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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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An Explicit Exact Solution of a Nonlinear Schrödinger Equation for Short Ultraintense Laser Pulse in an Underdense Plasma

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Chinese Physics Letters 1996年第8期13卷 561-564页

作者： GAO hong-jun Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088

A nonlinear Schrödinger equation for short ultraintense laser pulses in an underdense plasma has been discussed,and three types explicit exact solutions of this equation are obtained by using analytical method.

关键词： method intense equation

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基于三矩形谐振腔非通MIM波导的四重法诺传感

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原子与分子物理学报 2025年第3期42卷 116-123页

作者：王叶壮沈宏君陈俊坤王雅雯宁夏大学物理学院银川750000

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共... 详细信息

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共振.采用了有限时域差分方法计算了此结构的传输特性与Z方向的归一化磁场,并详细分析了其法诺共振的产生机理.通过计算结构几何参数调节后的透射光谱,从而得出了四处法诺共振峰透射率和共振位置可以通过改变结构几何参数而获得独立调节.此外还发现在结构中添加不同浓度的葡萄糖溶液可以实现高折射率传感灵敏度(S),获得最高灵敏度2736.98nm/RIU,可以看出此结构对于折射率变化有很高的灵敏度,这为设计和优化纳米级别的折射率传感器提供了新的思路,还可以应用于电路构建前进行性能测试.

关键词：金属-绝缘体-金属传感器谐振腔法诺共振灵敏度

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Volume-preserving Fields and Reeb Fields on 3-manifolds

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Acta Mathematica Sinica,English Series 2006年第4期22卷 971-988页

作者： hong jun LI Science College Xi'an Jiaotong University Xi'an 710049 P. R. China

Volume-preserving field X on a 3-manifold is the one that satisfies LxΩ = 0 for some volume Ω. The Reeb vector field of a contact form is of volume-preserving, but not conversely. On the basis of Geiges-Gonzalo＇s parallelization results, we obtain a volume-preserving sphere, which is a triple of everywhere linearly independent vector fields such that all their linear combinations with constant coefficients are volume-preserving fields. From many aspects, we discuss the distinction between volume-preserving fields and Reeb-like fields. We establish a duality between volume-preserving fields and h-closed 2-forms to understand such distinction. We also give two kinds of non-Reeb-like but volume-preserving vector fields to display such distinction.

关键词： Volume-preserving fields Contact forms Reeb-like fields Volume-preserving sphere Poisson matrices

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Experimental Investigation of Vibration Response of A Free-Hanging Flexible Riser Induced by Internal Gas-Liquid Slug Flow

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China Ocean Engineering 2018年第6期32卷 633-645页

作者： ZHU hong-jun ZHAO hong-lei GAO Yue State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University

The vibration response of a free-hanging flexible riser induced by internal gas-liquid slug flow was studied experimentally in a small-diameter tube model based on Froude number criterion. The flow regime in a curved riser model and the response displacements of the riser were simultaneously recorded by high speed cameras. The gas superficial velocity ranges from 0.1 m/s to 0.6 m/s while the liquid superficial velocity from 0.06 m/s to 0.3 m/*** slugging type 3, unstable oscillation flow and relatively stable slug flow were observed in the considered flow rates. Severe slugging type 3 characterized by premature gas penetration occurs at relatively low flow rates. Both the cycle time and slug length become shorter as the gas flow rate increases. The pressure at the riser base undergoes a longer period and larger amplitude of fluctuation as compared with the other two flow regimes. Additionally, severe slugging leads to the most vigorous in-plane vibration. However, the responses in the vertical and horizontal directions are not synchronized. The vertical vibration is dominated by the second mode while the horizontal vibration is dominated by the first mode. Similar to the vortex-induced vibration, three branches are identified as initial branch, build-up branch and descending branch for the response versus the mixture velocity of gas-liquid flow.

关键词： gas-liquid two-phase flow severe slugging liquid slug flexible riser flow-induced vibration

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More attention should be paid to the treatment of male infertility with drugs---testosterone： to use it or not？

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Asian Journal of Andrology 2014年第2期16卷 270-273,I0010页

作者： hong-jun Li Urological Department of the Peking Union Medical College Hospital (PUMCH) Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Testosterone replacement is strictly contraindicated for the treatment of male infertility was the advanced view from the ＇2013 European Association of Urology （EAU） guidelines on male infertility＇, and this view brings extensive concern and questions. Although sufficient numbers of well-performed and controlled clinical trials that provide evidence supporting drug treatment of male infertility are not available at present, the opportunity to prove that these drugs are effective should not be prevented, and rigorous examination of drug therapy should be encouraged and strengthened. Therefore, I believe the above conclusion in the EAU guidelines is poorly conceived.

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Flow-Induced Vibration of Four Cantilever Cylinders Arranged in A Square Configuration

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China Ocean Engineering 2021年第6期35卷 891-904页

作者： ZHU hong-jun LIU Wen-li WANG jun-lei State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450000China

Flow-induced vibration(FIV)of four separately mounted cantilever cylinders are experimentally investigated in a water *** four cylinders with top ends screwed vertically into a turntable platform are subjected to uniform flows with Reynolds number ranging from 3840 to 16520.A non-intrusive measurement with high-speed cameras is employed to simultaneously capture the time-varying in-line and cross-flow vibrations in the reduced velocity range of *** results highlight the continuous adjustment of flow regime caused by the spatial-temporal alteration of ***,the space-time varying flow interference contributes to the occurrence of multiple response *** transition from a dominant frequency to a broad-band response illustrates the enhancement of wake *** combination of wake flow interactions results in the irregular oscillation trajectories and the appearance of a response trough with the associated switching in vortex shedding *** dual-resonance phenomenon is observed in the four cylinders due to the complicated wake-structure *** greatest mechanical energy possessed by the four cylinders in an in-line square arrangement is mainly resulted from the downstream cylinders,signifying the positive role of wake excitation in extracting hydrokinetic energy from ambient flow.

关键词： flow-induced vibration mechanical energy cantilever cylinder time-varying spacing attack angle

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Numerical Simulation of the Vortex-Induced Vibration of A Curved Flexible Riser in Shear Flow

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China Ocean Engineering 2018年第3期32卷 301-311页

作者： ZHU hong-jun LIN Peng-zhi State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of fully three-dimensional(3 D) numerical simulations of flow past a free-to-oscillate curved flexible riser in shear flow were conducted at Reynolds number of 185–1015. The numerical results obtained by the two-way fluid–structure interaction(FSI) simulations are in good agreement with the experimental results reported in the earlier study. It is further found that the frequency transition is out of phase not only in the inline(IL) and crossflow(CF) directions but also along the span direction. The mode competition leads to the non-zero nodes of the rootmean-square(RMS) amplitude and the relatively chaotic trajectories. The fluid–structure interaction is to some extent reflected by the transverse velocity of the ambient fluid, which reaches the maximum value when the riser reaches the equilibrium position. Moreover, the local maximum transverse velocities occur at the peak CF amplitudes, and the values are relatively large when the vibration is in the resonance regions. The 3 D vortex columns are shed nearly parallel to the axis of the curved flexible riser. As the local Reynolds number increases from 0 at the bottom of the riser to the maximum value at the top, the wake undergoes a transition from a two-dimensional structure to a 3 D one. More irregular small-scale vortices appeared at the wake region of the riser, undergoing large amplitude responses.

关键词： vortex-induced vibration flexible riser shear flow fluid–structure interaction computational fluid dynamics

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Relative Quasisymmetry and Quasim?bius Mappings in Quasi-metric Spaces

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Acta Mathematica Sinica,English Series 2022年第3期38卷 547-559页

作者： hong jun LIU Xiao jun HUANG Yue FAN School of Mathematical Sciences Guizhou Normal UniversityGuiyang550001P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing401331P.R.China

The aim of this paper is to investigate the relationship between relative quasisymmetry and quasimöbius in quasi-metric spaces,and show that a homeomorphism f isη-quasisymmetric relative to A if and only if it isθ-q... 详细信息

关键词： Quasisymmetric mapping quasimobius mapping three-point condition quasi-metric space

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Effects of operating parameters on the flow field in slab continuous casting molds with narrow widths

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 238-248页

作者： Tao Zhang Jian Yang Gang-jun Xu hong-jun Liu jun-jun Zhou Wei Qin State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China Hunan Valin Lianyuan Iron&Steel Co. Ltd.Loudi 417000China

Computational simulations and high-temperature measurements of velocities near the surface of a mold were carried out by using the rod deflection method to study the effects of various operating parameters on the flow field in slab continuous casting(CC)molds with narrow widths for the production of automobile exposed *** agreement between the calculated results and measured subsurface velocities of liquid steel was obtained under different operating parameters of the CC *** simulation results reveal that the flow field in the horizontal plane located 50 mm from the meniscus can be used as the characteristic flow field to optimize the flow field of molten steel in the *** in casting speed can increase the subsurface velocity of molten steel and shift the position of the vortex core downward in the downward circulation *** flow field of liquid steel in a 1040 mm-wide slab CC mold can be improved by an Ar gas flow rate of 7 L·min^−1 and casting speed of 1.7 m·min^−*** the present experimental conditions,the double-roll flow pattern is generally stable at a submerged entry nozzle immersion depth of 170 mm.

关键词： flow field rod deflection method continuous casting narrow width numerical simulation operating parameters

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