的天然结构类似物:α-玉米赤霉烯醇(α-zearalanol,α-ZEL)、β-玉米赤霉烯醇(β-zearalanol,β-ZEL)与戊二酸酐酯化反应合成... 详细信息

目的探索一种可以在检测过程中实时监测玉米赤霉烯酮(zearalenone,ZEN)免疫亲和柱柱容量的方法。方法将两种ZEN的天然结构类似物:α-玉米赤霉烯醇(α-zearalanol,α-ZEL)、β-玉米赤霉烯醇(β-zearalanol,β-ZEL)与戊二酸酐酯化反应合成了ZEN的两种人工结构类似物(α-ZEL-G、β-ZEL-G),样品纯化后,通过荧光、紫外、高分辨率质谱法对其进行了鉴定;利用免疫亲和柱的抗体建立了竞争酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)曲线,通过半抑制浓度(half maximal inhibitory concentration,IC_(50))比较它们与抗体之间的亲和力。分别将α-ZEL-G和β-ZEL-G作为柱容量示踪物,与不同浓度的ZEN一起加入免疫亲和柱结合,探索建立一种免疫亲和柱柱容量实时监测的方法。结果ZEN、α-ZEL-G和β-ZEL-G的竞争ELISA曲线的IC_(50)分别为:2.0、1.3和10.0 ng/mL,表明α-ZEL-G与抗体的亲和力略高于ZEN,而β-ZEL-G与抗体的亲和力则明显低于ZEN与抗体的亲和力。实验结果表明:α-ZEL-G在不同柱容量的免疫亲和柱中会影响ZEN的回收率,而β-ZEL-G的加入量在柱容量50%时,不同浓度的ZEN的回收率大于80%。结论与抗体亲和力更低的β-ZEL-G更适合用于柱容量实时监测,在实际样品的检测中显示出良好的应用效果。

关键词：玉米赤霉烯酮免疫亲和柱高效液相色谱法柱容量实时监测

A CORBA-Based Integration Platform of Product Development Process Management for Concurrent Engineering

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Wuhan University Journal of Natural Sciences 2001年第3期6卷 699-703页

作者： zhao Jin min, Liu Ji hong, Guan Qiang, Jin Guo dong CAD Center, Huazhong University of Science & Technology, Wuhan 430074, China Huazhong University of Science & Technology CAD Center Wuhan China (GRID:grid.33199.31) (ISNI:***)

Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is designed and developed. The design principles for IP-PDPM are described. The system architecture and functions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.

关键词： Key words CORBA concurrent engineering integration platform product development process

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“十二五”期间聚烯烃产品开发趋势分析

合成树脂及塑料 2011年第5期28卷 1-6页

作者：赵红中国石油化工股份有限公司科技开发部北京100728

从催化剂、聚合工艺技术、产品质量和标准三方面分析了我国两大石化集团生产的聚丙烯(PP)、聚乙烯(PE)产品质量和生产工艺与先进技术和产品存在的差距,国内聚烯烃产品的新机遇以及中东等低成本产品对国内市场的挑战。提出了"十二五"期... 详细信息

从催化剂、聚合工艺技术、产品质量和标准三方面分析了我国两大石化集团生产的聚丙烯(PP)、聚乙烯(PE)产品质量和生产工艺与先进技术和产品存在的差距,国内聚烯烃产品的新机遇以及中东等低成本产品对国内市场的挑战。提出了"十二五"期间应重点开发PE100,PE125级耐压管材专用PE树脂、大中空容器专用PE树脂,特别是汽车油箱专用PE树脂;重点开发高熔体强度、透明度、结晶度、流动性能的PP树脂,这些产品广泛用于包装、汽车、家电和建筑领域。PP新产品开发的热点主要包括可用于汽车内外配件、高附加价值医用容器以及可替代金属和工程塑料的PP复合材料等。

关键词：聚烯烃产品开发趋势

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一种对等网中基于相互信任的两层信任模型

软件学报 2009年第7期20卷 1909-1920页

作者：金瑜古志民顾进广赵红武北京理工大学计算机科学技术学院北京100081 武汉科技大学计算机科学与技术学院湖北武汉430081

在P2P系统中,声誉模型是建立节点间信任关系的重要方法之一,但现有的P2P声誉模型几乎都是纯分散式的,具有信任收敛慢、信任管理复杂和网络开销大等缺点.在TLT(two-leveltrust)中,节点自发组织为信任簇,信任评价以簇为单位.每个簇由簇首... 详细信息

在P2P系统中,声誉模型是建立节点间信任关系的重要方法之一,但现有的P2P声誉模型几乎都是纯分散式的,具有信任收敛慢、信任管理复杂和网络开销大等缺点.在TLT(two-leveltrust)中,节点自发组织为信任簇,信任评价以簇为单位.每个簇由簇首和成员节点组成,簇首和成员节点之间是一种相互信任的关系:簇首为了提高自身的簇间服务信任,利用簇内服务信任观察成员节点的服务性能,过滤恶意的成员节点;成员节点为了提高服务声誉和接受更好的服务,利用代理信任考察簇首的管理能力.分析和仿真结果表明:在TLT中,节点的信任值收敛快,恶意行为能够被快速识别;TLT可扩展性好,如信任管理简单和网络开销小.

关键词：对等网络信任声誉两层安全

On-line Preconcentration and Determination of Trace Metals in Water Samples by Flow Injection Combined with Flame Atomic Absorption Spectrometry via Calix[4]arene Carboxylic Acid Packed Micro-column

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Chemical Research in Chinese Universities 2012年第1期28卷 26-30页

作者： GUO Da-wang, zhao Xiao-wei, JIA Qiong and ZHOU Wei-hong College of Chemistry, Jilin University, Changchun 130012, P. R. China Jilin Univ Coll Chem Changchun 130012 Peoples R China

An adsorbent calix[4]arene carboxylic acid was employed as the adsorption material for on-line flow in jection（FI） micro-column preconcentration coupled with flame atomic absorption spectrometry（FAAS） determination of trace heavy metals（Cu, Pb, Co, Ni and Cd）. Parameters such as the pH, loading time and flow rate of sample, and the concentration, volume and flow rate of eluent were optimized. The enrichment factors are 50.0, 56.5, 11.6, 12.1 and 19.1 for Cu, Pb, Co, Ni, and Cd, respectively, and a sample throughput of 20 h–1 was obtained. The limits of de tection for Cu, Pb, Co, Ni, and Cd were in a range of 1.56―3.91 μg/L, and the relative standard deviations（RSDs） were less than 2.76%（n=7）. Furthermore, the proposed method was successfully applied to the determination of Cu, Pb, Co, Ni, and Cd in certified reference materials and various water samples.

关键词： Calixarene carboxylic acid Preconcentration Flow injection Metal ion Flame atomic absorptionspectrometry(FAAS)

Factors influencing the sperm retrieval rate of microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome

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Asian Journal of Andrology 2023年第6期25卷 704-707页

作者： De-Feng Liu Han Wu Zhe Zhang Kai hong Hao-Cheng Lin Jia-Ming Mao Hui-Yu Xu Lian-Ming zhao Hui Jiang Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Department of Urology Peking University Third HospitalBeijing 100191China

To investigate the factors affecting the sperm retrieval rate of microdissection testicular sperm extraction(micro-TESE)in patients with nonmosaic Klinefelter syndrome(KS),64 patients with nonmosaic KS who underwent micro-TESE in the Center for Reproductive Medicine of Peking University Third Hospital(Beijing,China)between January 2016 and December 2017 were included in the *** on medical history,physical examination and laboratory examination results,and micro-TESE outcomes were *** were divided into two groups according to micro-TESE *** following factors were compared between the two groups by the Mann‒Whitney U test or Student’s t-test based on the distribution(nonnormal or normal)of the factors:age,testicular size,follicle-stimulating hormone level,luteinizing hormone level,testosterone level,and anti-Müllerian hormone *** overall success rate of sperm retrieval was 50.0%.Correlation analysis showed that testicular volume was positively correlated with testosterone *** a logistic regression model,age and anti-Müllerian hormone levels were found to be better predictors for the sperm retrieval rate than the other parameters.

关键词： Klinefelter syndrome prediction model sperm retrieval rate

基于领域知识辅助的机器学习方法对软磁金属玻璃性能的预测

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Transactions of Nonferrous Metals Society of China 2023年第1期33卷 209-219页

作者：李鑫单光存赵鸿滨石燦鴻北京航空航天大学仪器科学与光电工程学院北京100191 香港城市大学材料科学与工程系香港特别行政区有研科技集团有限公司智能传感功能材料国家重点实验室北京100088

提出一种领域知识辅助的机器学习方法,实现对软磁金属玻璃饱和磁化强度(B_(s))和临界尺寸(D_(max))的预测。基于公开的实验数据,建立软磁合金数据库。提出一个通用的特征空间,适用于面向不同预测任务的机器学习模型训练。结果表明,机器... 详细信息

提出一种领域知识辅助的机器学习方法,实现对软磁金属玻璃饱和磁化强度(B_(s))和临界尺寸(D_(max))的预测。基于公开的实验数据,建立软磁合金数据库。提出一个通用的特征空间,适用于面向不同预测任务的机器学习模型训练。结果表明,机器学习模型的预测能力比基于物理知识的估计方法精度更高。此外,领域知识辅助的特征选择可在有效减少特征数量的同时,不显著降低模型的预测精度。最后,对软磁金属玻璃临界尺寸的二分类预测进行讨论。

关键词：金属玻璃软磁性玻璃形成能力机器学习材料描述符

Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus

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Chinese Journal of Natural Medicines 2021年第11期19卷 874-880页

作者： LIU Hui-Bo LIU zhao-Ming CHEN Yu-Chan Tan Hai-Bo LI Sai-Ni LI Dong-Li LIU hong-Xin ZHANG Wei-Min State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Chemical and Environmental Engineering Wuyi UniversityJiangmen 529020China Program for Natural Products Chemical Biology Key Laboratory of Plant Resources Conservation and Sustainable UtilizationGuangdong Provincial Key Laboratory of Applied BotanySouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus *** the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction *** potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB *** 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).

关键词： Deep-see-derived fungus Phomopsis lithocarpus 2 3-Dihydro-1H-indene isomers Benzophenone derivatives