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Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages

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Journal of Molecular Cell Biology 2020年第7期12卷 543-555页

作者： Yi Rang Na Daun Jung Juha Song Jong-Wan Park Jung Joo hong Seung Hyeok seok Macrophage Lab Department of Microbiology and Immunology and Institute of Endemic DiseaseSeoul National University College of MedicineChongno-guSeoul 03080Republic of Korea Department of Biomedical Science BK21-Plus Education ProgramSeoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea Department of Pharmacology Seoul National University College of MedicineJongno-guSeoul 03080Republic of Korea Cancer Research Institute and Ischemic/Hypoxic Disease Institute Seoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea National Primate Research Center Korea Research Institute of Bioscience and BiotechnologyCheongju 28116Republic of Korea

Interleukin-10(IL-10)is the most potent anti-inflammatory cytokine in the body and plays an essential role in determining outcomes of many inflammatory *** metabolism is a critical determinant of immune cell function;however,it is currently unclear whether metabolic processes are specifically involved in IL-10 *** this study,we aimed to find the central metabolic molecule regulating IL-10 production of macrophages,which are the main producers of *** analysis identified that metabolic changes were predominantly enriched in Kupffer cells at the early inflammatory phase of a mouse endotoxemia *** them,pyruvate dehydrogenase kinase(PDK)-dependent acute glycolysis was negatively involved in IL-10 *** or knockdown of PDK selectively increased macrophage IL-10 ***,PDK inhibition increased IL-10 production via profound phosphorylation of adenosine monophosphate(AMP)-activated protein kinase alpha 1(AMPKα1)by restricting glucose uptake in lipopolysaccharide-stimulated ***α1 consequently activated p38 mitogen-activated protein kinase,c-Jun N-terminal kinase,and cyclic AMP-responsive element-binding protein to regulate IL-10 *** study uncovers a previously unknown regulatory mechanism of IL-10 in activated macrophages involving an immunometabolic function of PDK.

关键词： macrophage pyruvate dehydrogenase kinase AMP-activated protein kinase interleukin-10

2022 HP special volume:Interdisciplinary high pressure science and technology

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Matter and Radiation at Extremes 2023年第6期8卷 1-3页

作者： Ho-kwang Mao Bin Chen Huiyang Gou Kuo Li Jin Liu Lin Wang hong Xiao Wenge Yang Center for High Pressure Science and Technology Advanced Research 10 Xibeiwang East RoadHaidianBeijing 100094China

High pressure science and technology is a vast area of inter-disciplinary research that encompasses the fields of physics,chem-istry,geoscience,and materials science and in which the science of ordinary matter is only a special case under ambient ***,the physical variable of force exerted on the chem-ical bonding of a material,directly controls the material’s phys-ical and chemical properties.

关键词： properties. ambient ordinary

Highly Concentrated,Conductive,Defect-free Graphene Ink for Screen-Printed Sensor Application

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Nano-Micro Letters 2021年第6期13卷 17-30页

作者： Dong seok Kim Jae-Min Jeong hong Jun Park Yeong Kyun Kim Kyoung G.Lee Bong Gill Choi Department of Chemical Engineering Kangwon National UniversitySamcheokGangwon-do 25913Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Center for Nano Bio Development National Nanofab CenterDaejeon 34141Republic of Korea

Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible ***,the application of graphene fillers is limited by their restricted mass production and the low concentration of their *** this study,a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process.A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL^(−1)for graphene *** screen-printed graphene conductor exhibits a high electrical conductivity of 1.49×10^(4)S m^(−1)and maintains high conductivity under mechanical bending,compressing,and fatigue *** on the as-prepared graphene ink,a printed electrochemical sodium ion(Na^(+))sensor that shows high potentiometric sensing performance was ***,by integrating a wireless electronic module,a prototype Na^(+)-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a *** scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost,reproducible,and large-scale printing of flexible and wearable electronic devices.

关键词： Graphene ink Fluid dynamics Screen printing Ion sensor Real-time monitoring

Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes

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Nano Research 2020年第5期13卷 1347-1353页

作者： Young-Geun Park Eunkyung Cha Hyeon seok An Kyoung-Pil Lee Myoung Hoon Song hong Kyun Kim Jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Department of Ophthalmology School of MedicineKyungpook National UniversityDaegu41944Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases,such as age-related macular degeneration,because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal ***,the current phototherapeutic devices are opaque,bulky,and tethered forms,so they are not feasible for use in continuous treatment during the patient’s daily ***,we report wireless,wearable phototherapeutic devices with red light-emitting diodes for continuous *** light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact ***,fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not ***,these devices were operated wirelessly with control of the light *** addition,in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices.

关键词： transparent electronics wearable healthcare red light-emitting diodes phototherapies

Does robot-assisted laparoscopic radical prostatectomy enable to obtain adequate oncological and functional outcomes during the learning curve?From the Korean experience

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Asian Journal of Andrology 2009年第2期11卷 167-175页

作者： Young Hwii Ko Jeong Hyeon Ban seok Ho Kang hong seok Park Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon Vipul RPatel Department of Urology MIS&Robotic Urologic Surgery CenterKorea University School of MedicineSeoul 136705Korea Global Robotics Institute University of Central FloridaFlorida HospitalOrlandoFL 32803USA

To estimate the short-term results of robot-assisted laparoscopic radical prostatectomy(RALRP)during the learning curve,in terms of surgical,oncological and functional outcomes,we conducted a prospective survey on *** July 2007,a single surgeon performed 63 robotic prostatectomies using the same operative *** data,including pathological and early functional results of the patient,were collected prospectively and *** with the accumulation of the cases,the total operative time,setup time,console time and blood loss were significantly *** major complication was present in any *** was needed in six patients;all of them were within the initial 15 *** positive surgical margin rate was 9.8%(5/51)in pT2 *** most frequent location of positive margin in this stage was the lateral aspect(60%),but in pT3 disease multiple margins were the most frequent(41.7%).Overall,53(84.1%)patients had totally continent status and the median time to continence was 6.56 *** 17 patients who maintained preoperative sexual activity(Sexual Health Inventory for Men≥17),stage below pT2,followed up for>6 months with minimally one side of neurovascular bundle preservation procedure,12(70.6%)were capable of intercourse postoperatively,and the mean time for sexual intercourse after operation was 5.7 *** this series,robotic prostatectomy was a feasible and reproducible technique,with a short learning curve and low perioperative complication *** during the initial phase of the learning curve,satisfactory results were obtained with regard to functional and oncological outcome.

关键词： learning curve outcomes assessment radical prostatectomy robotics

High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction mode

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Asian Journal of Andrology 2010年第2期12卷 164-170页

作者： Young Hwii Ko Yu Jeong Woo Jin Wook Kim Hoon Choi seok Ho Kang Jeong Gu Lee Je Jong Kim hong seok Park Jun Cheon Department of Urology Korea University School of MedicineSeoul 136-705Korea

To evaluate the role of high-dose dietary zinc in the process of prostate malignancy,60 Sprague-Dawley rats were randomly divided into four groups：tumor induction with carcinogen and hormone （group 1）,oral zinc administration without tumor induction （group 2）,oral zinc administration with tumor induction （group 3） and a control without zinc administration or tumor induction （group 4）. Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group （P = 0.082）,intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g^-1,respectively. However,in group 3,zinc levels increased in both lobes to 59.3 and 12.1 μg g^-1,respectively,comparable with that of group 4 （54.5±14.6 and 14.1±2.4 μg g^-1）. In spite of these increases in zinc concentration,the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 （53.3% and 46.7%） compared with group 1 （33.3% and 33.3%） in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4,zinc administration did induce prostate intraepithelial neoplasm in group 2 （46.7% and 40.0%）. Thus,although high dietary zinc increased intraprostatic zinc concentrations,it promoted,instead of preventing,prostate intraepithelial neoplasm in a murine prostate malignancy induction model.

关键词： experimental animal model prostatic cancer prostatic intraepithelial neoplasia zinc

Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第9期14卷 1394-1398页

作者： hong seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan hong Woo Song Ha Randy L Jirtle Department of Radiation Oncology The Catholic University of Korea School of Medicine SeoulKorea Department of Radiation Oncology Gyeongsang National University Postgraduate School of MedicineGyeongsang Institute of Health Sciences Jinju 660-702Korea Department of Radiation Oncology The Catholic University of Korea School of MedicineSeoulKorea Department of Radiation Oncology Gyeongsang National University Postgraduate School of MedicineGyeongsang Institute of Health SciencesJinju 660-702 Korea Department of Surgery Gyeongsang National UniversityPostgraduate School of MedicineJinju 660-702Korea Department of Surgery Gyeongsang National University Postgraduate School of MedicineJinju 660-702Korea Department of Radiation Oncology Duke University Medical CenterDurhamNCUnited States

AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients.

关键词： Loss of heterozygosity Mannose 6-phosphate/ insulin-like growth factor 2 receptor Hepatocellular

Effects of Applied Stresses on Martensite Transformation in AISI4340 Steel

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Journal of Iron and Steel Research International 2007年第6期14卷 63-67页

作者： ZHAO hong zhuang seok-jae LEE Young-kook LEE LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China Department of Metallurgical Engineering Yonsei University Seoul 120-749 South Korea

This study aims at the experimental analysis of the transformation induced plasticity （TRIP） phenomenon. Experiments are conducted in which martensite is allowed to grow under the influence of a series of externally applied stresses. The magnitude of the applied stresses is less than 67% of the yield strength of austenite σγ （Ts）. Since there is no obvious difference between the transformation plasticity under tension and the compression for the lower applied stresses, only compressive stresses are applied. The results confirm that the transformation plasticity is proportional to the applied stress if the latter does not exceed 67 % of σγ （Ts）. The TRiP-strain, the kinetics, and their dependence on the applied stresses are studied. The comparison between calculated results and experimental results shows that the model accurately describes the phenomenon.

关键词： applied stress TRIP martensite transformation low-alloy steel

Iatrogenic atlantoaxial rotatory subluxation after thyroidectomy in a pediatric patient:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3351-3355页

作者： Woo-Joon hong Jung-Kil Lee Jong-Hwan hong Moon-Soo Han Shin-seok Lee Department of Neurosurgery Chonnam National University Hospital&Medical SchoolGwangju 61469South Korea Department of Rheumatology Department of Internal MedicineChonnam National University Medical School&HospitalGwangju 61469South Korea

BACKGROUND Atlantoaxial rotatory subluxation(AARS)is an uncommon disease with a greater prevalence among children than adults,and it is mostly associated with *** spinal injury accounts for a low percentage of ***,in AARS,20%-40%of cases are associated with surgery,and 48%are caused by ***,we describe our experience with a case of iatrogenic AARS after general *** SUMMARY A 12-year-old girl presented with right-sided torticollis and cervical motion *** patient had undergone thyroidectomy 2 mo *** tomography revealed AARS with bilateral locked *** the failure of repeated external reduction under general anesthesia,the patient underwent an open surgical *** patient gained atlantoaxial alignment without any ***-up radiographs showed a normal appearance without *** cervical spine of children is more predisposed to injury due to anatomical and biomechanical *** secondary to infection and surgery is known as Grisel’s syndrome,which involves non-traumatic *** cases of AARS after surgery and other procedures with no evidence of inflammation have been *** experience shows that surgery requiring hyperextension of the neck after general anesthesia should also be included as a risk *** Surgeons and anesthesiologists should be careful not to excessively extend the neck during pediatric ***,clinicians caring for pediatric patients with recent head and neck procedures must be aware of common AARS presentations.

关键词： Atlantoaxial joint Joint subluxation Adolescent Grisel’s syndrome Case report