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Biomedical and Environmental Sciences 2024年第3期37卷 325-330页

作者： MU hong Yun zhou hong Lei JING Zheng LU Wei ZHANG Jian Wei Jiangsu Agri-animal Husbandry Vocational College Taizhou 225300JiangsuChina Boehringer Ingelheim Animal Health(Shanghai)Co. LTD.Shanghai 200040China

Feline calicivirus(FCV)was a highly prevalent RNA virus causing upper respiratory tract infections in cats through the mouth and nose around the world,result in the death of cats especially under 1 year old with upper respiratory tract disease(URTD)and virulent systemic disease(FCV-VSD)[1].Infected cats usually presented with mouth ulcers,salivation and ***,both recovered cats and asymptomatic carriers can still carry and spread the FCV virus for extended periods of time,contributing to the potential for *** presented a significant threat to the health and lives of cats,and rare wildlife and took a heavy financial loss on the pet industry,making the prevention and control of the virus ***,rapid identification of FCV in clinical samples was necessary to prevent the spread of FCV and avoid financial loss.

关键词： prevention respiratory Probe

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： Yulu Shi Quan Kang hong zhou Xiaohan Yue Yang Bi Qing Luo Stem Cell Biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few known differentia-tion inducers,and little research has been done on their *** differentiation is associated with an increase in mitochondrial content and *** metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as well as up-regulation of aerobic glycolysis and pentose phosphate ***-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated with tumorigenesis and progression,as well as cancer cell *** found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and *** of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathway,promoted oxidative phosphorylation,and led to osteogenic *** also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro *** LETM1 was knocked down in vivo,there was reduced tumor formation and lung *** data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdown of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathway,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness

Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15

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Protein & Cell 2024年第7期15卷 547-552页

作者： Fumiaki Ito Hanjing Yang Z.hong zhou Xiaojiang S.Chen Molecular and Computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States California NanoSystems Institute University of CaliforniaLos AngelesCA90095United States Genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris Comprehensive Cancer Center University of Southern CaliforniaLos AngelesCA 90089United States Center of Excellence in NanoBiophysics University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,Coronaviruses have evolved a wide array of tactics to evade host antiviral *** host cells detect invading foreign nucleic acids including viral genome and viral replication intermediates,they activate interferon(IFN)signaling via cytoplasmic pattern recognition receptors(Kang et al.,2002;Kato et al.,2006).Remarkable stealth activities exhibited by coronaviruses are facilitated by a series of non-structural proteins(Nsps),such as Nsp15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is a uridine-specific endoribonuclease that mediates evasion of host detection of viral double-stranded RNA(dsRNA)(Bhardwaj et al.,2004;Deng et al.,2017;Frazier et al.,2021;Ivanov et al.,2004).Nsp15 targets a polyuridine[poly(U)]tract on the coronavirus negative strand RNA(Hackbart et al.,2020).Nsp15 limits the abundance and length of poly(U)within the negative strand RNA 5ʹ-extension by trimming down the initially synthesized poly(U)lead sequence to the optimal length that can suppress dsRNA formation but still serves as a template for poly(A)tail of the positive strand genome of the coronaviruses(Hofmann and Brian,1991).

关键词： p15 interferon template

Two Monte Carlo-based simulators for imaging-system modeling and projection simulation of flat-panel X-ray source

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Nuclear Science and Techniques 2024年第7期35卷 31-46页

作者： Meng-Ke Qi Ting He Yi-Wen zhou Jing Kang Zeng-Xiang Pan Song Kang Wang-Jiang Wu Jun Chen Ling-hong zhou Yuan Xu School of Biomedical Engineering Southern Medical UniversityGuangzhou510515China State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou510275China Department of Radiotherapy Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510515China

The advantages of a flat-panel X-ray source(FPXS)make it a promising candidate for imaging *** imaging-system modeling and projection simulation are critical for analyzing imaging performance and resolving overlapping projection issues in *** conventional analytical ray-tracing approach is limited by the number of patterns and is not applicable to FPXS-projection ***,the computation time of Monte Carlo(MC)simulation is independent of the size of the patterned arrays in *** study proposes two high-efficiency MC projection simulators for FPXS:a graphics processing unit(GPU)-based phase-space sampling MC(gPSMC)simulator and GPU-based fluence sampling MC(gFSMC)*** two simulators comprise three components:imaging-system modeling,photon initialization,and physical-interaction simulations in the ***-system modeling was performed by modeling the FPXS,imaging geometry,and *** gPSMC simulator samples the initial photons from the phase space,whereas the gFSMC simulator performs photon initialization from the calculated energy spectrum and fluence *** entire process of photon interaction with the geometry and arrival at the detector was simulated in parallel using multiple GPU kernels,and projections based on the two simulators were *** accuracies of the two simulators were evaluated by comparing them with the conventional analytical ray-tracing approach and acquired projections,and the efficiencies were evaluated by comparing the computation *** results of simulated and realistic experiments illustrate the accuracy and efficiency of the proposed gPSMC and gFSMC simulators in the projection calculation of various phantoms.

关键词： Flat-panel X-ray source(FPXS) Imaging-system modeling Projection simulation Monte Carlo-based simulators

Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

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Petroleum Science 2024年第1期21卷 567-581页

作者： Chong Lin Qi-Cong Xu Lie-Xiang Han Gao Li Hai He hong-Ling zhou Ji-Ping She CCDC Drilling&Production Technology Research Institute Guanghan618300SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key Lab of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(LCM)is a regular preventive and remedial measure for lost ***,conventional LCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling *** conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid ***,softer,and less frictional LCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** drilling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing

Multiscale and Auto-Tuned Semi-Supervised Deep Subspace Clustering and Its Application in Brain Tumor Clustering

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Computers, Materials & Continua 2024年第6期79卷 4741-4762页

作者： Zhenyu Qian Yizhang Jiang zhou hong Lijun Huang Fengda Li Khin Wee Lai Kaijian Xia School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China Department of Medical Imaging The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Department of Neurosurgery The Changshu Affiliated Hospital of Soochow UniversityChangshu215500China Department of Scientific Research The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Changshu Key Laboratory of Medical Artificial Intelligence and Big Data Suzhou215500China Department of Biomedical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data,particularly in the field of medical *** deep subspace clustering algorithms,which are mostly unsupervised,are limited in their ability to effectively utilize the inherent prior knowledge in medical *** MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process,thereby enhancing the discriminative power of the feature ***,the multi-scale feature extraction mechanism is designed to adapt to the complexity of medical imaging data,resulting in more accurate clustering *** address the difficulty of hyperparameter selection in deep subspace clustering,this paper employs a Bayesian optimization algorithm for adaptive tuning of hyperparameters related to subspace clustering,prior knowledge constraints,and model loss *** experiments on standard clustering datasets,including ORL,Coil20,and Coil100,validate the effectiveness of the MAS-DSC *** results show that with its multi-scale network structure and Bayesian hyperparameter optimization,MAS-DSC achieves excellent clustering results on these ***,tests on a brain tumor dataset demonstrate the robustness of the algorithm and its ability to leverage prior knowledge for efficient feature extraction and enhanced clustering performance within a semi-supervised learning framework.

关键词： Deep subspace clustering multiscale network structure automatic hyperparameter tuning semi-supervised medical image clustering

Deep learning-based lung sound analysis for intelligent stethoscope

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Military Medical Research 2024年第4期11卷 567-588页

作者： Dong-Min Huang Jia Huang Kun Qiao Nan-Shan Zhong hong-zhou Lu Wen-Jin Wang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina The Third People’s Hospital of Shenzhen Shenzhen 518112GuangdongChina Guangzhou Institute of Respiratory Health China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Auscultation is crucial for the diagnosis of respiratory system ***,traditional stethoscopes have inherent limitations,such as inter-listener variability and subjectivity,and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in *** emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and *** this basis,machine learning,particularly deep learning,enables the fully-automatic analysis of lung sounds that may pave the way for intelligent *** review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence(AI)in this *** focus on each component of deep learning-based lung sound analysis systems,including the task categories,public datasets,denoising methods,and,most importantly,existing deep learning methods,i.e.,the state-of-the-art approaches to convert lung sounds into two-dimensional(2D)spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung ***,this review highlights current challenges in this field,including the variety of devices,noise sensitivity,and poor interpretability of deep *** address the poor reproducibility and variety of deep learning in this field,this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://***/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis.

关键词： Deep learning Lung sound analysis Respiratory sounds

Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease

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World Journal of Diabetes 2024年第1期15卷 92-104页

作者： Lu-Lu Han Sheng-Hai Wang Ming-Yan Yao hong zhou Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Diabetic kidney disease(DKD),characterized by increased urinary microalbumin levels and decreased renal function,is the primary cause of end-stage renal *** pathological mechanisms are complicated and multifactorial;Therefore,sensitive and specific biomarkers are *** exosome originate from diverse renal cells in nephron segments and partially mirror the pathological changes in the *** microRNAs(miRNAs)in urinary exosome are remark-ably stable and highly tissue-specific for the *** Type 2 diabetic mellitus(T2DM)patients were recruited from the Second Hospital of Hebei Medical University and were divided into two groups:DM,diabetic pa-tients without albuminuria[urinary albumin to creatinine ratio(UACR)<30 mg/g]and DKD,diabetic patients with albuminuria(UACR≥30 mg/g).Healthy subjects were the normal control(NC)*** exosomal miR-145-5p,miR-27a-3p,and miR-29c-3p,were detected using real-time quantitative polymerase chain *** correlation between exosomal miRNAs and the clinical in-dexes was *** diagnostic values of exosomal miR-145-5p and miR-27a-3p in DKD were determined using receiver operating characteristic(ROC)*** functions of miR-145-5p were investigated by performing RESULTS Urinary exosomal expression of miR-145-5p and miR-27a-3p was more upregulated in the DKD group than in the DM group(miR-145-5p:4.54±1.45 vs 1.95±0.93,P<0.001;miR-27a-3p:2.33±0.79 vs 1.71±0.76,P<0.05)and the NC group(miR-145-5p:4.54±1.45 vs 1.55±0.83,P<0.001;miR-27a-3p:2.33±0.79 vs 1.10±0.51,P<0.001).The exosomal miR-145-5p and miR-27a-3p positively correlated with albuminuria and serum creatinine and negatively correlated with the estimated glomerular filtration ***-27a-3p was also closely related to blood glucose,gly-cosylated hemoglobin A1c,and low-density lipoprotein *** analysis revealed that miR-145-5p had a better area under the curve of 0.88[95%confidence interval(CI):0.784-0.985

关键词： Urinary exosome MicroRNA-145-5p MicroRNA-27a-3p Diabetic kidney disease Diagnostic biomarkers

Lactonization of dyes promoted by a coordination cage facilitates cavity-induced chromism as ion mobile detector

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Science China Chemistry 2024年第5期67卷 1554-1560页

作者： Liangliang Zhang Yu Liang Zhifeng Xiao Yuxuan Meng Jinyi Huang Xi Lin Ji Li hong-Cai zhou Yu Fang Strait Institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal University and Strait Laboratory of Flexible Electronics(SLoFE)Fuzhou 350017China State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Chemistry Texas A&M UniversityCollege StationTexas 77842-3012USA State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi’an 710072China

Dye molecules often change colors(so-called “chromism”) according to the environment variation. However, they are rarely induced by a catalytic amount of cavity. Through encapsulation in the cavity of a porous coordination cage(PCC-2), Rhodamine B(1) is transformed from red quinonoid form(1q) into colorless lactone form(1l) in aprotic polar solutions. The μ4-OH groups in the cavity of PCC-2 are shown to stabilize the uncommon zwitterion intermediate(1z), followed by converting to 1l, thus accelerating the equilibrium. The chromism is catalyzed by 0.25 mol% of PCC-2, and the reaction rate is improved by 80,400times. 1@PCC-2 can be further fabricated to a sol-gel that exhibits ion recognition properties. The resulting encapsulation and stabilization of an unconventional intermediate by a catalytic amount of the coordination cage provides fundamental insights into molecular isomerization and has potential use in chemical sensing.

关键词： porous coordination cage Zwitterion intermediate cavity Rhodamine B chromism

High-efficiency sodium storage of Co_(0.85)Se/WSe_(2) encapsulated in N-doped carbon polyhedron via vacancy and heterojunction engineering

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Carbon Energy 2024年第1期6卷 94-107页

作者： Ya Ru Pei hong Yu zhou Ming Zhao Jian Chen Li Xin Ge Wei Zhang Chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchunChina Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy Materials Electron Microscopy CenterJilin UniversityChangchunChina

With the advantage of fast charge transfer,heterojunction engineering is identified as a viable method to reinforce the anodes'sodium storage ***,vacancies can effectively strengthen the Na+adsorption ability and provide extra active sites for Na+***,their synchronous engineering is rarely ***,a hybrid of Co_(0.85)Se/WSe_(2) heterostructure with Se vacancies and N-doped carbon polyhedron(CoWSe/NCP)has been fabricated for the first time via a hydrothermal and subsequent selenization *** aberration-corrected transmission electron microscopy confirms the phase interface of the Co_(0.85)Se/WSe_(2) heterostructure and the existence of Se *** functional theory simulations reveal the accelerated charge transfer and enhanced Na+adsorption ability,which are contributed by the Co_(0.85)Se/WSe_(2) heterostructure and Se vacancies,*** expected,the CoWSe/NCP anode in sodium-ion battery achieves outstanding rate capability(339.6 mAh g^(−1) at 20 A g^(−1)),outperforming almost all Co/W-based selenides.

关键词： Co_(0.85)Se/WSe_(2)heterostructure density functional theory simulations N-doped carbon polyhedron Se vacancies sodium-ion batteries