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Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： hong geum-lan KIM Kyung-Hyun CHO Sung-Pil LEE Hui-Ju KIM Yae-Ji JUNG Ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

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The extract of Celtis choseniana Nakai alleviates testosterone-in-duced benign prostatic hyperplasia through inhibiting 5αreductase type 2 and the Akt/NF-κB/AR pathway

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Chinese Journal of Natural Medicines 2022年第7期20卷 518-526页

作者： hong geum-lan KIM Tae-Won LEE Hui-Ju KIM Yae-Ji KIM Kyung-Hyun JUNG Ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Republic of Korea

Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged *** choseniana Nakai(***)is medicinally used to alleviate pain,gastric disease,and lung *** this study,the effect of *** extract on BPH was investigated using testosterone-induced *** Dawley rats were divided into five groups:control,BPH(testosterone 5 mg·kg^(−1)),Fina(finasteride 2 mg·kg^(−1)),and ***(50 and 100 mg·kg^(−1)).After four weeks of TP treatment with finasteride or ***,prostate weights and DHT levels were *** addition,the prostates were histopathologically examined and measured for protein kinase B(Akt)/nuclear factor-κB(NF-κB)/AR signaling,proliferation,apoptosis,and ***-state weight and epithelial thickness were reduced in the *** groups compared with that in the BPH *** extract of *** acted as a 5αreductase inhibitor,reducing DHT levels in the ***,the extract of *** blocked the activation of p-Akt,nuclear NF-κB activation and reduced the expression of AR and PSA compared with ***,the ex-pression of Bax,PARP-1,and p53 increased,while the expression of bcl-2 *** present study demonstrated that ***-ana extract alleviated testosterone-induced BPH by suppressing 5αreductase and Akt/NF-κB activation,reducing AR signaling and in-ducing apoptosis and autophagy in the *** results suggested that *** probably contain potential herbal agents to alleviate BPH.

关键词： Apoptosis Androgen receptor Benign prostate hyperplasia Celtis choseniana Nakai 5α-Reductase type 2 NF-κB

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Numerical Simulations of Snow Accumulation in the Bogie Region of a Train Considering Snow Particle Rotation

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2337-2352页

作者： hong lan Jiye Zhang Yao Zhang Lu Cai State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China College of Railway Transportation Hunan University of TechnologyZhuzhou412000China GD Midea Air-Conditioning Equipment Co. Ltd.Foshan528311China

To investigate the influence of snow particle rotational motion on the accumulation of snow in the bogie region of high-speed trains,an Euler‒Lagrange numerical approach is *** study examines the effects of snow particle diameter and train speed on the ensuing *** is shown that considering snow particle rotational motion causes significant deviation in the particle trajectories with respect to non-rotating *** a deviation increases with larger snow particle diameters and higher train *** snow accumulation on the overall surface of the bogie increases,and the amount of snow on the vibration reduction device varies *** certain conditions,the amount of accumulated snow can increase by several orders of magnitudes.

关键词： High-speed train bogie snow particle rotation discrete phase model snow accumulation

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Microstructure Evolution and Nanomechanical Behavior of Micro-Area in Molten Pool of Selective Laser Melting(CoCrNi)_(82)Al_(9)Ti_(9)High-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1019-1033页

作者： hong-Wei Zhang Li-Wei lan Zhe-Yu Yang Chang-Chun Li Wen-Xian Wang College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Ministry of Education Key Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyTaiyuan030024China Shanxi-Zhejiang University New Materials and Chemical Research Institute Taiyuan030032China

In this work,the phase evolution mechanism and nanomechanical properties of(CoCrNi))(82)Al_(9)Ti_(9)high-entropy alloy(HEA)prepared by selective laser melting(SLM)in the molten pool were *** HEA contains multiple primary elements and undergoes high-temperature gradient and rapid cooling during *** leads to significant inhomogeneity of nano-scale microstructure characteristics and instability of *** optimizing process parameters,the microstructure evolution at the optimal parameter volume energy density of 440 J/mm^(3)was studied.A phase transition from BCC to FCC occurred in the melt *** the micro-area of the melt pool results in a temperature rise and the combustion-induced loss of Al ***,the Ni element content increases significantly outside the melt *** process enhances the phase stability of FCC and facilitates phase ***,rapid cooling leads to the formation of distinctive ultrafine equiaxial crystals inside the melt pool,accompanied by the generation of intracrystalline needle-like nano-scale *** the melt pool,the accumulation of energy results in the formation of coarse ***,the nano-hardness inside the molten pool is remarkably high at 11.79 GPa,while the outside the molten pool is reduced to 9.58 *** the fracture toughness outside the melt pool also *** with inside the melt pool,the residual stress outside the melt pool changed from compressive to tensile stress and decreased from 603.28 to 322.84 MPa.

关键词： High-entropy alloys Selective laser melting Microstructure evolution Nanoindentation

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Model for estimating the weight-loss ratio of damaged Korla fragrant pears

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 261-266页

作者： Yang Liu Yurong Tang hong Zhang Hao Niu Haipeng lan College of Mechanical and Electrical Engineering Tarim UniversityAlaer 843300XinjiangChina College of Water Resources and Architectural Engineering Tarim UniversityAlaer 843300XinjiangChina

To predict the weight-loss ratio of Korla fragrant pears effectively,improve commodity value and study the variation laws of the weight-loss ratio of damaged fragrant pears during storage,this study predicted the weight-loss ratio of fragrant pears by utilizing the generalized regression neural network(GRNN),support vector regression(SVR),partial least squares regression(PLSR)and error back propagation neural network(BPNN).The prediction performances of GRNN,SVR,PLSR and BPNN models were compared comprehensively,and the optimal model was *** addition,the optimal prediction model was *** results show that weight-loss ratio of fragrant pears increases gradually with the extension of storage *** storage,the weight-loss ratio of fragrant pears is positively related to the degree of *** trained GRNN,SVR,PLSR and BPNN models can be used to predict the weight-loss ratio of fragrant *** BPNN model is the most accurate in predicting the weight-loss ratio of damaged fragrant pears(R^(2)=0.9929;RMSE=0.2138).It has also been proved to have good predictive effect in production practice(R^(2)=0.9377,RMSE=0.7138).The research findings can provide references to predict the delivery quality and time of delivery of Korla fragrant pears.

关键词： Korla fragrant pears weight-loss ratio damages storage time

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Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： Xu Ren Yong-Ping Qu Chun-lan Zhu Xiao-hong Xu hong Jiang Yi-Xia Lu hong-Peng Xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

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Wigner function of optical cumulant operator and its dissipation in thermo-entangled state representation

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Chinese Physics B 2024年第6期33卷 205-210页

作者：张科李兰兰范洪义 School of Electronic Engineering Huainan Normal UniversityHuainan 232038China Department of Material Science and Engineering University of Science and Technology of ChinaHefei 230026China

To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive the general evolution formula of the Wigner function, and its relation to Weyl correspondence is also discussed. The method of integration within the ordered product of operators is essential to our discussion.

关键词： Wigner function optical cumulant operator dissipation evolution thermo-entangled state representation integration within ordered product of operators

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A Selenium Atom Involved Covalent Organic Framework for Window Ledge Photocatalytic Oxidation of Sulfides

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Chinese Journal of Chemistry 2024年第17期42卷 1960-1966页

作者： Fan Yang Xia Li hong-Yan Qu Jing-lan Kan Yuan Guo Yu-Bin Dong College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Normal UniversityJinanShandong250014China School of Light Industry and Engineering Qilu University of Technology(Shandong Academy of Sciences)JinanShandong 250353China

Covalent organic frameworks(coFs)driven photocatalytic organic transformations especially photooxidation reactions have become a fertile topic and attracted numerous research *** the charge generation and transport process is the key factor for achieving high catalytic *** one of the most effective strategies,the introduction of"heavy atoms"into the long-range ordered conjugated backbones can effectively facilitate the intersystem crossing(isc)process and hence improve the generation of active oxygens,which is beneficial for the *** this work,we designed and synthesized a benzoselenadiazole based covalent organic framework(COF)material,BSe-COF with heavy atom of selenium(Se),and a benzothiadiazole based BT-COF with isomorphic backbone for comparison.

关键词： Covalent organic framework Benzoselenadiazole Density functional theory Heavy atom Photocatalysis Photooxidation Singletoxygen Window ledge reaction

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Synthesis,phase transformation and applications of CeCO_(3)OH:A review

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Journal of Rare Earths 2024年第8期42卷 1403-1420,I0001页

作者： Zhou Zou Weihao Tian Xisong Mao Junqi Li Yuanpei lan Chaoyi Chen hong Yong Sohn Junshan Zhang Fengyuan Liu Department of Metallurgical Engineering College of Materials and MetallurgyGuizhou UniversityGuiyang55025China Guizhou Province Key Laboratory of Metallurgical Engineering and Process Energy Saving Guiyang550025China Guizhou Provincial University Key Laboratory of High-Performance Battery Materials Guiyang550025China Department of Materials Science and Engineering University of UtahSalt Lake CityUT84112USA

CeCO_(3)OH has a unique crystal structure and excellent optical,electronic and catalytic properties,which has been widely investigated for many ***,ceria obtained from CeCO_(3)OH has a morphology that is similar to that of the precursor,and the CeO_(2)-based products obtained from CeCO_(3)OH exhibit outstanding properties,such as catalytic performances,owing to their designed morphology and oxygen vacancies(OVs).To introduce CeCO_(3)OH into a wider range of potential researchers,we first systematically review the physico-chemical properties,synthesis,reaction and morphology tuning mechanism of CeCO_(3)OH,and summarize the conversion behavior from CeCO_(3)OH to ***,we thoroughly survey the applications of CeCO_(3)OH and its conversion *** for further investigations of CeCO_(3)OH are also made in this *** is hoped that the exhaustive co mpilation of the valuable properties and considerable potential investigations of CeCO_(3)OH will promote further applications of CeCO_(3)OH and CeO_(2)-based functional materials.

关键词： CeCO_(3)OH Morphology tuning CeO_(2) Catalyst lanthanide compounds Rare earths

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Effects of heat treatment on microstructures and properties of a heterostructured alloy with dissimilar components fabricated by WAAM

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Rare Metals 2024年第9期43卷 4441-4461页

作者： Ming-Cai Pan Jun-Qiang Xu Yong Peng Ning-Ning Liang Si lan Qi Zhou Ke-hong Wang School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Controlled Arc Intelligent Additive Manufacturing Technology Nanjing 210094China

Heat treatment significantly influences homogeneous material microstructures and mechanical properties,which can be improved by an optimal heat treatment ***,heat treatment application to heterogeneous materials presents significant challenges due to compositional and microstructural ***,a laminated heterostructured alloy comprising alternating316L stainless steel(SS)and 18Ni300 maraging steel(MS)layers fabricated using wire and arc additive manufacturing was investigated.A solution treatment was applied at900℃for 0.5 ***,the solution-treated and asfabricated(AF)samples were aged at 500℃for 4 h;these samples were denoted SA and AT,*** AT phase compositions and orientations were similar to those of *** SA 316L SS layer resembled that of AF,but the SA 18Ni300 MS layers exhibited a reduced austenite phase fraction and refined grain size,attributable to solid-state *** the AT sample,aging induced the formation of nanoscale acicularωphase and ellipsoidal Ni_(3)Ti,Fe_(2)Mo,and X precipitates in the 18Ni300 MS ***,the SA precipitates contained acicular Fe Ni_(2)and ellipsoidalω,Ni_(3)Ti,and X precipitates,and their fractions were lower than those in AT ***18Ni300 MS layer microhardness in the heat-treated samples increased due to nanoprecipitation,but the 316L SS layer microhardness resembled that of *** AT and SA ultimate tensile strengths increased to(1360±50)and(1473±41)MPa,respectively,attributable to precipitation *** SA 316L SS layer exhibited a high stress-induced martensite fraction,enhancing the ductility of heated samples.

关键词： Laminated heterostructured alloy Heat treatment Wire and arc additive manufacturing Microstructure Mechanical property

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