Single-crystalline lead halide perovskite nanowires are emerging as promising one-dimensional blocks for nanoscience and nanotechnology,and extensive studies of nano-lasers and nano-photodetectors have been ***,as per...
详细信息
Single-crystalline lead halide perovskite nanowires are emerging as promising one-dimensional blocks for nanoscience and nanotechnology,and extensive studies of nano-lasers and nano-photodetectors have been ***,as perfect confined structures,their optical waveguide performances have not been widely paid attention to up to ***,we report on the such issue on single-crystalline CsPbBr3nanowires and quantify it by near-field optical response *** waveguide is verified as total internal reflection mode at the visible band(532 nm),and its far-field end-facet coupling efficiency of 89.6%and propagation loss as low as 5.9 dB/mm are measured from the nanowire with cross-sectional geometry of~600 nm×300 *** evident bending loss exists in naturally curved nanowires,while it usually emerges in artificial-bended ones due to the wrinkled *** welded nanowire networks show significant advantages in integrated waveguides over the artificial assembled ones,due to the coupled photons at the space-confined end-facet *** surface reasoned by lattice degradation is detrimental to propagation loss,but it provides leaked channels for waveguide coupling on nanowire *** work studies the optical waveguide performance of perovskite nanowires with different geometries and goes a step further for integrated nanophotonics.
Advancements in high-throughput sequencing(HTS)of antibody repertoires(Ig-Seq)have unprecedentedly improved our ability to characterize the antibody repertoires on a large ***,currently,only a few studies explored the...
详细信息
Advancements in high-throughput sequencing(HTS)of antibody repertoires(Ig-Seq)have unprecedentedly improved our ability to characterize the antibody repertoires on a large ***,currently,only a few studies explored the influence of chronic HIV-1 infection on human antibody repertoires and many of them reached contradictory conclusions,possibly limited by inadequate sequencing depth and *** better understand how HIV-1 infection would impact humoral immune system,in this study,we systematically analyzed the differences between the IgM(HIV-IgM)and IgG(HIV-IgG)heavy chain repertoires of HIV-1 infected patients,as well as between antibody repertoires of HIV-1 patients and healthy donors(HH).Notably,the public unique clones accounted for only a negligible proportion between the HIV-IgM and HIV-IgG repertoires libraries,and the diversity of unique clones in HIV-IgG remarkably *** aspect of somatic mutation rates of CDR1 and CDR2,the HIV-IgG repertoire was higher than ***,the average length of CDR3 region in HIV-IgM was significant longer than that in the HH repertoire,presumably caused by the great number of novel VDJ rearrangement patterns,especially a massive use of ***,some of the B cell clonotypes had numerous clones,and somatic variants were detected within the clonotype lineage in HIV-IgG,indicating HIV-1 neutralizing *** in-depth characterization of HIV-IgG and HIV-IgM repertoires enriches our knowledge in the profound effect of HIV-1 infection on human antibody repertoires and may have practical value for the discovery of therapeutic antibodies.
The rapidly growing global data usage has demanded more efficient ways to utilize the scarce electromagnetic spectrum resource. Recent research has focused on the development of efficient multiplexing techniques in th...
详细信息
The rapidly growing global data usage has demanded more efficient ways to utilize the scarce electromagnetic spectrum resource. Recent research has focused on the development of efficient multiplexing techniques in the millimeter-wave band(1-10 mm, or 30-300 GHz) due to the promise of large available bandwidth for future wireless networks. Frequency-division multiplexing is still one of the most commonly-used techniques to maximize the transmission capacity of a wireless *** on the frequency-selective tunnelling effect of the low-loss epsilon-near-zero metamaterial waveguide, we numerically and experimentally demonstrate five-channel frequency-division multiplexing and demultiplexing in the millimeter-wave *** show that this device architecture offers great flexibility to manipulate the filter Q-factors and the transmission spectra of different channels, by changing of the epsilon-near-zero metamaterial waveguide topology and by adding a standard waveguide between two epsilon-near-zero channels. This strategy of frequency-division multiplexing may pave a way for efficiently allocating the spectrum for future communication networks.
We fabricated a three-dimensional microstructured optical waveguide(MOW)in a single-crystal using femtosecond-laser writing and phosphoric acid etching techniques,and observed excellent midinfrared waveguiding perform...
详细信息
We fabricated a three-dimensional microstructured optical waveguide(MOW)in a single-crystal using femtosecond-laser writing and phosphoric acid etching techniques,and observed excellent midinfrared waveguiding performance with low loss of^0.5 d B∕*** with a periodic arrangement were written inside the yttrium aluminum garnet(YAG)crystal via femtosecond laser inscription,and then etched by the phosphoric acid(H3 PO4)to form hollow *** evolution of the microstructure of tracks was investigated in *** function of the MOW was analyzed by different numerical methods,indicating the proposed MOW can effectively operate in quasi-single-mode pattern in the midinfrared wavelength range,which agrees well with our experiment results.
With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-w...
详细信息
With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.
Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence...
详细信息
Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the cat...
详细信息
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.
Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from...
详细信息
Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.
暂无评论